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Palladium nanoplates scotch breast cancer lung metastasis by constraining epithelial-mesenchymal transition

National Science Review 2021年第7期8卷 124-136页

作者： Shunhao Wang Jingchao Li Mei Chen liting ren Wenya Feng Lining Xu Xiaolan Chen Tian Xia Nanfeng Zheng Sijin Liu State Key Laboratory of Environmental Chemistry and Ecotoxicology Research Center for Eco-Environmental Sciences Chinese Academy of Sciences University of Chinese Academy of Sciences State Key Laboratory for Physical Chemistry of Solid Surfaces Collaborative Innovation Center of Chemistry for Energy Materials Department of Chemistry Xiamen University College of Materials Science and Engineering Hunan University Division of Nanomedicine Department of Medicine California Nano Systems Institute University of CaliforniaLos Angeles

Metastasis accounts for the majority of cancer deaths in many tumor types including breast ***-mesenchymal transition(EMT) is the driving force for the occurrence and progression of metastasis, however, no targeted strategies to block the EMT program are currently available to combat metastasis. Diverse engineered nanomaterials(ENMs) have been reported to exert promising anti-cancer effects, however, no ENMs have been designed to target EMT. Palladium(Pd) nanomaterials, a type of ENM, have received substantial attention in nanomedicine due to their favorable photothermal performance for cancer therapeutics. Herein, Pd nanoplates(Pd PL) were found to be preferentially biodistributed to both primary tumors and metastatic tumors. Importantly, Pd PL showed a significant inhibition of lung metastasis with and without near-infrared(NIR) irradiation. Mechanistic investigations revealed that EMT was significantly compromised in breast cancer cells upon the Pd PL treatment, which was partially due to the inhibition of the transforming growth factor-beta(TGF-β) signaling. Strikingly, the Pd PL was found to directly interact with TGF-β proteins to diminish TGF-β functions in activating its downstream signaling, as evidenced by the reduced phosphorylation of Smad2. Notably,TGF-β-independent pathways were also involved in undermining EMT and other important biological processes that are necessary for metastasis. Additionally, NIR irradiation elicited synergistic effects on PdPL-induced inhibition of primary tumors and metastasis. In summary, these results revealed that the Pd PL remarkably curbed metastasis by inhibiting EMT signaling, thereby indicating the promising potential of Pd PL as a therapeutic agent for treating breast cancer metastasis.

关键词： palladium nanoplates tumor targeting lung metastasis epithelial-mesenchymal transition TGF-β

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Carbon Monoxide Promotes the Catalytic Hydrogenation on Metal Cluster Catalysts

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Research 2020年第1期2020卷 702-710页

作者： Ruixuan Qin Pei Wang Pengxin Liu Shiguang Mo Yue Gong liting ren Chaofa Xu Kunlong Liu Lin Gu Gang Fu Nanfeng Zheng State Key Laboratory for Physical Chemistry of Solid Surfaces Collaborative Innovation Center of Chemistry for Energy Materialsand National&Local Joint Engineering Research Center for Preparation Technology of NanomaterialsCollege of Chemistry and Chemical EngineeringXiamen UniversityXiamen 361005China College of Science Huazhong Agricultural UniversityWuhan 430070China Institute of Physics Chinese Academy of SciencesBeijing 100190China

Size effect plays a crucial role in catalytic *** highly dispersed ultrasmall clusters with a limited number of metal atoms are one candidate of the next generation catalysts that bridge the single-atom metal catalysts and metal ***,for the unfavorable electronic property and their interaction with the substrates,they usually exhibit sluggish *** advantage of the small size,their catalytic property would be mediated by surface binding *** combination of metal cluster coordination chemistry brings new *** poisoning is notorious for Pt group metal catalysts as the strong adsorption of CO would block the active *** this work,we will demonstrate that CO could serve as a promoter for the catalytic hydrogenation when ultrasmall Pd clusters are *** means of DFT calculations,we show that Pd_(n)(n=2-147)clusters display sluggish activity for hydrogenation due to the too strong binding of hydrogen atom and reaction intermediates thereon,whereas introducing CO would reduce the binding energies of vicinal sites,thus enhancing the hydrogenation ***,supported Pd_(2)CO catalysts are fabricated by depositing preestablished[Pd_(2)(μ-CO)_(2)Cl_(4)]2-clusters on oxides and demonstrated as an outstanding catalyst for the hydrogenation of *** promoting effect of CO is further verified experimentally by removing and reintroducing a proper amount of CO on the Pd cluster catalysts.

关键词： reaction. hydrogenation introducing

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带有非齐次Dirichlet条件的Helmholtz方程柯西问题的傅里叶方法

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江西师范大学学报（自然科学版） 2019年第2期43卷 184-187页

作者：任丽婷熊向团西北师范大学数学与统计学院甘肃兰州730070

由于带有非齐次Dirichlet条件的Helmholtz方程柯西问题的解不连续依赖于数据,所以该问题是严重的不适定问题.利用傅里叶方法给出了该问题在无限条状区域上的正则化近似解,并相应给出了先验与后验的正则化参数选取规则及近似解与精确解... 详细信息

由于带有非齐次Dirichlet条件的Helmholtz方程柯西问题的解不连续依赖于数据,所以该问题是严重的不适定问题.利用傅里叶方法给出了该问题在无限条状区域上的正则化近似解,并相应给出了先验与后验的正则化参数选取规则及近似解与精确解的收敛误差估计.

关键词：不适定问题 Helmholtz方程柯西问题傅里叶方法 Dirichlet条件误差估计

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某危废项目填埋场渗滤液处理工艺研究

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氯碱工业 2022年第7期58卷 35-39,42页

作者：任立停辽宁星宇再生资源有限公司辽宁锦州121000

介绍了通辽市某危险废物处置项目的基本情况。针对安全填埋场渗滤液的主要理化指标,做了渗滤液除氟、除氨氮等预处理和蒸发的小试试验。根据小试试验结果,采用单效蒸发、A/O处理、生物转盘、滤布滤池等多种方法结合的处理工艺。实际处理... 详细信息

介绍了通辽市某危险废物处置项目的基本情况。针对安全填埋场渗滤液的主要理化指标,做了渗滤液除氟、除氨氮等预处理和蒸发的小试试验。根据小试试验结果,采用单效蒸发、A/O处理、生物转盘、滤布滤池等多种方法结合的处理工艺。实际处理后,渗滤液可达到回用水标准;还充分利用焚烧炉产生的蒸汽热能,做到节能环保;渗滤液蒸发产生的母液得到安全处置。对上述处理工艺进行了详细的效果分析和经济指标分析,并提出相关建议。

关键词：填埋场渗滤液蒸发脱盐生化处理零排放

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一种新的后验正则化方法求解Helmholtz方程的Cauchy问题

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甘肃科学学报 2019年第5期31卷 1-4页

作者：任丽婷西北师范大学数学与统计学院

由于Helmholtz方程的Cauchy问题的解不连续依赖于所给的Cauchy数据,Cauchy数据的一个小小扰动引起解有很大的变化,所以该问题是严重的不适定问题。为了解决该问题的不适定性,需要借助正则化方法进行求解,这种新的后验正则化方法的饱和... 详细信息

由于Helmholtz方程的Cauchy问题的解不连续依赖于所给的Cauchy数据,Cauchy数据的一个小小扰动引起解有很大的变化,所以该问题是严重的不适定问题。为了解决该问题的不适定性,需要借助正则化方法进行求解,这种新的后验正则化方法的饱和效应使得随着解的光滑性假设的提高而提高其收敛率,令正则化近似解与精确解之间误差估计达到最优。根据正则化的最优理论,误差估计的阶数是最优的,这种新的正则化方法可以借助于傅里叶变换和逆变换实现。考虑在半带状区域上Helmholtz方程的Cauchy问题,提出一种新的后验正则化方法得到其正则化近似解,并通过偏差原理得到后验正则化参数选取法则及正则化近似解与精确解之间最优的Holder型收敛误差估计。

关键词： Helmholtz方程的Cauchy问题新的后验正则化方法误差估计

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深水工况下弧面胸墙沉箱堤的反射形态分析

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海洋工程 2023年第2期41卷 153-160页

作者：任丽婷蒋学炼赵悦郄禄文刘俊涛天津城建大学天津市土木建筑结构防护与加固重点实验室天津300384 天津水运工程勘察设计院有限公司天津300456 南京水利科学研究院江苏南京210029 河北大学建筑工程学院河北保定071002

为推广应用新型弧面胸墙沉箱堤,结合模型试验和数值模拟对比分析了深水工况下弧面胸墙沉箱堤和削角胸墙沉箱堤的反射形态。波面和波压的数值结果与试验数据吻合良好,验证了数值方法的有效性。反射系数表明,入射波浪在与弧面胸墙沉箱堤... 详细信息

为推广应用新型弧面胸墙沉箱堤,结合模型试验和数值模拟对比分析了深水工况下弧面胸墙沉箱堤和削角胸墙沉箱堤的反射形态。波面和波压的数值结果与试验数据吻合良好,验证了数值方法的有效性。反射系数表明,入射波浪在与弧面胸墙沉箱堤相互作用过程中的能量损耗最小,其反射强于削角胸墙沉箱堤。波面和流速包络图显示,两种堤型均在堤前形成了部分立波系统,腹点和节点以四分之一波长的距离增量交替出现,胸墙和直立部分产生的反射波存在相位差,导致初始腹点的位置向海侧偏移。弧面胸墙沉箱堤前叠合波的相位差影响最小,腹点包络高度最大,节点包络高度最小,反射效应最明显。两种堤型前中下层水流的周期平均速度均较小且对称,表明底床泥沙不会产生趋势性输移,但迎浪基床上方的环流系统可能引起局部冲刷。相对而言,弧面胸墙沉箱堤前的环流强度最弱,更有利于冲刷防护。

关键词：弧面胸墙沉箱堤削角胸墙沉箱堤 RANS-VOF模型反射形态周期平均速度场

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Ag/SiO_2-ZnO-CeO_2催化剂上甘油与苯胺液固相高效催化合成3-甲基吲哚

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辽宁师范大学学报（自然科学版） 2018年第3期41卷 345-352页

作者：石雷杜秀芳任丽婷郝文文赵丹辽宁师范大学化学化工学院辽宁大连116029

3-甲基吲哚作为一种应用极广的氮杂环化合物,可以合成许多在工、农、医等领域有重要用途的化学品.以生物柴油副产物甘油为主要原料与苯胺反应合成3-甲基吲哚是目前最理想的合成方法,不仅价格低廉,而且绿色环保.以Ag/SiO_2为催化剂,向其... 详细信息

3-甲基吲哚作为一种应用极广的氮杂环化合物,可以合成许多在工、农、医等领域有重要用途的化学品.以生物柴油副产物甘油为主要原料与苯胺反应合成3-甲基吲哚是目前最理想的合成方法,不仅价格低廉,而且绿色环保.以Ag/SiO_2为催化剂,向其添加ZnO及CeO_2助剂,在不锈钢高压反应釜中通过液固相反应一锅高效催化合成3-甲基吲哚,通过H2程序升温还原、X射线粉末衍射、透射电镜、NH3程序升温脱附和热重等手段对催化剂进行表征.结果表明:加入ZnO助剂能增强活性组分银与SiO_2载体的相互作用,有效提高银在SiO_2-ZnO表面的分散度,并抑制银粒子在反应过程中的烧结.CeO_2助剂的加入能在一定程度上减弱催化剂的中强酸酸性,从而抑制反应过程中积碳的形成.当ZnO和CeO_2助剂含量分别为1.00和0.04mmol/g时,Ag/SiO_2-ZnO-CeO_2催化剂表现出很高的催化性能,反应16h,3-甲基吲哚的收率可以达到70%.该催化剂重复使用5次,其目标产物收率尚能达到63%.

关键词： 3-甲基吲哚 Ag/SiO2-ZnO-CeO2催化剂甘油苯胺液固相催化反应

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The effect of pore size and porosity of Ti6Al4V scaffolds on MC3T3-E1 cells and tissue in rabbits

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Science China(Technological Sciences) 2019年第7期62卷 1160-1168页

作者： LUAN HuiQin WANG liting ren WeiYan CHU Zhao Wei HUANG YunFei LU ChengLin FAN YuBo Key Laboratory of Intelligent Control and Rehabilitation Technology of the Ministry of Civil Affairs National Research Center for Rehabilitation Technical Aids Beijing 100176 China Beijing Key Laboratory of Rehabilitation Technical Aids for Old-Age Disability Beijing 100176 China Key Laboratory for Biomechanics and Mechanobiology of Ministry of Education School of Biological Science and Medical Engineering Beihang University Beijing 100191 China Shandong Weigao Orthopedic Device Company Limited Weihai 264209 China

Electron beam melting(EBM) allows the fabrication of specific porous titanium implants, whereas their in vitro and in vivo biological performance should be further investigated. In this study, we examined the porous Ti6 Al4 V scaffolds(low, 334.1 μm pore size with 55.4% porosity;middle, 383.2 μm pore size with 65.2% porosity;and high, 401.6 μm pore size with 78.1%porosity) fabricated through EBM. The structural characterization and mechanical properties of porous Ti6 Al4 V scaffolds were measured through micro-computed tomography(micro-CT), scanning electron microscopy, and a material testing ***3 T3-E1 cells were used to assess the proliferation and differentiation of the cells on different scaffolds at day 7 and day 14 based on the expression levels of genes, including alkaline phosphatase, bone morphogenetic protein-2, osteopontin and runtrelated transcription factor-2. Rabbits with distal femoral defects were utilized to evaluate bone ingrowth in the porous *** of the samples were subjected to micro-CT and histological analysis after 12 weeks. Results showed that compressive Young’s modulus of 0.3–1.1 GPa was similar to the trabecular bone. The three types of porous Ti6 Al4 V scaffolds were inclined to promote cell proliferation, whereas cell differentiation and bone ingrowth into the porous scaffolds were biased to the porous titanium with relatively large pores and porosity(middle and high). This study implied that the present porous implant design,which had the combined advantages of different pore sizes and porosity, might be meaningful and promising for trabecular bone defect restoration.

关键词： pore size porosity porous titanium alloy scaffolds osteogenesis bone defect

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Exploring the efficacy of(R)-PFI-2 hydrochloride in mitigating noise-induced hearing loss by targeting NLRP3 inflammasome and NF-κB pathway to reduce inner ear inflammation

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Journal of Otology 2024年第4期19卷 200-206页

作者： Dawei ren Xuemin Chen Hongdong Liu Menghua Li liting Zheng Pan Yong Mohe Huang Xi Shi Yice Xu Shujin Chen Yan Zhang Wei Zhu Department of Otorhinolaryngology the First Hospital of Jilin UniversityChangchun130021JilinChina Department of Otorhinolaryngology No.971 Hospital of People’s Liberation Army NavyQingdao266000Shandong ProvinceChina Senior Department of Otolaryngology-Head&Neck Surgery Chinese PLA General HospitalNational Clinical Research Center for Otolaryngologic DiseasesState Key Lab of Hearing ScienceMinistry of EducationBeijing Key Lab of Hearing Impairment Prevention and TreatmentBeijing100083China Artificial Auditory Laboratory of Jiangsu Province Xuzhou Medical UniversityXuzhou221000JiangsuChina Key Laboratory of Tropical Biological Resources of Ministry of Education School of Pharmaceutical SciencesHainan UniversityHaikou570228Hainan ProvineChina Song Li’s Academician Workstation of Hainan University School of Pharmaceutical SciencesYazhou BaySanya572000Hainan ProvineChina Department of Otolaryngology-Head and Neck Surgery The Central Hospital of XiaoganXiaogan432000HubeiChina ENT Department The People’s Hospital of Rongchang DistrictChongqing402460China

Noise-induced hearing loss(NIHL)is primarily driven by inflammatory processes within the cochlea,where noise exposure triggers the activation of the NOD-like receptor protein 3(NLRP3)inflammasome,leading to an inflammatory *** interaction between increased NLRP3 expression and NF-κB activity can further amplify cochlear *** findings reveal that(R)-PFI-2 hydrochloride,a selective inhibitor of the SETD7 enzyme,effectively inhibits the activation of the cochlear NF-κB pathway,suppresses the release of proinflammatory factors,and prevents inflammasome *** intervention disrupts the perpetuating cycle of inflammation,thereby alleviating damage to cochlear hair cells attributed to acoustic ***,(R)-PFI-2 hydrochloride emerges as a promising pharmacological candidate for NIHL,targeting and moderating the excessive immune and inflammatory responses implicated in the pathology of hearing loss.

关键词： NIHL (R)-PFI-2 hydrochloride NLRP3 NF-κB SETD7

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Molecular imaging:design mechanism and bioapplications

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Science China Chemistry 2023年第5期66卷 1336-1383页

作者： Lanlan Chen Yifan Lyu Xuan Zhang liting Zheng Qingqing Li Ding Ding Fengming Chen Yihao Liu Wei Li Yutong Zhang Qiuling Huang Zhiqiang Wang Tiantian Xie Qiang Zhang Yingyu Sima Ke Li Shuai Xu Tianbing ren Mengyi Xiong Ying Wu Jibin Song Lin Yuan Huanghao Yang Xiao-Bing Zhang Weihong Tan Molecular Science and Biomedicine Laboratory(MBL) State Key Laboratory of Chemo/Biosensing and Chemomet-ricsCollege of Chemistry and Chemical EngineeringAptamer Engineering Center of Hunan ProvinceHunan UniversityChangsha 410082China Key Laboratory for Analytical Science of Food Safety and Biology(Ministry of Education) College of ChemistryFuzhou UniversityFuzhou 350108China College of Chemistry Beijing University of Chemical TechnologyBeijing 100029China The Cancer Hospital of the University of Chinese Academy of Sciences(Zhejiang Cancer Hospital) Institute of Basic Medicine and Cancer(IBMC)Chinese Academy of SciencesHangzhou 310022China Institute of Molecular Medicine(IMM) State Key Laboratory of Oncogenes and Related Genes Renji HospitalShanghai Jiao Tong University School of MedicineCollege of Chemistry and Chemical EngineeringShanghai Jiao Tong UniversityShanghai 200240China College of Chemistry and Chemical Engineering Central South UniversityChangsha 410083China School of Chemistry and Chemical Engineering University of JinanJinan 250022China

Molecular imaging is a non-invasive method to image and analyze the concentration and activity of functional biomolecules in cells or in vivo at molecular level,and plays an increasing role in deep understanding of biological processes,early and accurate diagnosis of diseases,and evaluation of ***,numerous novel molecular imaging probes have been developed,involving every biomedical imaging modality,such as optical imaging,photoacoustic imaging,magnetic resonance imaging,single-photon-emission computed tomography,and positron emission *** this review,we summarize the development of current state-of-the-art molecular imaging *** introduce the design strategies of molecular probes and detailed imaging modalities,and highlight the properties of probes and biomedical imaging applications in cells and in vivo,including disease diagnosis,drug tracking,and imaging-guided *** we discuss the perspectives and challenges in this emerging *** expect this review could inspire more effective molecular imaging probes to be developed,achieving the goal towards clinical practices.

关键词： molecular imaging imaging probes multimodality biomedical applications diseases diagnosis

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