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Ataxia-telangiectasia complicated with Hodgkin's lymphoma:A case report

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World Journal of Clinical Cases 2020年第11期8卷 2387-2391页

作者： xiao-ling li Yi-lin Wang Department of Pediatrics(III) The Linyi People’s HospitalLinyi 276000Shandong ProvinceChina

BACKGROUND Ataxia-telangiectasia(AT)is a rare,autosomal recessive,multisystem *** most clinicians have low awareness of the disease,only scarce reports of AT exist in the literature,especially of cases with lymphoma/*** SUMMARY A 7-year-old girl with a history of recurrent respiratory tract infections was referred to our department because of unstable walking for 5 years and enlarged neck nodes for 2-mo *** examination revealed scleral telangiectasia and cerebellar *** alpha-fetoprotein,decreased serum immunoglobulin,and decreased T cell function were the major findings of laboratory *** analysis of cervical lymph node biopsy was suggestive of classical Hodgkin's *** examination showed heterozygous nucleotide variation of c.6679C>T and heterozygous nucleotide variation of c.5773 delG in the ATM gene;her parents were *** final diagnosis was AT with Hodgkin's *** Clinicians should strengthen their understanding of AT *** diagnosis plays an important role in its diagnosis and treatment.

关键词： Ataxia-telangiectasia Hodgkin's lymphoma Child Case report ATM gene

Investigation of Cationic Soapless P(St-co-DMAEMA) Latex and Its Electrostatic Adsorption of Laponite

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Chinese Journal of Polymer Science 2016年第10期34卷 1240-1250页

作者： jie shen jing xu yang hu jian-wu sun ling-xiao li 阚成友 Department of Chemical Engineering Key Laboratory of Advanced Materials of Ministry of Education Tsinghua University Beijing 100084 China

Cationic poly（styrene-co-N,N-dimethylaminoethyl methacrylate）（P（St-co-DMAEMA）） latexes were prepared in the absence of surfactant by using 2,2＇-azobis （2-methylpropionamidine） dihydrochloride （AIBA） as the initiator. The effects of the AIBA concentration, HC1/DMAEMA molar ratio and DMAEMA amount on the emulsion polymerization and the latex properties were investigated. The particle morphology and size, the zeta potential and the amino distribution of the P（St- co-DMAEMA） latexes were characterized by transmission electron microscope （TEM）, dynamic light scattering （DLS） and conductometric titration, respectively. Results showed that the emulsion polymerization performed smoothly with high monomer conversion and narrow particle size distribution under the optimized conditions with AIBA concentration of1 wt%, HC1/DMAEMA molar ratio of 1.2 and DMAEMA content of 5 wt%. The diameter of the dried latex particles decreased and the density of amino groups on the particle surfaces increased with increasing the DMAEMA content. The zeta potential of the P（St-co-DMAEMA） latexes was pH-dependent and the zero point was around at pH 7.2. A facile method was developed to fabricate P（St-co-DMAEMA）/laponite hybrid nanoparticles via electrostatic adsorption, in which the loading capacity of laponite platelets reached 17.7 wt%, and the resultant hybrid nanoparticles showed good thermal stability.

关键词： Cationic latex Soapless emulsion polymerization DMAEMA Polymeric-laponite nanoparticles.

Topology awareness algorithm for virtual network mapping

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Journal of Zhejiang University-Science C(Computers and Electronics) 2012年第3期13卷 178-186页

作者： xiao-ling li Huai-min WANG Chang-guo GUO Bo DING xiao-yong li Wen-qi BI Shuang TAN National Key Laboratory of Parallel and Distributed Processing National University of Defense Technology.Changsha 410073China School of Computer National University of Defense TechnologyChangsha 410073China China Electronic Systems Engineering Corporation Beijing 100039China The Northern Institute of Electronic Equipment of China Beijing 100083China

Network virtualization is recognized as an effective way to overcome the ossification of the Internet. However, the virtual network mapping problem (VNMP) is a critical challenge, focusing on how to map the virtual networks to the substrate network with efficient utilization of infrastructure resources. The problem can be divided into two phases: node mapping phase and link mapping phase. In the node mapping phase, the existing algorithms usually map those virtual nodes with a complete greedy strategy, without considering the topology among these virtual nodes, resulting in too long substrate paths (with multiple hops). Addressing this problem, we propose a topology awareness mapping algorithm, which considers the topology among these virtual nodes. In the link mapping phase, the new algorithm adopts the k-shortest path algorithm. Simulation results show that the new algorithm greatly increases the long-term average revenue, the acceptance ratio, and the long-term revenue-to-cost ratio (R/C).

关键词： Network virtualization Ossification Virtual network (VN) mapping Substrate network (SN) Topology awareness Acceptance ratio

Malakoplakia of the esophagus caused by human papillomavirus infection

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World Journal of Gastroenterology 2012年第45期18卷 6690-6692页

作者： Ya-li Yang Yu-Cheng Xie xiao-ling li Jing Guo Tao Sun Jing Tang Department of Pathology Yunnan Province Second People's Hospital Department of Pathology Changzhou Traditional Chinese Medical Hospital

Malakoplakia is a rare granulomatous disease probably caused by infection and characterized histologically by Michaelis-Gutmann *** report a more rarely seen case esophageal malakoplakia in a 54-year-old *** presented with coughing while eating and *** showed yellow nodules in the esophagus,and endoscopic ultrasonography showed a space-occupying lesion in the substratum of the esophageal *** findings highly resembled esophageal *** examination finally indentified this space-occupying lesion as malakoplakia and not *** showed that she had human papillomavirus(HPV) infection in the esophagus,which indicates that infection was responsible for the *** is believed to be the first case of malakoplakia in the esophagus,and more importantly,we established that HPV infection was the initiator of esophageal malakoplakia.

关键词： Malakoplakia Esophagus Michaelis-Gut- mann bodies Human papillomavirus infection

shRNA-interfering LSD1 inhibits proliferation and invasion of gastric cancer cells via VEGF-C/PI3K/AKT signaling pathway

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World Journal of Gastrointestinal Oncology 2019年第8期11卷 622-633页

作者： Hong-Ming Pan Wei-Ya Lang li-Jie Yao Yan Wang xiao-ling li Department of Biochemistry Qiqihar Medical UniversityQiqihar 161000Heilongjiang ProvinceChina Department of Histology and Embryology Qiqihar Medical UniversityQiqihar 161000Heilongjiang ProvinceChina Department of Anatomy Qiqihar Medical UniversityQiqihar 161000Heilongjiang ProvinceChina

BACKGROUND Histone Lysine Specific Demethylase 1(LSD1)is the first histone demethylase to be discovered,which regulates various biological functions by making lysine of histone H3K4,H3K9 and non-histone substrates *** regulation of LSD1 is closely related to the occurrence and development of gastric *** change of LSD1 expression level plays an important role in the proliferation and metastasis of gastric cancer *** study of its function and mechanism may provide a theoretical basis for early diagnosis and targeted therapy of gastric *** To investigate the effect of downregulation of lysine-specific demethylase 1(LSD1)expression on proliferation and invasion of gastric cancer cells and the possible regulatory mechanisms of the VEGF-C/PI3K/AKT signaling *** The LSD1-specific short hairpin RNA(shRNA)interference plasmid was transiently transfected,and expression of LSD1 was *** cell proliferation ability of LSD1 was observed by CCK-8 assay after downregulating expression of *** invasion assay was used to observe the change of cell invasion ability after downregulating expression of *** of phosphorylated phosphoinositide 3-kinase(p-PI3K),PI3K,p-AKT,AKT,vascular endothelial growth factor receptor(VEGFR)-3,matrix metalloproteinase(MMP)-2 and MMP-9 in each group was detected by Western *** The cell proliferation ability of transiently transfected LSD1-shRNA interference plasmid group was significantly lower than that of the control group(P<0.05).Transwell invasion assay showed that the number of cells across the membrane of the LSD1-shRNA transfection group(238.451±5.216)was significantly lower than that of the control group(49.268±6.984)(P<0.01).Western blotting showed that expression level of VEGF-C,p-PI3K,PI3K,p-AKT,AKT,VEGFR-3,MMP-2 and MMP-9 in the LSD1-shRNA group was significantly lower than that in the control group(P<0.05).CONCLUSION Downregulation of LSD1 expressio

关键词： Gastric cancer Lysine specific histone demethylase 1 Cell proliferation Cell invasion VEGF-C/PI3K/AKT signaling pathway

Increased activation of the caudate nucleus and parahippocampal gyrus in Parkinson's disease patients with dysphagia after repetitive transcranial magnetic stimulation:a case-control study

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Neural Regeneration Research 2022年第5期17卷 1051-1058页

作者： Pei-ling Huang Song-Jian Wang Rui-Feng Sun Zi-Man Zhu xiao-ling li Wen-Shan li Meng-Yue Wang Meng lin Wei-Jun Gong Department of Neurological Rehabilitation Beijing Rehabilitation Hospital of Capital Medical UniversityBeijingChina Beijing Key Laboratory of Fundamental Research on Biomechanics in Clinical Application School of Biomedical EngineeringCapital Medical UniversityBeijingChina Department of Neurological Rehabilitation Beijing Rehabilitation Medicine AcademyCapital Medical UniversityBeijingChina

Repetitive transcranial magnetic stimulation(r TMS)has been shown to effectively improve impaired swallowing in Parkinson's disease(PD)patients with ***,little is known about how r TMS affects the corresponding brain regions in this patient *** this casecontrol study,we examined data from 38 PD patients with dysphagia who received treatment at Beijing Rehabilitation Medicine Academy,Capital Medical *** patients received high-frequency r TMS of the motor cortex once per day for 10 successive *** in brain activation were compared via functional magnetic resonance imaging in PD patients with dysphagia and healthy *** results revealed that before treatment,PD patients with dysphagia showed greater activation in the precentral gyrus,supplementary motor area,and cerebellum compared with healthy controls,and this enhanced activation was weakened after ***,before treatment,PD patients with dysphagia exhibited decreased activation in the parahippocampal gyrus,caudate nucleus,and left thalamus compared with healthy controls,and this activation increased after *** addition,PD patients with dysphagia reported improved subjective swallowing sensations after r *** findings suggest that swallowing function in PD patients with dysphagia improved after r TMS of the motor *** may have been due to enhanced activation of the caudate nucleus and parahippocampal *** study protocol was approved by the Ethics Committee of Beijing Rehabilitation Hospital of Capital Medical University(approval No.2018 bkky017)on March 6,2018 and was registered with Chinese Clinical Trial Registry(registration *** CTR 1800017207)on July 18,2018.

关键词： brain regions caudate clinical trial dysphagia functional magnetic resonance imaging parahippocampal gyrus Parkinson's disease precentral gyrus repetitive transcranial magnetic stimulation saliva swallowing task

Antigens synthesis and antibodies preparation for furazolidone and its metabolite 3-amino-2-oxazolidinone

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Chinese Chemical Letters 2010年第9期21卷 1049-1052页

作者： Hua Ping Zhu Ting Ting liu Bing liu Hui ling Yin xiao Long li li Wang Shuo Wang Key Laboratory of Food Nutrition and Safety (Tianjin University of Science & Technology) Ministry of Education Tianjin 300457 China

Two haptens of 3-[（5-amino-furan-2-ylmethylene）amino]oxazolidin-5-one（FZ-NH_2） and 3-{[（4-carboxyphenyl）methylene]-amino} -2-oxazolidinone（CPAOZ） were *** FZ-NH2,immunogens were prepared by glutaraldehyde and diazo salt *** CPAOZ,immunogens were connected by the methods of the active ester and mixed acid *** with the combination,indirect competitive enzyme-linked immunosorbent assay（ic-EliSA） was developed with coating antigen of FZ-NH2 -OVA via the glutaraldehyde method and immunogen of CPAOZ-KLH via active ester *** furazolidone and its metabolite AOZ（NPAOZ as derivative）,the sensitivities（IC50） were 2.0μg/L and 2.5μg/L,limits of detection（IC15） were 0.09μg/L and 0.25μg/L,respectively.A sensitive method was developed for the simultaneous determination of furazolidone in feed and its metabolite AOZ in tissue.

关键词： Furzolidone AOZ Antigen Antibody EliSA

Single-cell analysis identifies phospholysine phosphohistidine inorganic pyrophosphate phosphatase as a target in ulcerative colitis

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World Journal of Gastroenterology 2023年第48期29卷 6222-6234页

作者： Yan-Fei Wang Ruo-Yu He Chan Xu xiao-ling li Yan-Fei Cao Department of Gastroenterology The Third Affiliated Hospital of Zhejiang Chinese Medical UniversityNo.219 Moganshan RoadXihu DistrictHangzhou 310005Zhejiang ProvinceChina Clinical laboratory The Third Affiliated Hospital of Zhejiang Chinese Medical UniversityNo.219 Moganshan RoadXihu DistrictHangzhou 310005Zhejiang ProvinceChina Elder Medicine Department The Third Affiliated Hospital of Zhejiang Chinese Medical UniversityNo.219 Moganshan RoadXihu DistrictHangzhou 310005Zhejiang ProvinceChina

BACKGROUND Ulcerative colitis(UC)is a chronic gastrointestinal disorder characterized by inflammation and ulceration,representing a significant predisposition to colorectal *** advances in single-cell RNA sequencing(scRNA-seq)technology offer a promising avenue for dissecting the complex cellular interactions and molecular signatures driving UC *** To utilize scRNA-seq technology to dissect the complex cellular interactions and molecular signatures that underlie UC *** In this research,we integrated and analyzed the scRNA-seq data from UC ***,we conducted mRNA and protein level assays as well as pathology-related staining tests on clinical patient *** In this study,we identified the sustained upregulation of inflammatory response pathways during UC progression,characterized the features of damaged endothelial cells in ***,we uncovered the downregulation of phospholysine phosphohistidine inorganic pyrophosphate phosphatase(LHPP)has a negative correlation with signal transducer and activator of transcription *** downregulation of LHPP in UC patient tissues and plasma suggests that LHPP may serve as a potential therapeutic target for *** paper highlights the importance of LHPP as a potential key target in UC and unveils its potential role in inflammation *** The findings suggest that LHPP may serve as a potential therapeutic target for UC,emphasizing its importance as a potential key target in UC and unveiling its role in inflammation regulation.

关键词： Ulcerative colitis Single-cell RNA sequencing Phospholysine phosphohistidine inorganic pyrophosphate phosphatase

Growth hormone therapy for children with KBG syndrome:A case report and review of literature

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World Journal of Clinical Cases 2020年第6期8卷 1172-1179页

作者： Xiu-Ying Ge Long Ge Wen-Wen Hu xiao-ling li Yan-Yan Hu Department of Child Health Maternal and Child Health Hospital of LinyiLinyi 276000Shandong ProvinceChina Department of Clinical Laboratory Linyi People’s HospitalLinyi 276000Shandong ProvinceChina Department of Pediatrics The People's Hospital of Lanshan DistrictLinyi 276000Shandong ProvinceChina Department of Pediatrics Linyi People’s HospitalLinyi 276000Shandong ProvinceChina

BACKGROUND The incidence of short stature in KBG syndrome is relatively *** on the therapeutic effects of growth hormone(GH)on children with KBG syndrome accompanied by short stature in the previous literature has not been *** SUMMARY Here we studied a girl with KBG syndrome and collected the data of children with KBG syndrome accompanied by short stature from previous studies before and after GH *** girl was referred to our department because of short *** examination revealed mild dysmorphic *** peak GH responses to arginine and clonidine were 6.22 and 5.40 ng/mL,*** level of insulin-like growth factor 1(IGF-1)was 42.0 ng/*** analysis showed a c.2635 dupG(***879fs)mutation in the ANKRD11 *** received GH *** the first year of GH therapy,her height increased by 0.92 standard deviation score(SDS).Her height increased from-1.95 SDS to-0.70 SDS after two years of GH *** were ten children with KBG syndrome accompanied by short stature who received GH therapy in reported *** SDS was improved in nine(9/10)of *** mean height SDS in five children with KBG syndrome accompanied by short stature increased from-2.72±0.44 to-1.95±0.57 after the first year of GH therapy(P=0.001).There were no adverse reactions reported after GH *** GH treatment is effective in our girl and most children with KBG syndrome accompanied by short stature during the first year of therapy.

关键词： Growth hormone therapy KBG syndrome ANKRD11 gene Short stature Children Case report