Inhibitory effects of bone morphogenetic protein 2 on TRPC expression,store-operated Ca2+ entry and basal[Ca2+]i in rat distal pulmonary arterial smooth muscle cells
作者单位：Emergency DepartmentThe 2nd Affiliated Hospital of Guangzhou Medical UniversityChina Division of Pulmonary & Critical Care MedicineJohns Hopkins Medical InstitutionsBaltimoreMD 21224United States Emergency DepartmentThe 2nd Affiliated Hospital of Guangzhou Medical UniversityChina. Guangzhou Institute of Respiratory DiseaseState Key Laboratory of Respiratory Diseases The 1st Affiliated Hospital of Guangzhou Medical University
会议名称：《中华医学会呼吸病学年会——2013（第十四次全国呼吸病...》
会议日期：2013年
学科分类：1001[医学-基础医学(可授医学、理学学位)] 100104[医学-病理学与病理生理学] 10[医学]
摘 要：Rationale Recent observations have demonstrated that bone morphogenetic protein 2(BMP2) and BMP4 might be involved in pulmonary arterial hypertension(PAH), yet the underlying mechanisms have been poorly ***2 and BMP4 belong to TGF-beta family and share highly similar amino acid sequence. However,BMP2 and BMP4 were found to play different roles in *** was reported that BMP4 can induce hypertension,while BMP2 can regulate apoptosis, inhibit proliferation and enhance K1.5 expression,