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Hydroxyapatite reinforced inorganic-organic hybrid nanocomposite as high-performance adsorbents for bilirubin removal in vitro and in pig models

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Bioactive Materials 2021年第12期6卷 4772-4785页

作者： Yamin Chai Zhuang Liu Yunzheng Du lichun Wang Jinyan lu Qian Zhang a Wenyan Han Tingting Wang Yameng Yu Lisha Sun Lailiang Ou Key Laboratory of Bioactive Materials Ministry of EducationCollege of Life SciencesNankai UniversityTianjin300071China General Hospital Tianjin Medical UniversityTianjin300052China

Highly efficient removal of bilirubin from whole blood directly by hemoperfusion for liver failure therapy remains a challenge in the clinical field due to the low adsorption capacity,poor mechanical strength and low biocompatibility of *** this work,a new class of nanocomposite adsorbents was constructed through an inorganic-organic co-crosslinked nanocomposite network between vinyltriethoxysilane(VTES)-functionalized hydroxyapatite nanoparticles(V-Hap)and non-ionic styrene-divinylbenzene(PS-DVB)resins(PS-DVB/V-Hap)using suspension ***,our adsorbent demonstrated substantially improved mechanical performance compared to the pure polymer,with the hardness and modulus increasing by nearly 3 and 2.5 times,***,due to the development of a mesoporous structure,the prepared PS-DVB/V-Hap3 exhibited an ideal adsorption capacity of 40.27 mg·g^(-1).More importantly,the obtained adsorbent beads showed outstanding blood compatibility and ***,in vivo extracorporeal hemoperfusion verified the efficacy and biosafety of the adsorbent for directly removing bilirubin from whole blood in pig models,and this material could potentially prevent liver damage and improve clinical *** together,the results suggest that PS-DVB/V-Hap3 beads can be used in commercial adsorption columns to threat hyperbilirubinemia patients through hemoperfusion,thus replacing the existing techniques where plasma separation is initially required.

关键词： Bilirubin Hydroxyapatite-polymer composite Adsorption Hemoperfusion Biocompatibility

Research Progress of Triterpenoid Secondary Metabolites in Cucurbitaceae Plants

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Agricultural Biotechnology 2019年第1期8卷 34-39,42页

作者： Zhiyi HU lichun ZHAO Fenglai lu Dianpeng LI College of Pharmacy Guangxi University of Chinese Medicine Guangxi Key Laboratory of Functional Phytochemicals Research and Utilization Guangxi Zhuang Autonomous Region and Chinese Academy of SciencesGuangxi Institute of Botany

In this paper,the advances in study on triterpenoids in Trichosanthes,Hemsleya,Gynostemma,Actinostemma and Siraitia Merr. plants were *** are the main secondary metabolites of Cucurbitaceae and have obvious pharmacological activity. It is noteworthy that in these plants,there are a variety of triterpenoids,which are diverse in structure. Triterpenoid saponins have greater potential for development.

关键词： Cucurbitacea Triterpenoids Secondary metabolites Trichosanthes Hemsleya Gynostemma Actinostemma Siraitia Merr

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止得咳颗粒在大鼠体内的代谢产物研究

中国药房 2024年第2期35卷 172-178页

作者：梁洁郑飘雪陈辉华黄春燕梁炎丽陆春莲谢晶晶马玉明彭嘉文赵立春陈日兰广西中医药大学药学院南宁530200 广西高校中药提取纯化与质量分析重点实验室南宁530200 中药固体制剂制造技术国家工程研究中心华南分中心南宁530200 广西壮瑶药工程技术研究中心南宁530200 钦州市检验检测中心广西钦州535000 广西中医药大学附属瑞康医院药剂科南宁530011

目的分析止得咳颗粒在大鼠体内的代谢产物并推测其代谢途径。方法将雄性SD大鼠随机分为空白组、给药组(止得咳颗粒,9.45 g/kg),每组灌胃超纯水或相应药液,每天2次,每次灌胃间隔6~8 h,连续3 d。收集各组大鼠血清、粪便、尿液样品,利用超... 详细信息

目的分析止得咳颗粒在大鼠体内的代谢产物并推测其代谢途径。方法将雄性SD大鼠随机分为空白组、给药组(止得咳颗粒,9.45 g/kg),每组灌胃超纯水或相应药液,每天2次,每次灌胃间隔6~8 h,连续3 d。收集各组大鼠血清、粪便、尿液样品,利用超高效液相色谱-四极杆-静电场轨道阱高分辨质谱(UPLC-Q-Exactive-MS)技术鉴定大鼠灌胃止得咳颗粒后上述生物样品中的代谢产物,并推测其代谢途径。结果大鼠灌胃止得咳颗粒后,在其血清、尿液、粪便样品中共鉴定出16个原型成分(如野鸢尾黄素、黄芩素、绿原酸等)和11个代谢产物(如山柰酚或木犀草素水合产物、绿原酸甲基化产物、黄芩苷羟基化产物)。其中,血清样品中鉴定出8个原型成分和4个代谢产物;尿液样品中鉴定出10个原型成分和7个代谢产物;粪便样品中鉴定出8个原型成分和5个代谢产物。结论止得咳颗粒在大鼠体内的代谢成分主要包括黄芩苷、野鸢尾黄素、绿原酸,主要涉及甲基化、羟基化、葡萄糖醛酸化等代谢途径。

关键词：止得咳颗粒超高效液相色谱-四极杆-静电场轨道阱高分辨质谱技术代谢产物代谢途径大鼠

Application of Rubidium in the Field of Medicine and Health

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Agricultural Biotechnology 2021年第4期10卷 113-119页

作者： lichun ZHAO Yucui lu Wenbin ZHANG Shilei DING Xiayun LIAO Jiaping PAN College of Pharmacy Guangxi University of Chinese MedicineNanning 530200China Guangxi Key Laboratory of Medicine and Food Homologous Resources Development Nanning 530200China Guangxi Zhongrubidium Health Industry Development Co. LtdNanning 530001China

With the continuous development of science and technology,the role of rare and precious metal resources in medical treatment,economy and strategy has become increasingly *** paper reviewed the application research of rare precious metal rubidium(Rb)in the field of medicine and health,mainly including the application significance of Rb in the field of medical and health,typical applications and problems in the field of medicine and health,and the important research significance of the research and development of medicine.

关键词： Rubidium Health medicine Development and application

A PRELIMINARY STUDY ON THE NUCLEAR POLYHEDROSIS VIRUS OF LARCH CASEBEARER

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Journal of Northeast Forestry University 1991年第2期2卷 109-110页

作者： Wang lichun Liu Kuanyu Wang Zhiying Zhang Guocai Qu ShaoyiNortheast Forestry UniversityCheng Huanzhang Xu shanbinDaxing’anling Forest Management BureauFeng Zenghe Sun Yufa lu KuichengShibazhan Forestry Bureau Northeast Forestry University China Daxing’anling Forest Management Bureau China Shibazhan Forestry Bureau China

The nucleopolyhedrosis virus(NPV) of larch case bearer (Dendrolimus superans) is in quadrangle or irregular form. It's diameter is ranged from 1.21 μm to 2.33 μm. There is one or many virions in each envelope. The s... 详细信息

关键词： Larch casebcarer Nucleopolyhedrosis virus(NPV)

Bone morphogenetic protein 2 downregulates TRPC expression,store-operated Ca2+ entry and basal[Ca2+]i in rat distal pulmonary arterial smooth muscle cells

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Bone morphogenetic protein 2 downregulates TRPC expression,s...

敲除CISH敲入并IL-15显著增强NK细胞抗肿瘤活性的研究

中华医学会急诊医学分会第十六次全国急诊医学学术年会

作者： Yi Zhang Weijun lu Ning Lai lichun Tian xin Duan Jiang Wang Emergency Department The 2nd Affiliated Hospital of Guangzhou Medical University Guangzhou Institute of Respiratory Disease State Key Laboratory of Respiratory Diseases2Department of Laboratory MedicineThe 1st Affiliated Hospital of Guangzhou Medical University Division of Pulmonary & Critical Care Medicine Johns Hopkins Medical InstitutionsBaltimoreMD 21224United States Fu Wai Hospital Chinese Academy of Medical Sciences and Peking Union Medical CollegeBeijingChina

Recent studies indicate that multiple bone morphogenetic protein(BMP) family ligands and receptors are involved in development of pulmonary arterial hypertension(PAH),yet the underlying mechanisms are incompletely *** BMP2 and BMP4 share high homology in amino acid sequence,they appear to exert divergent effects in chronic hypoxic pulmonary hypertension(CHPH).

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解放军医学院学报 2024年第3期45卷 290-295页

作者：刘传玲李营营李燕荣胡梦唐立春王海燕焦顺昌卢社莲赵卫红解放军总医院第一医学中心肿瘤内科北京100853 解放军总医院肿瘤医学部北京100853 鼎成肽源生物有限公司研发部北京102200

背景白细胞介素(interleukin,IL)-15是调节自然杀伤细胞(natural killer cell,NK细胞)功能的关键细胞因子,而CISH可负向调控IL-15信号通路,从而影响NK细胞功能。靶向CISH基因和IL-15基因对NK细胞进行基因编辑,可增强NK细胞抗肿瘤活性。... 详细信息

背景白细胞介素(interleukin,IL)-15是调节自然杀伤细胞(natural killer cell,NK细胞)功能的关键细胞因子,而CISH可负向调控IL-15信号通路,从而影响NK细胞功能。靶向CISH基因和IL-15基因对NK细胞进行基因编辑,可增强NK细胞抗肿瘤活性。目的探讨CISH基因、IL-15基因对NK细胞的细胞毒性的影响。方法采用AsCas12a Ultra基因编辑工具敲除CISH基因,并敲入IL-15基因,对NK细胞进行基因编辑,并通过基因测序检测CISH基因敲除效率,采用ELISA检测IL-15的表达,用LDH检测基因编辑后的NK细胞对H358细胞系的杀伤活性,评估CISH基因敲除、IL-15基因敲入对NK细胞抗肿瘤功能的影响。结果与对照组相比,CISH基因敲除组和CISH基因敲除+IL-15基因敲入组杀伤效率显著增强[E∶T=2∶1组,34.57%±6.32%vs 71.40%±5.81%和69.23%±4.28%,P<0.001]。结论敲除CISH基因可上调IL-15信号通路,增强NK细胞抗肿瘤活性。

关键词：自然杀伤细胞 CISH 白细胞介素-15 AsCas12a Ultra

鸽腺病毒通用型实时荧光PCR检测方法的建立与应用

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中国动物检疫 2024年第3期41卷 89-95页

作者：陈璐朱明慧丁雨李阳亓丽红房立春蒋文明王静静刘华雷李建亮于晓慧山东农业大学山东泰安271018 中国动物卫生与流行病学中心山东青岛266032 青岛农业大学山东青岛266109 宁夏大学宁夏银川750021 山东省农业科学院畜牧兽医研究所山东济南250199 农业农村部动物生物安全风险预警及防控重点实验室(南方) 山东青岛266032

鸽腺病毒(pigeon adenovirus,PiAdV)是影响鸽产业健康发展的重要病原之一。为实现PiAdV的高通量快速检测,根据GeneBank登录的PiAdV-A种和PiAdV-B种病毒pⅧ基因序列的共同保守区域设计特异性检测引物和探针,经反应条件优化,建立了一种Pi... 详细信息

鸽腺病毒(pigeon adenovirus,PiAdV)是影响鸽产业健康发展的重要病原之一。为实现PiAdV的高通量快速检测,根据GeneBank登录的PiAdV-A种和PiAdV-B种病毒pⅧ基因序列的共同保守区域设计特异性检测引物和探针,经反应条件优化,建立了一种PiAdV通用型实时荧光PCR检测方法,并对该方法进行了特异性、敏感性、重复性试验。结果显示:该方法的最佳探针浓度为0.2μmol/L,与鸽群其他常见病毒无交叉反应,对PiAdV的最低检测限为56.9 copies/μL,比常规PCR敏感性高100倍,组内和组间重复变异系数均小于1.8%。利用该方法和常规PCR方法对20份疑似PiAdV感染样品进行检测,发现PiAdV通用型实时荧光PCR检测方法的病毒阳性检出率高于常规PCR方法。结果表明,本研究建立的PiAdV通用型实时荧光PCR检测方法特异性强、敏感性高、可靠性好,可用于PiAdV感染的临床检测及流行病学调查。

关键词：鸽腺病毒通用型实时荧光PCR 检测方法

Inhibitory effects of bone morphogenetic protein 2 on TRPC expression,store-operated Ca2+ entry and basal[Ca2+]i in rat distal pulmonary arterial smooth muscle cells

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Inhibitory effects of bone morphogenetic protein 2 on TRPC e...