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Recurrence and cancerization of ameloblastoma: multivariate analysis of 87 recurrent craniofacial ameloblastoma to assess risk factors associated with early recurrence and secondary ameloblastic carcinoma

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Chinese Journal of Cancer Research 2017年第3期29卷 189-195页

作者： rong yang Zheqi liu Sandhya Gokavarapu Canbang Peng wei Cao Tong Ji Department of Oral and Maxillofacial-Head and Neck Oncology Shanghai Stomatology Key LaboratoryShanghai Ninth People's HospitalShanghai Jiao Tong University School of Medicine Head&Neck Oncology Reconstructive Surgery Department of Surgical OncologyKrishna Institute of Medical Science

Objective: The recurrence and progression of ameloblastoma are unpredictable. Therefore, we examined the influence of clinical factors on recurrence time and analyzed the clinical factors associated with early recurrence and cancerization. We then developed a staging system to predict early recurrence and cancerization. Methods: All of the primary craniofacial ameloblastoma patients treated in Shanghai Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine were recorded. There were 87 recurrent cases used to create a staging system and tested in a Cox regression analysis for risk factors associated with early recurrence or cancerization following surgery. Results: There were 890 craniofacial ameloblastoma patients, and 72 cases had recurrence. There were also 15 cases with cancerous recurrence. The overall recurrence rate was 9.78%, and the cancer rate was 1.69%. The primary cases were classified into the following 3 stages based on clinicopathological features: stage I, the maximum tumor diameter 6 cm or tumor invasion to the maxilla sinus/orbital floor/soft tissue; and stage III, tumor invasion of the skull base or metastasis into regional lymph nodes. When the method of surgery was controlled by partial correlation, the staging had significance with recurrence time (P=0.004). The Cox analysis showed the tumor stage was correlated with recurrence time (P=0.027) and cancerization time (P=0.002). However, the surgical method did not influence the recurrence time when adjusted for cofounding variables. Conclusions: Tumor larger than 6 cm and invasion to soft tissues or adjacent anatomical structures are associated with early recurrence. This staging system can be used to predict the risk factors of early recurrence and cancerization in ameloblastoma patients.

关键词： Recurrence ameloblastoma stage ameloblastic carcinoma cancerization

Au nanoclusters anchored on TiO_(2) nanosheets for high-efficiency electroreduction of nitrate to ammonia

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Nano Research 2024年第3期17卷 1209-1216页

作者： Miaosen yang Tianran wei Jia He Qian liu Ligang Feng Hongyi Li Jun luo Xijun liu School of Chemical Engineering Northeast Electric Power UniversityJilin 132012China Nanchang Institute of Technology Nanchang 330044China State Key Laboratory of Chemistry and Utilization of Carbon Based Energy Resources College of ChemistryXinjiang UniversityUrumqi 830017China State Key Laboratory of Featured Metal Materials and Life-cycle Safety for Composite Structures Guangxi Key Laboratory of Processing for Non-Ferrous Metals and Featured MaterialsSchool of ResourcesEnvironment and MaterialsGuangxi UniversityNanning 530004China Institute for New Energy Materials and Low-Carbon Technologies School of Materials Science and EngineeringTianjin University of TechnologyTianjin 300384China Institute for Advanced Study Chengdu UniversityChengdu 610106China School of Chemistry and Chemical Engineering Yangzhou UniversityYangzhou 225002China Guangzhou Panyu Polytechnic Guangzhou 511483China ShenSi Lab Shenzhen Institute for Advanced StudyUniversity of Electronic Science and Technology of ChinaLonghua DistrictShenzhen 518110China

Electrocatalytic nitrate reduction reaction(NO_(3)RR)offers a unique rationale for green NH_(3) synthesis,yet the lack of high-efficiency NO_(3)RR catalysts remains a great *** this work,we show that Au nanoclusters anchored on TiO_(2) nanosheets can efficiently catalyze the conversion of NO_(3)RR-to-NH_(3) under ambient conditions,achieving a maximal Faradic efficiency of 91%,a peak yield rate of 1923μg·h^(-1)·mgcat.-1,and high durability over 10 consecutive cycles,all of which are comparable to the recently reported metrics(including transition metal and noble metal-based catalysts)and exceed those of pristine TiO_(2).Moreover,a galvanic Zn-nitrate battery using the catalyst as the cathode was proposed,which shows a power density of 3.62 mW·cm^(-2) and a yield rate of 452μg·h^(-1)·mgcat.-*** simulations further indicate that the atomically dispersed Au clusters can promote the adsorption and activation of NO_(3)-species,and reduce the NO_(3)RR-to-NH_(3) barrier,thus leading to an accelerated cathodic *** work highlights the importance of metal clusters for the NH_(3) electrosynthesis and nitrate removal.

关键词： NH3 electrosynthesis Zn-nitrate battery Au nanoclusters nitrate reduction reaction(NRR) TiO_(2)nanosheets

Subcellular chemical imaging of structurally similar acridine drugs by near-field laser desorption/laser postionization mass spectrometry

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Nano Research 2020年第3期13卷 745-751页

作者： Xiaoling Cheng Zhibin Yin liu rong wei Hang Department of Chemistry and the MOE Key Lab of Spectrochemical Analysis&Instrumentation College of Chemistry and Chemical EngineeringXiamen UniversityXiamen 361005China State Key Laboratory of Marine Environmental Science Xiamen UniversityXiamen 361005China

Insights into the pharmacologic effect on cellular processes and the potential toxicological effects are vital to new drug development and evaluation,yet research on these subjects remains a great challenge due to the lack of information regarding the spatiotemporal distribution of drugs and metabolites within a single *** spectrometry imaging(MSI)has proven to be a label-free and high-throughput approach for visualizing drug distribution in spatial and temporal ***,single-cell drug imaging has been limited so far by detection sensitivity and microscale lateral ***,we report near-field laser desorption/laser postionization mass spectrometry(NDPI-MS)for single-cell imaging of two structurally similar drugs,proflavine and ethacridine,and subcellular distributions of proflavine at different drug concentrations were *** NDPI-MS imaging results indicate that proflavine was accumulated in lysosomes,which was verified by laser scanning confocal microscopy(LSCM).Additionally,a distinguished subcellular distribution pattern of ethacridine from proflavine could be visualized,highlighting the complexity of the interaction between the drugs and biological environment even though these two drugs possess similar *** together,the present results demonstrate the great potential of the integrated single-cell MSI platform for characterizing the drug distribution and its phenotype changes within individual cells,expediting the identification and evaluation of newly developed drugs.

关键词： near-field mass spectrometry acridine drugs single cell imaging laser postionization

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HTAP评测基准的评测能力综述

软件学报 2025年第1期36卷 424-445页

作者：翁思扬俞融王清帅胡梓锐倪葎张蓉周烜周傲英徐泉清杨传辉刘维杨攀飞华东师范大学数据科学与工程学院蚂蚁集团OceanBase 工业和信息化部电子第五研究所

对数据库系统即时修改数据的高效实时分析需求推动了数据库系统向同时支持OLTP业务和OLAP业务两种场景的HTAP数据库系统的快速发展.面对众多的HTAP数据库系统,为了推动HTAP数据库系统的公平比较和健康发展,定义和实现相应的评测基准来评... 详细信息

对数据库系统即时修改数据的高效实时分析需求推动了数据库系统向同时支持OLTP业务和OLAP业务两种场景的HTAP数据库系统的快速发展.面对众多的HTAP数据库系统,为了推动HTAP数据库系统的公平比较和健康发展,定义和实现相应的评测基准来评估HTAP数据库系统的新特性至关重要.首先,分析HTAP数据库系统的关键特征并抽象总结HTAP数据库系统实现的关键技术.然后,提炼出HTAP数据库系统的设计难点和构建HTAP评测基准的挑战,并基于此提出HTAP评测基准应考虑的设计维度,包括数据生成、负载生成、评价指标和一致性模型支持性.对比现有HTAP评测基准在设计维度和实现技术上的差异,总结评测基准在不同设计维度上的优劣.此外,运行已公开的典型评测基准,展示并分析它们对HTAP数据库系统关键特征的评测能力以及对不同HTAP数据库系统的横向对比的支持能力.最后,总结对HTAP评测基准的能力需求和未来的一些研究方向,指出语义一致的负载控制和新鲜数据访问度量是HTAP数据库系统评测基准定义的关键问题.

关键词： HTAP评测基准 HTAP数据库系统性能分析新鲜度

Functional Characterization of an Aldehyde Dehydrogenase Homologue in Rice

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Journal of Integrative Agriculture 2012年第9期11卷 1434-1444页

作者： yang Sheng-hui NIU Xiang-li luo Di CHEN Chang-dong YU Xu TANG wei LU Bao-rong liu Yong-sheng Key Laboratory for Bio-Resource and Eco-Environment Minstry of Education~College of Life Sciences Sichuan University Chengdu 610064 P.R.Chtina College of Life Sciences Chongqing University Chongqing 400044 P.R.China Key Laboratory for Biodiversity Science and Ecological Engineering Ministry of Education~Institute of Biodiversity Science Fudan University Shanghai 200433 P.R.China

The aldehyde dehydrogenase （ALDH） superfamily of NAD（P）-dependent enzymes, in general, oxidize a wide range of endogenous and exogenous aliphatic and aromatic aldehydes to their corresponding carboxylic acids and play an essential role in detoxification of reactive oxygen species （ROS） accumulated under the stressed conditions. In order to identify genes required for the stresses responses in the grass crop Oryza sativa, a homologue of ALDH gene （OsALDH22） was isolated and characterized. OsALDH22 is conserved in eukaryotes, shares high homology with the orthologs from aldehyde dehydrogenase subfamily ALDH22. The OsALDH22 encodes a protein of 597 amino acids that in plants exhibit high identity with the orthologs from Zea mays, Sorghum bicolor, Hordeum vulgare and Arabidopsis thaliana, respectively, and the conserved amino acid characteristics for ALDHs are present, including the possible NAD~ binding site （F-V-G-S- P-G-V-G）, the catalytic site （V-T-L-E-L-G-G-K） and the Cys active site. Semi-quantitative PCR and real-time PCR analysis indicates that OsALDH22 is expressed differentially in different tissues. Various elevated levels of OsALDH22 expression have been detected when the seedlings exposed to abiotic stresses including dehydration, high salinity and abscisic acid （ABA）. Transgenic rice plants overexpressing OsALDH22 show elevated stresses tolerance. On the contrary, down- 0 regulation of OsALDH22 in the RNA interference （RNAi） repression transgenic lines manifests declined stresses tolerance.

关键词： rice (Oryza sativa) aldehyde dehydrogenase abiotic stresses stress tolerance

Impact of Carbon Chain Structures in the Backbone on the Flexibility of Modified Polyarylene Sulfide Resins: Molecular Dynamics Simulations and Mesoscopic Analysis

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Chinese Journal of Polymer Science 2024年第4期42卷 544-557页

作者： Chi Zhang rong liu Jing-Yuan liu Wen-wei Jiang Key Laboratory of Fine Chemical Engineering and Functional Materials School of Chemical EngineeringSichuan UniversityChengdu610065China

In the domain of high-performance engineering polymers, the enhancement of mechanical flexibility in poly(phenylene sulfide) (PPS) resins has long posed a significant challenge. A novel molecular structure, designated as PP-He-IS, wherein imide rings and an aliphatic hexylene chain are covalently incorporated into the PPS backbone to enhance its flexibility, is introduced in this study. Molecular dynamics (MD) simulations are employed to systematically explore the effects of diversifying the backbone chain structures by substituting phenyl units with alkyl chains of varying lengths, referred to as PP-A-IS where “A” signifies the distinct intermediary alkyl chain configurations. Computational analyses reveal a discernable decrement in the glass transition temperature (Tg) and elastic modulus, counterbalanced by an increment in yield strength as the alkyl chain length is extended. Notably, the PP-He-IS variant is shown to exhibit superior yield strength while simultaneously maintaining reduced elastic modulus and Tg values, positioning it as an advantageous candidate for flexible PPS applications. Mesoscopic analyses further indicate that structures such as PP-He-IS, PP-Pe-IS, and PP-Bu-IS manifest remarkable flexibility, attributable to the presence of freely rotatable carbon-carbon single bonds. Experimental validation confirms that a melting temperature of 504 K which is lower than that of conventional PPS, and lower crystallinity are exhibited by PP-He-IS, thereby affording enhanced processability without compromising inherent thermal stability. Novel insights into the strategic modification of PPS for mechanical flexibility are thus furnished by this study, which also accentuates the pivotal role played by molecular dynamics simulations in spearheading high-throughput investigations in polymer material modifications.

关键词： Molecular dynamics simulations Polyarylene Sulfide Main-chain modifications Flexibility Aliphatic hexylene chain

Approaching ohmic contact to two-dimensional semiconductors

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Science Bulletin 2019年第19期64卷 1426-1435页

作者： Kailang liu Peng luo wei Han Sanjun yang Shasha Zhou Huiqiao Li Tianyou Zhai State Key Laboratory of Material Processing and Die & Mould Technology School of Material Sciences and Engineering Huazhong University of Science and Technology

Two-dimensional semiconductors have attracted immense research interests owing to their intriguing properties and promising applications in electronic and optoelectronic ***,the performance of these devices is drastically hindered by the large Schottky barrier at the electric contact interface,which is hardly tunable due to the Fermi level pinning *** this review,we will analyze the root causes of the contact problems for the two-dimensional semiconductor devices and summarize the strategies on the basis of different contact geometries,aiming to lift out the Fermi level pinning effect and achieve the ohmic ***,the remarkable improvement of the device performance thanks to these optimized contacts will be *** the end,the merits and limitations of these strategies will be discussed as well,which potentially gives a guideline for handling the electric contact issues in two-dimensional semiconductors devices.

关键词： Two-dimensional semiconductor Ohmic contact Fermi level pinning Schottky barrier

Clinical observation on Wang Juyi＇s applied channel theory in treating stroke-sequel patients

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Journal of Traditional Chinese Medicine 2018年第4期38卷 593-600页

作者： luo Lu Yu Zheng yang Yuyang liu Jing Zhou wei Wang Juyi World Federation of Acupuncture-Moxibustion Societies China Academy of Chinese Medical Sciences Beijing 100700 China Pidu Distric Hospital of Traditional Chinese Medicine Sichuan 611730 China Acumox and Tuina College Beijing University of Chinese Medicine Beijing 100029 China Acupuncture-Moxibustion Department Huguosi Traditional Chinese Medicine Hospital Attached Hospital of Beijing University of Chinese Medicine Beijing 100035 China Acupuncture-Moxisbution Research Institute China Academy of Chinese Medical Sciences Beijing 100700 China

OBJECTIVE:To explore the advantages of acupuncture treatment guided by channel palpation on stroke-sequel ***:This research was randomized,traditional acupuncture controlled trial using channel palpation acupuncture to treat stroke-sequel *** 148 patients who were randomly assigned to two experimental *** treatment group,i.e,the channel palpation group was treated with *** Juyi's Channel *** in control group received acupuncture according to New Century *** patient was needled at Renzhong(GV 26),Baihui(GV 20),Neiguan(PC 6),Jiquan(HT 1),Chize(LU 5),weizhong(BL 40),Sanyinjiao(SP 6),Zusanli(ST 36),and each acupuncture treatment was modified according different syndrome differentiations including liver yang rising [Taichong(LR 3),Taixi(KI 3)],wind-phlegm blocking collaterals [Fenglong(ST 40),Hegu(LI 4)],phlegm-heat occupying in the Fu-organs [Quchi(LI11),Neiting(ST 44),Fenglong(ST 40)],Qi deficiency with blood stasis [Qihai(CV 6),Xuehai(SP 10)],Yin Deficiency with wind [Taixi(KI 3),Fengchi(GB 20)];for wry mouth,add Jiache(ST 6),Dicang(ST 4);for paralyzed arms,add Jianyu(LI 15),Quchi(LI 11),Shousanli(LI 10) and Hegu(LI 4),for paralyzed legs,add Huantiao(GB 30),Yinlingquan(SP 9) and Fengshi(GB 31).The duration of each treatment was 6 *** the Fugl-Meyer score,the Stroke Specific Quality of Life scale(SS-QOL),and the National Institute of Health Stroke Scale(NIHSS) were assessed before treatments,after 6 and 12 weeks of treatments to evaluate the acupuncture effect in each *** data were collected and analyzed after the completion of treatment by SPSS 17 using paired sample ***:Totally 148 participants were recruited,and 136 eligible patients were included in this *** results showed that for FMA motor function and Fugl-Meyer balance function and NIHSS,there is no statistic difference between two groups at the baseline period,after 6-week treatment and after 12-week follow-up(P > 0

关键词： Acupuncture Channel Palpation Stroke-sequel Wang Juyi

Cleaning of high antimony smelting slag from an oxygen-enriched bottom-blown by direct reduction

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Rare Metals 2019年第8期38卷 800-804页

作者： Hong-Lin luo wei liu Wen-Qing Qin Yong-Xing Zheng Kang yang School of Minerals Processing and Bioengineering Central South University

Cleaning of high antimony smelting slag from an oxygen-enriched bottom-blown was tested by direct reduction in a laboratory-scale electric *** effects of added CaO,mass ratio of coal(experimental)to coal(theoretical)(ω)and the slag type on the reduction procedure were *** contents of Sb and Au were *** contamination of the metal phase was analyzed as this may impede the economical viability of this *** initial slag,coal and CaO were mixed and homogenized before charging into the furnace,and the residual slag averagely contains 1.26 ***^-1 Au and1.17 wt% ***,the iron contamination of antimony alloy becomes unacceptably high in this case as the metal phases contain up to 10 wt% *** the slag system with mass ratio of SiO2:FeO:CaO= 45:27:18,the residual slag obtained after reduction under these conditions averagely contains98 % in all experiments which is proved to be an economic and cleaning process.

关键词： High antimony slag Direct cleaning reduction Gold