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Transcranial photobiomodulation with near-infrared light:a promising therapeutic modality for Alzheimer's disease

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Neural Regeneration Research 2023年第9期18卷 1944-1945页

作者： hanli liu Damir Nizamutdinov Jason H.Huang Bioengineering Department the University of Texas at ArlingtonArlingtonTXUSA Neurosurgery Neuroscience InstituteBaylor Scott and White HealthTempleTXUSA Neurosurgery College of MedicineTexas A&M UniversityTempleTXUSA

Transcranial photobiomodulation(tPBM) is a noninvasive neuromodulation technique that delivers near-infrared(NIR) light with low irradiance(i.e.,power density in mW/cm2) in the wavelength range of 800-1070 *** recently published books or collected literature(Hamblin,2019;GonzalezLima,2021) and papers(Nizamutdinov et al. 2022)offer comprehensive reviews of the mechanism of action and potential clinical translations of tPBM for the treatment of a variety of diseases,including neurodegenerative diseases(Alzheimer’s disease(AD),and Parkinson’s disease),traumatic brain injury.

关键词： Alzheimer diseases

A DUAL-MODALITY OPTICAL BIOPSY APPROACH FOR IN VIVO DETECTION OF PROSTATE CANCER IN RAT MODEL

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Journal of Innovative Optical Health Sciences 2011年第3期4卷 269-277页

作者： VIKRANT SHARMA NIMIT PATEL JINHUI SHEN LIPING TANG GEORGE ALEXANDRAKIS hanli liu Department of Bioengineering Joint Graduate Program between University of Texas at Arlington and University of Texas Southwestern Medical Center University of Texas at Arlington TX 76019USA

Ultrasound-guided biopsy procedure for prostate cancer diagnosis,which is the current gold standard,involves quasi-random sampling of prostate tissue without any functional *** this study,we discuss the possibility to augment the detection of prostate cancer using a dual-modality optical approach,which can be coupled with the current needle biopsy *** techniques are light reflectance spectroscopy(LRS)that uses a broadband light source and a CCD array spectrometer,and auto-fluorescence lifetime measurement(AFLM)that uses a custom-designed,time-correlated single photon counting(TCSPC)*** LRS and AFLM were employed sequentially in this study to measure cancer tissue along with control tissue on a rat prostate tumor *** an excitation wavelength of 447 nm,we investigated auto-fluorescence decay curves at the emission wavelengths of 532,562,632 and 684 nm for in vivo and ex vivo *** results show that auto-fluorescence lifetimes at all measured emission wavelengths differ between control and cancerous tissues with 100% specificity and ***,absolute values of hemoglobin derivatives and scattering coe±cient were quantified using in vivo *** part of study also demonstrates that light scattering and absorption are significantly different between the control and cancerous ***,the study demonstrates that both LRS and AFLM may provide several intrinsic biomarkers for in vivo detection of prostate cancer.

关键词： Prostate cancer light reflectance spectroscopy auto-fluorescence lifetime

CDCA5基因在子宫颈癌组织细胞中表达变化及对肿瘤细胞增殖的影响

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山东医药 2024年第20期64卷 11-15页

作者：黄爱敏刘艳宋翰刘晗黎王希波山东第二医科大学临床医学院山东潍坊261042 潍坊市人民医院妇科

目的观察细胞分裂周期相关蛋白5(CDCA5)基因在子宫颈癌组织细胞中的表达变化,观察CDCA5基因过表达对子宫颈癌细胞增殖能力的影响,并探讨可能的分子机制。方法收集子宫颈癌组织和癌旁正常组织各60例,培养人宫颈上皮永生化细胞系H8和人... 详细信息

目的观察细胞分裂周期相关蛋白5(CDCA5)基因在子宫颈癌组织细胞中的表达变化,观察CDCA5基因过表达对子宫颈癌细胞增殖能力的影响,并探讨可能的分子机制。方法收集子宫颈癌组织和癌旁正常组织各60例,培养人宫颈上皮永生化细胞系H8和人子宫颈癌细胞系SiHa、C-33A、MS751、HeLa,采用实时荧光定量PCR法检测组织和细胞中的CDCA5 mRNA。将CDCA5 mRNA相对表达量最低的子宫颈癌细胞随机分为对照组、过表达组,分别转染pCDH空载体质粒、CDCA5过表达质粒,采用CCK-8实验、克隆形成实验检测细胞增殖能力,Western blotting法检测细胞中的p-ERK、p-AKT蛋白。结果子宫颈癌组织中CDCA5 mRNA相对表达量高于癌旁组织(P<0.05);子宫颈癌细胞系SiHa、C-33A、MS751、HeLa中CDCA5 mRNA表达高于H8细胞,其中HeLa细胞中相对表达量最低(P均<0.05)。过表达组24、48、72 h细胞增殖能力高于对照组,过表达组细胞平板克隆形成数量及p-ERK、p-AKT蛋白表达高于对照组(P均<0.05)。结论 CDCDA5基因在子宫颈癌组织、细胞中高表达,CDCDA5基因过表达可增强人子宫颈癌细胞的增殖能力,该作用可能与调控ERK/AKT信号通路有关。

关键词：细胞分裂周期相关蛋白5 子宫颈癌细胞增殖 ERK/AKT信号通路

RETINOBLASTOMA RELATED 1 switches mitosis to meiosis in rice

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Plant Communications 2024年第6期5卷 193-212页

作者： Yongjie Miao hanli You Huixin liu Yangzi Zhao Jiangzhe Zhao Yafei Li Yi Shen Ding Tang Baohui liu Kewei Zhang Zhukuan Cheng Guangdong Provincial Key Laboratory of Plant Adaptation and Molecular Design Innovative Center of Molecular Genetics and EvolutionSchool of Life SciencesGuangzhou UniversityGuangzhou 510006China Jiangsu Key Laboratory of Crop Genomics and Molecular Breeding/Zhongshan Biological Breeding Laboratory/Key Laboratory of Plant Functional Genomics of the Ministry of Education Agricultural College of Yangzhou UniversityYangzhou 225009China State Key Laboratory of Plant Genomics Institute of Genetics and Developmental BiologyInnovation Academy for Seed DesignChinese Academy of SciencesBeijing 100101China Zhejiang Provincial Key Laboratory of Biotechnology on Specialty Economic Plants Department of BiologyCollege of Life SciencesZhejiang Normal UniversityJinhua 321004China Jiangsu Co-Innovation Center for Modern Production Technology of Grain Crops/Jiangsu Key Laboratory of Crop Genetics and Physiology Yangzhou UniversityYangzhou 225009China

The transition from mitosis to meiosis is a critical event in the reproductive development of all sexually reproducing ***,the mechanisms that regulate this process in plants remain largely ***,we find that the rice(Oryza sativa L.)protein RETINOBLASTOMA RELATED 1(RBR1)is essential to the transition from mitosis to *** of RBR1 function results in hyper-proliferative sporogenous-celllike cells(SCLs)in the anther locules during early stages of reproductive *** hyperproliferative SCLs are unable to initiate meiosis,eventually stagnating and degrading at late developmental stages to form pollen-free *** results suggest that RBR1 acts as a gatekeeper of entry into ***,cytokinin content is significantly increased in rbr1 mutants,whereas the expression of type-B response factors,particularly LEPTO1,is significantly *** the known close association of cytokinins with cell proliferation,these findings imply that hyper-proliferative germ cells in the anther locules may be attributed to elevated cytokinin concentrations and disruptions in the cytokinin *** a genetic strategy,the association between germ cell hyper-proliferation and disturbed cytokinin signaling in rbr1 has been *** summary,we reveal a unique role of RBR1 in the initiation of meiosis;our results clearly demonstrate that the RBR1 regulatory module is connected to the cytokinin signaling pathway and switches mitosis to meiosis in rice.

关键词： RETINOBLASTOMA RELATED1 meiosis initiation cytokinin rice

Reconstructions for Continuous-Wave Diffuse Optical Tomography by a Globally Convergent Method

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Journal of Applied Mathematics and Physics 2014年第5期2卷 204-213页

作者： Jianzhong Su Yueming liu Zi-Jing Lin Steven Teng Aubrey Rhoden Natee Pantong hanli liu Department of Mathematics University of Texas at Arlington Arlington Texas USA Department of Bioengineering University of Texas at Arlington Arlington Texas USA

In this paper, a novel reconstruction method is presented for Near Infrared (NIR) 2-D imaging to recover optical absorption coefficients from laboratory phantom data. The main body of this work validates a new generation of highly efficient reconstruction algorithms called “Globally Convergent Method” (GCM) based upon actual measurements taken from brain-shape phantoms. It has been demonstrated in earlier studies using computer-simulated data that this type of reconstructions is stable for imaging complex distributions of optical absorption. The results in this paper demonstrate the excellent capability of GCM in working with experimental data measured from optical phantoms mimicking a rat brain with stroke.

关键词： Inverse Problems Diffuse Optical Tomography Medical and Biological Imaging Globally Convergence Method

Street Lamp Status Warning System Based on Internet of Things Technology

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Journal of Electronic Research and Application 2024年第4期8卷 154-160页

作者： hanli Wang Yuanzhi liu Yilin Wu College of Computer and Control Engineering Northeast Forestry UniversityHarbin 150040China College of Civil Engineering and Transportation Northeast Forestry UniversityHarbin 150040China College of Wildlife and Nature Reserves Northeast Forestry UniversityHarbin 150040China

This paper proposes a street light warning system based on Internet of Things(IoT)technology,which uses cameras to detect moving targets such as vehicles and pedestrians around the system and adjust the brightness of street lights according to road conditions to reduce unnecessary power *** system has a mature self-fault detection mechanism and is equipped with a wireless communication device for data exchange and timely communication with the host computer *** intelligent street lamp system in this paper can be used to reduce the occurrence of pedestrian and vehicle accidents at intersections,and at the same time reduce the consumption of manpower and material resources for street lamp troubleshooting,to achieve energy conservation and emission reduction.

关键词： Internet of Things Early warning system Intelligent transportation

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农村社会风险防控比较研究

经济问题探索 2007年第2期 60-64页

作者：刘汉利中国人民武装警察部队学院河北廊坊065000

本文首先说明了中国农村社会风险的区域差别及共有的问题,然后阐述了中国各地防控农村社会风险的不同特点,接着探讨了国外防控农村社会风险的独特经验,最后根据比较提出了中国各地共同适用的防控农村社会风险的对策。

关键词：农村社会风险防控比较研究中国

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欧拉羊种用母羊18月龄前阶段性培育试验

畜牧兽医杂志 2024年第3期43卷 9-12页

作者：刘汉丽万玛吉马登录张潭瑛张玉珍宫玉霞蔺成友杨秀兰徐才让甘南州畜牧工作站甘肃甘南747000

对2组60只体况相近的初生欧拉羊母羔羊采取不同方式培育,通过对饲养18月龄以来体重、体尺等主要表型性状的指标分析。结果表明:试验组羔羊初生到18月龄生长发育呈持续增长态势。断奶、6月龄、12月龄、18月龄体重比对照组分别提高5.15 kg... 详细信息

对2组60只体况相近的初生欧拉羊母羔羊采取不同方式培育,通过对饲养18月龄以来体重、体尺等主要表型性状的指标分析。结果表明:试验组羔羊初生到18月龄生长发育呈持续增长态势。断奶、6月龄、12月龄、18月龄体重比对照组分别提高5.15 kg、5.58 kg、6.31 kg、6.86 kg,差异极显著(P<0.01)。平均体高较对照组分别提高2.15 cm、2.24 cm、2.16 cm、2.37 cm,差异极显著(P<0.01)。平均体长较对照组分别提高2.68 cm、3.17 cm、3.41 cm、4.16 cm,差异极显著(P<0.01);平均胸围较对照组分别提高1.63 cm、2.72 cm,3.78 cm、4.43 cm,除断奶平均胸围指标差异显著(P<0.05)外,6月龄、12月龄和18月龄差异均极显著(P<0.01)。胸深、胸宽两项指标分别较对照组提高1.12 cm、1.27 cm、1.35 cm、1.29 cm,1.84 cm、1.60 cm、1.10 cm、1.89 cm,差异显著(P<0.05)。日增重、断奶成活率、周岁成活率均比对照组高,差异极显著(P<0.01)。试验组羊主要生产性能达到《欧拉羊》DB62/T490品种标准中特、一级羊水平,种用价值高,培育效果显著,对照组羊主要生产性能只达到3级羊标准,不能选留为种用。因此,“放牧+有效补饲”培育是高寒牧区藏羊资源优化利用较合理的方式。

关键词：欧拉羊繁殖特性适配年龄种羊培育藏羊资源优化利用有效补饲

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党组性质党委的初次尝试与历史经验——早期军政委员会考略

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武警学院学报 2021年第11期37卷 44-50页

作者：刘汉利中国人民警察大学公安政治学院河北廊坊065000

军政委员会是在特定历史条件下产生的,它孕育于军事政治苏维埃构想,产生于长征前夕,建立于红军改编时期,发展于全面抗战时期。军政委员会制度在诞生早期与党组性质党委制度在本质上具有一致性。在早期军政委员会制度下,党的绝对领导取... 详细信息

军政委员会是在特定历史条件下产生的,它孕育于军事政治苏维埃构想,产生于长征前夕,建立于红军改编时期,发展于全面抗战时期。军政委员会制度在诞生早期与党组性质党委制度在本质上具有一致性。在早期军政委员会制度下,党的绝对领导取得了一些珍贵的历史经验,这些经验对于党组性质党委的建设具有重要的启示意义。

关键词：党组性质党委早期军政委员会历史经验