Facile and efficient synthesis of 2-substituted-Nl-carbethoxy-2,3-dihydro-4(1H)-quinazolinones in fluorous solvent

作     者：Bai Ling Xu Jin Ping Chen Rong Zhang Qiao De Cai Fu 

作者机构：lnstitute of Materia Medica Chinese Academy of Medical Sciences Peking Union Medical College Beijing 100050 China Hebei University of Science and Technology Shijiazhuang 050018 China Department of Life Science and Technology Beijing University of Chemical Technology Beijing 100029 China 

出 版 物：《Chinese Chemical Letters》 (中国化学快报（英文版）)

年 卷 期：2008年第19卷第5期

页      面：537-540页

核心收录：

学科分类：081704[工学-应用化学] 07[理学] 08[工学] 0817[工学-化学工程与技术] 070303[理学-有机化学] 0703[理学-化学] 

基　　金：We are grateful to the National Natural Science Foundation of China(No.30672540) the Natural Science Foundation of Beijing(No.7072048)for financial support 

主　　题：Quinazolinones Trifluoroethanol Hexafluoroisopropanol Fluorous solvent Solvent effect 

摘      要：A facile, efficient and novel approach to access 2-substituted-N1-carbethoxy-2,3-dihydro-4（1H）-quinazolinones was developed by condensation of substituted N-carbethoxyanthranilamide with alkyl, aromatic or heteroaromatic aldehydes in the refluxing 2,2,2- trifluoroethanol or hexafluoroisopropanol using p-toluenesulfonic acid as catalyst.