Diastereoselective Synthesis of Arylidene Bis（3-arylamino- acrylates） via One-pot Domino Reactions

作     者：Zhenming Liu Lili Zhang Jing Sun Chaoguo Yan 

作者机构：Analysis and Test Center Yangzhou University Yangzhou Jiangsu 225002 China College of Chemistry & Chemical Engineering Yangzhou University Yangzhou Jiangsu 225002 China 

出 版 物：《Chinese Journal of Chemistry》 (中国化学（英文版）)

年 卷 期：2013年第31卷第4期

页      面：479-484页

核心收录：

学科分类：081702[工学-化学工艺] 08[工学] 0817[工学-化学工程与技术] 09[农学] 0904[农学-植物保护] 

基　　金：This work was financially supported by the National Natural Science Foundation of China (Grant No. 21172189) and the Priority Academic Program Devel- opment of Jiangsu Higher Education Institutions 

主　　题：domino reaction electron-deficient alkyne acrylate isatin stereoselectivity 

摘      要：The functionalized arylidene bis（3-arylaminoacrylates） were efficiently prepared by FeCl3 catalyzed one-pot domino reactions of primary amines, methyl propiolate and aromatic aldehydes. When isatins were utilized under similar conditions, only 2-oxoindolinyl 3-arylaminoacrylates were obtained in moderate yields. ^1H NMR data and single crystal structures indicated that this reaction has high diastereoselectivity.