检索结果-南通市图书馆

Frontiers of Materials Science 2024年第2期18卷 129-137页

作者： Huaying Hao lihong sun Jiaxuan Chen Jun Liang State Key Laboratory of Food Nutrition and Safety Tianjin University of Science&TechnologyTianjin 300457China College of Light Industry Science and Engineering Tianjin University of Science&TechnologyTianjin 300457China College of Food Science and Engineering Tianjin University of Science&TechnologyTianjin 300457China

The in vitro expansion of stem cells is important for their application in different life science fields such as cellular tissue and organ *** objective of this paper was to achieve static cell culture in vitro through peptide hydrogel-supported microspheres(MSs).The peptides,with their gel-forming properties,microstructures,and mechanical strengths characterized,were found to have good support for the MSs and to be *** internal structures of poly(L-lactic acid)microspheres(PLLA-MSs)and polystyrene microspheres(PS-MSs)made in thelaboratory were observed and statistically analyzed in terms of particle size and pore size,following which the co-cultured MSs with cells were found to have good cell *** addition,three-dimensional(3D)culturing of cells was performed on the peptide and microcarrier composite scaffolds to measure cell viability and cell *** results showed that the peptides could be stimulated by the culture medium to self-assembly form a 3D fiber network *** the peptide-Ms composite scaffold-based cell culture system,further enhancement of the cell culture effect was *** peptide-Ms composite scaffolds have great potential for the application in 3D cell culture and in vitro cellexpansion.

关键词： microcarrier microsphere peptide hydrogel cell scaffold three-dimensional culture cell expansion

新发展理念引领大型体育赛事开闭幕式运作管理的逻辑与实态

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

成都体育学院学报 2024年第3期50卷 143-150页

作者：孙丽红邱建钢成都体育学院四川成都610041

文章采用文献资料法、访谈法、逻辑分析法等研究方法,探究了新发展理念引领大型体育赛事开闭幕式运作管理的逻辑与实态。研究发现新发展理念引领大型体育赛事开闭幕式运作管理的逻辑是以宏观层面认识指导实践的命题转化作为逻辑出发点,... 详细信息

文章采用文献资料法、访谈法、逻辑分析法等研究方法,探究了新发展理念引领大型体育赛事开闭幕式运作管理的逻辑与实态。研究发现新发展理念引领大型体育赛事开闭幕式运作管理的逻辑是以宏观层面认识指导实践的命题转化作为逻辑出发点,以中观层面五大理念指导运作的过程作为逻辑连接点,最终将微观层面新理念指导现实问题解决作为逻辑落脚点。通过分析新发展理念引领北京2022冬奥会、成都第31届大运会和杭州第19届亚运会开闭幕式运作管理的成功实态,研究得出新发展理念引领大型体育赛事开闭幕式运作管理是在资源要素投入上秉持新发展理念、价值转换过程中贯彻新发展理念、开闭幕式呈现下阐释新发展理念,为未来大型体育赛事开闭幕式运作管理提供中国思路与理念借鉴。

关键词：新发展理念大型体育赛事开闭幕式体育管理

在线全文

学校读者我要写书评

暂无评论

超市菜肴类即烹预制菜营养现状调查

食品工业 2024年第4期45卷 339-343页

作者：田瑞菁徐婕孙丽红上海中医药大学公共健康学院上海201203

通过调查超市现售菜肴类即烹预制菜的营养标签规范度及营养状况,为完善与制定预制菜相关标准提供参考依据。共收集137份样本,对样本的营养标签标示、产品执行标准、能量和核心营养素含量、食品添加剂使用等情况进行统计分析。结果表明:... 详细信息

通过调查超市现售菜肴类即烹预制菜的营养标签规范度及营养状况,为完善与制定预制菜相关标准提供参考依据。共收集137份样本,对样本的营养标签标示、产品执行标准、能量和核心营养素含量、食品添加剂使用等情况进行统计分析。结果表明:目前超市现售菜肴类即烹预制菜的营养成分表标示率为99.3%,合格率为100%;产品执行标准缺乏统一性,以SB/T 10379—2012《速冻调制食品》占比最高;虽然菜肴类即烹预制菜的蛋白质含量高,但能量、脂肪、钠含量同样偏高;食品添加剂使用类别多样,但在原材料中占比较小,为原料总数的19.8%,碳酸氢钠为使用频率最高的食品添加剂。建议尽快完善针对预制菜的食品安全国家标准,并倡导正面营养标签在预制菜中的应用,引导消费者选择健康食品。

关键词：预制菜营养标签营养素含量

手术对N2期肺大细胞神经内分泌癌的生存影响:一项基于SEER数据库的倾向性匹配分析

在线全文

学校读者我要写书评

暂无评论

国际呼吸杂志 2024年第7期44卷 792-800页

作者：姚夏雷李慧民孙立红聊城市人民医院肿瘤内科聊城252000 聊城市人民医院呼吸与危重症医学科聊城252000

目的基于SEER数据库分析手术治疗后T0~4N2M0期肺大细胞神经内分泌癌(pLCNEC)患者的预后。方法在SEER数据库中检索2000-2019年病理诊断明确为大细胞神经内分泌癌/复合型大细胞神经内分泌癌(8013/3),且原发部位为肺的病例,共5450例。最终... 详细信息

目的基于SEER数据库分析手术治疗后T0~4N2M0期肺大细胞神经内分泌癌(pLCNEC)患者的预后。方法在SEER数据库中检索2000-2019年病理诊断明确为大细胞神经内分泌癌/复合型大细胞神经内分泌癌(8013/3),且原发部位为肺的病例,共5450例。最终纳入符合研究条件的T0~4N2M0期pLCNEC患者共600例。根据是否进行手术治疗分为非手术治疗组(386例)和手术治疗组(214例)。为减少人口学和临床特征基线差异对结果的影响,采用倾向评分匹配(PSM)分析对2组患者进行匹配,匹配因素包括性别、年龄、种族、手术、放疗、化疗、分期。比值为1,卡尺值为0.02。共匹配成功181对,其中精确匹配46对,模糊匹配135对。根据PSM后是否进行手术治疗分为手术组(181例)和非手术组(181例)。比较手术治疗组与非手术治疗组、手术组与非手术组患者的基线资料。采用Kaplan-Meier法绘制PSM后患者生存曲线,以及按T分期、放疗情况、化疗情况划分亚组的生存曲线,采用Log-rank检验进行比较。采用多因素Cox回归分析影响pLCNEC患者总生存期(OS)和肿瘤特异生存期(CSS)的因素。结果非手术治疗组中男197例,女189例,≥71岁的高龄患者较多(45.3%,175/386),T3~4N2M0期占大多数(58.3%,225/386),66.1%(255/386)的患者接受了放疗。手术治疗组中男123例,女91例,61~70岁患者较多(40.7%,87/214),T0~2 N2M0期占大多数(65.4%,140/214),43.9%(94/214)的患者接受了放疗。2组患者年龄、种族、放疗、T分期比较差异均有统计学意义(均P0.05)。PSM后,非手术组和手术组患者的基线特征比较差异均无统计学意义(均P>0.05)。PSM后,手术组中位OS为21个月(95%CI:16~26个月),非手术组中位OS为13个月(95%CI:10~16个月),手术组患者的生存状态优于非手术组患者的生存状态(χ^(2)=11.14,P<0.001)。多因素Cox回归分析显示男性、年龄≥71岁、黑人、T3~4期是影响T0~4N2M0期pLCNEC患者OS的独立危险因素,手术、化疗是影响T0~4N2M0期pLCNEC患者OS的独立保护因素;男性、年龄≥71岁、T3~4期是影响T0~4N2M0期pLCNEC患者CSS的独立危险因素,手术、化疗是影响T0~4N2M0期pLCNEC患者CSS的独立保护因素。T0~2期亚组中手术患者的生存状态优于非手术患者(χ^(2)=9.36,P=0.002),T3~4期亚组中手术与非手术患者的生存状态相近(χ^(2)=2.75,P=0.097)。行放疗亚组中,手术与非手术患者的生存状态相近(χ^(2)=0.98,P=0.323);未行放疗亚组中,手术患者的生存状态优于非手术患者(χ^(2)=14.51,P<0.001)。行化疗亚组中,手术患者的生存状态优于非手术患者(χ^(2)=11.44,P<0.001),未行化疗亚组中,手术与非手术患者的生存状态相近(χ^(2)=1.75,P=0.186)。结论对于T0~4N2M0期,尤其是T0~2N2M0期的pLCNEC患者,手术可以降低死亡风险,并且手术联合化疗较单纯化疗预后好。

关键词：癌神经内分泌肺大细胞神经内分泌癌倾向评分匹配分析手术总生存期

Effect of Pb Content on Phase Composition and Property of Bi-Pb-Sr-Ca-Cu-O System Superconductors

在线全文

学校读者我要写书评

暂无评论

Rare Metals 1990年第1期10卷 24-29页

作者： Ren, Hongtao Xiao, Ling Wang, Xiaoping Wang, Ruikun Zhao, Bolang sun, lihong General Research Inst for Non-ferrous Metals China

The addition of Pb in the superconductors of BiSrCaCuO system is very helpful for growth of the high-Tc phase (Tc 110K). We prepared a series of samples with nominal composition of Bi2-xPbxSr2Ca2Cu3Oy (0.1&lex&le2). The zero resistance transition temperature Tc of 106K and the critical transport current density Jc of 1 × 103A/cm2 at 77K have been obtained for the samples of Bi2-xPbxSr2Ca2Cu3Oy (x=0.2 and 0.3). The X-ray diffraction analysis and measurement of AC magnetic susceptibility confirmed that the material is comprised of single high-Tc phase. We also report the magnetic properties of this material as well as the results of TEM observation.

关键词： Bismuth Compounds Magnetic Properties Ceramic Materials Superconducting Lead Compounds Effects Microscopic Examination Transmission Electron Microscopy Oxides Phase Transitions

Adaptive Event-Triggered Time-Varying Output Group Formation Containment Control of Heterogeneous Multiagent Systems

在线全文

学校读者我要写书评

暂无评论

IEEE/CAA Journal of Automatica Sinica 2024年第6期11卷 1398-1409页

作者： lihong Feng Bonan Huang Jiayue sun Qiuye sun Xiangpeng Xie College of Information Science and Engineering Northeastern UniversityShenyang 110819China College of Automation and College of Artificial Intelligence Nanjing University of Posts and TelecommunicationsNanjing 210023China IEEE

In this paper,a class of time-varying output group formation containment control problem of general linear hetero-geneous multiagent systems(MASs)is investigated under directed *** MAS is composed of a number of tracking leaders,formation leaders and followers,where two different types of leaders are used to provide reference trajectories for movement and to achieve certain formations,***,compen-sators are designed whose states are estimations of tracking lead-ers,based on which,a controller is developed for each formation leader to accomplish the expected ***,two event-triggered compensators are proposed for each follower to evalu-ate the state and formation information of the formation leaders in the same group,***,a control protocol is designed for each follower,utilizing the output information,to guide the output towards the convex hull generated by the forma-tion leaders within the ***,the triggering sequence in this paper is decomposed into two sequences,and the inter-event intervals of these two triggering conditions are provided to rule out the Zeno ***,a numerical simulation is intro-duced to confirm the validity of the proposed results.

关键词： Adaptive control event-triggered mechanisms for-mation containment(FC) heterogeneous multiagent systems time-varying group formation.

Indocyanine Green-Conjugated Magnetic Prussian Blue Nanoparticles for Synchronous Photothermal/Photodynamic Tumor Therapy

在线全文

学校读者我要写书评

暂无评论

Nano-Micro Letters 2018年第4期10卷 324-338页

作者： Peng Xue Ruihao Yang lihong sun Qian Li Lei Zhang Zhigang Xu Yuejun Kang Faculty of Materials and Energy Institute for Clean Energy and Advanced Materials Southwest University Chongqing Engineering Research Center for Micro-Nano Biomedical Materials and Devices State Key Laboratory of Silkworm Genome Biology Southwest University

Indocyanine green(ICG) is capable of inducing a photothermal effect and the production of cytotoxic reactive oxygen species for cancer therapy. However, the major challenge in applying ICG molecules for antitumor therapy is associated with their instability in aqueous conditions and rapid clearance from blood circulation,which causes insufficient bioavailability at the tumor ***, we conjugated ICG molecules with Prussian blue nanoparticles enclosing a Fe_3O_4 nanocore, which was facilitated by cationic polyethyleneimine via electrostatic adsorption. The nanocarrier-loaded ICG formed stable aggregates that enhanced cellular uptake and prevented fluorescence quenching. Moreover, the strong superparamagnetism of the Fe_3O_4 core in the obtained nanocomposites further improved cellular internalization of the drugs guided by a localized magnetic field. The therapeutic efficacy of this nanoplatform was evaluated using tumor models established in nude mice, which demonstrated remarkable tumor ablation in vivo due to strong photothermal/photodynamic effects. This study provides promising evidence that this multifunctional nanoagent might function as an efficient mediator for combining photothermal and photodynamic cancer therapy.

关键词： Combination therapy Prussian blue nanoparticles Photothermal therapy Photodynamic therapy Indocyanine green

Ultrasound-induced biophysical effects in controlled drug delivery

在线全文

学校读者我要写书评

暂无评论

Science China(Life Sciences) 2022年第5期65卷 896-908页

作者： Lulu Zhang Zhuohua Lin Lan Zeng Fan Zhang lihong sun Suhui sun Ping Wang Menghong Xu Jinxia Zhang Xiaolong Liang Huiyu Ge Department of Ultrasound Peking University Third HospitalBeijing 100191China

Ultrasound is widely used in biomedical engineering and has applications in conventional diagnosis and drug *** advances in ultrasound-induced drug delivery have been summarized previously in several reviews that have primarily focused on the fabrication of drug delivery *** review discusses the mechanisms underlying ultrasound-induced drug delivery and factors affecting delivery efficiency,including the characteristics of drug delivery carriers and ultrasound ***,biophysical effects induced by ultrasound,namely thermal effects,cavitation effects,and acoustic radiation forces,are ***,the use of these biophysical effects to enhance drug delivery by affecting drug carriers and corresponding tissues is clarified in ***,recent advances in ultrasound-triggered drug delivery are *** issues and optimization strategies to improve therapeutic outcomes and reduce side effects are ***,current progress and future directions are discussed.

关键词： ultrasound biophysical effects drug delivery systems ultrasound parameters ultrasound-triggered drug delivery

Targeted drug delivery strategies for the treatment of rheumatoid arthritis

在线全文

学校读者我要写书评

暂无评论

Science China(Life Sciences) 2021年第7期64卷 1187-1189页

作者： Jinxia Zhang Ling Jiang lihong sun Ping Wang Suhui sun Menghong Xu Lulu zhang Shumin Wang Xiaolong Liang Ligang Cui Department of Ultrasound Peking University Third HospitalBeijing 100191China

A chronic autoimmune disease named rheumatoid arthritis(RA)is characterized mainly by synovitis,which has high morbidity,disability and mortality *** addition,the aetiology and pathogenesis of RA have not been fully *** is usually accompanied by persistent arthritic pain,swelling,stiffness,and functional disorders;in severe cases,it may result in cardiovascular,pulmonary,psychological and skeletal diseases(Scott et al.,2010).

关键词： mortality cardiovascular diseases

L型滑液囊支原体实时荧光定量PCR方法的建立与应用

在线全文

学校读者我要写书评

暂无评论

中国家禽 2024年第7期46卷 44-50页

作者：刘子卿任豆豆孙丽红王娟娟孟晨晨周守长刘冠慧许金朋河北工程大学生命科学与食品工程学院河北邯郸056038 华裕农业科技有限公司河北邯郸056000 河北省蛋鸡产业技术研究院河北邯郸056000

为建立一种快速、灵敏的检测我国优势基因型(L型)滑液囊支原体(MS)的方法,试验针对L型MS vlh A基因核苷酸序列保守区设计引物及Taq Man-MGB探针,将PCR扩增的vlh A基因克隆至p MD19-T载体,构建重组质粒vlh A-L作为阳性质粒标准品,建立实... 详细信息

为建立一种快速、灵敏的检测我国优势基因型(L型)滑液囊支原体(MS)的方法,试验针对L型MS vlh A基因核苷酸序列保守区设计引物及Taq Man-MGB探针,将PCR扩增的vlh A基因克隆至p MD19-T载体,构建重组质粒vlh A-L作为阳性质粒标准品,建立实时荧光定量PCR(q PCR)方法,并检验该方法的特异性、灵敏性和重复性。结果显示:该方法特异性良好,与C型MS-H株及其他鸡常见病原不发生交叉反应;重组质粒vlh A-L最小检出浓度为1.94×10^(1) copies/μL;组内和组间重复性变异系数均小于1%;临床样品检测结果与PCR测序结果吻合。研究表明,建立的q PCR方法特异性强、灵敏性高、重复性好,适用于检测我国L型MS感染情况,还可满足监测免疫MS-H株疫苗鸡群L型MS感染的要求。

关键词：滑液囊支原体 vlhA基因 L型 TaqMan-MGB探针实时荧光定量PCR