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世界核心医学期刊文摘（眼科学分册） 2005年第11期1卷 5-6页

作者： Van Den Born B.-J.H. Hulsman C.A.A. hoekstra J.B.L. 杨秀梅 Department of Internal Medicine Academic Medical Centre PO 22660 1100 DD Amsterdam Netherlands

Objective: to evaluate the additional value of funduscopy in the routine manag ement of patients with hypertension. Design: Systematic review. Participants: Ad ults aged 19 or more with hypertensive retinopathy. Data sources: Medline, Embas e, and the Cochrane Library from 1990. Review methods: Studies were included tha t assessed hypertensive retinopathy with blinding for blood pressure and cardiov ascular risk factors. Studies on observer agreement had to be assessed by two or more observers and expressed as a κstatistic. Studies on the association betwe en hypertensive retinopathy and hypertensive organ damage were carried out in pa tients with hypertension. the association between hypertensive retinopathy and c ardiovascular risk was carried out in unselected normotensive and hypertensive p eople without diabetes mellitus. Results: the assessment of microvascular change s in the retina is limited by large variation between observers. the positive an d negative predictive values for the association between hypertensive retinopath y and blood pressure were low (47%to 72%and 32%to 67%, respectively). Associ ations between retinal microvascular changes and cardiovascular risk were incons istent, except for retinopathy and stroke. the increased risk of stroke, however , was also present in normotensive people with retinopathy. these studies did no t adjust for other indicators of hypertensive organ damage. Conclusion: Evidence is lacking that routine funduscopy is of additional value in the management of hypertensive patients.

关键词：眼底检查高血压性系统性回顾视网膜病变视网膜微血管正常血压血管危险因素 Cochrane 盲法预测值

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Comparison of novel and standard diagnostic tools for the detection of Schistosoma mekongi infection in Lao People’s Democratic Republic and Cambodia

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Infectious Diseases of Poverty 2017年第1期6卷 1123-1135页

作者： Youthanavanh Vonghachack Somphou Sayasone Virak Khieu Robert Bergquist Govert Jvan Dam Pytsje thoekstra Paul L.A.M.Corstjens Beatrice Nickel Hanspeter Marti Jürg Utzinger Sinuon Muth Peter Odermatt Faculty of Basic Sciences University of Health SciencesMinistry of HealthVientianeLao People’s Democratic Republic Swiss tropical and Public Health Institute P.O.BoxCH-4002 BaselSwitzerland University of Basel P.O.BoxCH-4003 BaselSwitzerland National Institute of Public Health Ministry of HealthVientianeLao People’s Democratic Republic National Centre for Parasitology Entomology and Malaria ControlMinistry of HealthPhnom PenhCambodia Ingerod BrastadSweden Department of Parasitology Leiden University Medical CenterLeidenThe Netherlands Department of Molecular Cell Biology Leiden University Medical CenterLeidenThe Netherlands

Background:Given the restricted distribution of Schistosoma mekongi in one province in Lao People’s Democratic Republic(Lao PDR)and two provinces in Cambodia,together with progress of the national control programmes aimed at reducing morbidity and infection prevalence,the elimination of schistosomiasis mekongi seems ***,sensitive diagnostic tools will be required to determine whether elimination has been *** compared several standard and novel diagnostic tools in ***-endemic ***:the prevalence and infection intensity of *** were evaluated in 377 study participants from four villages in the endemic areas in Lao PDR and Cambodia using Kato-Katz stool examination,antibody detection based on an enzyme-linked immunosorbent assay(ELISA)and schistosome circulating antigen detection by lateral-flow *** highly sensitive test systems for the detection of cathodic and anodic circulating antigens(CCA,CAA)in urine and serum were ***:Stool microscopy revealed an overall prevalence of *** of 6.4%(one case in Cambodia and 23 cases in Lao PDR),while that of Opisthorchis viverrini,hookworm,trichuris trichiura,Ascaris lumbricoides and taenia *** 50.4%,28.1%,3.5%,0.3%and 1.9%,*** the urine samples,the tests for CCA and CAA detected *** infections in 21.0%and 38.7%of the study participants,*** the serum samples,the CAA assay revealed a prevalence of 32.4%,while a combination of the CAA assay in serum and in urine revealed a prevalence of 43.2%.there was a difference between the two study locations with a higher prevalence reached in the samples from Lao ***:the CCA,CAA and ELISA results showed substantially higher prevalence estimates for *** compared to Kato-Katz thick *** schistosomiasis mekongi in Lao PDR and Cambodia might thus have been considerably underestimated ***,sustained control efforts are still needed to break transmission of ***

关键词： Cambodia Food-borne trematodes Kato-Katz Lao People’s Democratic Republic Point-of-care circulating cathodic antigen Schistosoma mekongi Serology Soil-transmitted helminths Up-converting phosphorlateral-flow circulating anodic antigen

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地中海式饮食和生活方式对欧洲老年人群10年死亡率的影响：HALE项目

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美国医学会杂志（中文版） 2005年第5期24卷 285-285页

作者： Kim t. B. Knoops lisette C. P. G. M. de Groot Daan Kromhout 付志方（译）刘梅林（校）

背景：饮食和生活方式与全因死亡率、冠心病、心血管疾病及肿瘤有关，但是鲜有研究综合观察这些因素。

关键词：地中海式饮食生活方式年死亡率老年人群项目欧洲全因死亡率心血管疾病冠心病综合观

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