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Xenobiotic receptors in mediating the effect of sepsis on drug metabolism

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Acta Pharmaceutica Sinica B 2020年第1期10卷 33-41页

作者： Chuanzhu Lv ling huang Department of Emergency Hainan Clinical Research Center for Acute and Critical DiseasesThe Second Affiliated Hospital of Hainan Medical UniversityHaikou 570300China Emergency and Trauma College Hainan Medical UniversityHaikou 571101China Research Unit of Island Emergency Medicine Chinese Academy of Medical SciencesHainan Medical UniversityHaikou 571101China Research Center for Drug Safety Evaluation of Hainan Province Hainan Medical UniversityHaikou 571101China Hainan Province Key Laboratory for Drug Preclinical Study of Pharmacology and Toxicology Research Hainan Medical UniversityHaikou 571101China Key Laboratory of Emergency and Trauma of Ministry of Education Hainan Medical UniversityHaikou 571101China

Sepsis is an infection-induced systemic inflammatory *** immune response in sepsis is characterized by the activation of both proinflammatory and anti-inflammatory *** sepsis occurs,the expression and activity of many inflammatory cytokines are markedly *** receptors are chemical-sensing transcription factors that play essential roles in the transcriptional regulation of drug-metabolizing enzymes(DMEs).Xenobiotic receptors mediate the functional crosstalk between sepsis and drug metabolism because the inflammatory cytokines released during sepsis can affect the expression and activity of xenobiotic receptors and thus impact the expression and activity of *** receptors in turn may affect the clinical outcomes of *** focuses on the sepsis-induced inflammatory response and xenobiotic receptors such as pregnane X receptor(PXR),aryl hydrocarbon receptor(AHR),glucocorticoid receptor(GR),and constitutive androstane receptor(CAR),DMEs such as CYP1A,CYP2B6,CYP2C9,and CYP3A4,and drug transporters such as p-glycoprotein(P-gp),and multidrug resistance-associated protein(MRPs)that are affected by *** the xenobiotic receptor-mediated effect of sepsis on drug metabolism will help to improve the safe use of drugs in sepsis patients and the development of new xenobiotic receptor-based therapeutic strategies for sepsis.

关键词： Sepsis Inflammatory cytokines Xenobiotic receptors Drug metabolism Drug-metabolizing enzymes Drug transporters

Research on the Trajectory Tracking Control of a 6-DOF Manipulator Based on Fully-Actuated System Models

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Journal of Systems Science & Complexity 2022年第2期35卷 641-659页

作者： SUN Hao huang ling HE Liang School of Automation Harbin University of Science and TechnologyHarbin 150080China School of Software Northwestern Polytechnical UniversityXi’an 710072China

The multi-degree of freedom(muti-DOF)manipulator system is a complex control system with the strong coupling feature and high *** this paper,trajectory tracking control of a six-degree of freedom(6-DOF)manipulator based on fully-actuated system models and a direct parametric method is *** fully-actuated system model of the 6-DOF manipulator is established by using the Denavit Hartenberg(DH)notation and Euler-Lagrange dynamics.A disturbance observer is constructed to solve the nonlinear uncertainties such as unmodeled dynamics and external ***,a controller is designed using the direct parametric method to make the 6-DOF manipulator reach the desired position with high *** that,a switching control strategy is developed to suppress the peak value belonging to the *** results reveal the effect of the proposed control approach.

关键词： Direct parametric approach fully-actuated system manipulator nonlinear disturbance observer trajectory tracking

Sensitivity Analysis of Ensemble Simulations on a Torrential Rainfall Case over South China Using Multiple PBL and SL Parameterizations

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Journal of Tropical Meteorology 2020年第2期26卷 208-222页

作者： huang ling Guangzhou Institute of Tropical and Marine Meteorology CMAGuangzhou 510641 China

A good representation of the interaction between the planetary boundary layer(PBL)and the surface layer(SL)in numerical models is of great importance for the prediction of the initiation and development of *** study examined an ensemble that consists of the available suites of PBL and SL parameterizations based on a torrential rainfall event over south *** sensitivity of the simulations was investigated against objective measurements using multiple PBL and SL parameterization *** main causes of the bias from different parameterization schemes were further analysed by comparing the good and bad ensemble *** results showed that good members tended to underestimate the rainfall amount but presented a decent evolution of mesoscale convective systems that were responsible for the torrential *** the total energy mass flux(TEMF)scheme,the bad members overestimated the amount and spatial coverage of *** failure of the bad member was due to a spurious convection initiation(CI)resulting from the overestimated high-θe elevated *** spurious CI developed and expanded rapidly,causing intensive and extensive rainfall over south *** with previous studies,the TEMF scheme tends to produce a warmer and moister PBL *** detailed sensitivity analysis of this case may provide reference for the operational forecast of rainfall over south China using multiple PBL and SL parameterizations.

关键词： PBL SL parameterization torrential rain

Ensemble Based Diagnosis of the Track Errors of Super Typhoon Mangkhut(2018)

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Journal of Meteorological Research 2020年第2期34卷 353-367页

作者： ling huang Qilin WAN Chunxia LIU Huijun huang Institute of Tropical and Marine Meteorology of China Meteorological Administration Guangzhou 510000

Super Typhoon Mangkhut(2018)was the most high-impact typhoon in 2018 because of its long lifespan and significant *** operational track forecasts in the short-to-medium range(deterministic and probabilistic forecast)showed a great uncertainty and the forecast landing points varied with different lead *** study applied ensembles of high-resolution ECMWF forecasts to investigate the major factors and mechanisms of the bias production of the Mangkhut forecast *** ensembles with the largest track bias were analyzed to examine the possible bias associated *** results suggested that environmental steering flows were the main cause for the erroneous southward track error with a variance contribution of 72%.The tropical cyclone(TC)size difference and the interaction of the TC with the subtropical high(SH)were other two key factors that contributed to the track ***,larger TCs may have led to a stronger erosion of the southern part of the SH,and thus induced significant changes in the large-scale environment and eventually resulted in an additional northward movement of TC.

关键词： Super Typhoon Mangkhut ECMWF ensemble tropical cyclone track

Colour modulation and enhancement of upconversion emissions in K_(2)NaScF_(6):Yb/Ln(Ln=Er,Ho,Tm) nanocrystals

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Journal of Rare Earths 2021年第12期39卷 1477-1483,I0001页

作者： Yangbo Wang Huaiyong Li Hui Ma ling huang School of Materials Science and Engineering Liaocheng UniversityLiaocheng 252059China Institute of Advanced Materials Nanjing Tech UniversityNanjing 211816China

Effective colour modulation of upconversion emissions in lanthanide-doped nanomaterials becomes even more important for fundamental and applied ***,on the one hand,by raising the content of doped Yb^(3+)from 10 mol%to 50 mol%,a significant increase of the red/green emission ratio from 4.0 to 68.2 is observed in K_(2)NaScF_(6):Yb/Er *** yellow to red colour change is attributed to the increased cross relaxation between Er^(3+)and Yb^(3+)caused by the increased Yb^(3+)amount,^(4) S_(3/2)(Er^(3+))^(+2) F7/2(Yb^(3+))→4 I13/2(Er^(3+))^(+2) F5/2(Yb^(3+)).On the other hand,the upconversion green and red emission of K_(2)NaScF_(6):Yb/Er(20/2 mol%)nanocrystals are intensified 10.6 and 8.8 folds,respectively,after an active shell(K_(2)NaScF_(6):Yb)is epitaxially grown,which are more effective than the7.4-and 6.4-fold enhancement from an inert shell(K_(2)NaScF_(6))***,the shell thickness from2.85 to 9.5 nm through controlling the molar ratio of shell-precursor to core from 1:2 to 3:1 can be easily *** study will provide more opportunities for the application of K_(2)NaScF_(6):Yb/Ln nanoparticles in varied fields such as theranostics,photovoltaics,and photocatalysis.

关键词： Upconversion Emission modulation Core-shell K_(2)NaScF_(6) Rare earths

A Remark on Strong Law of Large Numbers for Weighted U-Statistics

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Acta Mathematica Sinica,English Series 2014年第9期30卷 1595-1605页

作者： Hyung-Tae HA Mei ling huang Department of Applied Statistics Gachon University Department of Mathematics and Statistics Brock University

Let （X, Xn; n≥ 1} be a sequence of i.i.d, random variables with values in a measurable space （S,8） such that E｜h（X1, X2,..., Xm）｜〈 ∞, where h is a measurable symmetric function from Sm into R = （-∞, ∞）. Let {wn,i1,i2 im ; 1 ≤ i1 〈 i2 〈 …… 〈im 〈 n, n ≥ m} be a matrix array of real numbers. Motivated by a result of Choi and Sung （1987）, in this note we are concerned with establishing a strong law of large numbers for weighted U-statistics with kernel h of degree m. We show that whenever SUP n≥m max1〈i1〈i2〈…〈im≤｜wn i1,i2 i,im｜〈∞, where 0 = Eh（X1, X2,..., Xm）. The proof of this result is based on a new general result on complete convergence, which is a fundamental tool, for array of real-valued random variables under some mild conditions.

关键词： Strong law of large numbers weighted U-statistics complete convergence

NUMERICAL BOUNDARY CONDITIONS FOR THE FAST SWEEPING HIGH ORDER WENO METHODS FOR SOLVING THE EIKONAL EQUATION

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Journal of Computational Mathematics 2008年第3期26卷 336-346页

作者： ling huang Chi-Wang Shu Mengping Zhang Department of Mathematics University of Science and Technology of China Hefei Anhui 230026 China Division of Applied Mathematics Brown University Providence RI 02912 USA Department of Mathematics University of Science and Technology of China Hefei 230026 China

High order fast sweeping methods have been developed recently in the literature to solve static Hamilton-Jacobi equations efficiently. Comparing with the first order fast sweeping methods, the high order fast sweeping methods are more accurate, but they often require additional numerical boundary treatment for several grid points near the boundary because of the wider numerical stencil. It is particularly important to treat the points near the inflow boundary accurately, as the information would flow into the computational domain and would affect global accuracy. In the literature, the numerical solution at these boundary points are either fixed with the exact solution, which is not always feasible, or computed with a first order discretization, which could reduce the global accuracy. In this paper, we discuss two strategies to handle the inflow boundary conditions. One is based on the numerical solutions of a first order fast sweeping method with several different mesh sizes near the boundary and a Richardson extrapolation, the other is based on a Lax-Wendroff type procedure to repeatedly utilizing the PDE to write the normal spatial derivatives to the inflow boundary in terms of the tangential derivatives, thereby obtaining high order solution values at the grid points near the inflow boundary. We explore these two approaches using the fast sweeping high order WENO scheme in [18] for solving the static Eikonal equation as a representative example. Numerical examples are given to demonstrate the performance of these two approaches.

关键词： Fast sweeping method WENO scheme Boundary condition

Special Topic:Up-Conversion Luminescence

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Journal of Analysis and Testing 2023年第4期7卷 325-326页

作者： Qian Liu ling huang College of Chemistry Nankai UniversityTianjin 300071China Department of Chemistry and Shanghai Key Laboratory of Molecular Catalysis and Innovative Materials Fudan UniversityShanghai 200438China

Photon upconversion is the conversion of low-energy photons(long wavelengths)into high-energy photons(short wavelengths).Single-particle,single-cell bioimaging with high temporal-spatial resolution and biological backgroundfree has already been accomplished via photon upconversion,utilizing the unique advantages of upconversion luminescence.

关键词： utilizing accomplished particle

Weakening sensitivity of global vegetation to long-term droughts

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Science China Earth Sciences 2018年第1期61卷 60-70页

作者： HE Bin huang ling CHEN ZiYue WANG HaiYan State Key Laboratory of Earth Surface Processes and Resource Ecology College of Global Change and Earth System Science Beijing Normal University College of Urban and Environmental Sciences Peking University

Droughts have dramatic direct and indirect impacts on vegetation and terrestrial ecosystem stability, including decreases in growth and subsequent decreases in CO_2 absorption. Although much research has been carried out on the response of vegetation to droughts, it remains unclear whether biomes are becoming more resistant or more vulnerable to drought. In this study, we used the Standardized Precipitation Evapotranspiration Index(SPEI, a multiscalar drought index) and the Normalized Difference Vegetation Index(NDVI, an indicator of vegetation growth) to detect the sensitivity of vegetation growth to droughts across 12–24 month timescales and to detect the change in this sensitivity over recent decades. We found that vegetation growth was most sensitive to 17–18 month droughts in water-limited regions, implying pronounce legacy effects from water conditions in previous years. In addition, we detected reduced coupling between drought and vegetation growth, probably caused by release moisture stress in water limited areas. Meanwhile, we observed a shortening of drought timescale to which vegetation most sensitively responded from an average of 18.1 to 17.2 months, suggesting the weakening of the drought legacy effect on vegetation growth. Results of this study contribute to the overall understanding of the resistance and resilience of ecosystems to drought conditions.

关键词： Drought Vegetation growth Response Sensitivity Legacy effect NDVI SPEI