检索结果-南通市图书馆

蛋白质结构预测模型AlphaFold2的应用进展

在线全文

学校读者我要写书评

暂无评论

生物工程学报 2024年第5期40卷 1406-1420页

作者：张弘王慧洁鲁睿捷兰家靖陈林洁何小柏杭州医学院检验医学院与生物工程学院浙江杭州310053 检验诊断关键技术浙江省工程研究中心浙江杭州310053 浙江省生物标志物与体外诊断转化重点实验室浙江杭州310053

蛋白质结构预测是生命科学和医学的重要研究领域,也是人工智能在科学研究中的重要应用场景。AlphaFold2是由DeepMind开发的一种基于深度学习的蛋白质结构预测系统,可以从氨基酸序列中高效地生成原子级精度的蛋白质空间结构。由于AlphaFo... 详细信息

蛋白质结构预测是生命科学和医学的重要研究领域,也是人工智能在科学研究中的重要应用场景。AlphaFold2是由DeepMind开发的一种基于深度学习的蛋白质结构预测系统,可以从氨基酸序列中高效地生成原子级精度的蛋白质空间结构。由于AlphaFold2优越的性能,自问世以来对蛋白质结构预测方面的研究提供了前所未有的助力,因此备受关注和研究。本文介绍了AlphaFold2的模型架构、亮点、局限性和应用进展,列举了几种其他类型的蛋白质结构预测模型,并讨论了其能力、优势及局限性并思考该蛋白质结构预测模型的未来发展方向。

关键词： AlphaFold2 蛋白质结构蛋白质结构预测深度学习

A New Position Calibration Method for MUSER Images

在线全文

学校读者我要写书评

暂无评论

Research in Astronomy and Astrophysics 2022年第10期22卷 202-216页

作者： Zhichao Zhou Yihua Yan linjie chen Wei Wang Suli Ma State Key Laboratory of Space Weather National Space Science CenterChinese Academy of SciencesBeijing 100190China National Astronomical Observatories Chinese Academy of SciencesBejing 100101China University of Chinese Academy of Sciences Beijing 100049China

The Mingantu Spectral Radioheliograph(MUSER),a new generation of solar dedicated radio imagingspectroscopic telescope,has realized high-time,high-angular,and high-frequency resolution imaging of the Sun over an ultra-broadband frequency *** pair of MUSER antennas measures the complex visibility in the aperture plane for each integration time and frequency *** corresponding radio image for each integration time and frequency channel is then obtained by inverse Fourier transformation of the visibility ***,the phase of the complex visibility is severely corrupted by instrumental and propagation ***,robust calibration procedures are vital in order to obtain high-fidelity radio *** there are many calibration techniques available—e.g.,using redundant baselines,observing standard cosmic sources,or fitting the solar disk—to correct the visibility data for the above-mentioned phase errors,MUSER is configured with non-redundant baselines and the solar disk structure cannot always be *** it is desirable to develop alternative calibration methods in addition to these available techniques whenever appropriate for MUSER to obtain reliable radio *** the case where a point-like calibration source contains an unknown position error,we have for the first time derived a mathematical model to describe the problem and proposed an optimization method to calibrate this unknown error by studying the offset of the positions of radio images over a certain period of the time *** experiments and actual observational data analyses indicate that this method is valid and *** MUSER’s practical data the calibrated position errors are within the spatial angular resolution of the *** calibration method can also be used in other situations for radio aperture synthesis observations.

关键词： instrumentation interferometers-Sun radio radiation-techniques interferometric-techniques image processing-methods data analysis-methods observational-Sun activity-(Sun:)solar-terrestrial relations

TIPS治疗围手术期颈-股动脉脉搏波传导速度的变化及影响因素分析

在线全文

学校读者我要写书评

暂无评论

中国超声医学杂志 2024年第7期40卷 805-808页

作者：刘丽清郑滨雨陈霖婕丁香赵晗孔慧茜刘勇桂林医学院附属医院超声科首都医科大学附属北京世纪坛医院超声科

目的探讨接受经颈静脉肝内门体静脉分流术(TIPS)治疗的肝硬化患者围手术期颈-股动脉脉搏波传导速度(cf-PWV)的变化及影响因素。方法回顾性收集诊治的肝硬化患者45例，均接受TIPS治疗。术前2周及术后2周内采用超声检测颈-R时间、股-R... 详细信息

目的探讨接受经颈静脉肝内门体静脉分流术(TIPS)治疗的肝硬化患者围手术期颈-股动脉脉搏波传导速度(cf-PWV)的变化及影响因素。方法回顾性收集诊治的肝硬化患者45例，均接受TIPS治疗。术前2周及术后2周内采用超声检测颈-R时间、股-R时间、△T,测量颈-股距离，并依此计算cf-PWV。应用终末期肝病模型(MELD)评分系统对每个患者进行评分，采用t检验比较两组间的超声检测参数及MELD评分，cf-PWV与各因素的关系采用多元逐步线性回归分析。结果术后MELD评分、血总胆红素、凝血酶原时间、国际标准化比值均较术前显著增高(P<0.01),而cf-PWV较术前显著降低(P<0.01)。多元线性回归分析显示，术前cf-PWV与术前MELD评分、年龄有线性回归关系(标准化回归系数b′=0.577、0.493,P<0.05);术后cf-PWV与术后MELD评分、年龄、总胆红素有线性回归关系(标准化回归系数b′=0.272、0.499、0.238,P<0.05)。结论接受TIPS治疗的肝硬化患者短期内血管弹性有所改善，其对血管弹性的长期影响仍需要研究。cf-PWV有望成为一种简便的评价肝硬化患者血管弹性功能动态变化的方法。

关键词：经颈静脉肝内门体静脉分流术颈-股动脉脉搏波传导速度血管弹性

Achieving long-cycling sodium-ion full cells in ether-based electrolyte with vinylene carbonate additive

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

Journal of Energy Chemistry 2021年第6期30卷 650-655,I0016页

作者： Juan Shi Lina Ding Yanhua Wan Liwei Mi linjie chen Dan Yang Yuxiong Hu Weihua chen Green Catalysis Center and College of ChemistryZhengzhou UniversityZhengzhou 450001HenanChina Henan Key Laboratory of Functional Salt Materials Center of Advanced Materials ResearchZhongyuan University of TechnologyZhengzhou 450007HenanChina College of Pharmacy Zhengzhou UniversityZhengzhou 450001HenanChina

Application of sodium-ion batteries is suppressed due to the lack of appropriate electrolytes matching cathode and anode ***-based electrolytes,preference of anode materials,cannot match with high-potential cathodes failing to apply in full ***,vinylene carbonate(VC)as an additive into NaCF_(3) SO_(3)-Diglyme(DGM)could make sodium-ion full cells applicable without preactivation of cathode and *** assembled FeS@C||Na3 V2(PO_(4))_(3)@C full cell with this electrolyte exhibits long term cycling stability and high capacity *** deduced reason is additive VC,whose HOMO level value is close to that of DGM,not only change the solvent sheath structure of Na^(+),but also is synergistically oxidized with DGM to form integrity and consecutive cathode electrolyte interphase on Na3 V2(PO_(4))_(3)@C cathode,which could effectively improve the oxidative stability of electrolyte and prevent the electrolyte *** work displays a new way to optimize the sodium-ion full cell seasily with bright practical application potential.

关键词： Cathode electrolyte interphase Sodium-ion batteries Full cell Ether-based electrolyte Vinylene carbonate DFT calculation

3D-printed porous functional composite scaffolds with polydopamine decoration for bone regeneration

在线全文

学校读者我要写书评

暂无评论

Regenerative Biomaterials 2023年第1期10卷 1233-1247页

作者： Jinn Qi Yili Wang Liping chen linjie chen Feng Wen Lijiang Huang Pfukwa Rueben Chunwu Zhang Huaqiong Li Department of Orthopaedics Joint Centre of Translational MedicineThe First Affiliated Hospital of Wenzhou Medical UniversityWenzhouZhejiang 325035P.R.China Joint Centre of Translational Medicine Zhejiang Engineering Research Center for Tissue Repair MaterialsWenzhou InstituteUniversity of Chinese Academy of SciencesWenzhouZhejiang 325011P.R.China University of Chinese Academy of Sciences Beijing 100049P.R.China The Second Affiliated Hospital of Wenzhou Medical University WenzhouZhejiang 325035P.R.China The Affiliated Xiangshan Hospital of Wenzhou Medical University NingboZhejiang 315700P.R.China Department of Chemistry and Polymer Science Stellenbosch UniversityMatielandStellenbosch 7602South Africa

Large size bone defects affect human health and remain a worldwide health problem that needs to be solved immediately.3D printing technology has attracted substantial attention for preparing penetrable multifunctional scaffolds to promote bone reconditioning and *** by the spongy structure of natural bone,novel porous degradable scaffolds have been printed using polymerization of lactide and caprolactone(PLCL)and bioactive glass 45S5(BG),and polydopamine(PDA)was used to decorate the PLCL/BG *** physicochemical properties of the PLCL/BG and PLCL/BG/PDA scaffolds were measured,and their osteogenic and angiogenic effects were characterized through a series of experiments both in vitro and in *** results show that the PLCL/BG2/PDA scaffold possessed a good compression modulus and brilliant *** proliferation,adhesion and osteogenesis of hBMSCs were improved in the PDA coating groups,which exhibited the best *** results of the SD rat cranium defect model indicate that PLCL/BG2/PDA obviously promoted osteointegration,which was further confirmed through immunohistochemical ***,PDA decoration and the sustained release of bioactive ions(Ca,Si,P)from BG in the 3D-printed PLCL/BG2/PDA scaffold could improve surface bioactivity and promote better osteogenesis and angiogenesis,which may provide a valuable basis for customized implants in extensive bone defect repair applications.

关键词： 3D printing bioactive glass composites polydopamine angiogenesis bone regeneration

Geologic,Fluid Inclusion and Stable Isotope Constraints on Mechanisms of Ore Deposition at the Datuanshan Copper Deposit,Middle-Lower Yangtze Valley,Eastern China

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Acta Geologica Sinica(English Edition) 2015年第3期89卷 746-765页

作者： CAO Yi DU Yangsong PANG Zhenshan DU Yilun KOU Shaolei chen linjie GAO Fuping ZHOU Guibi State Key Laboratory of Geological Processes and Mineral Resources China University of Geosciences Development and Research Center of China Geological Survey No.321 Geological Team of Bureau of Geology and Mineral Resources Exploration of Anhui Province Tongling Nonferrous Metals Group Co. Ltd.

The Datuanshan deposit is one of the largest and most representative stratabound copper deposits in the Tongling area,the largest ore district in the Middle-Lower Yangtze River metallogenic *** location of the orebodies is controlled by the interlayer-slipping faults between the Triassic and Permian strata,and all the orebodies are distributed in stratiform shape around the Mesozoic quartz monzodiorite *** on field evidence and petrographic observations,four mineralization stages in the Datuanshan deposit have been identified：the skarn,early quartz-sulfide,late quartzsulfide and carbonate *** is the main copper mineral and mainly formed at the late quartz-sulfide *** inclusions at different stages were studied for petrography,microthermometry,laser Raman spectrometry and stable *** types of fluid inclusions,including three-phase fluid inclusions（type 1）,liquid-rich fluid inclusions（type 2）,vapour-rich fluid inclusions（type 3） and pure vapour fluid inclusions（type 4）,were *** minerals from the skarn,early and late quartz-sulfide stages contain all fluid inclusion types,but only type 2 fluid inclusions were observed at the carbonate *** observations suggest that most of the inclusions studied in this paper are likely *** coexistence of different types of fluid inclusions with contrasting homogenization characteristics（to the liquid and vapour phase,respectively） and similar homogenization temperatures（the modes are 440-480℃,380-400℃ and 280-320℃ for the skarn,early and late quartz-sulfide stages,respectively） in the first three stages,strongly suggests that three episodes of fluid boiling occurred during these stages,which is supported by the hydrogen isotope *** Raman spectra identified CH_4 at the skarn and early quartz-sulfide *** with other geological features,the early ore-forming fluids were inferred to be under a relatively reduced *** CO_2 component ha

关键词： Stratabound skarn deposit fluid inclusions stable isotopes Datuanshan deposit Middle-Lower Yangtze Valley

Broadband radio spectral observations of the solar eclipse on 2008-08-01 and its implications on the quiet Sun atmospheric model

在线全文

学校读者我要写书评

暂无评论

Science China(Physics,Mechanics & Astronomy) 2009年第11期52卷 1765-1772页

作者： TAN BaoLin YAN YiHua ZHANG Yin TAN chengMin HUANG Jing LIU YuYing FU QiJun chen ZhiJun LIU Fei chen linjie JI GuoShu Key Laboratory of Solar Activity National Astronomical ObservatoriesChinese Academy of SciencesBeijing 100021China

Based on the joint-observations of the radio broadband spectral emissions of the solar eclipse on August 1, 2008 at Jiuquan (total eclipse) and Huairou (partial eclipse) at the frequencies of 2.00-5.60 GHz (Jiuquan), 2.60-3.80 GHz (Chinese solar broadband radiospectrometer, SBRS/Huairou), and 5.20-7.60 GHz (SBRS/Huairou), the authors assemble a successive series of broadband spectra with a frequency of 2.60-7.60 GHz to observe the solar eclipse synchronously. This is the first attempt to analyze the solar eclipse radio emission under the two telescopes located at different places with broadband frequencies in the periods of total and partial eclipses. With these analyses, the authors made a semiempirical model of the coronal plasma density of the quiet Sun, which can be expressed as ne 1.42×109(r-2+1.93r-5) (cm-3), in the space range of r=1.039-1.212 R , and made a comparison with the classic model.

关键词： atmospheric model eclipse quiet Sun radio emission plasma

Large-Scale Multi-Objective Optimization Algorithm Based on Weighted Overlapping Grouping of Decision Variables

在线全文

学校读者我要写书评

暂无评论

Computer Modeling in Engineering & Sciences 2024年第7期140卷 363-383页

作者： Liang chen Jingbo Zhang linjie Wu Xingjuan Cai Yubin Xu Shanxi Key Laboratory of Big Data Analysis and Parallel Computing Taiyuan University of Science and TechnologyTaiyuan030024China School of State Key Laboratory of Novel Software Technology Nanjing UniversityNanjing210008China

The large-scale multi-objective optimization algorithm(LSMOA),based on the grouping of decision variables,is an advanced method for handling high-dimensional decision ***,in practical problems,the interaction among decision variables is intricate,leading to large group sizes and suboptimal optimization effects;hence a large-scale multi-objective optimization algorithm based on weighted overlapping grouping of decision variables(MOEAWOD)is proposed in this ***,the decision variables are perturbed and categorized into convergence and diversity variables;subsequently,the convergence variables are subdivided into groups based on the interactions among different decision *** the size of a group surpasses the set threshold,that group undergoes a process of weighting and overlapping ***,the interaction strength is evaluated based on the interaction frequency and number of objectives among various decision *** decision variable with the highest interaction in the group is identified and disregarded,and the remaining variables are then reclassified into ***,the decision variable with the strongest interaction is added to each *** minimizes the interactivity between different groups and maximizes the interactivity of decision variables within groups,which contributed to the optimized direction of convergence and diversity exploration with different *** was subjected to testing on 18 benchmark large-scale optimization problems,and the experimental results demonstrate the effectiveness of our *** with the other algorithms,our method is still at an advantage.

关键词： Decision variable grouping large-scale multi-objective optimization algorithms weighted overlapping grouping direction-guided evolution

Engineered high-strength biohydrogel as a multifunctional platform to deliver nucleic acid for ameliorating intervertebral disc degeneration

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Bioactive Materials 2023年第7期25卷 107-121页

作者： Tao chen Qiuping Qian Pooyan Makvandi Ehsan Nazarzadeh Zare Qizhu chen linjie chen Zhiguang Zhang Hao Zhou Wenxian Zhou Hui Wang Xiangyang Wang Yu chen Yunlong Zhou Aimin Wu Department of Orthopaedics Key Laboratory of Orthopaedics of Zhejiang ProvinceThe Second Affiliated Hospital and Yuying Children’s Hospital of Wenzhou Medical UniversityWenzhouZhejiang325000China Zhejiang Engineering Research Center for Tissue Repair Materials Wenzhou InstituteUniversity of Chinese Academy of SciencesWenzhouZhejiang325000China Institute for Bioengineering School of EngineeringThe University of EdinburghEdinburghEH93FBUK School of Chemistry Damghan UniversityDamghan36716-45667Iran Wenzhou Medical University WenzhouZhejiang325000China Materdicine Lab School of Life SciencesShanghai UniversityShanghai200444China

Intervertebral disc degeneration(IVDD)is a leading cause of low back *** strategy of using functional materials to deliver nucleic acids provides a powerful tool for ameliorating ***,the immunogenicity of nucleic acid vectors and the poor mechanical properties of functional materials greatly limit their ***,antagomir-204-3p(AM)shows low immunogenicity and effectively inhibits the apoptosis of nucleus pulposus ***,a high-strength biohydrogel based on zinc-oxidized sodium alginate-gelatin(ZOG)is designed as a multifunctional nucleic acid delivery *** loaded with AM(ZOGA)exhibits great hygroscopicity,antibacterial activity,biocompatibility,and ***,ZOGA can be cross-linked with nucleus pulposus tissue to form a high-strength collagen network that improves the mechanical properties of the intervertebral disc(IVD).In addition,ZOGA provides an advantageous microenvironment for genetic expression in which AM can play an efficient role in maintaining the metabolic balance of the extracellular *** results of the radiological and histological analyses demonstrate that ZOGA restores the height of the IVD,retains moisture in the IVD,and maintains the tissue *** ZOGA platform shows the sustained release of nucleic acids and has the potential for application to ameliorate IVDD,opening a path for future studies related to IVD.

关键词： Intervertebral disc degeneration Hydrogel Nucleic acid MicroRNA Delivery Extracellular matrix