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Novel organoid model in drug screening: Past, present, and future

Liver Research 2021年第2期5卷 72-78页

作者： Xialin Nie Zhixing Liang Kun Li Haoyuan Yu Yuhan Huang linsen ye Yang Yang Guangdong Provincial Key Laboratory of Liver Disease Research GuangzhouChina School of Foreign Languages Sun Yat-sen UniversityGuangzhouChina Department of Hepatic Surgery and Liver Transplantation Center The Third Affiliated Hospital of Sun Yat-sen UniversityGuangzhouChina

Advances in the field of stem cells have led to the development of a technology called *** are cell cluster structures formed by the cultivation of stem cells in a three-dimensional environment in vitro,and they can simulate the living environment of cells in *** play an important role in the screening of drugs for tumor *** with traditional drug screening models,tumor organoid models derived from patient tumors have higher sensitivity,heterogeneity,and stability and can restore the real situation of tumors more *** have conducted a number of researches on the feasibility of using organoid technology in drug *** testing and comparing the effects of antitumor drugs in organoids and primary tumors,we can select the most appropriate treatment drugs for *** the past ten years,organoids from dozens of tissues and biological sample banks from several main organs have been established,and a large number of anticancer drugs have been screened *** article summarizes the advantages and disadvantages of traditional drug screening models,discusses the development history of organoid technology,and reviews the research results on organoids from tumor drug *** addition,the combination of organoid technology and other modern biotechnologies is put forward to further promote the role of organoid technology in the medical ***,this article reviews the history,progress,and prospect on organoids from the view of antitumor drug screening.

关键词： Organoid Drug screening Patient-derived cancer cell line(PDC)model Patient-derived xenograft(PDX)model Patient-derived organoid(PDO)model

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Prognostic Role and Potential Mechanisms of N6-methyladenosine-related Long Noncoding RNAs in Hepatocellular Carcinoma

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Journal of Clinical and Translational Hepatology 2022年第2期10卷 308-320页

作者： Tianxing Dai Jing Li linsen ye Haoyuan Yu Mingbin Deng Wei Liu Hua Li Yang Yang Guoying Wang Department of Hepatic Surgery and Liver Transplant Program The Third Affiliated Hospital of Sun Yat-Sen UniversityGuangzhouGuangdongChina Department of Infectious Diseases and Hepatology Unit Nanfang HospitalSouthern Medi-cal UniversityGuangzhouGuangdongChina Guangdong Key Laboratory of Liver Disease Research The Third Affiliated Hospital of Sun Yat-Sen UniversityGuangzhouGuangdongChina

Background and Aims:Numerous studies have explored the important role of N6-methyladenosine(m^(6)A)in ***,the interaction between m^(6)A and long noncoding RNAs(lncRNAs)is poorly ***,we systematically analyzed the role and prognostic value of m^(6)A-related lncRNAs in hepatocellular carcinoma(HCC).Methods:The m^(6)A-related lncRNAs were identified based on the correlation coefficients with m^(6)A-related genes in HCC from The Cancer Genome ***,a novel risk score model was determined using the least absolute shrinkage and selection operator Cox regression *** and multivariate Cox analyses were used to identify independent prog-nostic factors for overall survival(OS)of HCC;thereafter,a prognostic nomogram was ***:A total of 259 lncRNAs showed significant correlations with m^(6)A in HCC,while 29 lncRNAs had prognostic ***,six critical m^(6)A-related lncRNAs(NRAV,SNHG3,KDM4A-AS1,AC074117.1,AC025176.1,and AL031985.3)were screened out to construct a novel risk score model which classified HCC patients into high-and low-risk *** analy-ses revealed that patients in the high-risk group exhibited worse OS,both in the training and validation *** risk score was also identified as an independent prognostic factor of OS,and a nomogram was established and verified with superior prediction ***,the risk score signifi-cantly correlated with the expression of immune checkpoint genes and immune ***:These findings indicated the significant role of m^(6)A-related lncRNAs in HCC and the potential application of the novel risk score model for prognostic prediction.

关键词： Hepatocellular carcinoma N6-methyladenosine Long noncoding RNAs Prognosis Immune checkpoints

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Upregulation of TMCO3 Promoting Tumor Progression and Contributing to the Poor Prognosis of Hepatocellular Carcinoma

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Journal of Clinical and Translational Hepatology 2022年第5期10卷 913-924页

作者： Tianxing Dai linsen ye Mingbin Deng Guozhen Lin Rongqiang Liu Haoyuan Yu Wei Liu Yang Yang Guoying Wang Department of Hepatic Surgery and Liver Transplant Program The Third Affiliated Hospital of Sun Yat-Sen UniversityGuangzhouGuangdongChina Guangdong Key Laboratory of Liver Disease Research The Third Affiliated Hospital of Sun Yat-Sen UniversityGuangzhouGuangdongChina Department of Hepatic Surgery The Third People’s Hospital of ShenzhenShenzhenGuangdongChina Department of Hepatobiliary Surgery The First Affiliated Hospital of Guangzhou Medical UniversityGuangzhouGuangdongChina

Background and Aims:TMCO3,a member of the monovalent cation:proton antiporter-2 family,has been annotated as a Na^(+)/H^(+)antiporter,but its pathophysiological role is still *** aimed to investigate the expression profile,prognostic significance,and oncogenic role of TMCO3 in hepatocellular carcinoma(HCC).Methods:Bioinformatic analyses were conducted using transcriptome data from public databases to determine the expression,prognosis,and functional enrichment of TMCO3 in ***3 expression was further validated in an independent HCC cohort from our *** oncogenic role of TMCO3 in HCC was evaluated using in vitro and in vivo ***:The upregulated expression of TMCO3 was identified and verified in multiple HCC cohorts,and worse overall survival and recurrence-free survival were observed in patients with high TMCO3 *** overexpression and knockdown of TMCO3 could affect the proliferation and metastasis of HCC cells,which might be associated with the p53-induced cell cycle regulation and epithelial-mesenchymal transition,***,significant correlations were found between dysregulated TMCO3 and various antitumor *** role in sorafenib sensitivity was further identified by in vitro experiments and the potential mechanism might be related to the regulation of *** correlations were also identified between upregulation of TMCO3 and the increased infiltration of various immune cells and the elevated expression of multiple immune checkpoint genes in ***:Upregulated TMCO3 could act as an oncogenic mediator and promote sorafenib resistance in HCC,providing a potential therapeutic target for HCC treatment.

关键词： Hepatocellular carcinoma TMCO3 Sorafenib Oncogene,prognosis

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Camrelizumab(SHR-1210)treatment for recurrent hepatocellular carcinoma after liver transplant:A report of two cases

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Liver Research 2022年第2期6卷 111-115页

作者： Tianxing Dai Qing Yang Yingcai Zhang linsen ye Hua Li Shuhong Yi Wei Liu Yang Yang Guoying Wang Department of Hepatic Surgery Liver Transplantation CenterThe Third Affiliated Hospital of Sun Yat-sen UniversityGuangzhouGuangdongChina Organ Transplantation Institute of Sun Yat-sen University GuangzhouGuangdongChina Guangdong Key Laboratory of Liver Disease Research The Third Affiliated Hospital of Sun Yat-sen UniversityGuangzhouGuangdongChina

Immune checkpoint inhibitors are generally contraindicated for post-transplant ***,we report two patients with metastatic hepatocellular carcinoma(HCC)treated with camrelizumab(SHR-1210),an anti-programmed cell death 1(PD-1)agent,after liver *** undergoing immunotherapy,both patients underwent liver allograft biopsy and obtained negative PD-L1 expression in tumor and liver graft specimens by ***,camrelizumab(200 mg)was administered once every 3 *** immunotherapy,the targeted therapy was continued,and the immunosuppression regimen was adjusted to a low-dose *** graft rejection or other severe adverse reactions were *** disease remained stable(SD,mRECIST)for 3 months in one patient and 10 months in the ***,camrelizumab may have safety and potential benefits in advanced HCC after liver transplant.

关键词： Anti-programmed cell death 1(PD-1)agent Camrelizumab Hepatocellular carcinoma(HCC) Immune checkpoint inhibitors(ICIs) Liver transplant Recurrence

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Study on Surface Treatments on CdSe Wafers

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Journal of Rare Earths 2006年第Z1期24卷 272-275页

作者： Ren Rui Zhao Beijun Zhu Shifu He Zhiyu Wang Ruilin Wen Cai ye linsen Zhong Yuhang Zhu Xinghua Department of Materials Science Sichuan UniversityChengdu 610064China

The surface treatments on CdSe wafers were studied by means of SEM,XPS and micro-current test *** relations between electrical properties of CdSe wafers and surface topography,composition and structure were *** results show that the change of surface composition by etching is beneficial to decrease leakage ***,the increase of oxygen on surface caused by passivation can largely decrease leakage *** passivating time is 40 min,the wafers surface appears smooth and compact,which will decrease the density of surface state,the optimal electrical property of the wafer is therefore obtained.

关键词： CdSe crystal surface treatment etching passivation electrical property

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人工智能在肝移植中的应用

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临床肝胆病杂志 2022年第1期38卷 30-34页

作者：梁智星叶林森杨扬中山大学附属第三医院肝脏外科暨肝移植中心中山大学器官移植研究所广东省器官移植研究中心广州510630

随着5G和大数据时代的来临,多维度、大样本的复杂医疗数据为新时代临床医学带来众多机遇和挑战。与传统方法相比,人工智能可以更高效地挖掘庞大数据集中的隐藏联系,越来越多的学者将这一先进技术应用于疾病的诊断和治疗。经过半个多世... 详细信息

随着5G和大数据时代的来临,多维度、大样本的复杂医疗数据为新时代临床医学带来众多机遇和挑战。与传统方法相比,人工智能可以更高效地挖掘庞大数据集中的隐藏联系,越来越多的学者将这一先进技术应用于疾病的诊断和治疗。经过半个多世纪的发展和完善,肝移植已成为治疗各种终末期肝病最有效的方法。与其他领域的“单患者”数据分析不同,肝移植通常需要考虑供体和受体“双患者”的特征以及移植过程中的变量,产生较其他疾病更为庞大的医疗数据,这与人工智能的优势尤为契合。有效利用人工智能的手段、结合临床研究开展将为智能精准临床医学时代拉开新的序幕。对于人工智能在肝移植的交叉应用,需要全面讨论人工智能技术在肝移植中的优势和局限性,并提出该领域的未来方向。

关键词：肝移植人工智能机器学习深度学习

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投资者情绪、杠杆资金与股票价格——兼论2015～2016年股灾成因

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金融经济学研究 2017年第1期32卷 85-98页

作者：王健俊殷林森叶文靖上海立信会计金融学院金融学院上海201209 沈阳师范大学旅游管理学院辽宁沈阳110034

基于2015年所爆发的"股灾"选取2014~2016年数据,以个股层面的股价收益、股价波动以及基于VECM的市场宏观层面的股价泡沫作为主要被解释变量,通过主成分分析法构建投资者情绪,以两融余额作为杠杆资金的度量进行实证分析。研究结果表明,... 详细信息

基于2015年所爆发的"股灾"选取2014~2016年数据,以个股层面的股价收益、股价波动以及基于VECM的市场宏观层面的股价泡沫作为主要被解释变量,通过主成分分析法构建投资者情绪,以两融余额作为杠杆资金的度量进行实证分析。研究结果表明,微观层面投资者情绪显著加大了股价收益及波动风险并且存在风险补偿效应;融资融券总体表现出的融资强杠杆及融券弱风险对冲的特点存在着加大情绪对股价波动的净效应;宏观市场层面基于股价泡沫的VAR结果发现情绪与泡沫互为Granger原因,投资者情绪影响融资杠杆进而对股价泡沫和融券杠杆产生影响,股价泡沫的变化又反过来影响了投资者的情绪;上述三因素中,投资者情绪冲击的影响程度最大。由此提出稳定投资者情绪、有效运用和完善杠杆制度等监管建议。

关键词：股灾投资者情绪杠杆资金股票价格

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Be/CuCrZr合金扩散连接的界面行为

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稀有金属材料与工程 2010年第1期39卷 122-125页

作者：叶林森谌继明谢东华王锡胜许泽金陈伟中国工程物理研究院四川绵阳612900 核工业西南物理研究院四川成都610041

在不同表面粗糙度的Be侧镀Ti/Cu中间层,采用热等静压技术将铍与CuCrZr合金进行扩散连接。通过AES、SEM(EDS)、室温剪切试验和XRD等分析其镀层形貌及成分、界面特性与相结构。结果表明:9μmTi、35μmCu镀层带征较为均匀,影响扩散连接强... 详细信息

在不同表面粗糙度的Be侧镀Ti/Cu中间层,采用热等静压技术将铍与CuCrZr合金进行扩散连接。通过AES、SEM(EDS)、室温剪切试验和XRD等分析其镀层形貌及成分、界面特性与相结构。结果表明:9μmTi、35μmCu镀层带征较为均匀,影响扩散连接强度的元素较少,采用双靶单侧镀复合膜的工艺有利于减少Ti镀层的氧化;界面剪切强度明显提高,最高可达243MPa,Be表面粗糙度的不同对强度影响不明显;Be-Ti连接强度高,剪切断裂均发生在Cu镀层。

关键词：表面粗糙度 Be:CuCrZr合金镀层热等静压扩散连接

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镍基铸造高温合金的热等静压改性研究

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金属热处理 2014年第1期39卷 85-88页

作者：王伟李强杨维才叶林森中国工程物理研究院四川绵阳621900

研究了热等静压处理对镍基铸造高温合金内部缺陷及显微组织的影响。结果表明,铸态镍基高温合金中存在大量疏松、孔洞等缺陷,合金由γ相及γ'相两相共存,γ'相的数量较多但分布不均匀,并有少量已发生团聚。1040℃×2 h热等静压处理可明... 详细信息

研究了热等静压处理对镍基铸造高温合金内部缺陷及显微组织的影响。结果表明,铸态镍基高温合金中存在大量疏松、孔洞等缺陷,合金由γ相及γ'相两相共存,γ'相的数量较多但分布不均匀,并有少量已发生团聚。1040℃×2 h热等静压处理可明显减少合金中疏松和孔洞等显微缺陷,增加强化相数量,但γ'相有少量聚集长大。1200℃×2 h下热等静压处理基本消除了合金中的疏松组织,但仍存在少量的微孔,原始的γ'相溶化并重新析出了细小的二次γ'相。

关键词：镍基高温合金铸造合金热等静压显微组织缺陷

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退火温度对纯钒组织和性能的影响(英文)

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稀有金属材料与工程 2008年第9期37卷 1566-1569页

作者：谢东华刘柯钊鲜晓斌叶林森陈艳平中国工程物理研究院四川绵阳621900

研究了不同退火温度对热等静压(HIP)纯钒组织和力学性能的影响。结果表明,纯钒的退火过程呈明显的回复、再结晶、晶粒长大3个阶段;随退火温度升高,板条状马氏体含量减少,温度高于950℃退火时板条状马氏体消失;随着退火温度的升高,纯钒... 详细信息

研究了不同退火温度对热等静压(HIP)纯钒组织和力学性能的影响。结果表明,纯钒的退火过程呈明显的回复、再结晶、晶粒长大3个阶段;随退火温度升高,板条状马氏体含量减少,温度高于950℃退火时板条状马氏体消失;随着退火温度的升高,纯钒的拉伸强度降低,塑性先增加后降低;塑性在950℃退火时达最大值,延伸率、断面收缩率分别为35.2%、64%。

关键词：钒热等静压退火组织力学性能

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