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Nano Research 2017年第3期10卷 971-979页

作者： taekyung lim Jaejun Lee Jonghun Lee Sanghyun Ju Department of Physics Kyonggi University Suwon Gyeonggi-Do 443-760 Republic of Korea

In this study, we report the utilization of a three-dimensional （3D） porous graphene structure as liquid-vapor separation filter, which allows the passage of chemical vapors while blocking liquid chemicals and water. The blockage of liquid chemicals and water from semiconducting sensing regions is required to avoid abnormal transistor characteristics. In order to impart omniphobic characteristics, a （heptadecafluoro-1,1,2,2-tetrahydrodecyl）trichlorosilane （HDF-S） self-assembled monolayer was coated on the surface of the 3D porous graphene structure. The concentration of chemical agents in water could be consistently detected by observing the shift in the threshold voltage in the oxide nanowire transistor covered by the HDF-S self-assembled 3D graphene structure. The proposed monitoring method is expected to offer means for application in different environments by providing a stable sensing performance.

关键词： chemical detection graphene structure nanowire transistor self-assembled monolayer omniphobicity

Model development to estimate site index values for six major tree species in North Korea

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Journal of Forestry Research 2023年第2期34卷 387-400页

作者： Sohee Park A-Ram Yang Eun-hee Kim Joongbin lim Division of Global Forestry Department of Future Forest StrategyNational Institute of Forest ScienceSeoul 02455Republic of Korea Forest ICT Research Center National Institute of Forest ScienceSeoul 02455Republic of Korea

Due to considerable deforestation in North Korea,there is a need to plan forest restoration programs based on scientific forest *** this study,a methodology was developed for estimating the site index values of six major tree species and the forest productivity *** site index values of these tree species were derived in South Korea using the Chapman-Richards *** values were used with data from the 6th National Forest Inventory,which included 20 types of edaphic,topographic,and climatic factors,and random forest analysis—a widely used machine learning technique for spatial prediction—to develop a new model for estimating the site index values of these species across South *** prediction accuracy of this model was evaluated using the root mean square *** results show that the prediction accuracy was high,with a root mean square error of~***,the importance of the variables related to climate and geography was generally *** proposed site index estimation model for six tree species was applied across North Korea,and its effectiveness tested by comparing the estimated values with those reported in literature from North *** differences between the model outputs and recorded data in the northern alpine regions were presumably due to the lack of data for high-altitude regions in South *** model is based on the determination of the suitability of tree species in restoration ***,it can contribute to the evaluation of forest productivity in North Korea and may help plan efficient forest restoration programs.

关键词： Environmental factors Forest productivity Machine learning North Korea Random forest Site index

Direct high-resolution X-ray imaging exploiting pseudorandomness

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Light(Science & Applications) 2023年第5期12卷 776-788页

作者： kyeoReh Lee Jun lim Su Yong Lee YongKeun Park Department of Physics Korea Advanced Institute of Science and TechnologyDaejeon 34141Republic of Korea KAIST Institute for Health Science and Technology Korea Advanced Institute of Science and TechnologyDaejeon 34141Republic of Korea Pohang Accelerator Laboratory Pohang University of Science and TechnologyPohangKyungbuk 37637Republic of Korea Tomocube Inc Daejeon 34051Republic of Korea

Owing to its unique penetrating power and high-resolution capability,X-ray imaging has been an irreplaceable tool since its *** the significance,the resolution of X-ray imaging has largely been limited by the technical difficulties on X-ray lens *** lensless imaging methods have been proposed,but are yet relying on multiple measurements or additional constraints on measurements or *** we present coherent specklecorrelation imaging(CSI)using a designed X-ray *** has no prerequisites for samples or ***,from a single shot measurement,the complex sample field is retrieved based on the pseudorandomness of the speckle intensity pattern,ensured through a *** achieve a spatial resolution of 13.9 nm at 5.46 keV,beating the feature size of the diffuser used(300 nm).The high-resolution imaging capability is theoretically explained based on fundamental and practical *** expect the CSI to be a versatile tool for navigating the unexplored world of nanometer.

关键词： resolution speckle replace

A Novel Application of Multi-Resonant Dissipative Elastic Metahousing for Bearings

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Acta Mechanica Solida Sinica 2021年第4期34卷 449-465页

作者： Muhammad C.W.lim N.S.Vyas Department of Architecture and Civil Engineering City University of Hong KongKowloonHong Kong SARChina Department of Mechanical Engineering Indian Institute of Technology KanpurKanpur208016India

Bearing as an important machine element is widely used for industrial and automotive *** certain operational speed,bearings induce disturbing vibrations and noises that affect machine service life,productivity and passenger comfort in case of vehicle *** elastic metamaterials have caught considerable attention of scientific community due to their effective medium properties and peculiar dynamic characteristics including frequency bandgaps that can be effectively applied to attenuate and control undesirable vibration and *** a substantial amount of theoretical work for effective medium characteristics and dynamic properties of acoustic/elastic metamaterials has been reported,the practical design and application of these composite structures for real-life engineering problems still remain *** present study intends to investigate a potential application of dissipative elastic metamaterials in controlling the bearing-generated vibration and noises over an ultrawide frequency *** study is based on a simple analytical model together with rigorous finite element numerical *** has been established that the dissipative characteristic of resonant system caused by larger material mismatch broadens the local resonance bandgaps beyond the bounding resonance frequency at the cost of wave *** order to achieve broadband vibration and noise control,multi-resonant composite structures are embedded inside the bearing housing in five different *** reported results revealed the presence of broadband wave attenuation zone distributed from 3 to 52 kHz with consideration of material *** bearing-generated vibration and noises lying inside the wave attenuation zone will be *** feasibility study provides a new concept for the design and application of acoustic/elastic metamaterials in the bearing industry to improve machine service life and to enhance productivity and passenger comfo

关键词： Bearing metahousing Dissipative elastic metamaterials Frequency Local resonance bandgap Vibration attenuation zone

Effect of Lycopus lucidus *** on gut microflora and short chain fatty acid composition in Crj:CD-1 mice

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BIOCELL 2022年第9期46卷 2101-2109页

作者： EUN NA SUN YOUNG lim Ocean Science and Technology School Korea Maritime&Ocean UniversityBusanKorea2 Division of Convergence on Marine ScienceKorea Maritime&Ocean UniversityBusanKorea

We investigated the diversity and composition of microflora in feces of Lycopus lucidus Turcz.-fed *** addition,we evaluated the production of major cytokines(Interleukin-6 and-10)which are related to inflammation and fatty acid composition of several tissues.16S ribosomal DNA sequencing-based microbiome taxonomic profiling analysis was performed utilizing the EzBioCloud data *** mice fed on *** showed a significantly reduced number of lactic acid bacteria and coliform in the feces compared with the control group(p<0.05).16S rDNA sequencing analysis of fecal samples showed that *** supplementation decreased the community of harmful microflora(Enterobacteriaceae including Escherichia coli and Bacteroides sp.)in feces compared with the control group(p<0.05).There were no significant differences in mRNA expression of cytokine IL-6 and IL-10 between the control and *** fed *** fecal fatty acid composition in the *** group had percentages of 4:0,6:0,8:0 and 10:0 in the intestine but those short chain fatty acids were not detected in the control *** results showed that *** supplementation influenced gut environment by decreasing harmful microflora and increased the percentages of several short fatty acids.

关键词： Lycopus lucidus Turcz Fatty acid composition Intestinal microflora 16S rDNA sequencing Cytokines

Adjuncts to colonic cleansing before colonoscopy

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World Journal of Gastroenterology 2014年第11期20卷 2735-2740页

作者： Sanghoon Park Yun Jeong lim Department of Internal Medicine KEPCO Medical CenterKEPCO Medical FoundationSeoul 132-703South Korea Department of Internal Medicine Dongguk University Ilsan HospitalGoyang 411-773South Korea

Pre-procedural cleansing of the bowel can maximize the effectiveness and efficiency of ***,efficacy of the current gold standard colonic preparation method-high-volume oral administration of purgative agents 12-24 h prior to the procedure-is limited by several factors,such as patient compliance(due to poor palatability and inconvenience of the dosing regimen)and risks of complications(due to drug interactions or intolerance).Attempts to resolve these limitations have included providing adjunctive agents and methods to promote the colonic cleansing ability of the principal purgative agent,with the aim of lessening unpleasant side effects(such as bloating)and reducing the large ingested volume *** promising adjunctive agents are bisacodyl,magnesium citrate,senna,simethicone,metoclopramide,and prokinetics,and each are being investigated for their *** review provides an up to date summary of the reported investigations into the potencies and weaknesses of the key adjuncts currently being applied in clinic as supplements to the traditional bowel preparation *** the comparative analysis ofthese adjuncts showed that no single agent or method has yet achieved the goal of completely overcoming the limitations of the current gold standard preparation method,they at least provide endoscopists with an array of alternatives to help improve the suboptimal efficacy of the main cleansing solutions when used *** aid in this clinical endeavor,a subjective grade was assigned to each adjunct to indicate its practical *** addition,the systematic review of the currently available agents and methods provides insight into the features of each that may be overcome or exploited to create novel drugs and strategies that may become adopted as effective bowel cleansing adjuncts or alternatives.

关键词： Colonoscopy Cathartics Adjuncts Purgative agents Bowel preparation

A hybrid Jacobian control for uncalibrated robot visual servoing

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Progress in Natural Science:Materials International 2005年第6期15卷 564-568页

作者： TEO Chee-Leong,lim Siak-Piang Department of Mechanical Engineering National University of Singapore Singapore 117576 Department of Mechanical Engineering National University of Singapore Singapore 117576

This paper focuses on the visual servo control of an uncalibrated robotic arm with an eye-in-hand camera. Without a prior knowledge of the kinematics of the robotic arm or camera calibration, the proposed hybrid Jacobian controller can track a moving object using visual feedback and joint-space velocity feedback. The proposed hybrid control method is a combination of the uncalibrated visual servoing and approximate Jacobian feedback control. First, the Jacobian matrix from joint-space to image-space is estimated by recursive least-squares (RLS) algorithm, and then the approximate Jacobian feedback controller is designed by using visual feedback and joint-space velocity feedback. The performances of the proposed control methods are illustrated by computer simulations.

关键词： robot control uncalibrated visual servoing Jacobian control.

Electrostatic spraying for fine-tuning particle dimensions to enhance oral bioavailability of poorly water-soluble drugs

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Asian Journal of Pharmaceutical Sciences 2024年第5期19卷 139-151页

作者： Jung Suk Kim Seunghyun Cheon Mi RanWoo Sanghyun Woo Jee-Eun Chung Yu Seok Youn Kyung taek Oh Soo-Jeong lim Sae Kwang Ku Bao LoNguyen Jong Oh Kim Sung Giu Jin Han-Gon Choi College of Pharmacy Hanyang UniversityAnsan 15588South Korea School of Pharmacy Sungkyunkwan UniversitySuwon 440746South Korea College of Pharmacy Chung-Ang UniversitySeoul 156-756South Korea Department of Bioscience and biotechnology Sejong UniversitySeoul 143747South Korea Department of Anatomy and Histology College of Korean MedicineDaegu Haany UniversityGyeongsan 38610South Korea College of Pharmacy Yeungnam UniversityGyongsan 712749South Korea Department of Pharmaceutical Engineering Dankook UniversityCheonan 31116South Korea

While spray-drying has been widely utilized to improve the bioavailability of poorly water-soluble drugs,the outcomes often exhibit suboptimal particle size distribution and large particle sizes,limiting their *** this study,we introduce electrostatic spraying as an advanced technology tailored for poorly water-soluble drugs,enabling the fabrication of nanoparticles with fine and uniform particle size ***(1 g),as a model drug,copovidone(5 g),and sodium dodecyl sulfate(0.1 g)were dissolved in 200 ml ethanol and subjected to conventional-spray-dryer and electrostatic spray *** electrostatic spray-dried nanoparticles(ESDN)showed smaller particle sizes with better uniformity compared to conventional spray-dried nanoparticles(CSDN).ESDN demonstrated significantly enhanced solubility and rapid release in *** vitro studies revealed that ESDN induced apoptosis in HCT-116 cells to a greater extent,exhibiting superior cytotoxicity compared to ***,ESDN substantially improved oral bioavailability and antitumor efficacy compared to *** findings suggest that ESD shows potential in developing enhanced drug delivery systems for poorly water-soluble drugs,effectively addressing the limitations associated with CSD methods.

关键词： Electrostatic spray drying Poorly water-soluble drug Regorafenib Particle size distribution Oral bioavailability Oral antitumor efficacy

Hepatic adenoma mimicking a metastatic lesion on computed tomography-positron emission tomography scan

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World Journal of Gastroenterology 2013年第27期19卷 4432-4436页

作者： Darryl lim Ser Yee Lee Kiat Hon lim Chung Yip Chan Department of General Surgery Singapore General Hospital Department of Hepatopancreatobiliary and Transplant Surgery Singapore General Hospital Department of Surgical Oncology National Cancer Centre Duke-National University of Singapore (NUS) Graduate Medical School Department of Pathology Singapore General Hospital

Positron emission tomography (PET) using 18F-fluorodeoxyglucose ( 18F-FDG) is an imaging modality which reflects cellular glucose metabolism. Most malignant cells accumulate and trap 18F-FDG, allowing the visualisation of increased uptake. It is hence widely used to differentiate malignant from benign lesions. "False positive" findings of hepatic lesions have been described in certain instances such as hepatic abscesses, but are rare in cases involving hepatocellular adenomas. To our knowledge, there have been only 7 reports in the English literature documenting PET-avid hepatocellular adenomas; 6 of the 7 reports were published in the last 3 years with the first report by Patel et al. We report the case of a 44-year-old Chinese female patient with a history of cervical adenocarcinoma, referred for a hepatic lesion noted on a surveillance computed tomography (CT) scan. A subsequent CT-PET performed showed a hypermetabolic lesion (standardized uptake value 7.9) in segment Ⅳb of the liver. After discussion at a multidisciplinary hepato-pancreato-biliary conference, the consensus was that of a metastatic lesion from her previous cervical adenocarcinoma, and a resection of the hepatic lesion was performed. Histology revealed features consistent with a hepatocyte nuclear factor-1 α inactivated steatotic hepatocellular adenoma.

关键词： Hepatic adenoma Positron emission tomography 18F-fluorodeoxyglucose Hepatocellular adenoma Hepatocyte nuclear factor-1 α

Realization of Tip Tilting By 8-Step Line Tilting

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Communications in Theoretical Physics 2009年第9期52卷 549-554页

作者： CHEN Ying-Tian ZHANG Yang HU Sen HO Tso-Hsiu Boon Ham lim Chen Sin lim Department of Astronomy and Applied Physics University of Science and Technology of Cbina Hefei 230026 China Department of Mathematics University of Science and Technology of China Hefei 230026 China Institute of Theoretical Physics Chinese Academy of Sciences Beijing 100190 China

By direct calculation of rotation matrices of SO(3),we show how certain specific sequence of eight consecutiverotations of digital angles can yield a tilting of a facet *** also design a detailed program specifically to tiltan array of mirrors from planar orientation to the required focusing *** describe how to use the 8-step torealize the focusing of the mirror *** have found,in our designed program,an important feature of row-sharingduring the rotations for the columns and similarly the column-sharing during the rotations for the *** feature cansave a lot of operating time during the actual realization of the mechanical movements.

关键词： rotational group solar energy optical device tip tilting line tilting