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基于稀疏A^(*)与人工势场算法的EOSID路径规划

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现代计算机 2024年第5期30卷 56-60,76页

作者：杨军利李阿丹程颖李立坤中国民用航空飞行学院飞行技术学院广汉618300 中国东方航空武汉有限责任公司武汉430000 中国商用飞机有限责任公司上海200000

为提升起飞一发失效应急程序(EOSID)的制作效率,根据飞机性能限制和民航相关规章要求,提出了基于数字高程模型(DEM)的稀疏A和人工势场算法的ESOID全局路径规划方法,并进行了实例验证。结果表明,应用该方法可提升规划算法的局部避障能力... 详细信息

为提升起飞一发失效应急程序(EOSID)的制作效率,根据飞机性能限制和民航相关规章要求,提出了基于数字高程模型(DEM)的稀疏A和人工势场算法的ESOID全局路径规划方法,并进行了实例验证。结果表明,应用该方法可提升规划算法的局部避障能力及鲁棒性,生成的起飞一发失效三维路径与传统人工方法相近,为EOSID路径的自动规划提供了一种可行方法。

关键词： EOSID 路径规划稀疏A^(*) 人工势场法

低能量激光对机械压力作用下牙周膜成纤维细胞成骨分化作用的研究

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中国激光医学杂志 2024年第4期33卷 181-186,237,238页

作者：柳强刘亚辉李利坤郭建茹唐山职业技术学院附属医院口腔牙周科唐山市063004 唐山职业技术学院附属医院检验科唐山市063004 唐山职业技术学院附属医院病理科唐山市063004

目的探究低能量激光(low-level laser,LLL)对机械压力作用下人牙周膜成纤维细胞(human periodontal ligament fibroblasts,hPDLFs)成骨分化的作用。方法研究对象为体外培养hPDLFs,将细胞分为空白组、模型组和干预组,其中空白组细胞不给... 详细信息

目的探究低能量激光(low-level laser,LLL)对机械压力作用下人牙周膜成纤维细胞(human periodontal ligament fibroblasts,hPDLFs)成骨分化的作用。方法研究对象为体外培养hPDLFs,将细胞分为空白组、模型组和干预组,其中空白组细胞不给予机械压力或LLL干预;模型组细胞给予2 g/cm^(2)的机械静压力干预;干预组细胞给予机械压力后再行LLL干预。LLL激光照射波长为810 nm,光纤直径400μm,频率2.46 Hz,功率100 mW,光斑面积9.6 cm^(2),功率密度10 mW/cm^(2),能量密度值为3.75 J/cm^(2),干预24 h后,qPCR检测细胞成骨基因Runt相关转录因子2(Runt-related transcription factor 2,Runx2)、骨钙素(osteocalcin,OCN)、骨形态发生蛋白2(bone morphogenetic protein 2,BMP2)的mRNA水平,碱性磷酸酶(alkaline phosphatase,ALP)及茜素红(alizarin red,ARS)染色检测细胞成骨分化情况,Western blotting检测细胞BMP2蛋白及Smad1/5/9蛋白磷酸化水平。结果分离培养的hPDLFs表达波形丝蛋白及细胞角蛋白,符合hPDLFs特征。模型组和干预组细胞Runx2、OCN、BMP2的mRNA水平、ALP及ARS染色面积、BMP2蛋白及Smad1/5/9蛋白磷酸化水平显著高于空白组(P<0.05)。此外,干预组上述指标水平均显著高于模型组(P<0.05)。进一步对干预组细胞给予BMP/smad通路抑制剂LDN-193189处理,发现LDN-193189干预显著减少了细胞ALP及ARS染色面积(P<0.05)。结论LLL能够通过BMP2/Smad1/5/9通路促进机械压力作用下hPDLFs成骨分化。

关键词：低能量激光机械压力牙周膜成纤维细胞成骨分化

Shenyang Ice and Snow Festival:Qulck Before It Melts!

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China Today 2004年第12期53卷 70-71页

作者： li likun

For ice sculptures, go to Harbin; for snow sculptures, Shenyang is the place.

关键词：沈阳市冰雪节冰雕滑雪旅游胜地

Research on ozone formation sensitivity based on observational methods:Development history,methodology,and application and prospects in China

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Journal of Environmental Sciences 2024年第4期138卷 543-560页

作者： Wanghui Chu Hong li Yuanyuan Ji Xin Zhang likun Xue Jian Gao Cong An State Key Laboratory of Environmental Criteria and Risk Assessment Chinese Research Academy of Environmental SciencesBeijing 100012China Environment Research Institute Shandong UniversityQingdao 266237China

Observation-based method for O_(3)formation sensitivity research is an important tool to analyze the causes of ground-level O_(3)pollution,which has broad application potentials in determining the O_(3)pollution formation mechanism and developing prevention and control *** paper outlined the development history of research on O_(3)formation sensitivity based on observational methods,described the principle and applicability of the methodology,summarized the relative application results in China and provided recommendations on the prevention and control of O_(3)pollution in China based on relevant study results,and finally pointed out the shortcomings and future development prospects in this field in *** overview study showed that the O_(3)formation sensitivity in some urban areas in China in recent years presented a gradual shifting tendency from the VOC-limited regime to the transition regime or the NO_(x)-limited regime due to the implementation of the O_(3)precursors emission reduction policies;O_(3)pollution control strategies and precursor control countermeasures should be formulated based on local conditions and the dynamic control capability of O_(3)pollution control measures should be *** are still some current deficiencies in the study field in ***,it is recommended that a stereoscopic monitoring network for atmospheric photochemical components should be further constructed and improved;the atmospheric chemical mechanisms should be vigorously developed,and standardized methods for determining the O_(3)formation sensitivity should be established in China in the near future.

关键词： Observation-based method Ozone formation sensitivity Ozone pollution prevention and control VOCs NO_(x) OBM

Novel anti-androgen receptor signaling agents:Understanding the mechanisms of resistance

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Asian Journal of Urology 2014年第1期1卷 30-39页

作者： Styliani Karanika Theodoros Karantanos Jianhua Yin likun li Timothy C.Thompson Department of Genitourinary Medical Oncology The University of Texas MD Anderson Cancer CenterHoustonTXUSA Department of Epidemiology Second Military Medical UniversityShanghaiChina

Prostate cancer remains an intractable threat to the lives of men *** deaths from prostate cancer(PCa)in the United States have declined in recent years,in other parts of the world Pca mortality is *** introduction of 2nd generation antiandrogen receptor agents into the therapeutic armamentarium for metastatic castrationresistant prostate cancer(mCRPC)has resulted in modestly increased survival advantages as demonstrated by initial clinical ***,analysis of the molecular pathways affected by these agents may lead to new insight into mechanisms of resistance that drive mCRPC,including proliferation and survival signaling pathways that are derepressed by maximum repression of androgen *** therapies that involve anti-AR signaling agents together with agents that target these pathways establish a paradigm for the development of more effective treatment of *** this review,we briefly summarize the current clinical trial literature with regard to novel anti-AR signaling agents such as abiraterone acetate and *** discuss observational data that point to mechanisms of resistance that emerged from these *** further present and discuss recent experimental studies that address the mechanisms of resistance to these ***,we discuss novel and rational therapeutic approaches,including combination therapy,for patients with mCRPC.

关键词： Prostate cancer Castration-resistant prostate cancer Anti-androgen receptor agents Combination therapies

Interfacial built-in electric field and crosslinking pathways enabling WS_(2)/Ti_(3)C_(2)T_(x) heterojunction with robust sodium storage at low temperature

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Journal of Energy Chemistry 2024年第2期89卷 635-645,I0014页

作者： Jiabao li Shaocong Tang Jingjing Hao Quan Yuan Tianyi Wang likun Pan Jinliang li Shenbo Yang Chengyin Wang College of Chemistry and Chemical Engineering Yangzhou UniversityYangzhou 225002JiangsuChina Shanghai Key Laboratory of Magnetic Resonance School of Physics and Electronic Science East China Normal UniversityShanghai 200241China Siyuan Laboratory Guangdong Provincial Engineering Technology Research Center of Vacuum Coating Technologies and New Energy MaterialsGuangdong Provincial Key Laboratory of Nanophotonic ManipulationDepartment of PhysicsJinan UniversityGuangzhou 510632GuangdongChina Hongzhiwei Technology(Shanghai)CO.LTD Shanghai 200241China

Developing efficient energy storage for sodium-ion batteries(SIBs)by creating high-performance heterojunctions and understanding their interfacial interaction at the atomic/molecular level holds promise but is also ***,sluggish reaction kinetics at low temperatures restrict the operation of SIBs in cold ***,cross-linking nanoarchitectonics of WS_(2)/Ti_(3)C_(2)T_(x) heterojunction,featuring built-in electric field(BIEF),have been developed,employing as a model to reveal the positive effect of heterojunction design and BIEF for modifying the reaction kinetics and electrochemical ***,the theoretical analysis manifests the discrepancy in work functions leads to the electronic flow from the electron-rich Ti_(3)C_(2)T_(x) to layered WS_(2),spontaneously forming the BIEF and“ion reservoir”at the heterogeneous ***,the generation of cross-linking pathways further promotes the transportation of electrons/ions,which guarantees rapid diffusion kinetics and excellent structure ***,superior sodium storage performance is obtained for the WS_(2)/Ti_(3)C_(2)T_(x) heterojunction,with only 0.2%decay per cycle at 5.0 A g^(-1)(25℃)up to 1000 cycles and a high capacity of 293.5 mA h g^(-1)(0.1A g^(-1)after 100 cycles)even at-20℃.Importantly,the spontaneously formed BIEF,accompanied by“ion reservoir”,in heterojunction provides deep understandings of the correlation between structure fabricated and performance obtained.

关键词： WS_(2)/Ti_(3)C_(2)T_(x)heterojunction Built-in electric field Ion reservoir Reaction kinetics Sodium storage performance at low temperature

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Let There Be light

China Today 2008年第4期57卷 70-75页

作者： GAO YAN li likun

THE express train of the Chinese economy can only keep going when its fuel tank is full. like any part of the world, China depends heavily on electricity. In China’s case its power supply comes primarily from coal-burning power stations. With a tremendous trove of the flammable black rock, Shanxi Province in north China is traditionally the locomotive of the nation’s power industry. During an inspection of the province in July 2005, President Hu Jintao commented: "As a major coal producer, Shanxi should take advantage of its

关键词：中国经济发展能源管理电力系统

Small Port,Big Market

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China Today 2004年第12期53卷 63-66页

作者： li likun & ZHANG XIWEN

The city resembled a huge construction site, its skyline punctuated with tower cranes, and Manzhouli's enterprise registration office heaved with applicants.

关键词：苹果水果市场市场交易满州里市水果批发

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Deer City Legend

China Today 2003年第4期52卷 74-75页

作者： liU HUANZHI & li likun

MORE and more commodities,such as clothes,shoes,millinery,lighters and shavers,now bear the “Made in Wenzhou”*** woule appear that Wenzhou grooms the whole ***(deer city)District in central Wenzhou is the nucleus of... 详细信息

关键词：中国浙江温州市制鞋业剃须刀轻工业灯管业