Comparison of novel and standard diagnostic tools for the detection of Schistosoma mekongi infection in Lao People’s Democratic Republic and Cambodia

作     者：Youthanavanh Vonghachack Somphou Sayasone Virak Khieu Robert Bergquist Govert Jvan Dam Pytsje THoekstra Paul L.A.M.Corstjens Beatrice Nickel Hanspeter Marti Jürg Utzinger Sinuon Muth Peter Odermatt Vonghachack Youthanavanh;Sayasone Somphou;Khieu Virak;Bergquist Robert;Dam Govert J. van;Hoekstra Pytsje T.;Corstjens Paul L. A. M.;Nickel Beatrice;Marti Hanspeter;Utzinger Jürg;Muth Sinuon;Odermatt Peter

作者机构：Faculty of Basic SciencesUniversity of Health SciencesMinistry of HealthVientianeLao People’s Democratic Republic Swiss Tropical and Public Health InstituteP.O.BoxCH-4002 BaselSwitzerland University of BaselP.O.BoxCH-4003 BaselSwitzerland National Institute of Public HealthMinistry of HealthVientianeLao People’s Democratic Republic National Centre for ParasitologyEntomology and Malaria ControlMinistry of HealthPhnom PenhCambodia IngerodBrastadSweden Department of ParasitologyLeiden University Medical CenterLeidenThe Netherlands Department of Molecular Cell BiologyLeiden University Medical CenterLeidenThe Netherlands 

出 版 物：《Infectious Diseases of Poverty》 (贫困所致传染病（英文）)

年 卷 期：2017年第6卷第1期

页      面：1123-1135页

核心收录：

学科分类：0202[经济学-应用经济学] 02[经济学] 1004[医学-公共卫生与预防医学(可授医学、理学学位)] 1002[医学-临床医学] 020205[经济学-产业经济学] 1001[医学-基础医学(可授医学、理学学位)] 

基　　金：We are grateful to financial support of the Task Force for Global Health Neglected Tropical Diseases Support Centre the Department of Parasitology Leiden University Medical Center and the Swiss Tropical and Public Health Institute 

主　　题：Cambodia Food-borne trematodes Kato-Katz Lao People’s Democratic Republic Point-of-care circulating cathodic antigen Schistosoma mekongi Serology Soil-transmitted helminths Up-converting phosphorlateral-flow circulating anodic antigen 

摘      要：Background:Given the restricted distribution of Schistosoma mekongi in one province in Lao People’s Democratic Republic(Lao PDR)and two provinces in Cambodia,together with progress of the national control programmes aimed at reducing morbidity and infection prevalence,the elimination of schistosomiasis mekongi seems ***,sensitive diagnostic tools will be required to determine whether elimination has been *** compared several standard and novel diagnostic tools in ***-endemic ***:The prevalence and infection intensity of *** were evaluated in 377 study participants from four villages in the endemic areas in Lao PDR and Cambodia using Kato-Katz stool examination,antibody detection based on an enzyme-linked immunosorbent assay(ELISA)and schistosome circulating antigen detection by lateral-flow *** highly sensitive test systems for the detection of cathodic and anodic circulating antigens(CCA,CAA)in urine and serum were ***:Stool microscopy revealed an overall prevalence of *** of 6.4%(one case in Cambodia and 23 cases in Lao PDR),while that of Opisthorchis viverrini,hookworm,Trichuris trichiura,Ascaris lumbricoides and Taenia *** 50.4%,28.1%,3.5%,0.3%and 1.9%,*** the urine samples,the tests for CCA and CAA detected *** infections in 21.0%and 38.7%of the study participants,*** the serum samples,the CAA assay revealed a prevalence of 32.4%,while a combination of the CAA assay in serum and in urine revealed a prevalence of 43.2%.There was a difference between the two study locations with a higher prevalence reached in the samples from Lao ***:The CCA,CAA and ELISA results showed substantially higher prevalence estimates for *** compared to Kato-Katz thick *** schistosomiasis mekongi in Lao PDR and Cambodia might thus have been considerably underestimated ***,sustained control efforts are still needed to break transmission of ***