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Chinese Medical Journal 2023年第10期136卷 1249-1250页

作者： Yuewen Yang Zhihui liu Hongbo Lyu Xinrui Guo Haozheng Jiang lihong liu Dapeng Chen Comparative Medicine Department of Researching and Teaching Dalian Medical UniversityDalianLiaoning 116044China Department of Otorhinolaryngology Head and Neck SurgeryZhongnan Hospital of Wuhan UniversityWuhanHubei 430000China Department of Bone and Joint First Affiliated Hospital of Dalian Medical UniversityDalianLiaoning 116011China College of Basic Medical Sciences Dalian Medical UniversityDalianLiaoning 116044China

To the Editor:Colorectal cancer is one of the most common cancers worldwide,and chronic inflammation caused by colitis,especially ulcerative colitis,increases the risk of colorectal *** with sporadic colorectal cancer whose hallmark is constitutive activation of Wingless/b-catenin signaling and the adenomacarcinoma sequence,P53 and K-Ras mutations,which occur earlier,adenomatous polyposis coli occurs later during the progression of colitis-associated colorectal cancer(CAC).Surgery and chemotherapy are the preferred treatments of CAC,but long-term use of first-line chemotherapy agents such as 5-fluorouracil or irinotecan is limited by drug resistance or adverse ***,it is necessary for us to identify“green”*** Chinese medicines(TCMs)are complex and diverse and are found in *** anti-inflammatory,antibacterial,antiviral,antioxidant,antitumor,antiradiation,and immunomodulatory activity of TCMs have been extensively *** are more able than synthesized drugs to prevent inflammation from progressing to *** review summarizes the advantages of TCMs for treating CAC.

关键词： drugs chemotherapy Surgery treatment

Investigation and Analysis of Continuing Nursing Education Status and Needs of In-Service Nurses in Tibet

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Open Journal of Internal Medicine 2020年第2期10卷 223-231页

作者： Haihua Zou lihong liu Lijuan Dong Weiju Chen Nursing Department of the First Affiliated Hospital of Jinan University Guangzhou China Linzhi People’s Hospital Linzhi China

Objective: To investigate and analyze the current status of continuing nursing education (CNE) of in-service nurses in Tibet and their demand for continuing education. Methods: 663 active nurses in Tibet were taken as the research objects, and the self-developed questionnaire was used to investigate the current status and needs of CNE, and the correlation between the CNE needs of active nurses and their personal conditions was analyzed. Results: This study shows that 65.61% (435/663) of active nurses have not participated in any CNE, and 91.86% (609/663) of active nurses believe that they need to participate in CNE. The problems faced by active nurses in participating in CNE include funding restrictions, time limitation and ability limitation. Logistic stepwise regression analysis reveals that the age of active nurses and working years of nurses are negatively correlated with the funding restrictions for participating in CNE (P Conclusion: The problems faced by active nurses in Tibet in participating in CNE come from funding, time and ability. Young nurses with limited working experience cannot participate in CNE resulting from limited ability and funds;while senior nurses are mainly restricted by time. It is recommended that hospitals and nursing management in Tibet should solve these problems faced by nurses in

关键词： Tibet In-Service Nurses Continuing Education Current Situation Analysis Facing Problems Solutions

The combination of chidamide with the CHOEP regimen in previously untreated patients with peripheral T-cell lymphoma: a prospective, multicenter, single arm, phase 1b/2 study

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Cancer Biology & Medicine 2021年第3期18卷 841-848页

作者： Wei Zhang Liping Su lihong liu Yuhuan Gao Quanshun Wang Hang Su Yuhuan Song Huilai Zhang Jing Shen Hongmei Jing Shuye Wang Xinan Cen Hui liu Aichun liu Zengjun Li Jianmin Luo Jianxia He Jingwen Wang O.A.O’Connor Daobin Zhou Department of Hematology Peking Union Medical College HospitalBeijing 100730China Department of Hematology Shanxi Provincial Cancer HospitalTaiyuan 030013China Department of Hematology Fourth Hospital of Hebei Medical UniversityShijiazhuang 050011China Department of Hematology Chinese PLA General HospitalBeijing 100039China Department of Lymphoma the 307 Hospital of PLABeijing 100071China Department of Lymphoma Peking University Cancer Hospital and InstituteBeijing 100142China Department of Lymphoma Tianjin Medical University Cancer Institute and HospitalNational Clinical Research Center for CancerKey Laboratory of Cancer Prevention and TherapyTianjinTianjin’s Clinical Research Center for CancerTianjin 300060China Department of Hematology Beijing Friendship HospitalBeijing 100050China Department of Hematology Peking University Third HospitalBeijing 100191China Department of Hematology the First Affiliated Hospital of Harbin Medical UniversityHarbin 150081China Department of Hematology Peking University First HospitalBeijing 100034China Department of Hematology Beijing HospitalBeijing 100730China Department of Lymphoma Harbin Medical University Cancer HospitalHarbin 150081China Lymphoma Diagnosis and Treatment Center Institute of Hematology and Blood Diseases HospitalTianjin 300052China Department of Hematology Second Hospital of Hebei Medical UniversityShijiazhuang 050000China Department of Hematology Shanxi Provincial People’s HospitalTaiyuan 030012China Department of Hematology Beijing Tongren HospitalBeijing 100730China Columbia University Medical Center New York 10032-3784NYUSA

Objective:To assess the efficacy and safety of the novel histone deacetylase inhibitor,chidamide,in combination with cyclophosphamide,doxorubicin,vincristine,etoposide,and prednisone(Chi-CHOEP)for untreated peripheral T-cell lymphoma(PTCL).Methods:A prospective,multicenter,single arm,phase 1 b/2 study was conducted.A total of 128 patients with untreated PTCL(18–70 years of age)were enrolled between March 2016 and November 2019,and treated with up to 6 cycles with the Chi-CHOEP *** the phase 1 b study,3 dose levels of chidamide were evaluated and the primary endpoint was determination of the maximumtolerated dose and recommended phase 2 dose(RP2 D).The primary endpoint of the phase 2 study was 2-year progression-free survival(PFS).Results:Fifteen patients were enrolled in the phase 1 b study and the RP2 D for chidamide was determined to be 20 mg,twice a week.A total of 113 patients were treated at the RP2 D in the phase 2 study,and the overall response rate was 60.2%,with a complete response rate of 40.7%.At a median follow-up of 36 months,the median PFS was 10.7 months,with 1-,2-,and 3-year PFS rates of 49.9%,38.0%,and 32.8%,*** Chi-CHOEP regimen was well-tolerated,with grade 3/4 neutropenia occurring in approximately two-thirds of the *** unexpected adverse events(AEs)were reported and the observed AEs were ***:This large cohort phase 1 b/2 study showed that Chi-CHOEP was well-tolerated with modest efficacy in previously untreated PTCL patients.

关键词： Peripheral T-cell lymphoma chidamide histone deacetylase inhibitor epigenetic

Pulmonary toxicity induced by three forms of titanium dioxide nanoparticles via intra-tracheal instillation in rats

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Progress in Natural Science:Materials International 2009年第5期19卷 573-579页

作者： Ran liu, lihong Yin, Yuepu Pu, Geyu Liang, Juan Zhang, Yaoyao Su, Zhiping Xiao, Bing YeSchool of Public Health, Southeast University, Nanjing 210009, China [a]School of Public Health Southeast University Nanjing 210009 China

Titanium dioxide (TiO2) nanoparticles are in wide commercial use worldwide. To evaluate if acute pulmonary toxicity can be induced by nano-TiO2 particles, rats were intra-tracheally instilled with 0.5, 5, or 50 mg/kg of 5, 21, and 50 nm TiO2 primary particles. Toxic effects were determined with the coefficients of lung tissues to body weight, histopathology, biochemical parameters of blood, activity of lactate dehydrogenase (LDH), alkaline phosphatase (ALP) and acid phosphatase (ACP) in tissues, and the phagocytotic ability of alveolar macrophages (AMs). All the indicators were observed in sacrificed rats one week post-exposure. There was a significant difference of coefficients of pulmonary tissues between the high-dose group and the low-or moderate-dose groups with an exposure of 5 nm TiO2. At the same time, 5 nm TiO2 primary particles increased the activity of LDH and ALP when exposure dose was >5 mg/kg. A significant difference in LDH and ALP activity was observed between the 50 mg/kg group and 0.5 or 5 mg/kg group with exposure of 5 nm TiO2. Lung tissues showed increased ALP activity only if treated with 5 and 50 mg/kg of 21 nm TiO2 particles. There was no significant difference in LDH and ALP activity in the 50 nm TiO2 group and control group. Histo-pathologic examination of lung tissues indicated that the pulmonary response to exposure to TiO2 particles in rats manifested as dose-dependent inflammatory lesions, which mainly consisted of inflltration of inflammatory cells and interstitial thickening. Analysis of uptake of neutral red dye showed that 50 nm TiO2 particles significantly increased phagocytotic ability of AMs compared with controls (P<0.05), whereas exposure with 5 nm TiO2 reduced the phagocytotic ability of AMs when the exposure dose was 50 mg/kg. These results suggest that particle size and exposure dose may have important roles in pulmonary toxicity. The toxic effect of TiO2 nanopar-ticles in lung tissue exhibited a dose-response relationship. A

关键词： Titanium dioxide particles Nanoparticles Pulmonary toxicity Intra-tracheal instillation

Detection of CYP2E1,a Genetic Biomarker of Susceptibility to Benzene Metabolism Toxicity in Immortal Human Lymphocytes Derived from the Han Chinese Population

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Biomedical and Environmental Sciences 2011年第3期24卷 300-309页

作者： ZHANG Juan YIN lihong LIANG GeYu liu Ran FAN KaiHong PU YuePu Key Laboratory of Environmental Medicine Engineering Ministry of Education' School of Public HealthSoutheast University Nanjing 210009 Jiangsu China

Objective Cytochrome P450 2E1 （CYP2E1） is an important metabolizing enzyme involved in oxidative stress responses to benzene, a chemical associated with bone marrow toxicity and leukemia, We aimed to identify the CYP2E1 genetic biomarkers of susceptibility to benzene toxicity in support of environmental and occupational exposure prevention, and to test whether a model using immortal human lymphocytes might be an efficient tool for detecting genetic biomarkers. Methods Immortalized human lymphocyte cell lines with independent genotypes on four CYP2E1 SNP sites were induced with 0.01% phenol, a metabolite of benzene. CYP2E1 gene function was evaluated by mRNA expression and enzyme activity. DNA damage was measured by Single-Cell Gel Electrophoresis （SCGE）. Results Among the four SNPs, cells with rs2070673TT and rs2030920CC showed higher levels of ~YP2E1 transcription and enzymatic activity than the other genotypes in the same SNP site. Cells with higher gene expression genotypes also showed higher comet rates compared with lower gene expression genotypes. Conclusion These results suggest that CYP2E1 rs2070673 and rs2030920 might be the genetic biomarkers of susceptibility to benzene toxicity and that the immortalized human lymphocytes model might be an efficient tool for the detection of genetic biomarkers of susceptibility to chemicals.

关键词： Cytochrome P450 2E1 Single-nucleotide polymorphism Genetic biomarker Human immortalized B lymphocytes Benzene Phenol

A systematic review of magnesium sulfate for acute asthma in adults

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Journal of Chinese Pharmaceutical Sciences 2016年第8期25卷 621-631页

作者： Zhuo Ma Xiangli Cui lihong liu Pharmacy Department of Beijing Chao Yang Hospital Capital Medical University Beijing 100020 China

In order to provide evidence for making clinical decision, the role of intravenous and nebulized MgSO4 in treatment of adult＇s acute asthma was systematically estimated in the present study. Pubmed, Embase, Web of Sciences, the Cochrane Library and two Chinese literature databases （CNKI, WanFang） were systematically searched up to January 2016. Randomized controlled trails （RCTs） that compared the clinical outcomes of MgSO4 groups and placebo groups were included. The primary outcome was hospital admission. Secondary outcomes included pulmonary function, symptom scores, vital signs and adverse events. The methodological quality of the included studies was evaluated, and the forest plots with meta-analysis were drawn by RevMan 5.2. A total of 24 RCTs derived from 2931 patients were included. Both intravenous MgSO4 and nebulized MgSO4 treatments had no effect upon hospital admission （RR 0.91, 95% CI 0.80 to 1.03, P = 0.14; RR 0.78, 95% CI 0.56 to 1.08, P = 0.14）. Both intravenous MgSO4 and nebulized MgSO4 treatments were associated with significant evidence upon respiratory function （SMD 0.23, 95% CI 0.03 to 0.43, P = 0.02; SMD 0.37, 95% CI 0.11 to 0.64, P = 0.006）, but sensitivity analyses showed that outcomes were changed by omitting studies of less than 100 individuals （SMD 0.05, 95% C1-0.05 to 0.15, P = 0.35; SMD 0.05, 95% C1-0.16 to 0.25, P = 0.64）. There were no statistically significant differences in clinical symptom scores and vital signs （heart or pulse rate; systolic blood pressure; respiratory rate） in either form of MgSO4 compared with placebo groups （P〉0.05）. There were no serious adverse events reported in any literature. Overall, there was no role for intravenous and nebulized MgSO4 in the management of acute asthma in adults. Considering the low risk of serious adverse effects and easy availability, it seemed reasonable to use intravenous or nebulized MgSO4 treatment in adults with life threatening asthma in whom any potential benefit would justify th

关键词： Magnesium sulphate Adult asthma Systematic review

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论师生“角色分化与共享教学”

课程．教材．教法 2015年第5期35卷 28-34页

作者：刘历红西北师范大学教育学院甘肃兰州730070 郑州市金水区教育发展研究中心河南郑州450003

将师生在教学活动中既是教育者又是受教育者的教育现象进行角色明晰,使教师、学生的职业角色都分化出"教育者"和"学习者"两个行为角色,形成互相渗透、彼此合作,你中有我、我中有你的师生关系,课堂从而呈现出多维度、多层面的网状互动,... 详细信息

将师生在教学活动中既是教育者又是受教育者的教育现象进行角色明晰,使教师、学生的职业角色都分化出"教育者"和"学习者"两个行为角色,形成互相渗透、彼此合作,你中有我、我中有你的师生关系,课堂从而呈现出多维度、多层面的网状互动,在解决传统课堂因师生关系紧张和压力、学生学习被动等导致的教学效益低下问题的同时,还促使师生走向亦师亦友的境界。

关键词：师生角色分化共享教学和谐师生关系

Investigation and Analysis on the Management Standard of Blood Glucose Monitoring for Clinical Nurses in Nyingchi Region of Tibet

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Open Journal of Preventive Medicine 2020年第6期10卷 108-119页

作者： Haihua Zou lihong liu Lijuan Dong Tefan Zhang Peiru Zhou Nursing Department First Affiliated Hospital of Jinan University Guangzhou China Linzhi People’s Hospital Linzhi China

Background: In participating in the medical support work in the Nyingchi area of Tibet, the author found that the medical education resources in this area are scarce, and the clinical nurses in this area have relatively insufficient knowledge about blood glucose monitoring and management. Accurately understanding the knowledge-attitude/belief-practice (KAP) level of nurses in Nyingchi area on blood glucose management is of great significance to the development of blood glucose monitoring management guidance for nurses in this area. Therefore, this study investigated the current status of the management of blood glucose monitoring management standards for clinical nurses in Nyingchi, Tibet. Objective: To investigate and analyze the current situation of clinical nurses in Nyingchi region of Tibet to grasp the regulation of blood glucose monitoring and guide the implementation of the norm of blood glucose monitoring for clinical nurses. Methods: The research survey was carried out from March to April 2020. Random sampling method was used to select 134 clinical in-service nurses in Nyingchii, Tibet. The self-designed knowledge-attitude/belief-practice survey questionnaire for clinical nurses’ blood glucose monitoring and management in Tibet was used. Nurses’ blood glucose monitoring management “KAP” scores and related influencing factors are analyzed. Results: Blood sugar monitoring and management knowledge score is (36.78 ± 6.80), attitude dimension is (42.48 ± 6.42), practice dimension is (61.87 ± 10.24) and total score is (304.73 ± 36.24). The nurse’s department and whether to participate in diabetes training are the main influencing factors of the blood glucose monitoring management norms, knowledge and behavior (both P Conclusion: The standard knowledge of blood glucose monitoring and management of clinical nurses in Nyingchi region of Tibet is at the middle level, positive attitude and un

关键词： Tibet Region Clinical Nurse Blood Glucose Monitoring Knowledge-Attitude/Belief-Practice

Study on the Clinical Effect of Nursing Intervention on Reducing Outpatient Children's Pressure Ulcers Caused by Superficial Venous Indwelling Needle

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Study on the Clinical Effect of Nursing Intervention on Redu...