Novel organoid model in drug screening: Past, present, and future

作     者：Xialin Nie Zhixing Liang Kun Li Haoyuan Yu Yuhan Huang Linsen Ye Yang Yang Xialin Nie;Zhixing Liang;Kun Li;Haoyuan Yu;Yuhan Huang;Linsen Ye;Yang Yang

作者机构：Guangdong Provincial Key Laboratory of Liver Disease ResearchGuangzhouChina School of Foreign LanguagesSun Yat-sen UniversityGuangzhouChina Department of Hepatic Surgery and Liver Transplantation CenterThe Third Affiliated Hospital of Sun Yat-sen UniversityGuangzhouChina 

出 版 物：《Liver Research》 (肝脏研究（英文）)

年 卷 期：2021年第5卷第2期

页      面：72-78页

核心收录：

学科分类：08[工学] 080502[工学-材料学] 0805[工学-材料科学与工程（可授工学、理学学位）] 

基　　金：This work was supported by:National 13th Five-Year Science and Technology Plan Major Projects of China(2017ZX10203205) National Key R&D Plan(2017YFA0104304) National Natural Science Foundation of China(81770648,81972286) Guangdong Natural Science Foundation(2018A030313259,2015A030312013) Science and Technology Program of Guangdong Province(2017B020209004,20169013,2020B1212060019) Science and Technology Program of Guangzhou City(201508020262) Guangdong Basic and Applied Basic Research Foundation(2019A1515110654,2020A1515010574) the Fundamental Research Funds for the Central Universities(20ykpy38) and China Postdoctoral Science Foundation(2019TQ0369,2020M672987) 

主　　题：Organoid Drug screening Patient-derived cancer cell line(PDC)model Patient-derived xenograft(PDX)model Patient-derived organoid(PDO)model 

摘      要：Advances in the field of stem cells have led to the development of a technology called *** are cell cluster structures formed by the cultivation of stem cells in a three-dimensional environment in vitro,and they can simulate the living environment of cells in *** play an important role in the screening of drugs for tumor *** with traditional drug screening models,tumor organoid models derived from patient tumors have higher sensitivity,heterogeneity,and stability and can restore the real situation of tumors more *** have conducted a number of researches on the feasibility of using organoid technology in drug *** testing and comparing the effects of antitumor drugs in organoids and primary tumors,we can select the most appropriate treatment drugs for *** the past ten years,organoids from dozens of tissues and biological sample banks from several main organs have been established,and a large number of anticancer drugs have been screened *** article summarizes the advantages and disadvantages of traditional drug screening models,discusses the development history of organoid technology,and reviews the research results on organoids from tumor drug *** addition,the combination of organoid technology and other modern biotechnologies is put forward to further promote the role of organoid technology in the medical ***,this article reviews the history,progress,and prospect on organoids from the view of antitumor drug screening.