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A Network Pharmacology-Based Study on Antidepressant Effect of Salicornia europaea *** with Experimental Support in Chronic Unpredictable Mild Stress Model Mice

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Chinese Journal of Integrative Medicine 2022年第4期28卷 339-348页

作者： SUN Dan-chen WANG Ran-ran XU Hao zhu Xue-hui SUN Yan QIAO Shi-qing QIAO Wei Tianjin Key Laboratory on Technologies Enabling Development of Clinical Therapeutics and Diagnostics School of PharmacyTianjin Medical UniversityTianjin300070China

Objective:To investigate the pharmacodynamic material basis,mechanism of actions and targeted diseases of Salicornia europaea L.(SE)based on the network pharmacology method,and to verify the antidepressant-like effect of the SE extract by pharmacological ***:Retrieval tools including Chinese medicine(CM),PubMed,PharmMapper,MAS 3.0 and Cytoscape were used to search the components of SE,predict its targets and related therapeutic diseases,and construct the"Component-TargetPathway"network of SE for central nervous system(CNS)***,protein-protein interaction(PPI)network,Kyoto Encyclopedia of Genes and Genomes(KEGG)and Gene Ontology(GO)function annotation of depression-related targets were analyzed to predict the antidepressant mechanism of *** unpredictable mild stress(CUMS)model was used to construct a mouse model with depression-like *** the animals were randomly divided into 6 groups(n=10)including the normal group(nonstressed mice administered with distilled water),the CUMS group(CUMS mice administered with distilled water),the venlafaxine group(CUMS mice administered with venlafaxine 9.38 mg/kg),SE high-,medium-,and low-dose groups(CUMS mice administered with SE 1.8,1.35 and 0.9 g/kg,respectively).Then some relevant indicators were determined for experimental verification by the forced swim test(FST),the tail suspension test(TST)and open-field test(OFT).Dopamine(DA)concentration in hippocampus and cerebral cortex,IL-2 and corticosterone(CORT)levels in blood,and nuclear factor E2 related factor 2(Nrf2),kelch-like epichlorohydrin related protein 1(Keap1),NAD(P)H dehydrogenase[quinone]1(NQO1)and heme oxygenase-1(HO-1)levels in mice were measured by enzyme linked immunosorbent assay(ELISA)and Western blot respectively to explore the possible ***:The"target-disease"network diagram predicted by network pharmacology,showed that the potential target of SE involves a variety of CNS diseases,among which depression ac

关键词： Salicornia europaea L. network pharmacology tail suspension test forced swim test depression

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A Scheme of Interferometrie Measurement of an Atomic Wave Function

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Chinese Physics Letters 2000年第3期17卷 165-167页

作者： LIU Zheng-Dong zhu Shi-Yao LIN Yu ZENG liang PAN Qin-Min Department of Physics Zhejiang UniversityHangzhou 310027 Department of Physics Hong Kong Baptist UniversityHong Kong Institute of Polymer Science and Engineering Zhejiang UniversityHangzhou 310027

A new method to measure an atomic wave function is *** effectively solves the problem of an initially random phase of a travelling-wave laser *** relationship between the measured data and the atomic wave function is ... 详细信息

关键词： beam. wave function

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Influence of mechanical reduction amount on internal quality of continuous casting billets by thermal and numerical simulation

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Journal of Iron and Steel Research International 2023年第6期30卷 1234-1243页

作者： Dan-qing Jiang Shu-jian Sun Han Wu Yang-jian Xu Fu-hai zhu Zhen-qiang Zhang Jiang Wang Zhong-ming Ren School of Materials Science and Engineering Shanghai UniversityShanghai 200444China State Key Laboratory of Advanced Special Steel Shanghai UniversityShanghai 200444China

With establishment of thermal and numerical simulation models,the influence of reduction amount on solidification structure,segregation and shrinkage porosity of continuous casting(CC)billets was *** thermal–mechanical coupled simulation results indicated that with an increase in reduction amount,the temperature in the central area decreases,and the reduction efficiency firstly increases and then decreases,reaching the maximum value at reduction amount of 6 *** analysis showed that increasing the reduction amount is beneficial for the refinement of central solidification ***,the internal cracks are more likely to appear at higher reduction *** X-ray computerized tomography results revealed that a higher reduction amount can significantly reduce the volume fraction and equivalent diameter of the central shrinkage porosities of CC billets and increase the sphericity of ***,the macrosegregation of carbon along the central line is improved as the reduction amount increases;while the reduction amount exceeds 8 mm,the segregation degree will not change any more.

关键词： Mechanical reduction Solidification structure Porosity Thermal simulation Continuous casting billet

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陕西佛坪国家级自然保护区生态环境保护成效评估

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绿色科技 2024年第10期26卷 186-191页

作者：陈原玉冀晓丽曹庆朱琳王兰宁杨丽陕西佛坪国家级自然保护区管理局陕西佛坪723400

2023年陕西佛坪国家级自然保护区(以下简称佛坪保护区)采用量化分析评估方式,对生物多样性保护和生态系统服务功能的综合成效进行评估。本次评估能够科学直观地反映佛坪保护区的保护成效,并促进生态环境质量持续改善和升级。结果表明:... 详细信息

2023年陕西佛坪国家级自然保护区(以下简称佛坪保护区)采用量化分析评估方式,对生物多样性保护和生态系统服务功能的综合成效进行评估。本次评估能够科学直观地反映佛坪保护区的保护成效,并促进生态环境质量持续改善和升级。结果表明:生态环境变化评分(E_(C))为69.38,评估等级变好(65≤E_(C)<85);生态环境状况评分(E_(S))为96.75,等级为I级(E_(S)≥85),总体判定为优。基于评估结果,提出了运用先进技术、加大人才培养等对策。以期为自然保护区生态环境保护成效评估提供现实案例,并为今后同类型自然保护区生态环境保护提供参考。

关键词：佛坪国家级自然保护区生物多样性生态系统服务生态环境保护成效

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Modification of acidity of Mo-Fe/HZSM-5 zeolite via argon plasma treatment

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Frontiers of Chemical Science and Engineering 2008年第1期2卷 55-58页

作者： Xinli zhu Kailu YU Dangguo CHENG Yueping ZHANG qing XIA Changjun LIU Key Laboratory for Green Chemical Technology School of Chemical Engineering and TechnologyTianjin UniversityTianjin 300072China Department of Chemistry Tianjin UniversityTianjin 300072China

TheNH_(3)-TPDcharacterization wasconducted to confirm that the acidity of Mo-Fe/HZSM-5 zeolite could be selectively modified via the glow discharge plasma *** plasma catalyst treatment could totally change the distribution of aromatic products with higher methane conversion compared to the untreated *** polycyclic aromatics such as anthracene,pyrene and phenanthrene were also produced over the plasma treated catalyst,in addition to benzene,toluene and naphthalene,which were normally obtained over the untreated catalyst.

关键词： methane aromatization plasma acidity Mo-Fe/HZSM-5 zeolite

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Chemically revised conducting polymers with inflammation resistance for intimate bioelectronic electrocoupling

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Bioactive Materials 2023年第8期26卷 24-51页

作者： Sihao Qian Hsing-An Lin Qichao Pan Shuhua Zhang Yunhua Zhang Zhi Geng qing Wu Yong He Bo zhu State Key Laboratory for Modification of Chemical Fibers and Polymer Materials College of Materials Science and EngineeringDonghua UniversityShanghai201620China School of Materials Science and Engineering&Shanghai Engineering Research Center of Organ Repair Shanghai UniversityShanghai200444China Innovation Center for Textile Science and Technology Donghua UniversityShanghai201620China

Conducting polymers offer attractive mixed ionic-electronic conductivity,tunable interfacial barrier with metal,tissue matchable softness,and versatile chemical functionalization,making them robust to bridge the gap between brain tissue and electronic *** review focuses on chemically revised conducting polymers,combined with their superior and controllable electrochemical performance,to fabricate long-term bioelectronic implants,addressing chronic immune responses,weak neuron attraction,and long-term electrocommunication instability ***,the promising progress of zwitterionic conducting polymers in bioelectronic implants(≥4 weeks stable implantation)is highlighted,followed by a comment on their current evolution toward selective neural coupling and reimplantable ***,a critical forward look at the future of zwitterionic conducting polymers for in vivo bioelectronic devices is provided.

关键词： Bioelectronic Conducting polymer Zwitterion Antifouling Inflammation resistance

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Pancreatic cancer with ovarian metastases: A case report and review of the literature

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World Journal of Clinical Cases 2020年第21期8卷 5380-5388页

作者： Shun-Da Wang liang zhu Huan-Wen Wu Meng-Hua Dai Yu-Pei Zhao Department of General Surgery Peking Union Medical College HospitalChinese Academy of Medical Sciences&Peking Union Medical CollegeBeijing 100730China Department of Radiology Peking Union Medical College HospitalChinese Academy of Medical Sciences&Peking Union Medical CollegeBeijing 100730China Department of Pathology Peking Union Medical College HospitalChinese Academy of Medical Sciences&Peking Union Medical CollegeBeijing 100730China

BACKGROUND Pancreatic cancer with ovarian metastases is rare and easily *** patients are first diagnosed with ovarian *** report a rare case of ovarian metastases secondary to pancreatic *** also review the literature to analyze the clinical characteristics of,diagnostic methods for,and perioperative management strategies for this rare *** SUMMARY A 48-year-old woman with an abdominal mass presented to our *** tomography revealed lesions in the pancreas and lower *** examination and histological investigation of biopsy specimens revealed either an ovarian metastasis from a pancreatic neoplasm or two primary tumors,with metastasis strongly *** patient simultaneously underwent distal pancreatectomy plus splenectomy by a general surgeon and salpingo-oophorectomy with hysterectomy by a *** examination of the surgical specimen revealed a pancreatic adenocarcinoma(intermediate differentiation,mucinous)and a metastatic mucinous adenocarcinoma in the *** For this rare tumor,surgical resection is the most effective treatment,and the final diagnosis depends on tumor pathology.

关键词： Pancreas Ovary Pancreatic cancer Ovarian cancer Metastasis Case report

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Research on Two Types of Buffer Zone Impact on Surrounding Office Space Environment in Winter in Cold Climate Zone—a Fieldwork in Architectural Design Institute Building of Tsinghua University,Beijing

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Journal of Harbin Institute of Technology(New Series) 2014年第5期21卷 33-39页

作者： Ye-Hao Song Jun-Jie Li Ning zhu Jia-liang Wang Shi-Meng Hao School of Architecture Tsinghua University Key Laboratory of Eco Planning & Green Building Ministry of EducationTsinghua University

Building buffer zone space is not only one of essential approaches for better mental quality of interior building space, but also an important factor that may influence interior thermal comfort and energy consumption. This study aims to analyze regulative advantages of buffer zone to the surrounding functional spaces. Based on a fieldwork test in a typical office building in cold climate zone in Beijing,China,the monitor data show interior physical performance in the Winter. The research selects two types of different buffer zones in the same building. One is a south-faced greenhouse which has large dimension with plenty of vegetation,and the other is a simple atrium in the middle of five floor building with mount of skylights. The factors and their influence to surrounding functional spaces and the whole building are found out from the comparisons of collected data by floor to floor monitor test on both buffer zones at the same time. The comparisons of two types of buffer zones conclude that the greenhouse is more effective to air quality regulation but not so clearly wellperformed to thermal buffering as expected due to the dominate active central heating in the Winter. This fieldwork test results for building performance can be helpful for both architects and engineers in the early phase of sustainable design.

关键词： public building buffer zone building performance fieldwork test space effect

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Phylogenetic conservatism in threatened species responses to climate change differs between functional types in the Gongga Mountains of China

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Journal of Mountain Science 2023年第12期20卷 3568-3581页

作者： ZU Kui-ling Nawal SHRESTHA JIANG Yong JIA Guo-qing PENG Shi-jia zhu Xiang-yun WANG Zhi-heng Key Laboratory of National Forestry and Grassland Administration on Forest Ecosystem Protection and Restoration of Poyang Lake Watershed College of ForestryJiangxi Agricultural UniversityNanchang 330045China Institute of Ecology and Key Laboratory for Earth Surface Processes of the Ministry of Education College of Urban and Environmental SciencesPeking UniversityBeijing 100871China State Key Laboratory of Plant Diversity and Specialty Crops Institute of BotanyChinese Academy of SciencesBeijing 100093China State Key Laboratory of Herbage Improvement and Grassland Agro-ecosystems College of EcologyLanzhou UniversityGansuLanzhou 730000China Administration of Gongga Mountain National Nature Reserve Kangding 626000China

Climate change has become one of the most critical threats to global ***,whether phylogenetically related species respond to climate change in similar ways remains *** answer to this question is crucial for understanding the impacts of climate change and the conservation on the tree of *** integrating species distribution models with a molecular phylogeny of 50 threatened plant species from one of the global biodiversity hotspots,Gongga Mountains(***)in southwest China,we evaluated the responses of threatened plant species to future climate change,and estimated whether species responses are phylogenetically *** reconstruction was used to calculate the phylogenetic distance and null model to verify the reliability of the *** found that correlations between responses of different species to future climate change decreased with the increase in their phylogenetic distance in the monocotyledonous or herbaceous species,but not in the dicotyledonous and woody *** results suggested that the responses of herbaceous and monocotyledonous threatened species in *** to future climate change tend to be phylogenetically conserved,while the responses of woody and dicotyledonous threatened species are *** study provides evidence for the existence of phylogenetically non-random extinction in the monocotyledonous herbs in *** and highlights the importance of integrating phylogenetic information and evolutionary history into conservation *** also provide theoretical basis and technical support for designing effective conservation schemes for the protection of biodiversity under anthropogenic climate change.

关键词： Conservation strategies Climate suitability Mountain plants Phylogenetic distance Species distribution models

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Expression of insulin-like growth factor binding protein-2 in gastric carcinoma and its relationship with cell proliferation

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World Journal of Gastroenterology 2006年第39期12卷 6285-6289页

作者： liang-Hui Shi Xiao-Qun zhu Guo-Hai Zhao Ya-Bin Xia Yi-Sheng Zhang Department of Surgery Affiliated Yijishan Hospital. Wanna-n Medical College Wuhu 241001 Anhui Province China Departmentof Pathology Wannan Medical College Wuhu 241001 Anhui Province China

AIM: To investigate the expression of insulin-like growth factor binding protein-2 (IGFBP-2) in gastric carcinoma and its clinical significance and to explore its relationship with cell proliferation. METHODS: Expressions of IGFBP-2 and Ki-67 in 118 cases of gastric carcinoma and 40 cases of normal gastric mucosa were detected by EnVision immunohistochemical technique. RESULTS: Expression of IGFBP-2 in gastric carcinoma was higher than that in normal gastric mucosa (P 0.05). Expression of IGFBP-2 in advanced gastric carcinoma was higher than that in early gastric carcinoma (P < 0.05). Expression of IGFBP-2 in gastric carcinoma with lymph node metastasis was higher than that without lymph node metastasis (P < 0.01). IGFBP-2 expression was a positively related to the clinical stage of gastric carcinoma (P < 0.01). There was a positive correlation between IGFBP-2 and Ki-67 (P < 0.05). CONCLUSION: IGFBP-2 may be involved in carcino- genesis and progression of gastric carcinoma by promoting cell proliferation.

关键词： Gastric carcinoma Insulin-like growth factor binding protein Cell proliferation Immunohistochemistry

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