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A retrospective prognostic evaluation analysis using the 8th edition of American Joint Committee on Cancer(AJCC)cancer staging system for luminal A breast cancer

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Chinese Journal of Cancer Research 2017年第4期29卷 351-360页

作者： Jingming Ye Wenjun Wang ling xu xuening Duan Yuanjia Chengl ling Xin Hong Zhang Shuang Zhang Ting Li Yinhua Liu Breast Disease Center Peking University First Hospital Beijing 100034 China General Surgery Third People＇s Hospital of Datong City Datong 037008 China Deparunent of Pathology Peking University First Hospital Beijing 100034 China

Objective： We retrospectively analyzed the clinical prognostic value of the 8th edition of the American Joint Committee on Cancer （AJCC） staging system for luminal A breast cancer. Methods： Using both the anatomic and prognostic staging in the 8th edition of AJCC cancer staging system, we restaged patients with luminal A breast cancer treated at the Breast Disease Center, Peking University First Hospital from 2008 to 2014. Follow-up data including 5-year disease free survival （DFS）, overall survival （OS） and other clinic-pathological data were collected to analyze the differences between the two staging subgroups. Results： This study included 421 patients with luminal A breast cancer （median follow-up, 61 months）. The 5- year DFS and OS rates were 98.3% and 99.3%, respectively. Significant differences in 5-year DFS but not OS were observed between different anatomic disease stages. Significant differences were observed in both 5-year DFS and O S between different prognostic stages. Application of the prognostic staging system resulted in assignment of 175 of 421 patients （41.6%） to a different group compared to their original anatomic stages. In total, 102 of 103 patients with anatomic stage IlA changed to prognostic stage IB, and 24 of 52 patients with anatomic stage lib changed to prognostic stage IB, while 1 changed to prognostic stage liIB. Twenty-two of 33 patients with anatomic stage IliA were down-staged to IlA when staged by prognostic staging system, and the other 11 patients were down-staged to liB. Two patients with anatomic stage IIIB were down-staged to IliA. Among seven padents with anatomic stage IIIC cancer, two were down-staged to IliA and four were down-staged to stage I]IB. Conclusions： The 8th edition of AJCC prognostic staging system is an important supplement to the breast cancer staging system. More clinical trials are needed to prove its ability to guide selection of proper systemic therapy and predict prognosis of breast cancer.

关键词： AJCC cancer staging anatomic stage breast cancer luminal A prognosdc stage prognosis systemictherapy

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武汉市公立医院经济运行状况分析

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卫生软科学 2025年第1期39卷 67-72页

作者：罗程邝鹏蝶郭蓉芳徐凌胡英武汉市职业病防治院湖北武汉430014 武汉市中心医院湖北武汉430014 武汉市急救中心湖北武汉430000 武汉市卫生健康委员会湖北武汉430014

[目的]分析武汉市公立医院2019-2022年经济运行情况及其存在的问题,为公立医院改革和高质量发展提供参考。[方法]利用武汉市2019-2022年卫生健康年报数据,对武汉市公立医院经济运行情况进行描述性分析。[结果]2019-2022年,公立医院总体... 详细信息

[目的]分析武汉市公立医院2019-2022年经济运行情况及其存在的问题,为公立医院改革和高质量发展提供参考。[方法]利用武汉市2019-2022年卫生健康年报数据,对武汉市公立医院经济运行情况进行描述性分析。[结果]2019-2022年,公立医院总体收支盈余为正,财政补助收入占比提升15.35个百分点,医疗收入总额下降16.75个百分点;医院人员费用支出和占比逐年上升,折旧费用和其他费用年均增长16.42%和11.72%;公立医院运营效益和效率指标显著下降,运营成本不断上升;2019-2022年,医疗盈余由10.24亿元降为-9.22亿元,医院医疗亏损率从14.29%增至76.47%。[结论]武汉市公立医院总体上收支平衡,但面临较大经济运行压力,偿债能力和成本管控能力减弱,医疗亏损持续加大。建议完善公立医院补偿机制,加强公立医院运营管理,优化区域医疗资源规划。

关键词：公立医院经济运行财政补偿武汉

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Intelligent Control of Grate-kiln-cooler Process of Iron Ore Pellets Using a Combination of Expert System Approach and Takagi-Sugeno Fuzzy Model

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Journal of Iron and Steel Research International 2016年第5期23卷 434-441页

作者： Gui-ming YANG Xiao-hui FAN xu-ling CHEN Xiao-xian HUANG Zong-ping LI School of Minerals Processing and Bioengineering Central South University

Grate-kiln-cooler has become a major process of producing iron ore pellets in China. Due to the diversity of the raw materials used and the multi-device multi-variable characteristics,this process still encounters with control problem. An attempt was proposed to deal with this issue. The three-device-integrated feature of the process was firstly analyzed to obtain control strategy,and then an intelligent control system using a combination of expert system approach and Takagi-Sugeno（ T-S） fuzzy model was developed. Expert system approach was used to diagnose and remedy the abnormal conditions,while T-S fuzzy model was used to stabilize the thermal state. In the construction of T-S fuzzy rules,antecedents were identified by fuzzy c-mean clustering algorithm incorporated with subtractive clustering algorithm,and consequent parameters were identified by recursive least square algorithm. The control system was applied in a Chinese pelletizing plant and the application results demonstrated its effectiveness of stabilizing the thermal states within three devices.

关键词： intelligent control grate-kiln-cooler expert system fuzzy model iron ore pellet

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Wear behavior of high velocity arc sprayed 3Cr13 steel coating in oil containing sand

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中国有色金属学会会刊：英文版 2004年第Z1期14卷 370-373页

作者： DU ling-zhong xu Bin-shi DONG Shi-yun YANG Hua WU Yi-xiong College of Materials Science and Engineering Shanghai Jiaotong UniversityShanghai 200030 China National Key Laboratory for Remanufacturing Academy of Armored Force Engineering Beijing 100072 China National Key Laboratory for Remanufacturing Academy of Armored Force Engineering Beijing 100072 China National Key Laboratory for Remanufacturing Academy of Armored Force Engineering Beijing 100072 China National Key Laboratory for Remanufacturing Academy of Armored Force Engineering Beijing 100072 China College of Materials Science and Engineering Shanghai Jiaotong UniversityShanghai 200030 China

To improve the wear resistance of the machine components serving in desert areas, the 3Cr13 stainless steel coating was produced by the high velocity arc spraying technique. The microstructure and phase constitute of the coating were analyzed by SEM and XRD. The effects of sand content on the friction and wear behaviors of the coating under the lubrication of oil containing sand were investigated on a ball-on-disk tester. SEM was used to reveal the wear mechanisms of the coating. The results show that the wear volume increases with increasing the sand content in the oil, and the sprayed coating exhibits better triobological properties compared with the 1045 steel. The predominant wear mechanisms of the sprayed coating are micro-cutting, brittle fracture and delamination.

关键词： high velocity arc spraying coating friction and wear behavior oil sand

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Predictive methods for density and refractive index of naphthenic lubricating oils during solvent extraction process

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Petroleum Science 2023年第3期20卷 1934-1946页

作者： Xiao-ling xu Tian-Qi Wang Guang-Huai Chen Jun-Wei Hou Yan-Sheng Liu State Key Laboratory of Heavy Oil Processing China University of Petroleum(Bejing)at KaramayKaramayXinjiang834000China State Key Laboratory of Heavy oil Processing China University of Petroleum(Bejing)Bejing102200China

Lubricating oils are usually produced by solvent extraction to separate aromatics in order to achieve the desired specifications and better quality *** the different properties of lubricating oils,density and refractive index are some of the most important properties which can both be used for petroleum fluid *** of density and refractive index for naphthenic oils during solvent extraction by DMSO obtained by the pseudo-component approach and the quadratic correlation were both *** pseudo-component approach is a method to predict density and refractive index from composition while the latter merely relates density to refractive *** indicated that the predictions yielded by the pseudo-component method were in good agreement with experimental data for naphthenic *** the use of a function of refractive index(FRI_(20))as a pseudo-component property remarkably improved n_(20)predictions for the naphthenic ***,the density and refractive index predictions obtained by the quadratic correlation exhibited significantly higher de-viations for naphthenic oils than those for paraffinic *** a new modified correlation of the same functional form was proposed for naphthenic *** modification significantly improved predictions for naphthenic oils,which presented similar accuracy as the pseudo-component *** the previous correlation was still used for paraffinic ***,effect of temperature on density and refractive index of naphthenic oils was *** showed that the modified quadratic correlation was accurate for describing the relationship between density and refractive index of naphthenic oils at 20-90℃.The temperature dependence of density and refractive index for the raffinates and the extracts could be accurately described by the thermal coefficients for saturates and aromatics,*** the refractive index variation of the extracts with temperature,the

关键词： Density Refractive index Pseudo-components Paraffinic lubricating oils Naphthenic lubricating oils Solvent extraction

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Facile and efficient synthesis of 2-substituted-Nl-carbethoxy-2,3-dihydro-4(1H)-quinazolinones in fluorous solvent

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Chinese Chemical Letters 2008年第5期19卷 537-540页

作者： Bai ling xu Jin Ping Chen Rong Zhang Qiao De Cai Fu lnstitute of Materia Medica Chinese Academy of Medical Sciences Peking Union Medical College Beijing 100050 China Hebei University of Science and Technology Shijiazhuang 050018 China Department of Life Science and Technology Beijing University of Chemical Technology Beijing 100029 China

A facile, efficient and novel approach to access 2-substituted-N1-carbethoxy-2,3-dihydro-4（1H）-quinazolinones was developed by condensation of substituted N-carbethoxyanthranilamide with alkyl, aromatic or heteroaromatic aldehydes in the refluxing 2,2,2- trifluoroethanol or hexafluoroisopropanol using p-toluenesulfonic acid as catalyst.

关键词： Quinazolinones Trifluoroethanol Hexafluoroisopropanol Fluorous solvent Solvent effect

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Temperature Field Simulation Model for Rotary Kiln of Iron Ore Oxidized Pellet

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Journal of Iron and Steel Research International 2013年第4期20卷 16-19页

作者： FAN Xiao-hui LI Jun CHEN xu-ling WANG Yi GAN Min School of Minerals Processing and Bioengineering Central South University

Based on conduction,convection and radiation heat transfer among the flue gas,kiln wall,and the pellet bed material,and on the basis of the coal combustion and analysis of reaction heat of pellet induration in the rotary kiln,the temperature field model of rotary kiln was *** visual studio net,matlab and open source computer vision library as development tools,combining with the ActiveX data objects database technology,the temperature field simulation system for rotary kiln of iron ore oxidized pellet production was *** distribution of pellet and flue gas in rotary kiln was dynamically displayed.

关键词： iron ore oxidized pellet rotary kiln temperature distribution mathematical model

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Random Exponential Attractor for Stochastic Non-autonomous Suspension Bridge Equation with Linear Multiplicative White Noise

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Journal of Mathematical Research with Applications 2024年第1期44卷 81-112页

作者： ling xu Runjie LIU xue BAI College of Mathematics and Statistics Northwest Normal University

In this paper, we mainly consider the long-time behavior of stochastic non-autonomous suspension bridge equation by linear multiplicative white noise with small coefficient. First step,the well-posedness for the cocycle associated with the considered system is established. Second step, the existence of random attractor for the system is investigated. Third step, the upper semicontinuity of random attractor is also provided when the coefficient of random term approaches zero. Fourth step, we prove the regularity of random attractor in a higher regular space by the“iteration” method. Finally, we give the existence of a random exponential attractor for the considered system, which implies the finiteness of fractal dimension of random attractor.

关键词： stochastic non-autonomous suspension bridge equation multiplicative white noise random attractor fractal dimension random exponential attractor

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Characterization of astrocytes and microglial cells in the hippocampal CA1 region after transient focal cerebral ischemia in rats treated with Ilexonin A

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Neural Regeneration Research 2020年第1期15卷 78-85页

作者： Ai-ling xu Guan-Yi Zheng Hui-Ying Ye Xiao-Dong Chen Qiong Jiang Department of Traditional Chinese Medicine Fujian Medical University Union HospitalFuzhouFujian ProvinceChina Department of Neonatology People’s Hospital Affiliated to Fujian University of Traditional Chinese MedicineFuzhouFujian ProvinceChina Department of Neurology People’s Hospital of NanpingNanpingFujian ProvinceChina Burns Institute of Fujian Medical University Union Hospital FuzhouFujian ProvinceChina

Ilexonin A is a compound isolated from the root of Ilex pubescens,a traditional Chinese *** A has been shown to play a neuroprotective role by regulating the activation of astrocytes and microglia in the peri-infarct area after ***,the effects of ilexonin A on astrocytes and microglia in the infarct-free region of the hippocampal CA1 region remain *** cerebral ischemia models were established by 2-hour occlusion of the middle cerebral artery in *** A(20,40 or 80 mg/kg)was administered immediately after ischemia/*** astrocyte marker glial fibrillary acidic protein,microglia marker Iba-1,neural stem cell marker nestin and inflammation markers were detected by immunohistochemistry and western blot *** levels of tumor necrosis factor-αand interleukin 1βwere determined by enzyme linked immunosorbent assay in the hippocampal CA1 *** were activated immediately in progressively increasing numbers from 1,3,to 7 days post-ischemia/*** number of activated astrocytes further increased in the hippocampal CA1 region after treatment with ilexonin *** cells remained quiescent after ischemia/reperfusion,but became activated after treatment with ilexonin *** A enhanced nestin expression and reduced the expression of tumor necrosis factor-αand interleukin 1βin the hippocampus post-ischemia/*** results of the present study suggest that ilexonin A has a neuroprotective effect in the hippocampus after ischemia/reperfusion,probably through regulating astrocytes and microglia activation,promoting neuronal stem cell proliferation and reducing the levels of pro-inflammatory *** study was approved by the Animal Ethics Committee of the Fujian Medical University Union Hospital,China.

关键词： astrocytes hippocampal CA1 region ilexonin A microglia middle cerebral artery occlusion neural stem cell neuroprotection transient focal cerebral ischemia

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New methacrylic imidazolium poly (ionic liquid) gel with super swelling capacity for oil-in-water emulsions

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Nuclear Science and Techniques 2016年第3期27卷 1-10页

作者： Xing Zhang Shuo-Jue Wang Jing Peng Jiu-Qiang Li ling xu Mao-Lin Zhai Beijing National Laboratory for Molecular Sciences Radiochemistry and Radiation Chemistry Key Laboratory of Fundamental ScienceThe Key Laboratory of Polymer Chemistry and Physics of the Ministry of EducationCollege of Chemistry and Molecular EngineeringPeking University Department of Energy and Resources Engineering College of EngineeringPeking University

A new polymeric ionic liquid gel was prepared with 1-[(2-methacryloyloxy)ethyl]-3-methylimidazolium bromide(MEMImBr) via radiation-induced polymerization and cross-linking at room *** resultant PMEMImBr gel exhibits high strength and flexibility as well as special swelling behavior in oil-in-water(O/W)*** swelling behavior of PMEMImBr gel in emulsions is similar to that in water except that the swelling rate in emulsions is slightly smaller than that in *** organic solvents with higher polarity in the emulsions contribute to the swelling of PMEMImBr gels,and the O/W proportion of emulsion in the swollen gel equals approximately that of original emulsion when the concentration of organic solvent is lower than 0.2 g/g.

关键词：离子液体甲基咪唑乳液凝胶水油溶胀行为能力膨胀

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