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Targeting vulnerable microcircuits in the ventral hippocampus of male transgenic mice to rescue Alzheimer‑like social memory loss

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Military Medical Research 2025年第1期12卷 48-71页

作者： Hui-Yang Lei Gui-lin Pi Ting He Rui Xiong Jing-Ru Lv Jia-Le Liu Dong-Qin Wu Meng-Zhu Li Kun Shi Shi-Hong Li Na-Na Yu Yang Gao Hui-ling Yu lin-Yu Wei Xin Wang Qiu-Zhi Zhou pei-lin Zou Jia-Yang Zhou Ying-Zhou Liu Nai-Ting Shen Jie Yang Dan Ke Qun Wang Gong-Ping Liu Xi-Fei Yang Jian-Zhi Wang Ying Yang Department of Pathophysiology School of Basic MedicineKey Laboratory of Education Ministry of China/Hubei Province for Neurological DisordersTongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430030China Department of Traditional Chinese Medicine the Central Hospital of WuhanTongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430014China Key Laboratory of Modern Toxicology of Shenzhen Shenzhen Center for Disease Control and PreventionShenzhen 518055GuangdongChina Co‑Innovation Center of Neuroregeneration Nantong UniversityNantong 226000JiangsuChina

Background:Episodic memory loss is a prominent clinical manifestation of Alzheimer’s disease(AD),which is closely related to tau pathology and hippocampal *** to the heterogeneity of brain neurons,the specific roles of different brain neurons in terms of their sensitivity to tau accumulation and their contribution to AD-like social memory loss remain ***,further investigation is ***:We investigated the effects of AD-like tau pathology by Tandem mass tag proteomic and phosphoproteomic analysis,social behavioural tests,hippocampal electrophysiology,immunofluorescence staining and in vivo optical fibre recording of GCaMP6f and ***,we utilized optogenetics and administered ursolic acid(UA)via oral gavage to examine the effects of these agents on social memory in ***:The results of proteomic and phosphoproteomic analyses revealed the characteristics of ventral hippocampal CA1(vCA1)under both physiological conditions and AD-like tau *** tau progressively accumulated,vCA1,especially its excitatory and parvalbumin(PV)neurons,were fully filled with mislocated and phosphorylated tau(p-Tau).This finding was not observed for dorsal hippocampal CA1(dCA1).The overexpression of human tau(hTau)in excitatory and PV neurons mimicked AD-like tau accumulation,significantly inhibited neuronal excitability and suppressed distinct discrimination-associated firings of these neurons within *** excitatory and PV neurons in vCA1 at specific rhythms and time windows efficiently ameliorated tau-impaired social ***,1 month of UA administration efficiently decreased tau accumulation via autophagy in a transcription factor EB(TFEB)-dependent manner and restored the vCA1 microcircuit to ameliorate tau-impaired social ***:This study elucidated distinct protein and phosphoprotein networks between dCA1 and vCA1 and highlighted the susceptibility of the vCA1 microcircuit to AD-like tau

关键词： Alzheimer’s disease Tau protein Ventral hippocampus Social memory Ursolic acid Transcription factor EB(TFEB)

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中国式现代化背景下体育非遗智库建设定位与路径

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体育文化导刊 2025年第2期 38-44,94页

作者：苗慧龙佩林田祖国吉首大学体育科学学院湖南吉首416000 湖南大学体育学院长沙410000

运用文献资料、逻辑分析等方法,分析中国式现代化背景下体育非遗智库建设的必要性、定位,并提出路径。必要性:国家治理水平现代化需要,全面推进强国建设需要,中国式话语体系构建需要。定位:协调两个文明发展,服务广大人民群众,制定产业... 详细信息

运用文献资料、逻辑分析等方法,分析中国式现代化背景下体育非遗智库建设的必要性、定位,并提出路径。必要性:国家治理水平现代化需要,全面推进强国建设需要,中国式话语体系构建需要。定位:协调两个文明发展,服务广大人民群众,制定产业发展规划,深化文化内涵阐释。路径:健全人才建设体系,支持协调发展;增加数据透明程度,提高群众信任;拓展经费筹措渠道,保障研究独立;完善成果转化机制,发挥阐释成效。

关键词：体育管理体育非遗智库建设中国式现代化

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Lovastatin production by Aspergillus terreus in solid-state fermentation

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Journal of Zhejiang University-Science A(Applied Physics & Engineering) 2007年第9期8卷 1521-1526页

作者： WEI pei-lian XU Zhi-nan CEN pei-lin Institute of Biochemical Engineering Department of Chemical Engineering ＆ Bioengineering Zhejiang University Hangzhou 310027 China Department of Biochemical Engineering Zhejiang University of Science and Technology Hangzhou 310023 China

Lovastatin production by Aspergillus terreus ATCC 20542 in solid-state fermentation （SSF） was studied. Various substrates were used to evaluate the ability ofA. terreus to produce lovastatin. The results showed that either rice or wheat bran was suitable substrate for lovastatin production in SSF. The maximum yield of lovastatin （2.9 mg/g dry substrate） using rice as substrate was achieved after incubating for 11 d at the following optimized process parameters： 50%-60% initial moisture content, pH 5.5, incubation temperature 28 ℃.

关键词： Solid-state fermentation (SSF) Rice Lovastatin Aspergillus terreus

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EGCG and ECG induce apoptosis and decrease autophagy via the AMPK/mTOR and PI3K/AKT/mTOR pathway in human melanoma cells

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Chinese Journal of Natural Medicines 2022年第4期20卷 290-300页

作者： DU Bing-Xin lin pei lin Jun School of Life Sciences and Health Engineering Jiangnan UniversityWuxi 214122China

Catechins have been proven to exert antitumor effects in different kinds of ***,the underlying mechanisms have not been completely clarified *** study aimed to assess the effects and mechanisms of(-)-epigallocatechin-3-gallate(EGCG)and(-)-epicatechin-3-gallate(ECG)on human melanoma skin A375 *** showed that EGCG and ECG inhibited the proliferation of A375 cells and ECG showed better inhibitory *** cytometry analysis had shown that EGCG and ECG induced apoptosis and led to cell cycle *** and ECG decreased Bcl-2 expression and upregulated Caspase-3 protein level,indicating the development of ***,EGCG and ECG could decreased mitochondrial membrane potential of A375 *** addition,the expression of Beclin-1,LC3 and Sirt3 were downregulated at protein levels,which known to be associated with *** autophagy was increased by rapamycin,the apoptotic trend was not change,indicating that apoptosis and autophagy are ***,EGCG and ECG treatments decreased phosphorylated-AMPK(p-AMPK)and increased the ratios of P-PI3K,p-AKT and p-mTOR in melanoma ***,EGCG and ECG induced apoptosis via mitochondrial signaling pathway,downregulated autophagy through modulating the AMPK/mTOR and PI3K/AKT/mTOR signaling *** indicated that EGCG and ECG may be utilized in human melanoma treatment.

关键词： EGCG ECG Apoptosis Autophagy PI3K/AKT/mTOR

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基于SWMM模型的海绵城市建设效果评估

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中国农村水利水电 2025年第1期 70-77页

作者：张沛林杨建涛王森刘晋广州市增城区水务局广东广州511300 珠江水利委员会珠江水利科学研究院广东广州510611 水利部珠江河口治理与保护重点实验室广东广州510611

为定量评估广州市荔湖片区海绵城市建设成效,研究通过本底分析、资料收集等构建了片区排水分区尺度上的SWMM模型,并从年径流总量控制率、管网过流能力和内涝风险方面对广州市荔湖片区海绵城市建设效果进行了模拟分析,以期验证该区域按... 详细信息

为定量评估广州市荔湖片区海绵城市建设成效,研究通过本底分析、资料收集等构建了片区排水分区尺度上的SWMM模型,并从年径流总量控制率、管网过流能力和内涝风险方面对广州市荔湖片区海绵城市建设效果进行了模拟分析,以期验证该区域按照海绵城市建设实施方案开发建设后,片区防灾减灾能力,同时本研究成果可为南方高密度地区海绵城市建设对缓解城市内涝提供理论参考。通过对广州市荔湖片区模拟计算得出主要结论如下:(1)广州市荔湖片区低影响开发建设后,年径流总量控制率显著提升,2022年片区年径流总量控制率为81.46%,较2019年低影响开发建设前提升了15.37%;(2)对广州市荔湖片区低影响开发建设前后排水管网过流能力模拟分析,结果表明片区在低影响开发建设前,在不同重现期降雨条件下,管网均出现溢流情况,且随着设计重现期的增大,管网溢流比例增加。片区低影响开发建设后,在不同重现期降雨条件下,管网溢流情况均明显降低;(3)对广州市荔湖片区低影响开发建设后内涝风险模拟分析,结果显示在发生百年一遇24 h降雨(累计降雨量322 mm)时,片区基本为无风险区域,极少部分为低风险区域,荔湖片区海绵城市建设后能有效应对百年一遇暴雨。广州市荔湖片区通过海绵城市建设可有效降低雨水外排,提升了片区防灾减灾能力。

关键词： SWMM模型海绵城市效果评估年径流总量控制率过流能力荔湖片区

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Five Rutaceae family ethanol extracts alleviate H2O2 and LPS-induced inflammation via NF-κB and JAK-STAT3 pathway in HaCaT cells

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Chinese Journal of Natural Medicines 2022年第12期20卷 937-947页

作者： HONG Mengsa XIAO Kun lin pei lin Jun School of Life sciences and Health Engineering Jiangnan UniversityWuxi 214122China

This study was designed to investigate the effects of five Rutaceae family ethanol extracts(FRFEE):Citrus medica linn(CML),Citrus aurantium ***(CAD),Citrus medica ***(Noot.)Swingle(CMS),Citrus sinensis ***(CSO)and Zanthoxylum bungeanum Maxim(ZBM)on retarding the progression of H_(2)O_(2) and LPS-induced HaCaT *** inflammatory injury model was established by H_(2)O_(2) and *** alleviative effects of FRFEE were evaluated by detecting the activity of superoxide dismutase(SOD),glutathione(GSH)and the generation of reactive oxygen species(ROS).The inflammatory signaling pathways of NF-κB and JAK-STAT3 were detected by Western blotting,the mRNA expression levels of inflammatory factors and skin barrier factors were detected by RT-PCR.50%ethanol extracts of five medicinal and food homologous herbs of Rutaceae family showed different levels of anti-oxidant and anti-inflammatory *** FRFEE effectively improved SOD and GSH content and decreased ROS ***,FRFEE strongly suppressed two inflammatory signaling pathways NF-κB and *** RT-PCR examination of inflammatory factors and skin barrier factor revealed significant anti-inflammatory effects of *** was worth noting that among the five extracts,Zanthoxylum bungeanum Maxim extract had the best anti-inflammatory and anti-oxidation *** addition,it could strongly inhibit the expression of psoriasis factor *** summary,these results suggested that Zanthoxylum bungeanum Maxim extract could be used as an anti-psoriatic agent in the treatment of psoriasis among FRFEE.

关键词： Rutaceae Medicinal and food homologous herbs Oxidative stress Anti-inflammation Psoriasis

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促宫颈成熟球囊引产疗效及对分娩和新生儿结局的影响分析

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中国现代药物应用 2025年第1期19卷 38-41页

作者：林培宣康惠超泉州玛珂迩妇产医院妇产科 326000

目的探讨具备引产指征的产妇应用促宫颈成熟球囊引产的疗效以及对分娩和新生儿结局的影响。方法选择具备引产指征的产妇118例,以随机数表法分为对照组和观察组,每组59例。对照组行小剂量催产素引产,观察组应用促宫颈成熟球囊引产。比较... 详细信息

目的探讨具备引产指征的产妇应用促宫颈成熟球囊引产的疗效以及对分娩和新生儿结局的影响。方法选择具备引产指征的产妇118例,以随机数表法分为对照组和观察组,每组59例。对照组行小剂量催产素引产,观察组应用促宫颈成熟球囊引产。比较两组促进宫颈成熟率、促宫颈成熟期间临产情况、诱发临产时间、引产前后宫颈成熟度、分娩形式、新生儿结局以及顺产和阴道助产产妇产程时间。结果观察组促进宫颈成熟率96.61%显著高于对照组的84.75%,差异显著具备统计学意义(P0.05)。对照组诱发临产时间为(19.84±5.95)h,观察组诱发临产时间为(11.15±3.43)h;和对照组比较,观察组诱发临产时间较短,差异显著具备统计学意义(P<0.05)。引产后,两组Bishop评分均较引产前升高,且观察组Bishop评分(7.81±0.82)分高于对照组的(6.41±0.52)分,差异显著具备统计学意义(P<0.05)。观察组顺产率81.36%、新生儿正常率100.00%高于对照组的67.80%、91.53%,剖宫产率3.39%低于对照组的16.95%,差异显著具备统计学意义(P<0.05)。观察组顺产和阴道助产产妇第一产程、第二产程、总产程分别为(10.21±2.62)h、(39.71±12.11)min、(11.91±2.11)h,均短于对照组的(12.41±2.82)h、(54.61±13.22)min、(14.11±3.51)h,差异显著具备统计学意义(P<0.05)。结论对具备引产指征的产妇应用促宫颈成熟球囊引产可发挥显著效果,促使宫颈成熟率得到显著提升,改善母婴结局。

关键词：促宫颈成熟球囊引产妊娠结局新生儿结局

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京津冀环境行政执法一体化的困局及解决

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华北电力大学学报(社会科学版) 2025年第1期 73-83页

作者：杨林霈赵旭光中国人民大学刑事法律科学研究中心、法学院北京100872 华北电力大学人文与社会科学学院北京102206

在京津冀区域经济取得快速发展的同时,针对其产生的生态环境问题,地方政府采取了诸多举措,虽然取得了行之有效的成果,但是地方政府环境行政执法治理目标差异、环境行政执法机制不健全、环境行政执法监管不足、环境行政执法参与主体多元... 详细信息

在京津冀区域经济取得快速发展的同时,针对其产生的生态环境问题,地方政府采取了诸多举措,虽然取得了行之有效的成果,但是地方政府环境行政执法治理目标差异、环境行政执法机制不健全、环境行政执法监管不足、环境行政执法参与主体多元性不足仍是导致区域环境行政执法一体化进一步发展的阻碍。解决前述困局的思路在于以系统化的视角,从宏观和微观角度共同发力。宏观角度通过建立地方经济帮扶机制,实现执法目标趋同;健全环境行政执法机制,促进执法一体化实现;微观角度通过强化企业自身环境执法监管,形成联动合力;建立企业环境执法激励机制,促进参与主体多元性。由此促进京津冀环境行政执法一体化困局的解决,为京津冀区域协同新发展提供新动力。

关键词：环境行政执法一体化困局与解决

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A soft-contact hybrid electromagnetic–triboelectric nanogenerator for self-powered water splitting towards hydrogen production

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Nano Research 2024年第7期17卷 6567-6574页

作者： Fuxue Ma Yingjie Wu Shuge Dai pei lin Junlu Sun lin Dong Key Laboratory of Material Physics of Ministry of Education and School of Physics and MicroelectronicsZhengzhou UniversityZhengzhou 450000China

The effective acquisition of hydrogen energy from the ocean offers a promising sustainable solution for increasing global energy ***,a self-powered high-efficient hydrogen generation system is proposed by integrating a triboelectric–electromagnetic hybrid nanogenerator(TEHG),power management circuit(PMC),and an electrolytic *** the wind triggering,as-fabricated TEHG can effectively convert breeze energy into electric energy,which demonstrates a high output current of 20.3 mA at a speed rotation of 700 rpm and the maximal output power of 13.8 mW at a load of 10 MΩ.Remarkably,asdesigned self-powered system can perform a steady and continuous water splitting to produce hydrogen(1.5μL·min^(−1))by adding a matching capacitor between the PMC and electrolytic *** the circuit,the capacitor can not only function as a charge compensation source for water splitting,but also stabilize the working *** other self-powered water splitting systems,the proposed system does not need catalysts or the complex electrical energy storage/release process,thus improving the hydrogen production efficiency and reducing the *** work provides an effective strategy for clean hydrogen energy production and demonstrates the huge potential of the constructed self-powered system toward carbon neutralization.

关键词： wind energy harvester hybrid nanogenerator energy conversion and management hydrogen energy production

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Production of laccase by Coriolus versicolor and its application in decolorization of dyestuffs: (Ⅱ) Decolorization of dyes by laccase containing fermentation broth with or without self-immobilized mycelia

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Journal of Environmental Sciences 2003年第1期15卷 5-8页

作者： lin Jian ping LIAN Wei XIA Li ming CEN pei lin Department of Chemical Engineering and Bioengineering Zhejiang UniversityHangzhou 310027China.

The capability of decolorization for commercial dyes by Coriolus versicolor fermentation broth containing laccase with or without immobilized mycelium was evaluated. With cell free fermentation broth containing laccase, high decolorization ratio was achieved for acid orange 7, but not for the other dyes concerned. The immobilized mycelium was proved to be more efficient than the cell free system. All the four dyestuffs studied were found being decolourized with certain extent by immobilized mycelium. The repeated batch decolorization was carried out with satisfactory results. The experimental data showed that the continuous decolorization of wastewater from a printing and dyeing industry was possible by using the self immobilized C. Versicolor.

关键词： laccase textile dyes immobilized mycelium decolorization Coriolus versicolor

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