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甲状腺功能障碍与膝关节骨性关节炎因果关系的双向两样本孟德尔随机化分析

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现代医学 2024年第8期52卷 1159-1168页

作者：黄为廖建辉陈顺德吕武荣湖南省永州市中医医院骨伤科湖南永州425000 湖南省中医药研究院附属医院骨伤科湖南长沙410000

目的:使用孟德尔随机化(MR)分析甲状腺功能障碍(包括甲状腺功能亢进和甲状腺功能减退)与膝关节骨性关节炎(KOA)之间的相关性。方法:从布里斯托尔大学的IEU全基因组关联研究(GWAS)数据库中选择甲状腺功能亢进、甲状腺功能减退与KOA的GWA... 详细信息

目的:使用孟德尔随机化(MR)分析甲状腺功能障碍(包括甲状腺功能亢进和甲状腺功能减退)与膝关节骨性关节炎(KOA)之间的相关性。方法:从布里斯托尔大学的IEU全基因组关联研究(GWAS)数据库中选择甲状腺功能亢进、甲状腺功能减退与KOA的GWAS数据。通过设置关联强度和消除连锁不平衡,筛选出最后作为工具变量(IVs)的单核苷酸多态性(SNPs)。在正向MR分析中,研究以甲状腺功能亢进和甲状腺功能减退作为暴露,分别获取了5个、28个SNPs作为IVs,以KOA作为结局。在反向MR分析中,以KOA作为暴露获取了6个SNPs作为IVs,以甲状腺功能亢进和甲状腺功能减退作为结局。双向MR分析将逆方差加权(IVW)作为主要分析方法,其他4种方法(Weighted Mode、Weighted Median、Simple Mode、MR-Egger)作为辅助分析,来评估甲状腺功能障碍与KOA之间的因果关系。同时还采用了异质性和多效性检验,并使用留一法分析评估结果的稳定性。结果:遗传预测的甲状腺功能亢进与KOA的风险增加相关(IVW:OR=1.048,95%CI 1.026~1.070,P<0.001),未发现甲状腺功能减退与KOA(IVW:OR=1.029,95%CI 0.983~1.077,P=0.221)以及KOA与甲状腺功能亢进(IVW:OR=0.748,95%CI 0.205~2.736,P=0.661)和甲状腺功能减退(IVW:OR=0.997,95%CI 0.646~1.539,P=0.989)存在因果关联。结论:甲状腺功能亢进与KOA之间存在因果关系,在甲状腺功能减退对KOA的研究及反向研究中并未发现因果关联,该研究结果需要进一步的实验室研究进行验证,以及未来更大样本量的研究提供证据支持。

关键词：孟德尔随机化甲状腺功能障碍膝关节骨性关节炎因果关系

Potential control of DNA self-assembly on gold electrode

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Chinese Science Bulletin 2002年第5期47卷 370-375页

作者： Cunwang Ge Yibin Tan jianhui liao Yu Zhang Haiqian Zhang Ning Gu Southeast Univ Natl Key Lab Mol & Biomol Elect Nanjing 210096 Peoples R China

The self-assembly monolayer (SAM) was prepared with 2-aminoethanethiol (AET) on the gold electrode. A new approach based on potential was first used to control DNA self-assembly covalently onto the SAM with the activation of l-ethyl-3(3-dimethylaminopropyl)-carbodiimide (EDC) and N-hydroxysulfosuccinimide (NHS). The influence of potential on DNA self-assembly was investigated by means of cyclic voltammetry (CV), AC impedance, Auger electron spectrometry (AES) and atomic force microscopy (AFM). The result proves that controlled potential can affect the course of DNA self-assembly. More negative potential can restrain the DNA self-assembly, while more positive potential can accelerate the DNA self-assembly, which is of great significance for the control of DNA self-assembly and will find wide application in the field of DNA-based devices.

关键词： DNA self-assembly controlled potential DNA-based device gold electrode.

A hybrid memory architecture supporting fine-grained data migration

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Frontiers of Computer Science 2024年第2期18卷 31-41页

作者： Ye CHI jianhui YUE Xiaofei liao Haikun LIU Hai JIN National Engineering Research Center for Big Data Technology and System Services Computing Technology and System LabCluster and Grid Computing LabSchool of Computer Science and TechnologyHuazhong University of Science and TechnologyWuhan 430074China Department of Computer Science Michigan Technological UniversityMichigan 49931USA

Hybrid memory systems composed of dynamic random access memory(DRAM)and Non-volatile memory(NVM)often exploit page migration technologies to fully take the advantages of different memory *** previous proposals usually migrate data at a granularity of 4 KB pages,and thus waste memory bandwidth and DRAM *** this paper,we propose Mocha,a non-hierarchical architecture that organizes DRAM and NVM in a flat address space physically,but manages them in a cache/memory *** the commercial NVM device-Intel Optane DC Persistent Memory Modules(DCPMM)actually access the physical media at a granularity of 256 bytes(an Optane block),we manage the DRAM cache at the 256-byte size to adapt to this feature of *** design not only enables fine-grained data migration and management for the DRAM cache,but also avoids write amplification for Intel Optane *** also create an Indirect Address Cache(IAC)in Hybrid Memory Controller(HMC)and propose a reverse address mapping table in the DRAM to speed up address translation and cache ***,we exploit a utility-based caching mechanism to filter cold blocks in the NVM,and further improve the efficiency of the DRAM *** implement Mocha in an architectural *** results show that Mocha can improve application performance by 8.2%on average(up to 24.6%),reduce 6.9%energy consumption and 25.9%data migration traffic on average,compared with a typical hybrid memory architecture-HSCC.

关键词： non-volatile memory hybrid memory system data migration fine-grained caching

Deep-learning-based methods for super-resolution fluorescence microscopy

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Journal of Innovative Optical Health Sciences 2023年第3期16卷 85-100页

作者： jianhui liao Junle Qu Yongqi Hao Jia Li Shenzhen Key Laboratory of Photonics and Biophotonics Key Laboratory of Optoelectronic Devices and Systems of Ministry of Education and Guangdong Province College of Physics and Optoelectronic Engineering Shenzhen University Shenzhen 518060P.R.China NARI Group Corporation(State Grid Electric Power Research Institute)NARI Technology Co. Ltd.Nanjing 211106P.R.China

The algorithm used for reconstruction or resolution enhancement is one of the factors affectingthe quality of super-resolution images obtained by fluorescence ***-learning-basedalgorithms have achieved stateof-the-art performance in super-resolution fluorescence micros-copy and are becoming increasingly *** firstly introduce commonly-used deep learningmodels,and then review the latest applications in terms of the net work architectures,the trainingdata and the loss ***,we discuss the challenges and limits when using deeplearning to analyze the fluorescence microscopic data,and suggest ways to improve the reliability and robustness of deep learning applications.

关键词： Super-resolution fuorescence microscopy deep learning convolutional neural net-work generative adversarial network image reconstruction

The Directien and Patb ef China＇s Industrial Upgrading

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Qiu Shi 2012年第2期4卷 138-139页

作者： Li Gang liao jianhui Xiang Yini

Research on the Reform of Mixed Ownership by Natural Monopoly Enterprises in Developed Countries

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Research on the Reform of Mixed Ownership by Natural Monopol...

基于吡嗪连接的石墨烯电极单分子场效应晶体管

作者： Xiaobin Lin jianhui liao Haiyun Song Hanxiong Xiao State Grid Energy Research Institute CO. LTD.

The paper finds that mixed ownership is an important form of natural monopoly industries to introduce private capital and promote industry development. At the same time, compared with other privatization reform models, mixed ownership also has its inherent shortcomings, so it needs a series of prerequisites and supporting conditions. China is vigorously pursuing mixed ownership reforms in natural monopoly industries such as power grids, oil and gas, and railways. However, as China has less experience in reforms in this area, it is necessary to study the reform experience of foreign natural monopoly industries to learn lessons.

关键词： mixed ownership mixed ownership reforms reform experience

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物理化学学报 2021年第10期37卷 167-174页

作者：孙汉涛廖建辉侯士敏北京大学电子学系纳米器件物理与化学教育部重点实验室北京100871 北京大学纳米科学与技术研究中心北京100871

在单分子结中,核心分子与电极之间的连接基团对器件的力学、电学特性有着重要影响。连接基团的力学强度影响着器件的稳定性而其电子耦合强度则影响着分子结的电导值和导电极性。两端带邻苯二胺基团的分子可以和石墨烯电极边缘的邻醌基... 详细信息

在单分子结中,核心分子与电极之间的连接基团对器件的力学、电学特性有着重要影响。连接基团的力学强度影响着器件的稳定性而其电子耦合强度则影响着分子结的电导值和导电极性。两端带邻苯二胺基团的分子可以和石墨烯电极边缘的邻醌基团发生缩合反应,生成基于吡嗪连接的分子结。我们实验制备了基于吡嗪连接的石墨烯电极单分子场效应晶体管(FET)并研究了其电学性质。我们发现分子组装后器件的产率可以达到26%,证明了吡嗪连接基团用于构建石墨烯电极单分子器件的可行性。通过测量器件的电学性质,我们发现吡嗪连接与石墨烯电极之间的耦合强度对单分子场效应晶体管的导电极性有着决定性的影响。具体而言,弱耦合时器件为核心分子的最高占据轨道起主导作用的p-型FET而强耦合时器件为核心分子的最低空轨道起主导作用的n-型FET。

关键词：分子电子学石墨烯电极吡嗪连接基团单分子场效应晶体管耦合强度

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网购与传统购物模式的比较分析

中国流通经济 2014年第10期28卷 99-106页

作者：廖建辉中国社会科学院研究生院北京市102488

近年来,网购在我国急速发展,成就斐然。与传统购物模式相比,网购能够降低社会商品的总体价格水平,增加社会商品需求总量。此外,网购的出现和成功是符合比较优势的;网购用户规模的扩大会强化网购的影响;当前我国消费者收入水平不高是网... 详细信息

近年来,网购在我国急速发展,成就斐然。与传统购物模式相比,网购能够降低社会商品的总体价格水平,增加社会商品需求总量。此外,网购的出现和成功是符合比较优势的;网购用户规模的扩大会强化网购的影响;当前我国消费者收入水平不高是网购成功的重要因素之一;网购的进一步发展有利于技术进步、制造业规模扩张及就业增长。

关键词：网购传统购物电商

A Scheme for Allocating Carbon Emission Permits on the Basis of Carbon Capital Stocks

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Social Sciences in China 2016年第4期37卷 76-92页

作者：李钢廖建辉 Liu Yi Institute of Industrial Economics Chinese Academy of Social Sciences State Grid Energy Research Institute

To combat climate change, scholars across the globe have proposed a variety of carbon reduction schemes. These schemes are based on either current or historical emissions. However, because of difficulty in reconciling the interests of developing and developed countries, they have not been widely accepted. This article introduces the idea of carbon capital stocks, in the belief that stocks of carbon capital have a great influence on today＇s quality of life for people in all countries, and hence can be used as a measure of the historical responsibilities each country should assume. Consulting the findings and data of previous research, we calculate the social stocks of cement, steel, copper, and aluminum of three nations （China, Japan and the U.S.） and define their carbon emission coefficients. Based on the above, we obtain the current carbon capital stocks contained in the material stocks of the three nations. The results show that although China＇s total stocks of carbon capital have outpaced those of the U.S. and Japan, in per capita terms its carbon stocks are only a third of those of the U.S. and Japan. Therefore, developed countries have a solid material foundation for accepting liability for historical greenhouse gas emissions; there is a clear chain of responsibility linking the citizens of developed countries to fulfillment of their nations＇ historical obligations. This article suggests that schemes for global carbon emission reduction cover two types of accounting： one is fair accounting, which is based on a nation＇s historical obligations and on differences in per capita carbon capital between nations, and the other is equal accounting, which considers each country＇s population and reflects the present state of equality, The strength of the article lies in its unambiguous theoretical grounding, which helps balance the interests of developed countries as against those of developing countries and facilitates global technical operation and transfers for a joint

关键词： carbon capital carbon emissions reduction climate change