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A perspective on age-related changes in cell environment and risk of neurodegenerative diseases

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Neural Regeneration Research 2024年第4期19卷 719-720页

作者： alice Y.liu Department of Cell Biology and Neuroscience Rutgers State University of New JerseyPiscatawayNJUSA

“Age-related neurodegenerative disease”underscores human age as the primary risk factor for disease development:Alzheimer’s,Parkinson’s,and Huntington’s disease(HD)as *** for the age-dependent delay in disease manifestation,in particular for autosomal dominant forms of the disease,and the underlying cause(s)of specific neuron dysfunction and death to manifest as memory loss,anxiety,depression,and agitation in disease subjects remain *** are interested in understanding age-related changes in cell environment that can modulate the structure,function,aggregation.

关键词： Huntington Alzheimer death

Deciphering the epitranscriptome： A green perspective

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Journal of Integrative Plant Biology 2016年第10期58卷 822-835页

作者： alice Burgess School of Biological Sciences The University of Adelaide South Australia 5005 Australia School of Agriculture Food and Wine The WaiteResearch Institute The University of Adelaide South Australia 5005 Australia The University of Adelaide and Shanghai Jiao Tong University Joint International Centre for Agriculture and Health Joint International Research Laboratory of Metabolic & Developmental Sciences AdelaideAustralia

The advent of high-throughput sequencing technol- ogies coupled with new detection methods of RNA modifica- tions has enabled investigation of a new layer of gene regulation - the epitranscriptome. With over loo known RNA modifications, understanding the repertoire of RNA modifications is a huge undertaking. This review summarizes what is known about RNA modifications with an emphasis on discoveries in plants. RNA ribose modifications, base methyl- ations and pseudouridylation are required for normal develop- ment in Arabidopsis, as mutations in the enzymes modifying them have diverse effects on plant development and stress responses. These modifications can regulate RNA structure, turnover and translation. Transfer RNA and ribosomal RNA modifications have been mapped extensively and their functions investigated in many organisms, including plants. Recent work exploring the locations, functions and targeting of N6-methyladenosine （m^6A）, 5-methylcytosine （m^5C）, pseudour- idine （up）, and additional modifications in mRNAs and ncRNAs are highlighted, as well as those previously known on tRNAs and rRNAs. Many questions remain as to the exact mechanisms of targeting and functions of specific modified sites and whether these modifications have distinct functions in the different classes of RNAs.

关键词： RNA modifications epitranscriptome RNA 5-methylcytosine (m^5C) N^6-methyladenosine (m^6A) Pseudouridine (φ) Arabidopsis

Optimization of Photo-Fenton Catalyst Preparation Based Bamboo Carbon Fiber by Response Surface Methodology

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Journal of Renewable Materials 2023年第1期11卷 147-165页

作者： Yizhang Wang Zhaoyang Yu Jinbo Hu Shanshan Chang Yuan liu Ting Li Gonggang liu Xiaodong(alice)Wang College of Materials Science and Engineering Central South University of Forestry and TechnologyChangsha410004China Hunan Taohuajiang Bamboo Science&Technology Co. Ltd.Yiyang413400China Department of Wood and Forest Sciences Laval UniversityQuebecG1V 0A6Canada

In this paper,the residue from bamboo factory has been used to design photo-Fenton catalyst,which has the advantages of low cost and magnetic *** photo-Fenton catalytic performance of the biocarbon-based catalyst was excellent and its optimal preparation process was also explored by response surface ***,bamboo-carbon fiber was selected as the photo-Fenton catalyst ***,the surface of the car-bon fiber was modified,with which dopamine,nano-Fe_(3)O_(4) and nano-TiO_(2) were successively loaded by hydro-thermal *** the single factor tests,four factors including dopamine concentration,ferric chloride mass,P25 titanium dioxide mass and liquid-solid ratio were selected as the characteristic *** degradation efficiency of photo-Fenton catalyst to methylene blue(MB)solution was treated as the response *** the analysis of the response surface optimization,it was shown that the significance sequence of the selected 4 factors in terms of the MB degradation efficiency was arranged as follows:dopamine concentration>liquid-solid ratio>P25 titanium dioxide quality>ferric chloride *** optimal process parameters of fiber-carbon catalyst were affirmed as follows:the 1.7 mg/mL concentration of dopamine,the 1.2 g mass of ferric chloride,the 0.2 g mass of P25 titanium dioxide and the liquid-solid ratio of 170 mL/*** experiment-measured average MB degra-dation efficiency performed by the optimized catalyst was 99.3%,which was nearly similar to the model-predicted value of 98.9%.It showed that the prediction model and response surface model were accurate and *** results from response surface optimization could provide a good reference to design bamboo-based Fenton-like catalyst with excellent catalytic performance.

关键词： Photo-fenton catalysis bamboo fiber carbon fiber response surface optimization methylene blue

Multi-Material ALE with AMR for Modeling Hot Plasmas and Cold Fragmenting Materials

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Plasma Science and Technology 2015年第2期17卷 117-128页

作者： alice KONIGES Nathan MASTERS Aaron FISHER David EDER Wangyi liu Robert ANDERSON David BENSON Andrea BERTOZZI Lawrence Berkeley National Laboratory Lawrence Livermore National Laboratory Jacobs School of Engineering 9500 Gilman Dr.UCSDLa JollaCA 92093USA Department of Mathematics 520 Portola PlazaUCLALos AngelesCA 90095USA

We have developed a new 3D multi-physics multi-material code, ALE-AMR, which combines Arbitrary Lagrangian Eulerian （ALE） hydrodynamics with Adaptive Mesh Refinement （AMR） to connect the continuum to the microstructural regimes. The code is unique in its ability to model hot radiating plasmas and cold fragmenting solids. New numerical techniques were developed for many of the physics packages to work efficiently on a dynamically moving and adapting mesh. We use interface reconstruction based on volume fractions of the material components within mixed zones and reconstruct interfaces as needed. This interface reconstruction model is also used for void coalescence and fragmentation. A flexible strength/failure framework allows for pluggable material models, which may require material history arrays to determine the level of accumulated damage or the evolving yield stress in J2 plasticity models. For some applications laser rays are propagating through a virtual composite mesh consisting of the finest resolution representation of the modeled space. A new 2nd order accurate diffusion solver has been implemented for the thermal conduction and radiation transport packages. One application area is the modeling of laser/target effects including debris/shrapnel generation. Other application areas include warm dense matter, EUV lithography, and material wall interactions for fusion devices.

关键词： multi-physics simulations arbitrary lagrangian eulerian hydrodynamics,adaptive mesh refinement fragmentation laser ray tracing NIF

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The neutron star zoo

Frontiers of physics 2013年第6期8卷 679-692页

作者： alice K. Harding Astrophysics Science Division NASA Goddard Space Flight Center Greenbelt MD 20771 USA

Neutron stars are a very diverse population, both in their observational and their physical properties. They prefer to radiate most of their energy at X-ray and gamma-ray wavelengths. But whether their emission is powered by rotation, accretion, heat, magnetic fields or nuclear reactions, they are all different species of the same animal whose magnetic field evolution and interior composition remain a mystery. This article will broadly review the properties of inhabitants of the neutron star zoo, with emphasis on their high-energy emission.

关键词： stars neutron stars pulsars binary stars

Biomarkers vs imaging in the early detection of hepatocellular carcinoma and prognosis

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World Journal of Clinical Cases 2019年第12期7卷 1367-1382页

作者： Lavinia alice Balaceanu Department of Internal Medicine Carol Davila University of Medicine and Pharmacy Sf. Ioan Clinical Emergency Hospital

Hepatocellular carcinoma (HCC) is the 5th most frequently diagnosed cancer in the world, according to the World Health Organization. The incidence of HCC is between 3/100000 and 78.1/100000, with a high incidence reported in areas with viral hepatitis B and hepatitis C, thus affecting Asia and Africa predominantly. Several international clinical guidelines address HCC diagnosis and are structured according to the geographical area involved. All of these clinical guidelines, however, share a foundation of diagnosis by ultrasound surveillance and contrast imaging techniques, particularly computed tomography, magnetic resonance imaging, and sometimes contrast-enhanced ultrasound. The primary objective of this review was to systematically summarize the recent published studies on the clinical utility of serum biomarkers in the early diagnosis of HCC and for the prognosis of this disease.

关键词： Hepatocellular carcinoma Biomarkers Imaging Ultrasonography Computed tomography Magnetic resonance imaging

Patterns of floristic inventory and plant collections in Myanmar

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Plant Diversity 2023年第6期45卷 302-308页

作者： Thant Sin Aung alice CHughes Phyo Kay Khine Bo liu Xiao-Li Shen Ke-Ping Ma State Key Laboratory of Vegetation and Environmental Change Institute of BotanyChinese Academy of SciencesBeijing 100093China University of Chinese Academy of Sciences Beijing 100049China University of Hong Kong Department of Ecology and Biodiversity The University of Hong Kong School of Biological SciencesChina Center for Integrative Conservation Xishuangbanna Tropical Botanical GardenChinese Academy of SciencesMenglunYunnan 666303China Minzu University of China Beijing 100081China

Myanmar is one of the most biodiverse countries in the Asia-Pacific region due to a wide range of climatic and environmental *** diversity in Myanmar is largely unknown,resulting in a lack of comprehensive conservation *** developed a database of higher plants in Myanmar derived from herbarium specimens and literature sources,and analyzed patterns of diversity inventories and collection inconsistencies,aiming to provide a baseline floristic data of Myanmar and act as a guide for future research *** collected 1,329,354 records of 16,218 *** show that the collection densities at the township level was variable,with 5% of townships having no floristic *** ecoregion had an average collection density of greater than 1 specimen/km2and the lowest collection density was found in the Kayah-Karen Montane Rainforests,which covered 8% of Myanmar’s total *** highest sampling densities were found in Mandalay Region,Chin State,and Yangon *** floristic collections over the past three centuries,knowledge of the distribution of the vast majority of plant taxa remained limited,particularly for gymnosperms,pteridophytes,and *** botanical surveys and further analyses are needed to better describe Myanmar’s floristic *** important strategy to promote knowledge of the biodiversity patterns in Myanmar is to improve the collection and digitalization of specimens and to strengthen cooperation among countries.

关键词： Biodiversity Ecoregion Higher plants Hotspots Myanmar Specimens

Energy tunnels:concept and design aspects

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Underground Space 2018年第4期3卷 268-276页

作者： Marco Barla alice Di Donna Department of Structural Building and Geotechnical EngineeringPolitecnico di TorinoCorso Duca degli Abruzzi 2410129 TorinoItaly

Geotechnical structures are increasingly employed as energy geostructures in Europe and *** being constructed for their primary structural role,they are equipped to exchange heat with the ground and supply thermal energy for heating and cooling of buildings and de-icing of *** technology can play a fundamental role in the current challenge of addressing the increasing need for clean and renewable sources of *** study investigates the possibility of thermal activation of tunnel ***,attention will be paid on a new energy segment,which can be used together with tunnel boring machine tunneling to create so-called energy *** and mechanical designs need to be developed by making effective use of computational methods to quantify the exploitable heat and assess the possible consequences on the surrounding ground and the structure *** on how to proceed in this direction will be provided in this study,showing how thermo-hydro and thermo-mechanical numerical analyses can be used to achieve a proper and effective design of energy *** examples of possible applications will also be presented.

关键词： Energy tunnel Geothermal energy Heating and cooling Geotechnical design

National Carbon Capture Center:advancing fossil energy technology solutions

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Clean Energy 2020年第3期4卷 300-304页

作者： Jo alice Driggers Southern Company National Carbon Capture CenterWilsonvilleALUSA

Introduction The National Carbon Capture Center is the primary carbon-capture research facility for the US Department of Energy(DOE).Through its role as a neutral test site,the centre is advancing technologies to reduce greenhouse-gas(GHG)emis-sions from fossil-fueled power plants,while also supporting the development of technology solutions for carbon-dioxide(CO_(2))utilization and direct air capture(DAC).

关键词： solutions dioxide neutral