Single-cell analysis identifies phospholysine phosphohistidine inorganic pyrophosphate phosphatase as a target in ulcerative colitis
作者机构：Department of GastroenterologyThe Third Affiliated Hospital of Zhejiang Chinese Medical UniversityNo.219 Moganshan RoadXihu DistrictHangzhou 310005Zhejiang ProvinceChina Clinical laboratoryThe Third Affiliated Hospital of Zhejiang Chinese Medical UniversityNo.219 Moganshan RoadXihu DistrictHangzhou 310005Zhejiang ProvinceChina Elder Medicine DepartmentThe Third Affiliated Hospital of Zhejiang Chinese Medical UniversityNo.219 Moganshan RoadXihu DistrictHangzhou 310005Zhejiang ProvinceChina
出 版 物：《World Journal of Gastroenterology》 (世界胃肠病学杂志（英文版）)
年 卷 期：2023年第29卷第48期
页 面：6222-6234页
核心收录：
学科分类：1002[医学-临床医学] 100214[医学-肿瘤学] 10[医学]
基 金：Science and Technology Programme of Traditional Chinese Medicine in Zhejiang Province No.2023ZF114
主 题：Ulcerative colitis Single-cell RNA sequencing Phospholysine phosphohistidine inorganic pyrophosphate phosphatase
摘 要：BACKGROUND Ulcerative colitis(UC)is a chronic gastrointestinal disorder characterized by inflammation and ulceration,representing a significant predisposition to colorectal *** advances in single-cell RNA sequencing(scRNA-seq)technology offer a promising avenue for dissecting the complex cellular interactions and molecular signatures driving UC *** To utilize scRNA-seq technology to dissect the complex cellular interactions and molecular signatures that underlie UC *** In this research,we integrated and analyzed the scRNA-seq data from UC ***,we conducted mRNA and protein level assays as well as pathology-related staining tests on clinical patient *** In this study,we identified the sustained upregulation of inflammatory response pathways during UC progression,characterized the features of damaged endothelial cells in ***,we uncovered the downregulation of phospholysine phosphohistidine inorganic pyrophosphate phosphatase(LHPP)has a negative correlation with signal transducer and activator of transcription *** downregulation of LHPP in UC patient tissues and plasma suggests that LHPP may serve as a potential therapeutic target for *** paper highlights the importance of LHPP as a potential key target in UC and unveils its potential role in inflammation *** The findings suggest that LHPP may serve as a potential therapeutic target for UC,emphasizing its importance as a potential key target in UC and unveiling its role in inflammation regulation.
维普期刊数据库