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Chinese journal of Cancer 2014年第1期33卷 40-45页

作者： linda Dirven Neil K.Aaronson jan j.Heimans Martin j.B.Taphoorn Department of Neurology VU University Medical CenterPO Box 7057 1007 MB Amsterdam Netherlands Division of Psychosocial Research and Epidemiology The Netherlands Cancer InstitutePO Box 90203 1006 BE Amsterdam Netherlands Department of Neurology Medical Center HaaglandenPO Box 432 2501 CK The Hague Netherlands

Gliomas are malignant primary brain tumors and yet incurable. Palliation and the maintenance or improvement of the patient's quality of life is therefore of main importance. For that reason, health-related quality of life(HRQoL) has become an important outcome measure in clinical trials, next to traditional outcome measures such as overall and progression-free survivals, and radiological response to treatment. HRQoL is a multidimensional concept covering physical, psychological, and social domains, as well as symptoms induced by the disease and its treatment. HRQoL is assessed by using self-reported, validated questionnaires. Various generic HRQoL questionnaires, which can be supplemented with a brain tumor- specific module, are available. Both the tumor and its treatment can have a negative effect on HRQoL. However, treatment with surgery, radiotherapy, chemotherapy, and supportive treatment may also improve patients' HRQoL, in addition to extending survival. It is expected that the impact of HRQoL measurements in both clinical trials and clinical practice will increase. Hence, it is important that HRQoL data are collected, analyzed, and interpreted correctly. Methodological issues such as selection bias and missing data may hamper the interpretation of HRQoL data and should therefore be accounted. In clinical trials, HRQoL can be used to assess the benefits of a new treatment strategy, which should be weighed carefully against the adverse effects of that treatment. In daily clinical practice, HRQoL assessments of an individual patient can be used to inform physicians about the impact of a specific treatment strategy, and it may facilitate the communication between the physicians and the patients.

关键词：生活质量胶质瘤健康患者放射治疗临床试验质量评估临床实践

Molecular Mechanisms of Ethylene-Auxin Interaction

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Molecular Plant 2013年第6期6卷 1734-1737页

作者： linda Robles Anna Stepanova jose Alonso Department of Plant and Microbial Biology North Carolina State University

During the century-long history of plant hormone research, the focus in this area has shifted from the original physi- ological experiments to molecular, genetic, biochemical, and, more recently, genomic approaches. During this jour- ney, we have learned about the many effects these natural compounds have on plant growth and development at the morphological and molecular levels. We have also uncov- ered how these molecules are sensed by the plant cell and how they trigger signaling cascades that relay information to the nucleus, ultimately culminating in a transcriptional cas- cade. With this fundamental knowledge at hand, the main efforts in the field have turned towards a more integrative systems approach, in which the function of a hormone is considered in the context of the complex and dynamic net of interactions with other hormones or, more broadly, with other developmental and environmental signals. Initially, due to the complexity of the problem, most crosstalk studies have focused on pairwise interactions between two or few hormones. Special attention has been given to the interac- tions between ethylene and auxin, perhaps in part because of the experimental tractability of some of the processes in which the interaction between these two hormones is most manifested. An excellent review has been recently written describing the many different processes in which these two hormones are known to interact, either synergistically, such as root growth inhibition, or antagonistically, as is the case for lateral root formation （Muday et al., 2012）. Rather than following this process-centered approach, herein we decided to focus on the molecular mechanisms involved in the inter- action between ethylene and auxin. We take a closer look at the best-known transcriptional and posttranscriptional points of interaction, as well as revisit the most recent experimental findings that suggested additional levels of ethylene-auxin crosstalk.

关键词：刺柏属激素类内皮缩血管肽类生长和发育胰岛素抑制(心理学) 注意力综述

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计算机科学引论影印版

Do intra-operative fluids influence the need for post-operative cardiotropic support after a PDA ligation？

2004年

作者： Timothy j.O'Leary linda I.O'Leary

本书概括地介绍了计算机科学与信息技术的主要领域、各种应用及其对社会的影响。全书由15章和一些附录组成，主要内容包括：信息技术概述；因特网、万维网与电子商务；基本应用软件（包括字处理、表处理、数据库管理系统、文字和图形演... 详细信息

ISBN: (纸本)789493514X;7040145987

本书概括地介绍了计算机科学与信息技术的主要领域、各种应用及其对社会的影响。全书由15章和一些附录组成，主要内容包括：信息技术概述；因特网、万维网与电子商务；基本应用软件（包括字处理、表处理、数据库管理系统、文字和图形演示、集成化软件包等）；专用软件（包……

关键词： Electronic data processing.

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中国当代儿科杂志 2011年第1期13卷 1-7页

作者： Brigitte LEMYRE 刘玲 Gregory Paul MOORE Sarah linda LAWRENCE Nicholas j.BARROWMAN Department of Pediatrics University of Ottawa Department of Neonatology Children's Hospital of Guiyang

Objective To investigate the effect of intra-operative intravenous fluids on post-operative hemodynamic *** We performed a retrospective cohort study of 98 preterm infants who underwent a patent ductus arteriosus(PDA) ligation in one NICU between 2001 and *** primary outcome was the need for cardiotropic support within 24 hrs of *** Twenty-seven infants(28%) required post-operative cardiotropic *** amount of intra-operative fluids varied between 0 and 50.4 mL/kg(median:10.2 mL/kg).No intra-operative fluid was recorded in 26 *** were not associated with the need for post-operative cardiotropic support(P=0.10).Using a multivariate logistic regression model,age at ligation,weight at ligation and pre-operative FiO2 were significant predictors of post-operative cardiotropic *** Intra-operative fluids do not appear to be associated with the need for post-operative cardiotropic support.A prospective cohort study may help identify modifiable risk factors and improve outcomes in this population.

关键词：《中国当代儿科杂志》期刊摘要编辑部 PDA

Factor analysis identifies subgroups of constipation

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World journal of Gastroenterology 2011年第11期17卷 1468-1474页

作者： Philip G Dinning Mike jones linda Hunt Sergio E Fuentealba jamshid Kalanter Denis W King David Z Lubowski Nicholas j Talley Ian j Cook Department of Gastroenterology St.George HospitalUniversity of New South WalesKogarahNSW 2217Australia Department of Psychology Macquarie UniversityNSW 2109Australia Gastroenterology Research Unit Nepean HospitalUniversity of SydneySydneyNSW 2050Australia Department of Colorecta Surgery St.George HospitalKogarahNSW 2217Australia Gastroenterology and Hepatology Mayo ClinicJacksonvilleFL 32224United States

AIM:To determine whether distinct symptom groupings exist in a constipated population and whether such grouping might correlate with quantifiable pathophysiological measures of colonic ***:One hundred and ninety-one patients presenting to a Gastroenterology clinic with constipation and 32 constipated patients responding to a newspaper advertisement completed a 53-item,wide-ranging selfreport *** hundred of these patients had colonic transit measured *** analysis determined whether constipation-related symptoms grouped into distinct aspects of *** analysis was used to determine whether indi-vidual patients naturally group into distinct ***:Cluster analysis yielded a 4 cluster solution with the presence or absence of pain and laxative unresponsiveness providing the main *** all clusters there was a considerable proportion of patients with demonstrable delayed colon transit,irritable bowel syndrome positive criteria and regular stool *** majority of patients with these characteristics also reported regular laxative ***:Factor analysis identified four constipation subgroups,based on severity and laxative unresponsiveness,in a constipated ***,clear stratification into clinically identifiable groups remains imprecise.

关键词： Factor analysis Constipation Symptoms Clusters Laxatives

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COMPUTING TODAY /

Integrated Risk Identification, Analysis, and Assessment:A Dynamic Household Economy Analysis Methodology and Example

2004年

作者： TIMOTHY j. O'LEARY linda I. O'LEARY.

Includes index.

ISBN: (纸本)0072565985

Includes index.

关键词： Electronic digital computers.

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International journal of Disaster Risk Science 2013年第2期4卷 77-88页

作者： Bob Alexander linda j.Cox junko Mochizuki Rural Livelihood Risk Management Consulting P.O.Box 1251HonoluluHI 96807USA Department of Natural Resource and Environmental Management University of Hawai`i at ManoaHonoluluHI 96822USA

Many methodologies identify, analyze, and assess static risks to quantify potential disaster losses based on past and current events. Static methodologies will not, however, capture how climate change and adaptation are rapidly affecting the natural and social systems in many areas. Local and global changes such as those associated with development investments, livelihood pressures, political stability, and demographic trends are also affecting many areas, especially in emerging economies. Risk identification, analysis, and assessment methodologies must integrate all changes dynamically so that risk reduction and development decisions can be based on future needs. After a theoretical explanation of how to integrate dynamic changes, a static Household Economy Analysis(HEA) completed for a rapidly changing area of East Timor was altered using current trends to make the analysis more dynamic. Some inherent difficulties exist with a more dynamic approach and recommendations for overcoming them are presented. Research, government, and nongovernment personnel interested in integrated approaches to risk reduction and development decision-making in areas subject to rapid change will find the study useful.

关键词： integrate disaster interested

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Prescott微生物学原理影印版

Closed 3-stop Center and Periphery in Graphs

丛书名：国外优秀生命科学教学用书

2009年

作者：（美）joanne M. Willey （美）linda M. Sherwood （美）Christopher j. Woolverton

Prescott’s微生物学原理是在Prescott，Harley，andKlein’sMicrobiology（第7版），（简称《PHK微生物学》）的基础上发展出来的精简版。本书秉承《PHK微生物学》博大精深、新颖、系统的特点，为我们提供了涵盖微生物学所有领域的干... 详细信息

ISBN: (纸本)9787040256819

Prescott’s微生物学原理是在Prescott，Harley，andKlein’sMicrobiology（第7版），（简称《PHK微生物学》）的基础上发展出来的精简版。本书秉承《PHK微生物学》博大精深、新颖、系统的特点，为我们提供了涵盖微生物学所有领域的干净流畅的知识精要。作者在易读性上下了很多功夫，以进化、生态和多样性为主线将一些重要论题再次进行了综合和整理。每章集中介绍重要概念，并将...

关键词： Microbiology.

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Acta Mathematica Sinica,English Series 2012年第3期28卷 439-452页

作者： linda EROH Ralucca GERA Steven j. WINTERS Department of Mathematics University of Wisconsin Oshkosh Department of Applied Mathematics Naval Postgraduate School

A delivery person must leave the central location of the business, deliver packages at a number of addresses, and then return. Naturally, he/she wishes to reduce costs by finding the most efficient route. This motivates the following： Given a set of k distinct vertices S = {x1, x2,..., xk } in a simple graph G, the closed k-stop-distance of set S is defined to be

关键词： Central appendage number peripheral appendage number Steiner distance