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Nano Research 2024年第1期17卷 407-415页

作者： Yumei Ma lijie Zhang Kang Zhu Binze Zhang Ranran Peng Changrong Xia Ling huang State Key Laboratory of Chemistry and Utilization of Carbon Based Energy Resources College of ChemistryXinjiang UniversityUrumqi 830046China Department of Materials Science and Engineering University of Science and Technology of ChinaHefei 230026China

Promoting the oxygen reduction reaction(ORR)is critical for commercialization of intermediate-temperature solid oxide fuel cells(IT-SOFCs),where Sr_(2)Fe_(1.5)Mo_(0.5)O_(6)−δ(SFM)is a promising cathode by working as a mixed ionic and electronic *** this work,doping of In^(3+)greatly increases the oxygen vacancy concentration and the content of adsorbed oxygen species in Sr_(2)Fe_(1.5)Mo_(0.5−x)InxO_(6−δ)(SFMInx),and thus effectively promotes the ORR *** a typical example,SFMIn_(0.1)reduces the polarization resistance(R_(p))from 0.089 to 0.046Ω∙cm^(2)at 800°C,which is superior to those doped with other metal *** addition,SFMIn0.1 increases the peak power density from 0.92 to 1.47 W∙cm^(−2)at 800°C with humidified H_(2)as the fuel,indicating that In3+doping at the Mo site can effectively improve the performance of SOFC cathode material.

关键词： solid oxide fuel cell cathode In3+doping oxygen reduction reaction(ORR) Sr_(2)Fe_(1.5)Mo_(0.5)O_(6-δ)

Brain Encoding and Decoding in fMRI with Bidirectional Deep Generative Models

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Engineering 2019年第5期5卷 948-953页

作者： Changde Du Jinpeng Li lijie huang Huiguang He Research Center for Brain-Inspired Intelligence and National Laboratory of Pattern Recognition Institute of AutomationChinese Academy of Sciences(CAS)Beijing 100190China School of Artificial Intelligence University of Chinese Academy of SciencesBeijing 100049China Center for Excellence in Brain Science and Intelligence Technology Chinese Academy of SciencesShanghai 200031China

Brain encoding and decoding via functional magnetic resonance imaging(fMRI)are two important aspects of visual perception *** previous researchers have made significant advances in brain encoding and decoding models,existing methods still require improvement using advanced machine learning *** example,traditional methods usually build the encoding and decoding models separately,and are prone to overfitting on a small *** fact,effectively unifying the encoding and decoding procedures may allow for more accurate *** this paper,we first review the existing encoding and decoding methods and discuss the potential advantages of a“bidirectional”modeling ***,we show that there are correspondences between deep neural networks and human visual streams in terms of the architecture and computational ***,deep generative models(e.g.,variational autoencoders(VAEs)and generative adversarial networks(GANs))have produced promising results in studies on brain encoding and ***,we propose that the dual learning method,which was originally designed for machine translation tasks,could help to improve the performance of encoding and decoding models by leveraging large-scale unpaired data.

关键词： Brain encoding and decoding Functional magnetic resonance imaging Deep neural networks Deep generative models Dual learning

外源添加物对桑黄液体发酵菌丝体和多糖含量的影响

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农业工程 2024年第3期14卷 97-103页

作者：戴永琪朱雨馨沈梦玲朱蕴兰范晓博周芸好黄立杰徐州工程学院食品与生物工程学院江苏省食品生物加工工程技术研究中心江苏省食品资源开发与质量安全重点建设实验室江苏徐州221018

为了探究外源添加物对桑黄液体发酵菌丝体产量及胞内、胞外多糖含量的影响,在桑黄液体发酵培养基中分别加入不同浓度的油酸、α-萘乙酸、维生素B2和桑白皮水提物4种添加物,经液体发酵后,测定了菌丝体产量及胞内、胞外多糖含量。试验结... 详细信息

为了探究外源添加物对桑黄液体发酵菌丝体产量及胞内、胞外多糖含量的影响,在桑黄液体发酵培养基中分别加入不同浓度的油酸、α-萘乙酸、维生素B2和桑白皮水提物4种添加物,经液体发酵后,测定了菌丝体产量及胞内、胞外多糖含量。试验结果显示,4种外源添加物都能显著增加桑黄菌丝体产量和多糖含量(P<0.05),其中最优外源添加物为油酸,当油酸浓度2.4 mL/L时,菌丝体产量最高,达2.86 mg/mL,是空白对照的7.15倍,在此油酸浓度下,胞外多糖含量最大,达56.04 mg/mL,是空白对照的7.71倍;当油酸浓度1.2 mL/L时,桑黄胞内多糖含量最高,达60.07 mg/g,是空白对照的3.96倍。其他3种添加物也可以不同程度地提高桑黄菌丝体及胞内、胞外多糖含量(P<0.05)。4种外源添加物是有效提高桑黄液体发酵菌丝体产量和多糖含量的诱导因子。

关键词：桑黄外源添加物菌丝体多糖含量诱导因子

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少数民族地区农村居民突发公共卫生事件知信行现状及影响因素分析

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中国预防医学杂志 2024年第2期25卷 186-192页

作者：唐金鸿廖建英舒林焰黄祎晨关连鹏张桂仙黄丽洁梁建成右江民族医学院公共卫生与管理学院广西壮族自治区百色533000 广东医科大学公共卫生学院暨南大学基础医学与公共卫生学院山东第一医科大学公共卫生与健康管理学院梧州市疾病预防控制中心

目的了解少数民族地区农村居民突发公共卫生事件知信行现状及影响因素,为开展相关健康知识宣传教育,提高其自身防护能力及卫生应急能力提供参考。方法2021年12月—2022年5月,采用多阶段随机抽样方法,抽取少数民族地区百色3个县(区)农村... 详细信息

目的了解少数民族地区农村居民突发公共卫生事件知信行现状及影响因素,为开展相关健康知识宣传教育,提高其自身防护能力及卫生应急能力提供参考。方法2021年12月—2022年5月,采用多阶段随机抽样方法,抽取少数民族地区百色3个县(区)农村常住居民进行问卷调查,评估突发公共卫生事件知信行现状,采用有序logistic回归模型进行多因素分析。结果541名农村居民突发公共卫生事件知信行总体良中率77.81%,良率12.75%,其中健康知识、信念和行为良中率分别为61.73%、81.70%和81.33%,良率分别为7.76%、18.67%和28.65%。有序logistic回归分析显示,年龄、文化程度、职业、收入水平、健康状况、是否了解严重急性呼吸综合征(severe acute respiratory syndrome,SARS)和是否了解健康宣教是影响农村居民知信行总体的主要影响因素(P<0.05)。结论农村居民对突发公共卫生事件应对态度与信念较为积极,但知识和行为水平有待进一步提升,高年龄组、低文化程度者、农民/工人、低收入者和健康状况较差者等为重点关注的对象,应采取针对性的健康教育措施,加强少数民族地区农村居民对突发公共卫生事件的认知,促进养成良好的防护行为。

关键词：少数民族农村居民突发公共卫生事件知信行

Artificial intelligence-based ultrasound imaging technologies for hepatic diseases

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iLIVER 2022年第4期1卷 252-264页

作者： Longfei Ma Rui Wang Qiong He lijie huang Xingyue Wei Xu Lu Yanan Du Jianwen Luo Hongen Liao Department of Biomedical Engineering School of MedicineTsinghua UniversityBeijing100084China Graduate School at Shenzhen Tsinghua UniversityShenzhen518055GuangdongChina

Ultrasound(US)imaging is a non-invasive,real-time,economical,and convenient imaging modality that has been widely used in diagnosing and treating hepatic *** intelligence(AI)technology can predict or make decisions based on the experience of clinical experts and knowledge obtained from training *** technology can help clinicians improve the detection efficiency and evaluate hepatic diseases,promote clinical treatment of the liver,and predict the response of the liver after *** review summarizes the current rapid development of US technology and related AI methods in the diagnosis and treatment of hepatic *** topics include steatosis grading,fibrosis staging,detection of focal liver lesions,US image segmentation,multimodal image registration,and other *** present,the field of AI in US imaging is still in its early *** the future progress of AI technology,AI-based US imaging can further improve diagnosis,reduce medical costs,and optimize US-based clinical *** technology has broad prospects for application to hepatic diseases.

关键词： Artificial intelligence Ultrasound imaging Hepatic diseases Diagnosis and treatment

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高级别浆液性卵巢癌类器官模型的建立及鉴定

癌症进展 2024年第15期22卷 1634-1636,1722页

作者：黄丽洁程璐璐谢云青林晓为崔好高嫣妮福建医科大学肿瘤临床学院/福建省肿瘤医院肿瘤分子生物学研究室福州3500140 福建医科大学肿瘤临床学院/福建省肿瘤医院检验科福州3500140

目的建立并鉴定高级别浆液性卵巢癌类器官模型。方法选取行卵巢癌细胞减灭术的10例高级别浆液性卵巢癌患者的卵巢癌组织,将卵巢癌组织消化成单细胞,在基质胶中培养7天,构建高级别浆液性卵巢癌类器官模型。比较类器官与原发肿瘤的形态... 详细信息

目的建立并鉴定高级别浆液性卵巢癌类器官模型。方法选取行卵巢癌细胞减灭术的10例高级别浆液性卵巢癌患者的卵巢癌组织,将卵巢癌组织消化成单细胞,在基质胶中培养7天,构建高级别浆液性卵巢癌类器官模型。比较类器官与原发肿瘤的形态学特征、免疫组化特征和苏木精-伊红(HE)染色结果。结果 10例患者的高级别浆液性卵巢癌类器官模型均成功构建。光学显微镜显示类器官数量可观,形态呈类圆形3D立体结构。HE染色显示,在高倍镜下,类器官细胞核异型性明显,局部区域形成微乳头状结构。免疫组化显示黏蛋白16(MUC16)强阳性,p53弥漫性强阳性,类器官与原发肿瘤的免疫组化染色情况一致。结论体外成功构建的高级别浆液性卵巢癌类器官模型具有明显的上皮性特征,与原发肿瘤高度相似,可用于卵巢癌的药物筛选和基础研究建模。

关键词：类器官高级别浆液性卵巢癌模型药物筛选

Exosomes derived from mesenchymal stem cells ameliorate early inflammatory responses following traumatic brain injury

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Exosomes derived from mesenchymal stem cells ameliorate earl...

Sequence-controlled dynamic covalent units enable decoupling of mechanical and self-healing performance of polymers

2018年浙江省神经外科学学术年会

作者： lijie huang Haoqi Ni Qichuan Zhuge the First Affiliated Hospital of Wenzhou Medical University

Objective Traumatic brain injury (TBI) is a leading cause of mortality and disability worldwide. Although there are treatment guidelines for TBI, there exists no best treatment option or medicine for this condition. Recently,mesenchymal stem cells (MSCs) derived exosomes have drawn lots of attention in the treatment of brain disorders with some results highlighting its neuroprotective effects through neurogenesis and angiogenesis after TBI. However,

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Science China Chemistry 2024年

作者： Luzhi Zhang Hongfei huang lijie Sun Xiaopeng Ma Hui Tan Zhengwei You Respiratory Department Shenzhen Children's Hospital Affiliated to Shantou University Medical College State Key Laboratory for Modification of Chemical Fibers and Polymer Materials College of Materials Science and EngineeringInstitute of Functional MaterialsShanghai Key Laboratory of Lightweight CompositeShanghai Engineering Research Center of Nano-Biomaterials and Regenerative MedicineDonghua University Yangtze Delta Region Institute (Huzhou) University of Electronic Science and Technology of China

Sequence regulation provides an effective approach to controlling the properties of polymer ***,this approach remains an open question in the field of dynamic polymers,which emerge as more and more important new generation ***,we systematically investigate the effect of sequence control of dynamic covalent units in tuning the properties of *** sequence-controlled poly(oxime-urethanes) are *** dynamic oxime-urethane groups are relatively dispersed (SCP-1) or concentrated (SCP-2) distributed in their molecular *** sequence control strategy provides an efficient way to decouple the mechanical and self-healing performance of polymers,which is one of the most pressing challenges in the *** relatively dispersed oxime-urethane groups in SCP-1 not only facilitate the reorganization of the dynamic covalent bonds but also increase the probability of the reformation of hydrogen *** reversible dissociation/reassociation of dynamic bonds is conducive to dissipating energy to enhance mechanical performance and promote self-healing *** a result,SCP-1 exhibits much faster self-healing than SCP-2,and its tensile strength is nearly twice that of *** addition,energy dissipation capacity and degradation behavior also show significant sequence ***,this work reveals a new molecular structure-property relationship and provides a powerful strategy to construct high-performance polymers.

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PolyacrylicAcid-Coated Nanoparticles for the Treatment of TissurePlasminogen Activator in Stroke

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压膜法测腈纶纺丝原液的固体含量与NaSCN含量

2014浙江省神经外科学学术年会

作者： lijie huang Jixian Wang Zhuge Qichuan Kunlin Jin Department of Neurosurgery the First Affiliated Hospital of Wenzhou Medical University

Purpose:Nanoparticle basedthrombolysisis a challenged treatment of *** aim of our study is to investigate the efficacy of targeted thrombolysis with recombinant tissue plasminogen activator(rtPA).Methods:The rtPA is covalently bound to magnetic nanoparticle(MNP)and retained to the target site by an external *** acid-coated MNP was synthesized,rtPA was immobilized to PAA-MNP through carbodiimide-mediated amide bound *** in vitro test,the blood clot was formed in PE tubing with anti-coagulatedplasma,fibrin and calcium *** in vivo test,4 groups of the ferric chloride induced distal middle cerebral artery occlusion model was designed and treated with PBS,MNP,rtPA and MNP-rtPA ***:The immobilization efficacy is 80.7±1.5μg rtPA bound to 1mg *** vitro testing with blood clot in PE tube,the mean lysed percent increased rapidly with the MNP and rtPA in the rotated magnetic field,from 1.28%to 77.40%.The lysis efficiency of MNP-rtPA is 27.3±1.3%and increased to 42.8±2.8%with the rotation of magnetic *** mean infarcted areas of the 4 groups are 0.09±6.07mm,18.28±2.69mm,8.65±3.63mm and 4.40±***:the magnetic targeted MNP-rtPA accelerated thrombolysis and is available to reduce infarction area in brain *** approach may achieve feasible and effective treatment for embolic cerebral ischemia.

关键词： tissue plasminogen activator magnetic nanoparticle middle cerebral artery occlusion thrombolysis

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合成纤维工业 2006年第4期29卷 63-65页

作者：黄利捷中国石化股份公司安庆分公司安徽安庆246001

用压膜法测定腈纶纺丝原液的固体含量(P)与NaSCN含量(w)并与拉丝法进行比较。结果表明：压膜法测定腈纶纺丝原液的P和w的准确度和精密度较拉丝法的高,且分析时间较短；压膜法测定P和w的相对标准偏差分别为0．136%,0．169%,而拉丝法测定... 详细信息

用压膜法测定腈纶纺丝原液的固体含量(P)与NaSCN含量(w)并与拉丝法进行比较。结果表明：压膜法测定腈纶纺丝原液的P和w的准确度和精密度较拉丝法的高,且分析时间较短；压膜法测定P和w的相对标准偏差分别为0．136%,0．169%,而拉丝法测定分别为1．218%,1．032%；压膜法测定的纺丝原液的P与粘度相对应,且与粘度的对数呈线性关系,而拉丝法则没有。

关键词：聚丙烯腈纺丝原液压膜法拉丝法固体含量硫氰酸钠粘度