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Platinum nanoparticles supported MoS2 nanosheet for simultaneous detection of dopamine and uric acid

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Science China Chemistry 2016年第3期59卷 332-337页

作者： Jie Chao Xiaoyan Han Haofan Sun Shao Su Lixing Weng lianhui wang Key Laboratory for Organic Electronics&Information Displays Institute of Advanced MaterialsNational Syngerstic Innovation Center for Advanced MaterialsNanjing University of Posts&TelecommunicationsNanjing210023China College of Geography and Biological Information Nanjing University of Posts and TelecommunicationsNanjing210023China

Herein, platinum nanoparticles-decorated molybdenum disulfide （PtNPs@MoS2） nanocomposite has been synthesized via a microwave-assisted hydrothermal method, which was characterized by transmission electron microscopy （TEM） and powder X-ray diffraction （XRD）. This MoSz-based nanocomposite modified glass carbon electrode （PtNPs@MoSz/GCE） exhibited excellent electrocatalytic activity toward dopamine （DA） and uric acid （UA） due to their synergistic effect. Two well-defined oxidation peaks of DA and UA were obtained at PtNPs@MoS2/GCE with a large peak separation of 160 mV （DA-UA）, sug- gesting that the modified electrode could individually or simultaneously analyze DA and AA. Under the optimal conditions, the peak currents of DA and UA were linearly dependent on their concentrations in the range of 0.5-150 and 5-1000 gmol/L with detection limit of 0.17 and 0.98 gmol/L, respectively. The proposed MoSz-based sensor can also be employed to examine DA and UA in real samples with satisfactory results. Therefore, the PtNPs@MoS2 nanocomposite might offer a good possibil- ity for electrochemical sensing and other electrocatalytic applications.

关键词： molybdenum disulfide platinum nanoparticles dopamine uric acid

Recent advances in multi-metallic-based nanozymes for enhanced catalytic cancer therapy

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BMEMat(BioMedical Engineering Materials) 2024年第1期2卷 30-48页

作者： Mingjin Cui Bo Xu lianhui wang Key Laboratory for Organic Electronics and Information Displays and Jiangsu Key Laboratory for Biosensors Institute of Advanced Materials(IAM)Jiangsu National Synergetic Innovation Center for Advanced Materials(SICAM)School of Chemistry and Life SciencesNanjing University of Posts and TelecommunicationsNanjingChina

Nanozymes have emerged as a promising alternative to natural enzymes,effectively addressing natural enzymes'inherent *** and potential applications of nanozyme span across various fields,with catalytic tumor therapy being one prominent *** has sparked significant interest and exploration in the utilization of nanozymes for targeted cancer *** advancements in interdisciplinary research,nanotechnology,biotechnology,and catalytic technology have led to the emergence of multi-metallicbased nanozymes,which exhibit tremendous potential for further *** review focuses on investigating the synergistic effects of multimetallicbased nanozymes,aiming to enhance our understanding of their catalytic activities and facilitate their broader *** comprehensively survey the remarkable achievements in the synthesis,catalytic mechanisms,and the latest applications of multi-metallic-based nanozymes in cancer catalytic ***,we identify the current limitations and prospects of multi-metallic-based nanozymes in the development of new materials and the application of novel technologies,along with the potential challenges associated with catalytic cancer *** review underscores the significance of multi-metallic-based nanozymes and emphasizes the need for continued exploration as well as their potential impact on the development of novel materials and the realization of breakthroughs in catalytic tumor therapy.

关键词： cancer therapy multi-metallic nanomaterials nanozyme activities synergistic effects

急性后循环缺血性脑卒中患者睡眠状态变化与预后影响因素的研究

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中国全科医学 2025年第5期28卷 548-553页

作者：张萍淑薛晶邢爱君王连辉马倩符永山元小冬华北理工大学附属开滦总医院神经内科河北省唐山市063000 华北理工大学附属开滦总医院心内科河北省唐山市063000 河北省神经生物机能重点实验室河北省唐山市063000

背景脑卒中患者通常伴有睡眠状态紊乱失衡,这在临床治疗中极易被忽视,且目前针对睡眠状态是否对该类疾病预后产生影响的研究较少。目的探究急性后循环缺血性脑卒中患者睡眠状态变化与预后影响的因素。方法选取2019年12月—2023年12月在... 详细信息

背景脑卒中患者通常伴有睡眠状态紊乱失衡,这在临床治疗中极易被忽视,且目前针对睡眠状态是否对该类疾病预后产生影响的研究较少。目的探究急性后循环缺血性脑卒中患者睡眠状态变化与预后影响的因素。方法选取2019年12月—2023年12月在华北理工大学附属开滦总医院诊治的急性后循环缺血性脑卒中患者60例为病例组,根据患者出院时改良Rankin(mRS)评分,将病例组分为预后良好亚组45例,预后不良亚组15例。选取同时期无脑血管狭窄且无急性缺血性脑卒中患者52例作为对照组。收集患者一般及临床资料,比较病例组与对照组患者昼夜睡眠-觉醒节律、日间睡眠-觉醒节律、夜间睡眠-觉醒节律指标以及预后良好亚组与预后不良亚组梗死脑区分布的差异性。采用多因素Logistic回归分析探讨急性后循环缺血性脑卒中患者预后不良的影响因素。结果病例组睡眠呼吸暂停低通气指数(AHI)高于对照组(P<0.05)。病例组睡眠周期颠倒、日间睡眠增多、夜间入睡困难所占比例高于对照组(P<0.05)。病例组日间总睡眠时间、入睡后清醒时间、浅睡眠期、深睡眠期、非快速眼动(NREM)睡眠期、快速眼动(REM)睡眠期、REM睡眠期占比、深睡眠期占比高于对照组,NREM睡眠期占比、浅睡眠期占比低于对照组(P<0.05)。病例组夜间总睡眠时间、浅睡眠期、NREM睡眠期高于对照组(P<0.05)。预后不良亚组桥脑梗死占比高于预后良好亚组(P<0.05)。多因素Logistic回归分析结果显示,日间深睡眠期(OR=1.203,95%CI=1.032~1.401)、桥脑梗死(OR=16.497,95%CI=1.142~238.391)是急性后循环缺血性脑卒中预后不良的影响因素(P<0.05)。结论急性后循环缺血性脑卒中患者AHI增高,睡眠状态特征为睡眠周期颠倒、日间睡眠增多、夜间入睡困难,且日间深睡眠期、桥脑梗死是患者预后不良的影响因素。

关键词：卒中脑梗死,后循环睡眠状态预后病例对照研究影响因素分析

Rhodium-catalyzed oxidative homologation of N-pyrimidyl indolines with alkynes via dual C—H activation: Facile synthesis of benzo[g] indolines

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Chinese Chemical Letters 2018年第6期29卷 907-910页

作者： lianhui wang Dan Xiong Lianghua Jie Chudan Yu Xiuling Cui Engineering Research Center of Molecular Medicine Ministry of Education Key Laboratory of Fujian Molecular Medicine Key Laboratory of Xiamen Marine and Gene Drugs School of Biomedical Sciences Huaqiao University

We herein report a highly regioselective rhodium-catalyzed C6-and C7—H bond functionalization of indolines with alkynes by using 2-pyrimidine as a directing group. Moreover, NH-free benzo[g]indole unit could be obtai... 详细信息

关键词： Rhodium Indoline Alkyne Benzo[g]indoline C—H activation

Self-assembly of Micrometer-long DNA Nanoribbons with Four Oligonucleotides

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Chinese Journal of Chemistry 2015年第5期33卷 522-526页

作者： Jie Chao Xiangyuan Ouyang Hongzhen Peng Shao Su lianhui wang Key Laboratory for Organic Electronics and Information Displays&Institute of Advanced Materials(IAM) Jiangsu National Synergetic Innovation Center for Advanced Materials(SICAM)Nanjing University of Posts&TelecommunicationsNanjingJiangsu 210023China Division of Physical Biology and Bioimaging CenterShanghai Synchrotron Radiation FacilityCAS Key Laboratory of Interfacial Physics and TechnologyShanghai Institute of Applied PhysicsChinese Academy of SciencesShanghai 201800China

DNA nanostructures have found widespread applications in areas including nanoelectronics and ***,traditional DNA origami needs a long single-stranded virus DNA and hundreds of short DNA strands,which make this method complicated and ***,we present a protocol for the assembly of DNA nanoribbons with only four *** nanoribbons with different dimensions were successfully assembled with a 96-base scafford strand and three short *** biotinylated nanoribbons could also be decorated with *** approach suggests that there exist great design spaces for the creation of simple nucleic acid nanostructures which could facilitate their application in plasmonic or drug delivery.

关键词： self-assembly DNA origami nanoribbons

Synthesis of 2-trifluoromethylquinolines through rhodium-catalysed redox-neutral[3+3]annulation between anilines and CF_(3)-ynones using traceless directing groups

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Organic Chemistry Frontiers 2022年第2期9卷 413-419页

作者： Haichao Huang Hailong wang Chao Gong Zhenjing Zhuang Wenmin Feng Si-Hai Wu lianhui wang School of Medicine Huaqiao UniversityQuanzhou362021P.R.China

Rhodium-catalysed regioselective redox-neutral[3+3]-cycloaddition of anilines with CF_(3)-ynones was achieved via a traceless directing group strategy.A variety of substituted 2-trifluromethylquinoline compounds were ... 详细信息

关键词： properties. aniline neutral

Synthesis, Structural Characterization and Reactivity of a Bis（phosphine）（silyl） Platinum（ll） Complex

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Chinese Journal of Chemistry 2015年第10期33卷 1206-1210页

作者： Yonghua Li Wenjin Zeng Wenyong Lai Shigeru Shimada Shi wang lianhui wang Wei Huang Key Laboratory for Organic Electronics and Information Displays & Institute of Advanced Materials (IAM) Jiangsu National Synergetic Innovation Center for Advanced Materials (S1CAM) Nanjing University of Posts & Telecommunications Nanjing Jiangsu 210023 China Research Institute for Innovation in Sustainable Chemistry National Institute of Advanced Industrial Science and Technology (AIST) Tsukuba Central 5 l-l-l Higashi Tsukuba Ibaraki 305-8565 Japan

Treatment of 1,2-C6H4（SiH3）（SiH3）（1） with Pt（dmpe）（PEt3）2 （dmpe=Me2PCHeCH2PMe2） in the ratio of 1 ： 1 leads to the complex {1,2-C6H4（SiH2）（SiH2）}PtH （dmpe）（2）, which can react with proton organic reagent bearing hydroxy group with low steric hindrance to form a tetra-alkoxy substituted silyl platinum（II） compound （3）. Com- pounds 2 and 3 are the very rare examples of silyl transition-metal complexes derived from this chelating hydrosi- lane ligand. To the best of our knowledge, there are only 6 examples of silyl metal complexes prepared from this ligand with such structural features registered in the Cambridge Structural Database, among them, only one silyl platinum（II） compound is presented. The structures of complexes 2 and 3 were unambiguously determined by mul- tinuclear NMR spectroscopic studies and single crystal X-ray analysis.

关键词： silyl chelating platinum multinuclear NMR

Phosphine-phosphonium ylides as ligands in palladium-catalysed C2-H arylation of benzoxazoles

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Chinese Chemical Letters 2020年第12期31卷 3250-3254页

作者： Zhenyu Yao Xing Lin Remi Chauvin lianhui wang Emmanuel Gras Xiuling Cui Engineering Research Centre of Molecular Medicine of Ministry of Education Key Laboratory of Fujian Molecular MedicineKey Laboratory of Precision Medicine and Molecular Diagnosis of Fujian UniversitiesKey Laboratory of Xiamen Marine and Gene DrugsSchool of Biomedical SciencesHuaqiao UniversityXiamen 361021China Laboratory of Coordination Chemistry(LCC) CNRS&Universite'de Toulouse(UPSINP)Toulouse 31077 Cedex 4France

As balanced electron-rich P,C-chelating ligands,phosphine-phosphonium-ylides are considered for their ability to in situ promote palladium-catalysed direct C(sp^2)—H *** methyl phosphonium salts of 2,2’-bis(diphenylphosphino)-1,1’-binaphtyl("methyl-BINAPIUM")as ylide precursors under optimized reaction conditions,arylation of benzoxazole was found to proceed in moderate to high yield to give functional 2-aryl benzoxazoles.A strong anion effect of the non-salt free ylide was evidenced(TfO^->I^->PF6^-≈salt-free).This first example of phosphonium ylides as ligands in catalytic C-H activation extends the prospect of their general implementation in homogeneous transition metal catalysis.

关键词： Electron-rich Ligands Phosphine-phosphonium-ylides Benzixazole C-H activation

Ingeniously designed Ni-Mo-S/ZnIn_(2)S_(4) composite for multi-photocatalytic reaction systems

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Chinese Chemical Letters 2022年第3期33卷 1468-1474页

作者： Jing Chen Yumei Tang Shihao wang Lingbin Xie Cheng Chang Xiaolei Cheng Mingming Liu Longlu wang lianhui wang College of Electronic and Optical Engineering&College of Microelectronics Jiangsu Province Engineering Research Center for Fabrication and Application of Special Optical Fiber Materials and DevicesNanjing University of Posts and TelecommunicationsNanjing 210023China State Key Laboratory of Organic Electronics and Information Displays&Jiangsu Key Laboratory for Biosensors Institute of Advanced Materials(IAM)&Institute of Flexible Electronics(Future Technology)Nanjing University of Posts and TelecommunicationsNanjing 210023China

Molybdenum disulfide (MoS_(2)) with low cost, high activity and high earth abundance has been found to be a promising catalyst for the hydrogen evolution reaction (HER), but its catalytic activity is considerably limited due to its inert basal planes. Here, through the combination of theory and experiment, we propose that doping Ni in MoS_(2) as catalyst can make it have excellent catalytic activity in different reaction systems. In the EY/TEOA system, the maximum hydrogen production rate of EY/Ni-Mo-S is 2.72 times higher than that of pure EY, which confirms the strong hydrogen evolution activity of Ni-Mo-S nanosheets as catalysts. In the lactic acid and Na_(2)S/Na_(2)SO_(3) systems, when Ni-Mo-S is used as co-catalyst to compound with ZnIn_(2)S_(4) (termed as Ni-Mo-S/ZnIn_(2)S_(4)), the maximum hydrogen evolution rates in the two systems are 5.28 and 2.33 times higher than those of pure ZnIn_(2)S_(4), respectively. The difference in HER enhancement is because different systems lead to different sources of protons, thus affecting hydrogen evolution activity. Theoretically, we further demonstrate that the Ni-Mo-S nanosheets have a narrower band gap than MoS_(2), which is conducive to the rapid transfer of charge carriers and thus result in multi-photocatalytic reaction systems with excellent activity. The proposed atomic doping strategy provides a simple and promising approach for the design of photocatalysts with high activity and stability in multi-reaction systems.

关键词： Molybdenum disulfide(MoS_(2)) Ni-Mo-S nanosheets Multi-reaction systems Hydrogen evolution reaction(HER) Atomic doping strategy