Potential control of DNA self-assembly on gold electrode

作     者：Cunwang Ge Yibin Tan Jianhui Liao Yu Zhang Haiqian Zhang Ning Gu 

作者机构：Southeast Univ Natl Key Lab Mol & Biomol Elect Nanjing 210096 Peoples R China 

出 版 物：《Chinese Science Bulletin》 (中国科学通报)

年 卷 期：2002年第47卷第5期

页      面：370-375页

核心收录：

学科分类：0710[理学-生物学] 071010[理学-生物化学与分子生物学] 081704[工学-应用化学] 07[理学] 08[工学] 0817[工学-化学工程与技术] 

基　　金：This work was supported by the National Natural Science Foundation of China (Grant Nos. 69890220 and 60171005) the Natural Science Foundation of Jiangsu Province (China) (Grant Nos. BK99006 and BK2001131) the Promotional Foundation of the Ministry of 

主　　题：DNA self-assembly controlled potential DNA-based device gold electrode. 

摘      要：The self-assembly monolayer (SAM) was prepared with 2-aminoethanethiol (AET) on the gold electrode. A new approach based on potential was first used to control DNA self-assembly covalently onto the SAM with the activation of l-ethyl-3(3-dimethylaminopropyl)-carbodiimide (EDC) and N-hydroxysulfosuccinimide (NHS). The influence of potential on DNA self-assembly was investigated by means of cyclic voltammetry (CV), AC impedance, Auger electron spectrometry (AES) and atomic force microscopy (AFM). The result proves that controlled potential can affect the course of DNA self-assembly. More negative potential can restrain the DNA self-assembly, while more positive potential can accelerate the DNA self-assembly, which is of great significance for the control of DNA self-assembly and will find wide application in the field of DNA-based devices.