检索结果-南通市图书馆

Noninvasive evaluation of hepatic fibrosis in children with infant hepatitis syndrome

在线全文

学校读者我要写书评

暂无评论

World Journal of Gastroenterology 2006年第44期12卷 7155-7160页

作者： Zhi-Xian Li Yun He Ji Wu Bu-Lin Zhang Hong Yang ling-ling wang Yun Ma Kang-Lai Wei Department of Ultrasound First Affiliated Hospital Guangxi Medical University Nanning 530021 Guangxi Zhuang Autonomous Region China Department of Pediatrics First Affiliated Hospital Guangxi Medical University Nanning 530021 Guangxi Zhuang Autonomous Region China Department of Pathology First Affiliated Hospital Guangxi Medical University Nanning 530021 Guangxi Zhuang Autonomous Region China

AIM： To elucidate the impact of hemodynamic parameters on ultrasonography and serum fibrosis markers for the assessment of liver fibrosis in the children with infant hepatitis syndrome （IHS）. METHODS： Forty-one children with IHS and 46 healthy infants were examined by ultrasonography, and several hemodynamic indices such as peak systolic velocity （PSV） and resistant index （RI） of proper hepatic artery （PHA） were measured. Serum fibrosis markers including hyaluronic acid （HA）, pre-collagen type-Ⅲ （PC-Ⅲ）, collagen type Ⅳ （C-Ⅳ）, and laminin （LN） were assayed by radioimmunoassays. In children with IHS, liver tissues were obtained either by ultrasound-guided liver biopsy （n = 35） or in the course of operation （n = 6）. The stages of hepatic fibrosis were scored as mild （S1 and S2）, moderate （S3）, or severe （S4） according to liver histological diagnosis. Multiple groups comparative and Spearman correlative analyses were carried out. RESULTS： Histopathologically, 39 children （95.1%） were found to have hepatic fibrosis, 12 of them stage Sl or S2, 12 stage S3, and 15 stage S4. PSV, RI of the PHA, and serum HA showed a consecutive increase from mild to severe hepatic fibrosis and a close positive correlation with hepatic fibrosis in IHS group （r = 0.717, 0.745 and 0.712, respectively, P = 0.001）. The Doppler waveform of HV was also positively correlated with the degree of hepatic fibrosis in IHS group （r = 0.783, P 〈 0.001）.CONCLUSION： Combination of ultrasonic studies on the hepatic hemodynamics with the evaluation of serum HA may provide an indicator for hepatic fibrosis in patients with IHS, This may be a useful noninvasive method for the diagnosis and evaluation of the prognosis of IHS.

关键词： Infant hepatitis syndrome Hepatic fibrosis Doppler ultrasonography Hemodynamics Hyaluronic acid

5 -Lipoxygenase and cysteinyl leukotriene receptors in brain injury and repair

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

中国药理通讯 2005年第4期22卷 32-33页

作者： Er - Qing Wei Wei - Ping Zhang Meng - ling wang ling - Hui Zeng Department of Pharmacology School of Medicine Zhejiang University Hangzhou 310031

Diabetes patients with comorbidities had unfavorable outcomes following COVID-19:A retrospective study

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

World Journal of Diabetes 2021年第10期12卷 1789-1808页

作者： Shun-Kui Luo Wei-Hua Hu Zhan-Jin Lu Chang Li Ya-Meng Fan Qi-Jian Chen Zai-Shu Chen Jian-Fang Ye Shi-Yan Chen Jun-Lu Tong ling-ling wang Jin Mei Hong-Yun Lu Department of Endocrinology and Metabolism the Fifth Affiliated Hospital of Sun Yat-sen UniversityZhuhai 519000Guangdong ProvinceChina Department of Respiratory Medicine The First Hospital of JingzhouClinical Medical CollegeYangtze UniversityJingzhou 434000Hubei ProvinceChina Department of Cardiology Hubei No.3 People’s Hospital of Jianghan UniversityWuhan 430033Hubei ProvinceChina School of Health Sciences Wuhan UniversityWuhan 430071Hubei ProvinceChina Department of Emergency Medicine The Fifth Hospital in WuhanWuhan 430050Hubei ProvinceChina People's Hospital of Jiayu County Jiayu 437200Hubei ProvinceChina Department of Gerontology The Fifth Affiliated Hospital of Sun Yat-sen UniversityZhuhai 519000Guangdong ProvinceChina Department Wenzhou Medical UniversityWenzhou 325035Zhejiang ProvinceChina Central Laboratory Ningbo First Hospital of Zhejiang UniversityNingbo 315010Zhejiang ProvinceChina Department of Endocrinology and Metabolism Zhuhai Hospital Affiliated with Jinan UniversityZhuhai 519000Guangdong ProvinceChina

BACKGROUND Previous studies have shown that diabetes mellitus is a common comorbidity of coronavirus disease 2019(COVID-19),but the effects of diabetes or anti-diabetic medication on the mortality of COVID-19 have not been well *** To investigate the outcome of different statuses(with or without comorbidity)and anti-diabetic medication use before admission of diabetic after *** In this multicenter and retrospective study,we enrolled 1422 consecutive hospitalized patients from January 21,2020,to March 25,2020,at six hospitals in Hubei Province,*** primary endpoint was in-hospital *** material,demographic information,clinical data,laboratory parameters,radiographic characteristics,treatment and outcome were extracted from electronic medical records using a standardized data collection *** of the laboratory data except fasting plasma glucose(FPG)were obtained in first hospitalization,and FPG was collected in the next day *** clinical symptoms,vital signs at admission and comorbidities were *** treatment data included not only COVID-19 but also diabetes *** duration from the onset of symptoms to admission,illness severity,intensive care unit(ICU)admission,and length of hospital stay were also *** data were checked by a team of sophisticated *** Patients with diabetes were 10 years older than non-diabetic patients[(39-64)vs(56-70),P<0.001]and had a higher prevalence of comorbidities such as hypertension(55.5%vs 21.4%,P<0.001),coronary heart disease(CHD)(9.9%vs 3.5%,P<0.001),cerebrovascular disease(CVD)(3%vs 2.2%,P<0.001),and chronic kidney disease(CKD)(4.7%vs 1.5%,P=0.007).Mortality(13.6%vs 7.2%,P=0.003)was more prevalent among the diabetes *** analysis revealed that patients with diabetes who took acarbose had a lower mortality rate(2.2%vs 26.1,P<0.01).Multivariable Cox regression showed that male sex[hazard ratio(HR)2.59(1.68-3.99),P<0.001],hypertensi

关键词： Diabetes Coronavirus disease 2019 Mortality Risk factors Acarbose

森林火灾后云南高原森林真菌群落响应的物种特异性

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Journal of Plant Ecology 2023年第1期16卷 37-49页

作者： ling-ling wang Qing-Qiu Zhou Wen-Hua Su Yun-Jian Xu Qin-Dong Qian Xiong Yang De-Yun Chen Zhe Chen Jian-Ping Wu Yunnan Key Laboratory of Plant Reproductive Adaptation and Evolutionary Ecology/Institute of Biodiversity Yunnan UniversityKunming 650500China Key Laboratory of Soil Ecology and Health in Universities of Yunnan Province School of Ecology and Environmental SciencesYunnan UniversityKunming 650500China

森林地下部分包含了丰富的真菌多样性。森林火灾产生的高温和对地上植被的破坏,会改变真菌的群落组成并影响后期森林的恢复。云南是我国重要的林区,也是森林火灾的频发区。本文旨在研究以云南松(Pinus yunnanensis)和柠檬桉(Eucalyptus ... 详细信息

森林地下部分包含了丰富的真菌多样性。森林火灾产生的高温和对地上植被的破坏,会改变真菌的群落组成并影响后期森林的恢复。云南是我国重要的林区,也是森林火灾的频发区。本文旨在研究以云南松(Pinus yunnanensis)和柠檬桉(Eucalyptus citriodora)为主要树种的混交林在林冠火发生后地下真菌的响应。实验采集了两种树种下的矿质土、根际土和细根3个位点的样品,通过高通量测序手段,分析了真菌的多样性、群落组成、网络结构和生态营养型等信息。结果发现,3个采样点之间的群落组成具有显著性差异,矿质土壤中的alpha多样性高于根际土壤和细根中的alpha多样性。对于树种而言,柠檬桉的真菌网络复杂程度高于云南松。两种树种的前10个优势属以腐生真菌为主,其中云南松的毛霉菌门相对丰度高于柠檬桉。在生物标志物的比较中,云南松的根和根际土壤中均以外生菌根真菌为主,而柠檬桉的根和根际土壤则表现为以腐生真菌和共生真菌为主。我们的研究结果表明森林火灾后云南高原典型森林中真菌群落的响应具有物种特异性。

关键词：真菌林火根际土细根云南松(Pinus yunnanensis) 柠檬桉(Eucalyptus citriodora) 云南高原

Molecular Targets of Combined Natural Antioxidants Against Diabetes in Streptozotocin-induced Diabetic Mice

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Chemical Research in Chinese Universities 2012年第1期28卷 96-102页

作者： SONG Yang1,2, GAO Zhong-li2, DU Zhen-wu1, PIAO Song-lan1, wang ling-ling1, wang Qing3 and ZHANG Gui-zhen1 1. Central Research Department, 2. Department of Orthopaedics, 3. Department of Endocrinology, China-Japan Union Hospital of Jilin University, Changchun 130033, P. R. China Jilin Univ China Japan Union Hosp Dept Endocrinol Changchun 130033 Peoples R China Jilin Univ China Japan Union Hosp Cent Res Dept Changchun 130033 Peoples R China Jilin Univ China Japan Union Hosp Dept Orthopaed Changchun 130033 Peoples R China

Natural antioxidants, due to the different chemical structures and their unique biological protection effects on islet cell, have been received much attention in applied chemistry field for developing a new diabetic drug. However, the molecular targets of the islet cell protection have been remained obscure. For investigating molecular targets of combined natural antioxidant’s（CNA） roles in against diabetes, type 1 diabetic mouse model was made by multiple injection of low doses of streptozotocin into C57BL mice. Two combinations of natural antioxidants were orally supplemented to the mice. Blood glucose level, glutathione peroxidase（GSH-Px） and superoxide dismutase （SOD） activities, and malondialdehyde（MDA） contents were measured via biochemical assays. Tumor necrosis factor α（TNF-α）, interferon γ（IFN-γ） and Interleukin-12（IL-12） in CD4＋ Peripheral blood mononuclear cells（PBMC） were evaluated with flow cytometry（FCM）. In situ hybridization（ISH） and immunohistochemistry（IHC） were used to detect insulin gene expression. The results demonstrate both the combinations significantly： increased GSH-px and SOD, but decreased MDA levels in pancreas（p〈0.05―0.01）; up-regulated insulin expression at both mRNA and protein levels in islet cells（p〈0.05―0.01）; down-regulated TNF-α and IL-12 expression in PBMC（p〈0.05―0.01）. Our data suggest that the CAN may regulate multiple key molecular targets related to β cell function, including reduction of oxidative stress and pre-inflammatory cytokines, and upregulate insulin gene expression to reduce the development of diabetes.

关键词： Combined natural antioxidant Diabetes Insulin gene expression Oxidative stress Pro-inflammatory cytokine

Preparation and electrochemical property of Cs0.35V2O5/Cu composite material

在线全文

学校读者我要写书评

暂无评论

Journal of Chemistry and Chemical Engineering 2008年第6期2卷 52-55页

作者： CAO Xiao-yu YANG Jun XIE ling-ling LIU Xing wang Hong-yan YAN Xiang-yang School of Chemistry and Chemical Engineering Henan University of Technology Zhengzhou 450001 China

Cs0.35V2O5 was successfully synthesized as cathode material for lithium secondary battery by the rheological phase reaction method from Cs2CO3 and NH4VO3. The Cs0.35V2O5/Cu composite material was prepared by the displacement reaction in CuSO4 solution using zinc powder as a reductant. The structure and electrochemical property of the so-prepared powders were characterized by means of XRD （powder X-ray diffraction） and the galvanostatic discharge-charge techniques. The results show that the electrochemical property of Cs0.35V2O5/Cu composite material is significantly improved compared to the bulk Cs0.35V2O5 material. The Cs0.35V2O5/Cu composite material exhibits the first discharge capacity as high as 164.3 mAh.g -1 in the range of 4.2-1.8V at a current rate of 10 mA.g-1 and remains at a stable discharge capacity of about 110 mAh.g-1 within 40 cycles.

关键词： lithium secondary batteries cathode material Cs0.35V2O5/Cu composite material electrochemical property

Block copolymer of am and dmaam by atrp

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Block copolymer of am and dmaam by atrp

苯基笼状倍半硅氧烷(TSP-POSS)改性聚氨酯的分子模拟和热性能研究

2005年全国高分子学术论文报告会

作者： Xiao-Ju Lu, Shu-ling Gong, ling-Zhi Meng, ling-ling wang, Cheng Li, College of Chemistry and Molecular Sciences, Wuhan University, Wuhan 430072

＜正＞In this paper cyclic four-N-atom compound（TAT）was synthesized and used as ligand of atom transfer radical *** of AM by ATRP was carried out in room temperature using methyl-2-chrolopropionate（MCP）as initiato... 详细信息

关键词： polydentate cyclic ligand aqueous medium ATRP

来源： cnki会议评论

在线全文

cnki会议

学校读者我要写书评

暂无评论

高分子学报 2015年第3期25卷 266-276页

作者：王玲玲张明刘咏潘睿李来才四川师范大学化学与材料科学学院"特种废水处理"四川省高校重点实验室成都610066

采用分子力学及分子动力学方法,构建了质量百分比分别为0 wt%、3.06 wt%、6.56 wt%、10.13wt%、12.11 wt%、15.36 wt%和19.87 wt%共7种TSP-POSS杂化聚氨酯的分子结构模型,通过对均方位移、径向分布函数、XRD衍射图谱的分析,在分子水平... 详细信息

采用分子力学及分子动力学方法,构建了质量百分比分别为0 wt%、3.06 wt%、6.56 wt%、10.13wt%、12.11 wt%、15.36 wt%和19.87 wt%共7种TSP-POSS杂化聚氨酯的分子结构模型,通过对均方位移、径向分布函数、XRD衍射图谱的分析,在分子水平上研究了半笼型TSP-POSS的引入对聚氨酯分子链结构及热性能的影响.结果表明,当TSP-POSS含量低于12.11 wt%时,随着TSP-POSS质量分数的增加,分子链之间的平均距离增大,分子间相互作用减小,聚合物分子链的运动性增强;当TSP-POSS含量高于12.11 wt%时,TSP-POSS自身会团聚成晶簇,降低了聚合物分子链的运动能力并由无定形聚集状态转变为层状半结晶结构.通过对7种体系的体积-温度函数分析,证明TSP-POSS的引入在一定程度上能显著提高聚氨酯杂化材料的玻璃化转变温度,在一定程度上增强其热稳定性.

关键词：分子力学分子动力学笼状倍半硅氧烷聚氨酯热性能研究

Mechanism of inflammatory response and therapeutic effects of stem cells in ischemic stroke:current evidence and future perspectives

在线全文

学校读者我要写书评

暂无评论

Neural Regeneration Research 2025年第1期20卷 67-81页

作者： Yubo wang Tingli Yuan Tianjie Lyu ling Zhang Meng wang Zhiying He Yongjun wang Zixiao Li Vascular Neurology Department of NeurologyBeijing Tiantan HospitalCapital Medical UniversityBeijingChina China National Clinical Research Center for Neurological Diseases Beijing Tiantan HospitalCapital Medical UniversityBeijingChina Shanghai Engineering Research Center of Stem Cells Translational Medicine ShanghaiChina National Center for Healthcare Quality Management in Neurological Diseases Beijing Tiantan HospitalCapital Medical UniversityBeijingChina Institute for Regenerative Medicine Shanghai East HospitalSchool of Life Sciences and TechnologyTongji UniversityShanghaiChina Chinese Institute for Brain Research BeijingChina Research Unit of Artificial Intelligence in Cerebrovascular Disease Chinese Academy of Medical SciencesBeijingChina Beijing Engineering Research Center of Digital Healthcare for Neurological Diseases BeijingChina

Ischemic stroke is a leading cause of death and disability worldwide,with an increasing trend and tendency for onset at a younger ***,in particular,bears a high burden of stroke *** recent years,the inflammatory response after stroke has become a research hotspot:understanding the role of inflammatory response in tissue damage and repair following ischemic stroke is an important direction for its *** review summarizes several major cells involved in the inflammatory response following ischemic stroke,including microglia,neutrophils,monocytes,lymphocytes,and ***,we have also highlighted the recent progress in various treatments for ischemic stroke,particularly in the field of stem cell ***,understanding the complex interactions between inflammation and ischemic stroke can provide valuable insights for developing treatment strategies and improving patient *** cell therapy may potentially become an important component of ischemic stroke treatment.

关键词： cell therapy immune cell inflammatory ischemic stroke stem cell