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iRGD-reinforced, photo-transformable nanoclusters toward cooperative enhancement of intratumoral penetration and antitumor efficacy

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Nano Research 2020年第10期13卷 2706-2715页

作者： Jing Yan Rongying Zhu Fan Wu Ziyin Zhao Huan Ye Mengying Hou Yong Liu lichen Yin Institute of Functional Nano and Soft Materials(FUNSOM) Jiangsu Key Laboratory of Carbon-Based Functional Materials and DevicesCollaborative Innovation Center of Suzhou Nano Science&TechnologySoochow UniversitySuzhou 215123China Department of Thoracic Surgery The Second Afliated Hospital of Soochow UniversitSuzhou 215004China

Insufficient intratumoral penetration greatly hurdles the anticancer performance of nanomedicine. To realize highly efficient tumor penetration in a precisely and spatiotemporally controlled manner, far-red light-responsive nanoclusters (NCs) capable of size shrinkage and charge conversion were developed and co-administered with iRGD to synergistically improve the intratumoral penetration and the anticancer efficacy. The NCs were constructed using the singlet oxygen-sensitive (SOS) polyethylene glycolpolyurethane-polyethylene glycol (PEG-(1O2)PU-PEG) triblock copolymer to encapsulate the doxorubicin (DOX)-loaded, chlorin e6 (Ce6)-conjugated polyamindoamine (PAMAM) dendrimer (DCD) via the double-emulsion method. Co-administration of iRGD notably increased the permeability of NCs within tumor vasculature and tumor tissues. In addition, upon far-red light irradiation (660 nm) of tumors at low optical density (10 mW/cm2), the generated 1O2 could disintegrate the NCs and release the DCD with positive surface charge and ultra-small size (~ 5 nm), which synergized with iRGD to enable deep intratumoral penetration. Consequently, the local 1O2 at lethal concentrations along with the released DOX efficiently and cooperatively eradicated tumor cells. This study provides a convenient approach to spatiotemporally promote the intratumoral penetration of nanomedicine and mediate programmed anticancer therapy.

关键词： intratumoral penetration light-responsiveness singlet oxygen-degradable polymer size shrinkage charge conversion iRGD

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Wear Resistance of 3Cr2W8V Rough Surfaces

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Journal of Bionic Engineering 2005年第2期2卷 81-86页

作者： ZhouHong WangWei RenLu-quan LiYue lichen KeyLaboratoryofAutomobileMaterials（MinistryofEducation China）JilinUniversityChangchun130022P.R.China KeyLaboratoryofTerrain-MachineBionicsEngineering（MinistryofEducation China）JilinUniversityChangchun130022P.R.China DepartmentofElementTeaching JilinUniversityChangchun130012P.R.China

Three types of rough surface were processed by laser irradiation on the 3Cr2W8V material hot-work die steel surface. The wear experiments with smooth surface and rough surface samples were repeated on the pin-tray wear machine. According to the wear results, we studied the regularity of wear resistance of different rough surface samples. The results indicated that bionic rough surface can improve the wear resistance of the material and the wear resistance can be increased 1-2 times, compared with the smooth surface. Also, the wear resistance of the rough surface was affected by laser current and duration of impulse. The bigger the laser current or the impulse duration, the better is the wear resistance. When the distance between the same kind of units which are distributed on the surfaces is changed, the wear resistance changes. The wear resistance of a bionic rough surface on which the grid units were distributed at spacing of 1 mm was the best. And we designed the wear models.

关键词： wear bionic rough surface laser

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Carbon-based supports for the electrocatalysis under industrially relevant conditions

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Science China Chemistry 2024年第4期67卷 1051-1055页

作者： Xue Yang Xianrui Gu Yang Song Guolin Hou Cheng Wang lichen Liu Wei Lin Center for Renewable Energy SINOPEC Research Institute of Petroleum ProcessingBeijing 100083China Engineering Research Center of Advanced Rare Earth Materials Department of ChemistryTsinghua UniversityBeijing 100084China

1 *** materials are ideal catalyst supports for functional metal components due to their appropriate physicochemical characteristics,such as high surface areas,tunable pore structures,variable morphologies and versatile surface properties based on chemical modifications,low cost and facile preparations from diverse precursors[1,2].

关键词： versatile facile supports

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Novel transmission property of zero-index metamaterial waveguide doped with gain and lossy defects

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Chinese Physics B 2023年第10期32卷 531-536页

作者：朱琼干柴立臣路海 Department of Science Taiyuan Institute of TechnologyTaiyuan 030008China Engineering Laboratory for Optoelectronic Technology and Advanced Manufacturing School of PhysicsHenan Normal UniversityXinxiang 453007China

Taking inspiration from quantum parity–time(PT) symmetries that have gained immense popularity in the emerging fields of non-Hermitian optics and photonics, the interest of exploring more generalized gain-loss interactions is never seen down. In this paper we theoretically present new fantastic properties through a zero-index metamaterial(ZIM) waveguide loaded gain and loss defects. For the case of epsilon-and-mu-near-zero(EMNZ) based ZIM medium, electromagnetic(EM)waves are cumulative and the system behaves as an amplifier when the loss cavity coefficient is greater than the gain cavity coefficient. Conversely, when loss is less than gain, EM waves are dissipated and the system behaves as an ***, our investigation is extended to non-Hermitian scenarios characterized by tailored distributions of gain and loss in the epsilon-near-zero(ENZ) host medium. The transport effect in ZIM waveguide is amplified in one mode, while it is dissipative in the other mode, which breaks the common sense and its physic is analyzed by magnetic flux. That is which cavity has the smaller loss/gain coefficient, the larger its magnetic flux, which cavity dominates. This paper is of significant importance in the manipulation of electromagnetic waves and light amplification as well as the enhancement of matter interactions.

关键词： zero-index metamaterial non-Hermitian gain-loss interaction magnetic flux

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RESEARCH ON MODEL AND METHOD OF NETWORK-BASED COOPERATIVE COMMERCE CHAIN IN AUTOMOBOLE INDUSTRY

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Chinese Journal of Mechanical Engineering 2003年第4期16卷 405-407页

作者： Xiong lichen ZichenZhang FeiGu XinjianInstitute of Modem AdvancedProduction Engineering,Zhejiang University,Hangzhou 310027, China Institute of Modern Advanced Production Engineering Zhejiang University Hangzhou 310027 China

Based on the analysis on the development of the cooperative commerce inautomobile industry, the systematic model of the cooperative commerce chain in automobile industryis illustrated, the flow of agent-based NCCC (network-based cooperative commerce chain) system isdescribed, and the method and NCCC system in automobile industry are developed, and so thecorrectness and the feasibility of the theory and the method are confirmed.

关键词： Cooperative commerce Automobile industry Intelligent agent

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RNA ac^(4)C modification in cancer biology:from regulatory mechanisms to clinical applications

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Science China(Life Sciences) 2024年第4期67卷 832-835页

作者： Lijun Tao Yunqing Lu Zhuojia Chen lichen Ge Junming He Jianxin Peng Hongsheng Wang School of Pharmaceutical Sciences Sun Yat-sen UniversityGuangzhou 510006China Sun Yat-sen University Cancer Center State Key Laboratory of Oncology in South ChinaCollaborative Innovation Center for Cancer MedicineGuangzhou 510060China Department of Hepatobiliary Surgery Guangdong Province Traditional Chinese Medical HospitalGuangzhou 510120China

RNA modifications are increasingly recognized for their significance in diverse physiological and pathological processes,with over 170 types of chemical modifications having been discovered since *** these modifications,N4-acetylcytidine(ac^(4)C)is the first acetylated modification identified on eukaryotic RNAs,previously reported in transfer RNA(t RNA)and ribosomal RNA(rRNA)。

关键词： clinical (4) modification

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MicroRNA-208a silencing against myocardial ischemia/reperfusion injury mediated by reversibly camouflaged biomimetic nanocomplexes

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Nano Research 2023年第8期16卷 11176-11185页

作者： Jianhui Lu Jiaheng Zhang Wen Yan Chenglong Ge Yang Zhou Rongying Zhu Shanzhou Duan lichen Yin Yongbing Chen Department of Thoracic Surgery Suzhou Key Laboratory of Thoracic OncologyThe Second Affiliated Hospital of Soochow UniversitySuzhou 215004China Center of Stomatology The Second Affiliated Hospital of Soochow UniversitySuzhou 215004China Jiangsu Key Laboratory for Carbon-Based Functional Materials and Devices Institute of Functional Nano&Soft Materials(FUNSOM)Collaborative Innovation Center of Suzhou Nano Science&TechnologySoochow UniversitySuzhou 215123China

MicroRNA-208a(miR-208a)plays critical roles in the severe fibrosis and heart failure post myocardial ischemia/reperfusion(IR)***-208a inhibitor(mI)with complementary RNA sequence can silence the expression of miR-208a,while it is challenging to achieve efficient and myocardium-targeted ***,biomimetic nanocomplexes(NCs)reversibly coated with red blood cell membrane(RM)were developed for the myocardial delivery of *** construct the NCs,membrane-penetrating helical polypeptide(PG)was first adopted to condense mI and form the cationic inner core,which subsequently adsorbed catalase(CAT)via electrostatic interaction followed by surface coating with *** membrane-coated NCs enabled prolonged blood circulation after systemic administration,and could accumulate in the injured myocardium via passive *** the oxidative microenvironment of injured myocardium,CAT decomposed H_(2)O_(2)to produce O_(2)bubbles,which drove the shedding of the outer RM to expose the positively charged inner core,thus facilitated effective internalization by cardiac *** on the combined contribution of mI-mediated miR-208a silencing and CAT-mediated alleviation of oxidative stress,NCs effectively ameliorated the myocardial microenvironment,hence reducing the infarct size as well as fibrosis and promoting recovery of cardiac *** study provides an effective strategy for the cytosolic delivery of nucleic acid cargoes in the myocardium,and it renders an enlightened approach to resolve the blood circulation/cell internalization dilemma of cell membrane-coated delivery systems.

关键词： myocardial ischemia/reperfusion(IR)injury microRNA-208a silencing red blood cell membrane reversible membrane coating H_(2)O_(2)responsiveness membrane-penetratingα-helical polypeptide

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3C DUCT DESIGN METHOD

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Acta Mechanica Sinica 2002年第2期18卷 67-74页

作者： Huan-RueiShiu Feng-ChuOu Sih-lichen DepartmentofMechanicalEngineeringNationalTaiwanUniversityTaipei Taiwan10617R.O.C.

A new 3C duct design method is proposed for designing a high quality, energy-efficiency cost-effective air duct system. It not only considers the demand of volume flow rate, but also takes into consideration a number of issues including system pressure balance, noise, vibration, space limitation and total system cost. This new method comprises three major calculation procedures:initial computer-aided design (CAD), computer-aided simulation (CAS) and correction processes (CP). An example is presented in this study to understand the characteristics of 3C method. It shows that 3C duct design method provides a simple computation procedure for an optimum air duct system. It also shortens the design schedule, prevents human calculation errors, and reduces the dependence on designer experience. In addition to apply in a new duct system design, 3C duct design method is also a powerful design tool for the expansion of an existing duct system.

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Efficient and targeted drug/siRNA co-delivery mediated by reversibly crosslinked polymersomes toward anti-inflammatory treatment of ulcerative colitis (UC)

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Nano Research 2019年第3期12卷 659-667页

作者： Xin Xu Weijing Yang Qiujun Liang Yanan Shi Wenxin Zhang Xiao Wang Fenghua Meng Zhiyuan Zhong lichen Yin Jiangsu Key Laboratory for Carbon-Based Functional Materials and Devices Institute of Functional Nano and Soft Materials (FUNSOM) the Collaborative Innovation Center of Suzhou Nano Science and Technology Soochow University Suzhou 215123 China Biomedical Polymers Laboratory and Jiangsu Key Laboratory of Advanced Functional Polymer Design and Application College of Chemistry Chemical Engineering and Materials Science Soochow University Suzhou 215123 China

Co-delivery of anti-inflammatory siRNA and hydrophilic drug provides a promising approach for the treatment of ulcerative colitis (UC). However, lack of a suitable and efficient co-delivery carrier poses critical challenge against their utilization. We herein developed macrophage-targeting, reversibly crossli nked polymersomes (TKPR-RCP) based on the TKPR-modified, poly(ethyle ne glycol)-b-poly(trimethylene carbonate-codithiolane trimethylene carbonate)-b-polyethylenimine (PEG-P(TMC-DTC)-PEI) triblock copolymer, which could efficiently encapsulate TNF-α siRNA and dexamethasone sodium phosphate (DSP) in their hydrophilic core. The cationic PEI segments provided additional electrostatic interactions with cargo molecules to promote the encapsulatiion, and disulfide crosslinking of the polymersome membrane endowed the TKPR-RCP with high colloidal stability. Because the cationic PEI was embedded in the hydrophilic core, the polymersomes displayed neutral surface charge and thus possessed high serum stability. The TKPR-RCP co-encapsulating TNF-α siRNA and DSP could be efficiently internalized by macrophages (~98%) and undergo redox-responsive membrane de-crosslinking to accelerate cargo release in the cytoplasm, thus inducing efficient gene silencing and anti-inflammatory effect .Intravenous injectio n of the co-delivery TKPR-RCP mediated pote nt and cooperative anti-inflammatory effect in inflamed colons of UC mice, and significantly prevented animals from colonic injury. This study therefore provides a promising approach for the co-delivery of hydrophilic drug/siRNA toward the treatment of inflammatory bowel diseases.

关键词： ulcerative colitis (UC) anti-inflammatory therapy polymersomes reversible crosslinking siRNA/drug co-delivery macrophage targeting

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Macrophage-targeting gene silencing orchestrates myocardial microenvironment remodeling toward the anti-inflammatory treatment of ischemia-reperfusion (IR) injury

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Bioactive Materials 2022年第11期7卷 320-333页

作者： Yao Wang Mengying Hou Shanzhou Duan Ziyin Zhao Xuejie Wu Yongbing Chen lichen Yin Department of Cardiothoracic Surgery the Second Affiliated Hospital of Soochow UniversitySuzhou215002China Institute of Functional Nano and Soft Materials(FUNSOM) Jiangsu Key Laboratory for Carbon-Based Functional Materials and DevicesSoochow UniversitySuzhou215123China Yancheng First Hospital Affiliated Hospital of Nanjing University Medical SchoolYancheng224005China

Ischemia-reperfusion (IR) injury represents a major cause of myocardial dysfunction after infarction and thrombolytic therapy, and it is closely related to the free radical explosion and overwhelming inflammatory responses. Herein, macrophage-targeting nanocomplexes (NCs) are developed to mediate efficient co-delivery of siRNA against MOF (siMOF) and microRNA-21 (miR21) into myocardial macrophages, cooperatively orches-trating the myocardial microenvironment against IR injury. Bioreducible, branched poly(β-amino ester) (BPAE-SS) is designed to co-condense siMOF and miR21 into NCs in a multivalency-reinforced approach, and they are surface-decorated with carboxylated mannan (Man-COOH) to shield the positive surface charges and enhance the serum stability. The final MBSsm NCs are efficiently internalized by myocardial macrophages after systemic administration, wherein BPAE-SS is degraded into small segments by intracellular glutathione to promote the siMOF/miR21 release, finally provoking efficient gene silencing. Thus, cardiomyocyte protection and macro-phage modulation are realized via the combined effects of ROS scavenging, inflammation inhibition, and autophagy attenuation, which ameliorates the myocardial microenvironment and restores the cardiac function via positive cellular crosstalk. This study renders promising solutions to address the multiple systemic barriers against in vivo nucleic acid delivery, and it also offers new options for IR injury by manipulating multiple reciprocal bio-reactions.

关键词： Myocardial ischemia-reperfusion(IR)injury Reduction-responsive branched poly(β-amino ester) siRNA/miRNA delivery Anti-inflammation Microenvironment remodeling

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