Xenobiotic receptors in mediating the effect of sepsis on drug metabolism

作     者：Chuanzhu Lv Ling Huang Chuanzhu Lv;Ling Huang

作者机构：Department of EmergencyHainan Clinical Research Center for Acute and Critical DiseasesThe Second Affiliated Hospital of Hainan Medical UniversityHaikou 570300China Emergency and Trauma CollegeHainan Medical UniversityHaikou 571101China Research Unit of Island Emergency MedicineChinese Academy of Medical SciencesHainan Medical UniversityHaikou 571101China Research Center for Drug Safety Evaluation of Hainan ProvinceHainan Medical UniversityHaikou 571101China Hainan Province Key Laboratory for Drug Preclinical Study of Pharmacology and Toxicology ResearchHainan Medical UniversityHaikou 571101China Key Laboratory of Emergency and Trauma of Ministry of EducationHainan Medical UniversityHaikou 571101China 

出 版 物：《Acta Pharmaceutica Sinica B》 (药学学报（英文版）)

年 卷 期：2020年第10卷第1期

页      面：33-41页

核心收录：

学科分类：1007[医学-药学(可授医学、理学学位)] 1006[医学-中西医结合] 100706[医学-药理学] 100602[医学-中西医结合临床] 10[医学] 

基　　金：supported by grants from the National Natural Science Foundation of China(8140130969and 8176130232) Hainan Provincial Science and Technology Major Project(ZDKJ201804,China) 

主　　题：Sepsis Inflammatory cytokines Xenobiotic receptors Drug metabolism Drug-metabolizing enzymes Drug transporters 

摘      要：Sepsis is an infection-induced systemic inflammatory *** immune response in sepsis is characterized by the activation of both proinflammatory and anti-inflammatory *** sepsis occurs,the expression and activity of many inflammatory cytokines are markedly *** receptors are chemical-sensing transcription factors that play essential roles in the transcriptional regulation of drug-metabolizing enzymes(DMEs).Xenobiotic receptors mediate the functional crosstalk between sepsis and drug metabolism because the inflammatory cytokines released during sepsis can affect the expression and activity of xenobiotic receptors and thus impact the expression and activity of *** receptors in turn may affect the clinical outcomes of *** focuses on the sepsis-induced inflammatory response and xenobiotic receptors such as pregnane X receptor(PXR),aryl hydrocarbon receptor(AHR),glucocorticoid receptor(GR),and constitutive androstane receptor(CAR),DMEs such as CYP1A,CYP2B6,CYP2C9,and CYP3A4,and drug transporters such as p-glycoprotein(P-gp),and multidrug resistance-associated protein(MRPs)that are affected by *** the xenobiotic receptor-mediated effect of sepsis on drug metabolism will help to improve the safe use of drugs in sepsis patients and the development of new xenobiotic receptor-based therapeutic strategies for sepsis.