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Chinese Journal of Chemistry 2013年第12期31卷 1546-1550页

作者： lili zhang jing sun chaoguo yan College of Chemistry & Chemical Engineering Yangzhou University Yangzhou Jiangsu 225002 China

The one-pot sequential reaction of arylamines, methyl propiolate and 2-aryl-3-nitrochromenes without any catalyst in refluxing ethanol afforded the polysubstituted 3-（3-nitro-2-phenylchroman-4-yl）-3-arylaminoacrylates in good yields and with high diastereoselectivity. Reaction mechanism was believed involving the initial formation of β-enamino ester and sequential Michael addition.

关键词： chromene propiolate acrylate arylamine one-pot reaction diastereoselectivity

Diastereoselective Synthesis of Functionalized Tetrahydropyrimidin-2-thiones via ZnCl2 Promoted One-pot Reactions

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Chinese Journal of Chemistry 2014年第2期32卷 172-178页

作者： Zhenming Liu lili zhang jing sun chaoguo yan Analysis and Test Center Yangzhou UniversityYangzhouJiangsu 225002China College of Chemistry&Chemical Engineering Yangzhou UniversityYangzhouJiangsu 225002China

In the presence of zinc chloride,the in situ generatedβ-enamino ester from the reaction of morpholine,piperidine and pyrrolidine with methyl propiolate reacted,with aromatic aldehydes and thiourea in ethanol resulting in the functionalized tetrahydropyrimidin-2-thiones in satisfactory yields and with good *** aromatic aldehydes bearing electron-withdrawing group were used in the reaction,the 4-hydroxytetrahydropyrimidin-2-thione derivatives were obtained as the main product.

关键词： one-pot reaction domino reaction electron-deficient alkyne thiourea pyrimidin-2-thione

Diastereoselective Synthesis of Arylidene Bis（3-arylamino- acrylates） via One-pot Domino Reactions

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Chinese Journal of Chemistry 2013年第4期31卷 479-484页

作者： Zhenming Liu lili zhang jing sun chaoguo yan Analysis and Test Center Yangzhou University Yangzhou Jiangsu 225002 China College of Chemistry & Chemical Engineering Yangzhou University Yangzhou Jiangsu 225002 China

The functionalized arylidene bis（3-arylaminoacrylates） were efficiently prepared by FeCl3 catalyzed one-pot domino reactions of primary amines, methyl propiolate and aromatic aldehydes. When isatins were utilized under similar conditions, only 2-oxoindolinyl 3-arylaminoacrylates were obtained in moderate yields. ^1H NMR data and single crystal structures indicated that this reaction has high diastereoselectivity.

关键词： domino reaction electron-deficient alkyne acrylate isatin stereoselectivity

A novel four-component reaction involving ring-opening/recyclization of 1,3-thiazolidinedione

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Science China Chemistry 2010年第4期53卷 863-868页

作者： sun jing, XIA Eryan, zhang lili & yan chaoguo College of Chemistry & Chemical Engineering, yangzhou University, yangzhou 225002, China College of Chemistry & Chemical Engineering Yangzhou University Yangzhou China

The multicomponent reactions of 1,3-thiazolidinedione, malononitrile, aromatic aldehydes and α-phenylethylamine or β-phenylethylamine in acetonitrile at room temperature produce dihydrothiophene ureidoformamide derivatives in moderate yields through a domino ring-opening/recyclization reaction of 1,3-thiazolidinedione. On treatment with DDQ, dihydrothiophenes are dehydrogenated to convert efficiently to thiophenes in the mild condition.

关键词： multicomponent reaction ring-opening recyclization dihydrothiophene thiazolidinedione

Effects on the STAT3-shRNA in Non-Small-Cell Lung Cancer Therapy: Design, Induction of Apoptosis, and Conjugation with Chitosan-Based Gene Vectors

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Journal of Ocean University of China 2021年第5期20卷 1097-1108页

作者： zhang Wangwang zhang yan JIANG Zhiwen sun Le WANG Litong GU Zhiyang LI Wenya GUO lili CHEN Xiaotong zhang Haibin HAN Baoqin CHANG jing College of Marine Life Science Ocean University of ChinaQingdao 266003China Laboratory for Marine Drugs and Bioproducts Pilot National Laboratory for Marine Science and Technology(Qingdao)Qingdao 266235China

STAT3 plays a particularly important role in several cancer-related signal transduction *** STAT3 via RNA interference or small molecule inhibitors induces the apoptosis of tumor cells,thereby inhibiting the growth of the *** this study,short-hairpin RNA sequences targeting the STAT3 genes were designed,synthesized,and then connected to pGPU6/GFP/Neo plasmids as the shRNA-expression *** expression of STAT3-shRNA was analyzed by real-time PCR,western blotting,and cell apoptosis assay to study the growth and apoptosis of the ***,the effect of STAT3 knockdown on the NCI-H1650 cells was studied in a tumor mouse *** results revealed that,after an in vitro transfection,the proliferation of NCI-H1650 cells was inhibited,and the cells were induced to *** mRNA and protein expression levels of STAT3 were downregulated in the STAT3-shRNA *** vivo,the tumor mass and volume in the STAT3-shRNA group were significantly lower than in the other two *** the in vivo and in vitro results demonstrated a long-period inhibiting effect on NSCLC,especially in vivo,when the tumor inhibition rate could reach 50%in the STAT3-shRNA group,which is an exciting ***,the study of the conjugation of STAT3-shRNA and chitosan-based vectors revealed that they could be combined steadily with good cytocompati-bility and transfection *** results together provide convincing evidence for the application of STAT3-shRNA used in the treatment of non-small lung cancer,which could be a promoting prospect for the development of gene therapy.

关键词： signal transducer and activator of transcription 3 short-hairpin RNA target downregulation chitosan-based vectors gene therapy

Efficient drug delivery and anticancer effect of micelles based on vitamin E succinate and chitosan derivatives

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Bioactive Materials 2021年第10期6卷 3025-3035页

作者： Xiaotong Chen Junxiang Gu Le sun Wenya Li lili Guo Zhiyang Gu Litong Wang yan zhang Wangwang zhang Baoqin Han jing Chang College of Marine Life Science Ocean University of ChinaQingdao266003PR China Laboratory for Marine Drugs and Bioproducts Pilot National Laboratory for Marine Science and Technology(Qingdao)Qingdao266235PR China

Nanocarriers have emerged as a promising cancer drug delivery ***-drug resistance caused by overexpression of multiple-drug excretion transporters in tumor cells is the major obstacle to successful *** E derivatives have many essential functions for drug delivery applications,such as biological components that are hydrophobic,stable,water-soluble enhancing compounds,and anticancer *** addition,vitamin E derivatives are also effective mitocan which can overcome multi-drug resistance by binding to P ***,we developed a carboxymethyl chitosan/vitamin E succinate nano-micellar system(O-CMCTS-VES).The synthesized polymers were characterized by Fourier Transform IR,and 1H NMR *** mean sizes of O-CMCTS-VES and DOX-loaded nanoparticles were around 177 nm and 208 *** drug loading contents were 6.1%,13.0%and 10.6%with the weight ratio of DOX to O-CMCTS-VES corresponding 1:10,2:10 and 3:10,and the corresponding EEs were 64.3%,74.5%and 39.7%.Cytotoxicity test,hemolysis test and histocompatibility test showed that it had good biocompatibility in vitro and in *** release experiments implied good pH sensitivity and sustained-release *** DOX/O-CMCTS-VES nanoparticles can be efficiently taken up by HepG2 cancer cells and the tumor inhibition rate is up to 62.57%.In the in vivo study by using H22 cells implanted Balb/C mice,DOX/O-CMCTS-VES reduced the tumor volume and weight efficiently with a TIR of 35.58%.The newly developed polymeric micelles could successfully be utilized as a nanocarrier system for hydrophobic chemotherapeutic agents for the treatment of solid tumors.

关键词： Vitamin E succinate Chitosan Multi-drug resistance Drug delivery Nanocarrier

基于柱[5]芳烃的新型双-[1]轮烷的设计与合成

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有机化学 2019年第12期39卷 3483-3489页

作者：张润淼王陈威孙晶颜朝国姚勇扬州大学化学化工学院江苏扬州225000 南通大学化学化工学院江苏南通226019

以不同长度的亚烷基二胺单元作为柱[5]芳烃边缘侧链的一系列柱[5]单酰胺衍生物,在氯仿中能够形成准[1]轮烷.基于这一中间体准[1]轮烷的合成,通过柱[5]单酰胺衍生物和双水杨醛的缩合反应,成功构建了8个柱芳烃的机械自锁分子(MSMs),即双-... 详细信息

以不同长度的亚烷基二胺单元作为柱[5]芳烃边缘侧链的一系列柱[5]单酰胺衍生物,在氯仿中能够形成准[1]轮烷.基于这一中间体准[1]轮烷的合成,通过柱[5]单酰胺衍生物和双水杨醛的缩合反应,成功构建了8个柱芳烃的机械自锁分子(MSMs),即双-[1]轮烷.通过多种方法详细地对新合成的双-[1]轮烷进行了研究,包括1HNMR, 13CNMR,2D NOESY NMR和MS分析,发现这类新型MSMs与Cu2+有较强的识别作用,两者之间以1∶2进行络合.

关键词：柱芳烃双-轮烷准轮烷机械互锁分子

T Cell Mineralocorticoid Receptor Controls Blood Pressure by Regulating Interferon Gama

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T Cell Mineralocorticoid Receptor Controls Blood Pressure by...

不同分子分型乳腺癌患者临床病理特征及预后因素分析

第十一届海峡两岸心血管科学研讨会、2017年全国心脑血管药理学术会议、中国卒中学会第一次新药研讨会

作者： sun Xuenan Li Chao Liu Yuan Du Linjuan Zeng Mengru Zheng Xiaojun zhang Wuchang Liu yan Zhu Mingjiang Kong Deping Zhou Li Lu Limin Shen Zhuxia Yi Yi Du lili Qin Mu Liu Xu Hua Zichun sun Shuyang Yin Huiyong Zhou Bin Yu Ying zhang Zhiyuan Duan Shengzhong Laboratory of Oral Microbiology Shanghai Research Institute of StomatologyNinth People's HospitalSchool of StomatologyShanghai Jiao Tong University School of Medicine Shanghai Key Laboratory of Stomatology Shanghai Jiao Tong University School of Medicine Shanghai Institutes for Biological sciences Department of Physiology and Pathophysiology Shanghai Medical CollegeFudan University Department of Cardiology Jing'an District Centre Hospital of Shanghai(Huashan Hospital Fudan University Jing’an Branch) Department of Cardiology Shanghai Chest HospitalShanghai Jiao Tong University The State Key Laboratory of Pharmaceutical Biotechnology School of Life SciencesNanjing University Department of Oral and Maxillofacial-Head Neck Oncology Ninth People's HospitalShanghai Jiao Tong University School of Medicine Institute of Biochemistry and Cell Biology Shanghai Institutes for Biological SciencesChinese Academy of SciencesUniversity of the Chinese Academy of Sciences Department of Pharmacology School of Basic Medical SciencesTianjin Medical University

Rational:Hypertension remains to be a global public health burden and demands novel intervention strategies such as targeting T cells and T cell-derived *** receptor(MR)antagonists have been clinically used to treat *... 详细信息

关键词： T Cell Mineralocorticoid Receptor Controls Blood Pressure by Regulating Interferon Gama

来源： cnki会议评论

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肿瘤研究与临床 2023年第11期35卷 833-839页

作者：王伟刚田保国徐晓琴王艳杜丽莉张晓芳孙婷史艳春荆结线山西省肿瘤医院、中国医学科学院肿瘤医院山西医院、山西医科大学附属肿瘤医院医学检验部太原030013

目的探讨不同分子分型乳腺癌患者临床病理特征、生存情况及预后影响因素的差异,为乳腺癌的防治提供依据。方法回顾性分析2015年1月至2016年12月在山西省肿瘤医院住院的新发女性乳腺癌患者临床病理资料,对患者进行随访。比较不同分子分... 详细信息

目的探讨不同分子分型乳腺癌患者临床病理特征、生存情况及预后影响因素的差异,为乳腺癌的防治提供依据。方法回顾性分析2015年1月至2016年12月在山西省肿瘤医院住院的新发女性乳腺癌患者临床病理资料,对患者进行随访。比较不同分子分型患者临床病理特征。随访截至2021年6月30日。采用Kaplan-Meier法分析患者生存情况,采用Cox比例风险模型分析不同分子分型患者总生存(OS)影响因素。结果Luminal A型、Luminal B型、人类表皮生长因子受体2(HER2)过表达型和三阴性乳腺癌(TNBC)患者分别为272例(14.9%)、1005例(55.2%)、277例(15.2%)、268例(14.7%)。4组间患者诊断年龄、初潮年龄、绝经状态、绝经年龄、病理类型、肿瘤长径、T分期、N分期,组织学分级、TNM分期分布差异均有统计学意义(均P<0.05)。中位随访60个月,Luminal A型、Luminal B型、HER2过表达型和TNBC患者的5年OS率分别为93.8%、89.2%、77.6%和78.0%,差异有统计学意义(χ^(2)=58.76,P<0.001)。M分期是Luminal A型乳腺癌患者OS独立影响因素(HR=16.789,95%CI 4.972~56.690,P<0.001),T分期(HR=2.721,95%CI 1.715~4.319)、N分期(HR=4.460,95%CI 2.399~8.291)、M分期(HR=3.364,95%CI 1.988~6.670)是Luminal B型乳腺癌患者OS独立影响因素(均P<0.001),N分期(HR=4.428,95%CI 1.836~10.677)、M分期(HR=13.489,95%CI 6.043~30.107)是HER2过表达型乳腺癌患者OS独立影响因素(均P<0.01),T分期(HR=3.052,95%CI 1.575~5.915)、N分期(HR=2.492,95%CI 1.298~4.785)、M分期(HR=33.012,95%CI 8.606~126.637)是TNBC患者OS独立影响因素(均P<0.01)。结论不同分子分型乳腺癌患者临床病理特征及预后影响因素不同,HER2过表达型和TNBC患者的预后较差。针对不同分子分型乳腺癌患者,临床医师应提供个体化治疗和随访方案。

关键词：乳腺肿瘤免疫表型分型疾病特征预后

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乳腺癌与甲状腺疾病关系的临床研究

肿瘤研究与临床 2022年第3期34卷 215-220页

作者：王伟刚田保国徐晓琴王艳杜丽莉张晓芳孙婷史艳春荆结线山西省肿瘤医院中国医学科学院肿瘤医院山西医院山西医科大学附属肿瘤医院病因室太原030013

目的探讨乳腺癌与甲状腺疾病的关系,为乳腺癌患者患甲状腺疾病的防治提供依据。方法收集2018年3月至2019年8月在山西省肿瘤医院住院的511例新发乳腺癌患者,选取同期住院的年龄匹配的303例新发乳腺良性疾病患者和341名健康体检者。对3组... 详细信息

目的探讨乳腺癌与甲状腺疾病的关系,为乳腺癌患者患甲状腺疾病的防治提供依据。方法收集2018年3月至2019年8月在山西省肿瘤医院住院的511例新发乳腺癌患者,选取同期住院的年龄匹配的303例新发乳腺良性疾病患者和341名健康体检者。对3组进行甲状腺B型超声检查及甲状腺功能检测。通过查阅病历,收集患者的一般情况及临床病理资料,比较3组甲状腺疾病患病的差异。比较乳腺癌患者治疗前、化疗中期和化疗末期甲状腺功能的变化情况。结果乳腺癌组、乳腺良性疾病组和健康对照组的甲状腺功能减退症患病率[32.5%(166/511)、25.7%(78/303)、21.7%(74/341)]、甲状腺结节患病率[50.7%(259/511)、43.2%(131/303)、41.6%(142/341)]和甲状腺影像报告和数据系统(TI-RADS)4级及以上甲状腺结节的患病率[15.4%(40/259)、14.5%(19/131)、4.9%(7/142)]比较,差异均有统计学意义(均P<0.05)。乳腺癌患者组促甲状腺激素(TSH)和游离甲状腺素(fT4)的异常率均高于乳腺良性疾病组和健康对照组[34.1%(174/511)比26.1%(79/303)%、23.5%(80/341),24.9%(127/511)比8.6%(26/303)%、3.2%(11/341)],差异均有统计学意义(均P<0.05)。乳腺癌患者治疗前、化疗中期、化疗末期fT4、游离三碘甲状腺氨酸(fT3)、甲状腺免疫球蛋白抗体(TgAb)和甲状腺过氧化物酶抗体(TPOAb)水平差异均有统计学意义(均P<0.05)。乳腺癌患者化疗末期fT4、TgAb和TPOAb的异常率均低于化疗前[11.5%(59/511)比24.9%(127/511),5.1%(26/511)比17.4%(89/511),11.9%(61/511)比20.4%(104/511)],差异均有统计学意义(均P<0.001)。结论乳腺癌与甲状腺疾病有一定的关系。临床医师在乳腺癌患者治疗及随访过程中,应关注甲状腺疾病及甲状腺功能的变化,以便尽早发现,对甲状腺疾病进行规范化治疗。

关键词：乳腺肿瘤甲状腺疾病甲状腺结节