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Fault-Tolerant Dynamical Consensus of Double-Integrator Multi-Agent Systems in the Presence of Asynchronous Self-Sensing Function Failures

第十三届全国免疫学学术大会

作者： linbo yin Zining Zhang Hong Shang The First Affiliated Hospital of China Medical University

Human immunodeficiency virus-infected long-term non-progressors(LTNPs) are of particular importance because of their unique disease progression characteristics. Defined by the maintenance of normal CD4+T cells after more than eight years of infection, these LTNPs are heterogeneous. Some long-term non-progressors have ongoing viral production, while others do not and are able to control viral production. The underlying basis for this heterogeneity has not been clearly elucidated. For this study, miRNA expression profiles of LTNPs were assessed and microRNA-19 b(miR-19 b) levels were found to be significantly increased in peripheral blood mononuclear cells of LTNPs with lower rather than higher levels of viral load. We made clear that miR-19 b can regulate the CD8+T cell functions in HIV infection, which has not been addressed before. Overexpression of miR-19 b promoted CD8+T cell proliferation, as well as interferon-γ and Granzyme B expression, while inhibiting CD8+T cells apoptosis induced by T cells receptor stimulation. The target of miR-19 b was found to be the "phosphatase and tensin homolog", which regulates CD8+T cells function during HIV infections. Furthermore, we found that miR-19 b can directly inhibit viral production in in-vitro HIV infected T *** results highlight the importance of miR-19 b to control viral levels, which facilitate an understanding of human immunodeficiency virus pathogenesis and provide potential targets for improved immune intervention.

关键词： CD8+T cells long-term non-progressors microRNA-19b phosphatase and tensin homolog

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Journal of Shanghai Jiaotong university(Science) 2024年第4期29卷 613-624页

作者： WU Zhihai XIE linbo Engineering Research Center of Internet of Things Technology Applications of the Ministry of Education School of Internet of Things EngineeringJiangnan UniversityWuxiJiangsu214122China

Double-integrator multi-agent systems(MASs)might not achieve dynamical consensus,even if only partial agents suffer from self-sensing function failures(SSFFs).SSFFs might be asynchronous in real engineering *** existing fault-tolerant dynamical consensus protocol suitable for synchronous SSFFs cannot be directly used to tackle fault-tolerant dynamical consensus of double-integrator MASs with partial agents subject to asynchronous *** by these facts,this paper explores a new fault-tolerant dynamical consensus protocol suitable for asynchronous ***,multi-hop communication together with the idea of treating asynchronous SSFFs as multiple piecewise synchronous SSFFs is used for recovering the connectivity of network topology among all normal ***,a fault-tolerant dynamical consensus protocol is designed for double-integrator MASs by utilizing the history information of an agent subject to SSFF for computing its own state information at the instants when its minimum-hop normal neighbor set ***,it is theoretically proved that if the strategy of network topology connectivity recovery and the fault-tolerant dynamical consensus protocol with proper time-varying gains are used simultaneously,double-integrator MASs with all normal agents and all agents subject to SSFFs can reach dynamical ***,comparison numerical simulations are given to illustrate the effectiveness of the theoretical results.

关键词： double-integrator multi-agent systems asynchronous self-sensing function failures fault-tolerant dynamical consensus network topology connectivity recovery

Historical biogeography and evolutionary diversification of Lilium(Liliaceae): New insights from plastome phylogenomics

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Plant Diversity 2024年第2期46卷 219-228页

作者： Nian Zhou Ke Miao Changkun Liu linbo Jia Jinjin Hu Yongjiang Huang Yunheng Ji CAS Key Laboratory for Plant Diversity and Biogeography of East Asia Kunming Institute of BotanyChinese Academy of SciencesKunmingYunnan 650201China University of Chinese Academy of Sciences Beijing 100049China Key Laboratory of Bio-Resources and Eco-Environment of Ministry of Education College of Life SciencesSichuan UniversityChengduSichuan 610065China Yunnan Key Laboratory for Integrative Conservation of Plant Species with Extremely Small Population Kunming Institute of BotanyChinese Academy of SciencesKunmingYunnan 650201China

Here, we infer the historical biogeography and evolutionary diversification of the genus Lilium. For this purpose, we used the complete plastomes of 64 currently accepted species in the genus Lilium(14plastomes were newly sequenced) to recover the phylogenetic backbone of the genus and a timecalibrated phylogenetic framework to estimate biogeographical history scenarios and evolutionary diversification rates of Lilium. Our results suggest that ancient climatic changes and geological tectonic activities jointly shaped the distribution range and drove evolutionary radiation of Lilium, including the Middle Miocene Climate Optimum(MMCO), the late Miocene global cooling, as well as the successive uplift of the Qinghai-Tibet Plateau(QTP) and the strengthening of the monsoon climate in East Asia during the late Miocene and the Pliocene. This case study suggests that the unique geological and climatic events in the Neogene of East Asia, in particular the uplift of QTP and the enhancement of monsoonal climate, may have played an essential role in formation of uneven distribution of plant diversity in the Northern Hemisphere.

关键词： Asian monsoon Climatic changes Distribution range Evolutionary complexity Radiative diversification Species diversity Qinghai-Tibet Plateau(QTP)

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Deregulated microRNA-21 expression in monocytes from HIV-infected patients contributes to elevated IP-10 secretion in HIV infection

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Deregulated microRNA-21 expression in monocytes from HIV-inf...

Bio-inspired Attachment Mechanism of Dynastes Hercules:Vertical Climbing for On-Orbit Assembly Legged Robots

第十二届全国免疫学学术大会

作者： Wu Xian Zhang Lele yin linbo Fu Yajing Jiang Yongjun Ding Haibo Chu Zhenxing Shang Hong Zhang Zining Key Laboratory of AIDS Immunology of National Health and Family Planning Commission Department of Laboratory Medicinethe First Affiliated HospitalChina Medical University

Objective:Persistent activation and inflammation impair immune response and trigger disease progression in HIV *** evidence supports the supposition that excessive production of interferon-inducible protein 10(IP-10),leads to immune dysfunction and disease *** this study,we sought to elucidate the factors triggering the significant up-regulation of IP-10,especially at a post-transcriptional level in HIV ***:miRNA mimics/inhibitors were transfected into THP-1 and the differentiated THP-1 macrophages(THP-lMA).IP-10 and IFN-stimulated gene 15(ISG15) mRNA levels were measured by qRT-PCR and IP-10 protein secretion was detected by *** of IP-10 as direct target of miR-21 was performed by luciferase *** monocyte from HIV infected patients were sorted to detect the expression of ***:Bolstering miR-21 levels using mimics resulted in the obvious suppression of lipopolysaccharide(LPS)-induced IP-10 protein production,but not transcription or stability of IP-10 *** levels of miR-21 in monocytes of HIVinfected patients were considerably lower than those of healthy controls(HCs),whereas IP-10 levels in plasma exhibited the opposite *** was a trend of negative correlation between miR-21 expression in monocytes and plasma IP-10 *** LPS-stimulated IP-10 protein prodoction was not affected by miR-21 modulation in THP-1 derived *** an IP-10 upstream molecule,when ISG15 was inhibited,the capacity of miR-21 to inhibit IP-10 protein production was ***:IP-10 is under the control of both ISG15 and *** transcriptional activation induced by enhanced ISG15 production is stronger than fine-tuning effect of post-transcriptional regulation mediated by miR-21 in THP-1-MA *** current study offers a comprehensive understanding of the regulation of IP-10 in HIV infection.

关键词： IP-10 microRNA-21 ISG15 inflammatory response HIV infection

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Journal of Bionic Engineering 2024年第1期21卷 137-148页

作者： Yuetian Shi Xuyan Hou Zhonglai Na Jie Zhou Nan Yu Song Liu linbo Xin Guowei Gao Yuhui Liu School of Mechatronics Engineering Harbin Institute of TechnologyHarbin 150001China

With the increasing size of space facilities,on-orbit assembly requires robots to move on different heights of *** paper proposes a bio-inspired attachment mechanism for robot feet to enable climbing on different heights of *** by the attachment and grasping abilities of Dynastes Hercules,we utilize its foot microstructures,such as microhooks and setae,to achieve efficient contact and firm grip with the *** morphology and arrangement of these structures can inspire the design of robot feet to improve their grasping and stability *** study the biological structure of Dynastes Hercules,design and optimize the bio-inspired structure,analyze the influence of various factors from theoretical and experimental perspectives,and verify the feasibility of the scheme through *** propose an ideal climbing strategy that provides useful reference for robot applications in ***,the influence laws of various factors in this paper can be applied to robot foot design to improve their operation ability and stability performance in the space *** bio-inspired mechanism can improve robot working range and efficiency,which is critical for on-orbit assemblyin space.

关键词： Space assembly robot Truss climbing Bionic structure Dynastes Hercules tarsus

Investigation and mitigation of Mott neuronal oscillation fluctuation in spiking neural network

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Science China(Information Sciences) 2024年第2期67卷 291-301页

作者： Lindong WU Zongwei WANG Lin BAO linbo SHAN Zhizhen YU Yunfan YANG Shuangjie ZHANG Guandong BAI Cuimei WANG John ROBERTSON Yuan WANG Yimao CAI Ru HUANG School of Integrated Circuits Peking University Beijing Advanced Innovation Center for Integrated Circuits State Key Laboratory of Information Photonics and Optical Communications Beijing University of Posts and Telecommunications Department of Engineering University of Cambridge

Mott devices, featuring low hardware cost and high energy efficiency, have been demonstrated as a key oscillatory element in artificial neurons to enable spiking neural networks(SNNs) such as conversionbased SNNs(CSNNs). However, there will be inevitably non-ideal fluctuation in the oscillation behavior,causing the accuracy degradation of networks. In this paper, we investigate the Mott neuronal oscillation fluctuation(NOF) through experiments and modeling. The results show that the NOF phenomenon conforms to Gaussian distribution and originates from thermal fluctuation induced switching voltage variations. We construct a two-layer CSNN for image recognition tasks to study the NOF effect and propose the activation function boundary(AFB) method to strengthen the stability of the network. The results indicate that AFB can improve the accuracy of CSNN by up to 15.5% by tightening output distribution.

关键词： Mott neuron oscillation fluctuation variation-aware Mott neuronal model conversion-based spiking neural network activation function boundary

CIPs@Mn_(0.8)Zn_(0.2)Fe_(2)O_(4)-CNTs复合材料低频吸波性能研究

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无机材料学报 2024年第1期39卷 71-80,I0003,I0004页

作者：陈海燕唐志鹏尹良君张林博徐鑫电子科技大学电子科学与工程学院国家电磁辐射控制材料工程技术中心多频谱吸波材料与结构教育部重点实验室成都611731 中国科学技术大学材料科学与工程系能量转换材料重点实验室合肥230026

随着5G无线通信与低频雷达侦察技术的飞速发展,低频电磁波辐射已成为当代的严重问题。目前,中高频段吸波材料的研究已趋于成熟,而设计低频段吸波材料仍面临巨大的挑战,亟待研究者们解决。基于四分之一波长相消机制,本研究设计了0.5~3 GH... 详细信息

随着5G无线通信与低频雷达侦察技术的飞速发展,低频电磁波辐射已成为当代的严重问题。目前,中高频段吸波材料的研究已趋于成熟,而设计低频段吸波材料仍面临巨大的挑战,亟待研究者们解决。基于四分之一波长相消机制,本研究设计了0.5~3 GHz低频段复合吸波材料。采用简单的一步水热法,诱导铁氧体在羰基铁粉与碳纳米管表面生长,制备出CIPs@Mn_(0.8)Zn_(0.2)Fe_(2)O_(4)-CNTs三元复合材料,对比研究了碳纳米管含量对材料吸收峰频率的影响。实验结果表明,引入碳纳米管,一方面为材料带来了界面极化、偶极极化等额外的损耗机制,增加了材料的衰减系数;另一方面基于四分之一波长相消机制,高介电与高磁导率的耦合,使材料在低频段获得良好的阻抗匹配。最终,在4 mm厚度下,样品分别在2.11与1.75 GHz处,获得了–40.8与–32.1 dB的反射损耗,–10 dB带宽分别为1.70~2.70 GHz和1.40~2.20 GHz。该复合材料制备工艺简单,低频吸收性能良好,具有很大的应用潜力,为开发更有效的低频吸波材料提供了新的思路和方法。

关键词：碳纳米管复合材料羰基铁粉波长相消低频吸波

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Distinct Effects of Three Tea Varieties Made Green Teas on Improving Diabetic Dyslipidemia Induced by High-Fat Diet in C57BL/6J Mice

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Food Science and Human Wellness 2024年

作者： Wei Gu Zhutong Wang Guohuo Wu Huimin Guo Huijun Cheng Cong Li linbo Chen Daxiang Li Zhongwen Xie State Key Laboratory of Tea Plant Biology and Utilization， School of Tea and Food Sciences & Technology， Anhui Agricultural University Center for Biotechnology， Anhui Agricultural University College of Life Sciences， Anhui Agricultural University Tea Research Institute， Yunnan Academy of Agricultural Sciences

Currently， cultivated tea plants are classified into three varieties， namely， C. sinensis var. sinensis， C. sinensis var. assamica， and C. sinensis var. kucha. Three tea varieties made green teas (TVGTs) are widely consumed worldwide. However， a comparative investigation of the beneficial effects， mechanism， and characteristic compounds of TVGTs has not been reported. Here， three representative tea plant varieties， namely， C. sinensis var. sinensis cv. Fuding (FD)， C. sinensis var. assamica cv. Yunkang 10 (YK)， and C. sinensis var. kucha (KC)， planted in the same garden， were used to make green teas utilizing the same standard procedure. Our findings show that the TVGTs effectively improved hyperglycemia， obesity， dyslipidemia， fatty liver， and mesenteric artery (MA) hypercontractility in mice with diabetes and obesity induced by a high-fat diet (HFD) after 11- and 22-week interventions， with YK being the most effective at 22 weeks. Liver lipidomics indicated that the TVGTs restored the glycerophospholipid and sphingolipid balance and reduced triglycerides， with YK demonstrating superior effects. The TVGTs， particularly YK， suppressed triglyceride synthesis through the ARV1-FXR-SHP-SREBP-1c pathway. A chemical profile analysis revealed that YK green tea had enriched active compounds， including caffeine， quinic acid， L-theanine， gallic acid， and catechins， compared with FD and KC green teas， which may contribute to ameliorating diabetic dyslipidemia via synergistic action. As a representative tea variety of C. sinensis var. assamica， YK green tea was found to be superior to the other two green teas in preventing and treating diabetic dyslipidemia， especially with long-term consumption. These data provide important information for tea plant breeders and tea consumers.

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Data-driven Event-triggered Automatic Parking Control for Unmanned Vehicles with Data Dropouts

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Data-driven Event-triggered Automatic Parking Control for Un...

Anti-Inflammatory Glycosaminoglycan Oligosaccharides from Colwellia psychrerythraea 34H Capsule:Synthesis and Biological Evaluation

第35届中国过程控制会议

作者： Zhiwei Zhao Huarong Zhao Ming Xu Li Peng linbo Xie School of Internet of Things Engineering Jiangnan University Zhejiang Runva Mechanical & Electrical Co. LTD

This paper investigates a data-driven event-triggered automatic parking control issue for unmanned vehicles with data dropout. Firstly, a dynamic analysis of the automatic parking control process is conducted, transforming the automatic parking problem into a vehicle body angle tracking problem. Then, an event-triggered mechanism is designed to reduce the communication burden. Meanwhile, an input-based compensation algorithm is formulated to relieve the effects of data dropout in both feedback and forward channels. Furthermore, a data-driven event-triggered automatic parking control scheme is proposed,and rigorous proof of the proposed method is given. Finally, several simulation studies are presented to verify the effectiveness of the designed method.

关键词： Model-free adaptive control automatic parking control event-triggered control data dropout noise

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CCS Chemistry 2024年第7期6卷 1698-1711页

作者： Zhongtang Li Xiaoyu Sun Yuchao Wang Ao Sun linbo Fu Tongtong Geng Zihui Zhang Ximin Lv Qian Wang Jing Wang Baodi Gou Xiangbao Meng Zhongjun Li State Key Laboratory of Natural and Biomimetic Drugs School of Pharmaceutical SciencesPeking UniversityBeijing 100191

Capsular polysaccharides(CPS)of Colwellia psychrerythraea 34H consist of linear tetrasaccharides repeating units in a glycosaminoglycan-like *** biological function is likely involved in the cold adaptation of microbial *** low availability of these glycosaminoglycan structures greatly limits the study of their functions and biological ***,an efficient semisynthetic strategy for CPS tetrasaccharide derivatives is achieved by using disaccharide units degraded from hyaluronic *** new synthetic process is suitable for largescale preparation,and several rare tetrasaccharide derivatives containing GalA-GalNAc were readily obtained in high *** evaluation of their anti-inflammatory effects demonstrated that these CPS tetrasaccharides effectively attenuated the lipopolysaccharide-induced sepsis and acute lung injury by decreasing macrophage infiltration and secretion of microphage-related cytokines in *** these results suggest that this new type of CPS tetrasaccharide can be developed as an anti-inflammation agent.

关键词： glycosaminoglycan oligosaccharide glycosylation anti-inflammatory agent acute lung injury