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NEW AVENUE FOR ASIA-PACIFIC ECONOMIC GROWTH

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China Report ASEAN 2021年第12期6卷 44-47页

作者： lin duo Zhang Tengjun the Department for Asia-Pacific Studies China Institute of International Studies (CIIE) CIIE Department for Asia-Pacific Studies

On November 2,the ASEAN Secretariat announced that six ASEAN members(Brunei,Cambodia,Laos,Singapore,Thailand,and Vietnam)and four non-ASEAN members(China,Japan,New Zealand,and Australia)had submitted Instruments of Ratification/Acceptance(IOR/A)of the Regional Comprehensive Economic Partnership(RCEP)agreement,thus reaching the minimum number of IOR/A for the entry into force of the free trade agreement(FTA).

关键词： ASEAN Singapore Zealand

High seroprevalence of toxoplasma gondii and HIV-1 co-infection among drug users in Yunnan province, southwest China

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Science China(Life Sciences) 2016年第8期59卷 857-859页

作者： Xin Chen Mei Ye Yan-Heng Zhou Feng-Liang Liu lin duo Hong Li Wei Pang Yong-Tang Zheng Key Laboratory of Animal Models and Human Disease Mechanisms of the Chinese Academy of Sciences & Yunnan Province Kunming Institute of Zoology Chinese Academy of Sciences Kunming 650223 China The Second People's Hospital of Yunnan Province Kunming 650021 China Yunnan Center for Disease Control and Prevention Kunming 650022 China Kunming College of Life Science University of Chinese Academy of Sciences Kunming 650204 China

Dear Editor, Toxoplasma gondii was discovered more than 100 years ago and has a broad-spectrum of intermediate hosts in addi- tion to its definitive host, felids. Although it does not cause symptomatic illness in most adults, it can lead to mental retardation in congenitally infected children and serious diseases in immunocompromised patients （Hill et al., 2005）. The first report of T. gondii infection in China was pub- lished in Chinese in 1964; subsequently, many other cases have been carried out. Currently, most publications about the seroprevalence of T. gondii infection in Yunnan have examined infections in pets, domestic animals, and wild animals; however, few previously published studies have assessed human T. gondii infection in Yunnan province.

关键词： users Toxoplasma retardation illness southwest infected likely prone children conclusion

Study on Basic Biomarkers of Alzheimer's Disease with Depression

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Chinese Journal of Biomedical Engineering(English Edition) 2023年第1期32卷 19-24,38页

作者： SHI Lei lin duo-duo WANG Wei-bing WU Hai-long Xiamen Xianyue Hospital Xiamen Fujian 361000China

Objective:To establish a rat model of Alzheimer’s disease with depression,and to explore the common serum indicators that can be used to assess the occurrence of depression in Alzheimer’s disease patients by routine blood ***:120 healthy male SD rats were randomly divided into healthy group,control group,dementia group and dementia with depression group,with 30 rats in each *** rats in the three groups were tested for the basic biological markers by means of routine serum ***:30 rats in each healthy group and control group,28rats in dementia group and 27 rats in dementia with depression group completed the *** were statistical differences in the levels of each biomarker in the four groups of rats(P0.05);The levels of serum IL-1β,IL-6,TNF-α,CRP,and Hcy in the dementia group were higher than those in the healthy group and the control group,and the 5-HT levels were lower than those in the healthy group and the control group(P0.05).Conclusion:The occurrence of depressive symptoms in Alzheimer’s rats can be predicted to some extent by routine serum IL-1β,IL-6,TNF-α,CRP,Hcy and 5-HT levels,and it is inferred that the above indicators can be used as important biological markers to assess the occurrence of depression in Alzheimer’s patients.

关键词： Alzheimer's disease depression biological markers

Erratum to:Holocene temperature variation recorded by branched glycerol dialkyl glycerol tetraethers in a loess-paleosol sequence from the north-eastern Tibetan Plateau

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Frontiers of Earth Science 2024年第2期18卷 460-461页

作者： Tianxiao WANG duo WU Tao WANG lin CHEN Shilong GUO Youmo LI Chenbin ZHANG Key Laboratory of Western China’s Environmental Systems(Ministry of Education) College of Earth and Environmental SciencesLanzhou UniversityLanzhou 730000China Alpine Paleoecology and Human Adaptation Group(ALPHA) Institute of Tibetan Plateau ResearchChinese Academy of SciencesBeijing 100101China

Erratum to:*** *** 10.1007/s11707-023-1094-6 The original version of this article unfortunately contained a *** presentation of was *** corrected figure is given below.

关键词： alkyl corrected Plateau

From macroautophagy to mitophagy:Unveiling the hidden role of mitophagy in gastrointestinal disorders

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World Journal of Gastroenterology 2024年第23期30卷 2934-2946页

作者： duo-Lun Gao Meng-Ran lin Nan Ge Jin-Tao Guo Fan Yang Si-Yu Sun Department of Gastroenterology Engineering Research Center of Ministry of Education for Minimally Invasive Gastrointestinal Endoscopic TechniquesShengjing Hospital of China Medical UniversityShenyang 110004Liaoning ProvinceChina

In this editorial,we comment on an article titled“Morphological and biochemical characteristics associated with autophagy in gastrointestinal diseases”,which was published in a recent issue of the World Journal of *** focused on the statement that“autophagy is closely related to the digestion,secretion,and regeneration of gastrointestinal cells”.With advancing research,autophagy,and particularly the pivotal role of the macroautophagy in maintaining cellular equilibrium and stress response in the gastrointestinal system,has garnered extensive ***,the significance of mitophagy,a unique selective autophagy pathway with ubiquitin-dependent and independent variants,should not be *** recent decades,mitophagy has been shown to be closely related to the occurrence and development of gastrointestinal diseases,especially inflammatory bowel disease,gastric cancer,and colorectal *** interplay between mitophagy and mitochondrial quality control is crucial for elucidating disease mechanisms,as well as for the development of novel treatment *** the pathogenesis behind gastrointestinal diseases and providing individualized and efficient treatment for patients are subjects we have been *** article reviews the potential mechanism of mitophagy in gastrointestinal diseases with the hope of providing new ideas for diagnosis and treatment.

关键词： Mitophagy Gastrointestinal diseases Parkin Autophagic receptor Colorectal cancer Gastric cancer Inflammatory bowel disease

Degradation and biocompatibility of one-step electrodeposited magnesium thioctic acid/magnesium hydroxide hybrid coatings on ZE21B alloys for cardiovascular stents

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Journal of Magnesium and Alloys 2024年第1期12卷 120-138页

作者： Zhao-Qi Zhang Bing-Zhi Li Pei-duo Tong Shao-Kang Guan Li Wang Zheng-Hui Qiu Cun-Guo lin Rong-Chang Zeng School of Material Science and Engineering&Henan Key Laboratory of Advanced Magnesium Alloy&Key Laboratory of Materials Processing and Mold Technology(Ministry of Education) Zhengzhou University100 Science RoadZhengzhou 450001China State Key Laboratory for Marine Corrosion and Protection Luoyang Ship Material Research InstituteQingdao 266101China Corrosion Laboratory for Light Metals College of Material Science and EngineeringShandong University of Science and TechnologyQingdao 266590China

Constructing a functional hybrid coating appears to be a promising strategy for addressing the poor corrosion resistance and insufficient endothelialization of Mg-based ***,the steps for preparing composite coatings are usually complicated and ***,a novel composite coating,composed of bioactive magnesium thioctic acid(MTA)layer formed by deposition and corrosion-resistant magnesium hydroxide(Mg(OH)_(2))layer grown in situ,is simply fabricated on ZE21B alloys via one-step *** electron microscopy(SEM)shows that the electrodeposited coating has a compact and uniform *** the high adhesion of the MTA/Mg(OH)_(2)hybrid coating is also confirmed by the micro-scratch *** test,scanning kelvin probe(SKP),and hydrogen evolution measurement indicate that the hybrid coating effectively reduces the degradation rate of Mg *** experiment and cell culture trial detect that the composite coating is of fine ***,the preparation mechanism of MTA/Mg(OH)_(2)hybrid coatings is discussed and *** coating shows a great potential application for cardiovascular stents.

关键词： Magnesium alloy Corrosion resistance Hybrid coating Endothelialization Biocompatibility

Classification of congenital cataracts based on multidimensional phenotypes and its association with visual outcomes

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International Journal of Ophthalmology(English edition) 2024年第3期17卷 473-479页

作者： Yuan Tan Ying-Shi Zou Ying-lin Yu Le-Yi Hu Ting Zhang Hui Chen ling Jin duo-Ru lin Yi-Zhi Liu Hao-Tian lin Zhen-Zhen Liu State Key Laboratory of Ophthalmology Zhongshan Ophthalmic CenterSun Yat-sen UniversityGuangdong Provincial Key Laboratory of Ophthalmology and Visual ScienceGuangdong Provincial Clinical Research Center for Ocular DiseasesGuangzhou 510060Guangdong ProvinceChina

●AIM:To establish a classification for congenital cataracts that can facilitate individualized treatment and help identify individuals with a high likelihood of different visual outcomes.●METHODS:Consecutive patients diagnosed with congenital cataracts and undergoing surgery between January 2005 and November 2021 were *** on visual outcomes and the phenotypic characteristics of ocular biometry and the anterior and posterior segments were extracted from the patients’medical records.A hierarchical cluster analysis was *** main outcome measure was the identification of distinct clusters of eyes with congenital cataracts.●RESULTS:A total of 164 children(299 eyes)were divided into two clusters based on their ocular *** 1(96 eyes)had a shorter axial length(mean±SD,19.44±1.68 mm),a low prevalence of macular abnormalities(1.04%),and no retinal abnormalities or posterior *** 2(203 eyes)had a greater axial length(mean±SD,20.42±2.10 mm)and a higher prevalence of macular abnormalities(8.37%),retinal abnormalities(98.52%),and posterior cataracts(4.93%).Compared with the eyes in Cluster 2(57.14%),those in Cluster 1(71.88%)had a 2.2 times higher chance of good best-corrected visual acuity[<0.7 logMAR;OR(95%CI),2.20(1.25–3.81);P=0.006].●CONCLUSION:This retrospective study categorizes congenital cataracts into two distinct clusters,each associated with a different likelihood of visual *** innovative classification may enable the personalization and prioritization of early interventions for patients who may gain the greatest benefit,thereby making strides toward precision medicine in the field of congenital cataracts.

关键词： classification congenital cataract phenotype visual acuity cluster analysis

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计算机软件版权与专利交叉保护立法探析

武汉理工大学学报（社会科学版） 2012年第5期25卷 728-731页

作者：林承铎中国人民大学国际关系学院北京100872

计算机软件传统的知识产权保护主要是通过著作权的保护来实现。但近30年来,美国与欧盟等西方国家掀起一系列对软件赋予专利权保护的研究。美国是最先提出软件可专利性研究的国家,而欧盟则历经从反对到有条件地给予专利保护的过程。在认... 详细信息

计算机软件传统的知识产权保护主要是通过著作权的保护来实现。但近30年来,美国与欧盟等西方国家掀起一系列对软件赋予专利权保护的研究。美国是最先提出软件可专利性研究的国家,而欧盟则历经从反对到有条件地给予专利保护的过程。在认定标准上,欧盟认为计算机软件可专利性的标准是申请的案件必须具备"技术性贡献",而美国只需要该软件具有"实用性"即可获得专利保护。计算机软件专利保护对我国在相关领域的立法与实践有着重要的借鉴意义。

关键词：计算机软件版权保护专利保护

Natural product-induced oxidative stress-synergistic anti-tumor effects of chemotherapeutic agents

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Traditional Medicine Research 2024年第3期9卷 10-23页

作者： Shu-Fan Wang Shi-Qi Dong Quan Dong Wen-Xin lin Mei Dong duo Liu Department of Pharmacy Harbin Medical University Cancer HospitalHarbin 150086China

Reactive oxygen species are closely related to tumor *** recent years,reactive oxygen species has become a hot spot in tumor therapy,and many natural substances in nature contain compound components with anti-tumor ***,there is a lack of discussion on the synergistic anti-tumor effects of natural products in combination with chemotherapeutic drugs through reactive oxygen *** terms“natural products”,“reactive oxygen species”,“anti-tumor”,and“chemotherapy”were used to identify the synergistic effects of natural *** conducted a systematic literature search in PubMed and Web of Science databases for relevant research articles and reviews published in recent *** systematically summarized the studies related to anti-tumor active ingredients in natural compounds in the field of reactive oxygen species in recent years.A total of 77 relevant literatures were *** them,45 literatures containing various natural products such as terpenoids,flavonoids,alkaloids,*** anti-tumor effects by regulating reactive oxygen species levels,and 32 literatures regarding adjunctive role of natural products in anti-tumor *** this study,we found that natural products exert anti-tumor effects by elevating reactive oxygen species *** provides strong theoretical support for future clinical studies.

关键词： nature products tumor reactive oxygen species combination chemotherapy oxidative stress