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Signal Transduction and Targeted Therapy 2024年第5期9卷 1981-2013页

作者： Ying Xia Ming Sun Hai Huang Wei-lin jin Center for Clinical Laboratories The Affiliated Hospital of Guizhou Medical UniversityGuiyang 550004PR China The First Affiliated Hospital of Guizhou University of Traditional Chinese Medicine Guiyang 550001PR China School of Clinical Laboratory Science Guizhou Medical UniversityGuiyang 550004PR China Division of Gastroenterology and Hepatology Department of Medicine andDepartment of OncologySidney Kimmel Comprehensive Cancer CenterJohns Hopkins University School of MedicineBaltimoreMD 21287USA Institute of Cancer Neuroscience Medical Frontier Innovation Research CenterThe First Hospital of Lanzhou UniversityThe First Clinical Medical College of Lanzhou UniversityLanzhou 730000PR China

Cancer,a complex and multifactorial disease,presents a significant challenge to global *** significant advances in surgical,radiotherapeutic and immunological approaches,which have improved cancer treatment outcomes,drug therapy continues to serve as a key therapeutic ***,the clinical efficacy of drug therapy is often constrained by drug resistance and severe toxic side effects,and thus there remains a critical need to develop novel cancer *** promising strategy that has received widespread attention in recent years is drug repurposing:the identification of new applications for existing,clinically approved *** repurposing possesses several inherent advantages in the context of cancer treatment since repurposed drugs are typically cost-effective,proven to be safe,and can significantly expedite the drug development process due to their already established safety *** light of this,the present review offers a comprehensive overview of the various methods employed in drug repurposing,specifically focusing on the repurposing of drugs to treat *** describe the antitumor properties of candidate drugs,and discuss in detail how they target both the hallmarks of cancer in tumor cells and the surrounding tumor *** addition,we examine the innovative strategy of integrating drug repurposing with nanotechnology to enhance topical drug *** also emphasize the critical role that repurposed drugs can play when used as part of a combination therapy *** conclude,we outline the challenges associated with repurposing drugs and consider the future prospects of these repurposed drugs transitioning into clinical application.

关键词： drugs integrating spite

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Surface plasmon-coupled radiative heat transfer between graphene-covered magnetic Weyl semimetals

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Science China Technological Sciences 2024年第11期67卷 3405-3412页

作者： SONG jinlin YAO XinJie jin lin CHEN Lei ZHAO HaiLong CHENG Qiang School of Electrical and Information Engineering Wuhan Institute of Technology State Key Laboratory of Coal Combustion School of Energy and Power EngineeringHuazhong University of Science and Technology

Weyl semimetals(WSMs) have recently attracted considerable research attention because of their remarkable optical and electrical properties. In this study, we investigate the near-field radiative heat transfer(NFRHT) between graphene-covered Weyl slabs, particularly focusing on the supported coupled surface plasmon polaritons(SPPs). Unlike bare Weyl slabs where the epsilon-near-zero(ENZ) effect contributes the most to the NFRHT, adding a monolayer graphene sheet yields coupled SPPs, i.e.,the coupling of graphene SPPs(GSPPs) and Weyl SPPs(WSPPs), which dominates the NFRHT. The graphene sheet greatly suppresses the ENZ effect by compressing the parallel wavevector, thereby enabling the heat transfer coefficient(HTC) to be significantly changed. Further, for the graphene-covered magnetic Weyl slab configuration, an increase in the number of Weyl nodes suppresses the SPP coupling and ENZ effect, thereby weakening the NFRHT with a regulation ratio of 4.4 whereas an increase in the Fermi level slightly influences the NFRHT. Several typical heterostructures are also proposed for comparison, and results show that a mono-cell structure has the largest total HTC. Our findings will facilitate the understanding of surface plasmon-coupled radiative heat transfer and enable opportunities in energy harvesting and thermal management at the nanoscale based on WSM-based systems.

关键词： near-field radiative heat transfer Weyl semimetal surface plasmon polariton epsilon-near-zero graphene

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CAGCN:Centrality-Aware Graph Convolution Network for Anomaly Detection in Industrial Control Systems

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Journal of Computer Science & Technology 2024年第4期39卷 967-983页

作者： Jun Yang Yi-Qiang Sheng jin-lin Wang Hong Ni National Network New Media Engineering Research Center Institute of AcousticsChinese Academy of SciencesBeijing 100190China School of Electronic Electrical and Communication EngineeringUniversity of Chinese Academy of SciencesBeijing 100049China

In industrial control systems,the utilization of deep learning based methods achieves improvements for anomaly ***,most current methods ignore the association of inner components in industrial control *** industrial control systems,an anomaly component may affect the neighboring components;therefore,the connective relationship can help us to detect anomalies *** this paper,we propose a centrality-aware graph convolution network(CAGCN)for anomaly detection in industrial control *** the traditional graph convolution network(GCN)model,we utilize the concept of centrality to enhance the ability of graph convolution networks to deal with the inner relationship in industrial control *** experiments show that compared with GCN,our CAGCN has a better ability to utilize this relationship between components in industrial control *** performances of the model are evaluated on the Secure Water Treatment(SWaT)dataset and the Water Distribution(WADI)dataset,the two most common industrial control systems datasets in the field of industrial anomaly *** experimental results show that our CAGCN achieves better results on precision,recall,and F1 score than the state-of-the-art methods.

关键词： graph convolution network(GCN) data mining network centrality anomaly detection industrial control system

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Single-cell and bulk transcriptomics identifies a tumor-specific CD36+cancer-associated fibroblast subpopulation in colorectal cancer

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Cancer Communications 2024年第4期44卷 495-498页

作者： jin Wang Ming-Jia Xi Qing Lu Bi-Han Xia Yu-Zhi Liu jin-lin Yang Department of Gastroenterology and Hepatology West China HospitalSichuan UniversityChengduSichuanP.R.China Sichuan University-University of Oxford Huaxi Joint Center for Gastrointestinal Cancer Frontiers Science Center for Disease-Related Molecular NetworkWest China HospitalSichuan UniversityChengduSichuanP.R.China

Dear Editor,Cancer-associated fibroblasts(CAFs)are highly ver-satile and plastic cells in the tumor *** have been identified as actively involved in can-cer progression and metastasis through their various roles in remodeling the extracellular matrix,suppressing the immune response and reprogramming tumor metabolism[1].However,many challenges exist in revealing the func-tional phenotypes and mechanisms of CAFs in different cancers due to limited understanding of CAF hetero-geneity[2].

关键词： CD36 metabolism colorectal

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Overexpression of Kdm6b induces testicular differentiation in a temperature-dependent sex determination system

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Zoological Research 2024年第5期45卷 1108-1115页

作者： Qiran Chen Wei Sun lin jin Yingjie Zhou Fang Li Chutian Ge College of Biological and Environmental Sciences Zhejiang Wanli UniversityNingboZhejiang 315100China Institute of Animal Sex and Development Zhejiang Wanli UniversityNingboZhejiang 315100China

In reptiles,such as the red-eared slider turtle(Trachemys scripta elegans),gonadal sex determination is highly dependent on the environmental temperature during embryonic *** complex process,which leads to differentiation into either testes or ovaries,is governed by the finely tuned expression of upstream genes,notably the testis-promoting gene Dmrt1 and the ovary-promoting gene *** studies have identified epigenetic regulation as a crucial factor in testis development,with the H3K27me3 demethylase KDM6B being essential for Dmrt1 expression in ***,whether KDM6B alone can induce testicular differentiation remains *** this study,we found that overexpression of Kdm6b in *** embryos induced the male development pathway,accompanied by a rapid increase in the gonadal expression of Dmrt1 at 31°C,a temperature typically resulting in female ***,this sex reversal could be entirely rescued by Dmrt1 *** findings demonstrate that Kdm6b is sufficient for commitment to the male pathway,underscoring its role as a critical epigenetic regulator in the sex determination of the red-eared slider turtle.

关键词： Temperature-dependent sex determination Sex reversal Kdm6b Dmrt1 T.s.elegans

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Characteristics of Elderly-Onset Rheumatoid Arthritis Patients With COVID-19

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Infectious Microbes & Diseases 2024年第1期6卷 36-42页

作者： Lanlan Xiao Xinlei Ma jinzhi Wu Junyu Liang Weiqian Chen jin lin Department of Rheumatology the First Affiliated HospitalZhejiang University School of MedicineHangzhouChina

This study aimed to investigate the clinical characteristics of elderly-onset rheumatoid arthritis(EORA)patients with *** ret-rospectively enrolled EORA patients diagnosed with COVID-19 from December 2022 through February 2023 and followed them *** characteristics of the patients and clinical data on COVID-19 were collected,and EORA-related data at the onset of rheu-matoid arthritis and during COVID-19 episodes were evaluated.A total of 102 EORA outpatients were enrolled and stratified into the COVID-19 group(n=60)and the non–COVID-19 group(n=42).In the COVID-19 group,56(93.3%)had symptoms,8(13.3%)had viral pneumonia,and 4(6.7%)developed severe *** logistic regression analysis showed that lack of COVID-19 vac-cination(P=0.016 and P=0.030,respectively)and having interstitial lung disease(P=0.013 and P=0.001,respectively)were inde-pendent risk factors for viral pneumonia and severe *** with the general population,EORA patients did not show significantly higher susceptibility to COVID-19 or a higher risk of severe ***,EORA patients with interstitial lung disease require special consideration during COVID-19 episodes.

关键词： COVID-19 elderly-onset rheumatoid arthritis COVID-19 vaccine interstitial lung disease

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Design and application of copper/lithium composite anodes for advanced lithium metal batteries

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Rare Metals 2024年第3期43卷 942-970页

作者： Bin Zhang Ji-Ping Ma Yang Zhao Tong Li jin-lin Yang Zhan-ling Zhang Shi-Zhong Wei Guang-Min Zhou School of Materials Science and Engineering Henan University of Science and TechnologyLuoyang 471003China Shenzhen Geim Graphene Center Tsinghua Shenzhen International Graduate SchoolTsinghua UniversityShenzhen 518055China School of Physical and Mathematical Sciences Nanyang Technological UniversitySingapore 637371Singapore Shenzhen Geim Graphene Center Tsinghua-Berkeley Shenzhen InstituteTsinghua Shenzhen International Graduate SchoolTsinghua UniversityShenzhen 518055China

Lithium(Li)is a promising candidate for nextgeneration battery anode due to its high theoretical specific capacity and low reduction ***,safety issues derived from the uncontrolled growth of Li dendrite and huge volume change of Li hinder its practical application.C onstructing dendrite-free composite Li anodes can significantly alleviate the above ***(Cu)-based materials have bee n widely used as substrates of the composite electrodes due to their chemical stability,excellent conductivity,and good mechanical ***/lithium(Cu/Li)composite anodes significantly regulate the local current density and decrease Li nucleation overp otential,realizing the uniform and dendrite-free Li *** this review,Cu/Li composite methods including electrodeposition,melting infusion,and mechanical rolling are systematically summarized and ***,design strategies of Cu-based current collectors for high performance Cu/Li composite anodes are *** challenges and future development for Cu/Li composite anodes are presented and *** hope that this review can provide a comprehensive understanding of Cu/Li composite methods of the latest development of Li metal anode and stimulate more research in the future.

关键词： Lithium metal batteries Cu/Li composite anode Electrodeposition Thermal melting infusion Mechanical rolling

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The m^(6)A regulator KIAA1429 stabilizes RAB27B mRNA and promotes the progression of chronic myeloid leukemia and resistance to targeted therapy

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Genes & Diseases 2024年第2期11卷 993-1008页

作者： Fangyi Yao Fangmin Zhong Junyao Jiang Ying Cheng Shuai Xu jing Liu jin lin jing Zhang Shuqi Li Meiyong Li Yanmei Xu Bo Huang Xiaozhong Wang Jiangxi Province Key Laboratory of Laboratory Medicine Jiangxi Provincial Clinical Research Center for Laboratory MedicineDepartment of Clinical LaboratoryThe Second Affiliated Hospital of Nanchang UniversityNanchangJiangxi 330006China

Chronic myeloid leukemia(CML)is a common adult *** the acute phase of the disease and the adverse effects of anti-cancer treatments can lead to a poor *** N6-methyladenine(m^(6)A)modification plays an important regulatory role in various physiological and pathological ***1429 is a known m^(6)A regulator,but the biological role of KIAA1429 in CML is *** this study,we observed that the m^(6)A levels and KIAA1429 expression were significantly up-regulated in patients with blast phase ***,KIAA1429 regulated the total level of RNA m^(6)A modification in the CML cells and promoted the malignant biological behaviors of CML cells,including proliferation,migration,and imatinib *** KIAA1429 in CML cells reduced the stability of RAB27B mRNA through the m^(6)A/YTHDF1 axis,consequently inhibiting CML proliferation and drug efflux,ultimately increasing the sensitivity of CML cells to ***,the knockdown of RAB27B also inhibited the proliferation and drug resistance of CML cells and promoted their ***,a recently developed anti-cancer agent,suppressed the expression of KIAA1429 and CML cell proliferation and promoted cell *** also inhibited the tumorigenesis of CML cells in *** combined use of rucaparib and imatinib enhanced the sensitivity of CML cells to *** study provides evidence that elevated KIAA1429 expression in the blast phase of CML enhances the stability of RAB27B mRNA through the m^(6)A/YTHDF1 axis to up-regulate RAB27B expression,thereby promoting CML *** exerts inhibitory effects on KIAA1429 expression and thus reduces CML progression.

关键词： Chronic myeloid leukemia KIAA1429 N6-methyladenine RAB27B Rucaparib YTHDF1

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医学CT序列图像的混合去噪算法

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东北大学学报（自然科学版） 2024年第4期45卷 464-473页

作者：陈锦林原培新东北大学机械工程与自动化学院辽宁沈阳110819

医学CT(computer tomography)序列图像会因为各种原因而掺杂噪声,去噪能够有效地提高图像的质量.常见的去噪算法都是针对单张图像进行,考虑到CT序列图像之间具有很高的相似性,本文提出一种基于相邻图像结构相似性的混合去噪算法.该算法... 详细信息

医学CT(computer tomography)序列图像会因为各种原因而掺杂噪声,去噪能够有效地提高图像的质量.常见的去噪算法都是针对单张图像进行,考虑到CT序列图像之间具有很高的相似性,本文提出一种基于相邻图像结构相似性的混合去噪算法.该算法首先计算序列图像的最大和最小灰度值,根据灰度值绘制直方图,设定相关阈值参数,根据筛选之后的直方图计算窗宽窗位,然后进行调窗处理.之后计算目标图像与其前后相邻图像之间的结构相似性,最后根据结构相似性对3张图片混合使用BM3D和高斯滤波2种去噪算法.通过对比实验表明,该算法在均方误差、峰值信噪比和结构相似性三方面都有所提高,能够有效地提高图像质量.

关键词：医学CT序列图像结构相似性混合去噪算法直方图调窗处理

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互联网行政许可事项设定的逻辑与进路

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治理研究 2024年第1期40卷 141-157,160页

作者：林华金麟中国政法大学习近平法治思想研究院中国政法大学法学院

我国互联网行政许可事项的设定面临着法律规范层级与许可事项重要性不匹配、法律规范稳定性与互联网高速发展不相容、许可事项碎片化与互联网有效治理不和谐等多重困境。互联网行政许可事项的设定需回应“因何设定”的实质逻辑和“如何... 详细信息

我国互联网行政许可事项的设定面临着法律规范层级与许可事项重要性不匹配、法律规范稳定性与互联网高速发展不相容、许可事项碎片化与互联网有效治理不和谐等多重困境。互联网行政许可事项的设定需回应“因何设定”的实质逻辑和“如何设定”的形式逻辑。在实质逻辑面向上,立法者需要区分互联网基础服务领域的许可事项和“互联网+”领域的许可事项,进行功能分析的二阶判断。在形式逻辑面向上,互联网行政许可事项存在“特有型”和“交叉型”两类方式。在“辅助性原则”和回应型法的指引下,互联网基础服务领域的许可事项和“互联网+”领域的许可事项需要分别匹配“特有型”和“交叉型”的设定方式,保证许可设定权限合法和事项重要性程度匹配,遵循“同一性原则”合理选择法条类型,以实现实体领域行政许可事项与互联网行政许可事项的体系衔接。

关键词：互联网行政许可行政许可事项行政许可设定互联网法

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