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Dual template-induced construction of three-dimensional porous SiO2/NC/Co-CNTs heterostructure with highly dispersed active sites for efficient oxygen evolution reaction

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Tungsten 2024年第3期6卷 585-595页

作者： Hai-Qi Zhang Xiao-Jun Zeng qing-qing Zhang Zu-liang Zhang Chu-Long Jin Rong-Hai Yu School of Materials Science and Engineering Jingdezhen Ceramic University School of Materials Science and Engineering Beihang University

The development and exploration of efficient and economical electrocatalysts for oxygen evolution reaction（OER） represents the main bottleneck to unlocking a sustainable energy scenario based on elec trocataly tic water *** scale integration of three-dimensional（3D） porous heterostructure with highly dispersed active sites and good structural stability is ***,a dual template route is developed to construct the 3D porous SiO2/nitrogen-doped carbon（NC）/Co-carbon nano tubes（CNTs） hetero ***,the hard template（SiO2nano spheres） contributes to 3D porous structure,increases the specific surface area,and promotes the contact area of the *** the same time,the soft template（basic zinc carbonate） can control the growth of 1D CNTs and facilitate the exposure of the active ***,3D porous SiO2/NC/Co-CNTs hetero structure inherits highly dispersed Co nanoparticles coated by *** conductive channels and abundant N hetero atoms doping are reasonably constructed by a dual template ***,SiO2/NC/Co-CNTs catalyst provides an extraordinary activity for the OER in alkaline media,with a low overpotential of 298 mV at a current density of 10 mA·***,SiO2/NC/Co-CNTs hetero structure enables excellent long-term durability with a 10 mV decay in overpotential after 3000 cyclic voltammetry cycles,and 97% remain in current density over 20 *** is believed that this dual template strategy can provide a new and simple way to construct a highly dispersed active site in electrocatalysts.

关键词： Dual template High dispersion Porous heterostructure Conductive channels Oxygen evolution reaction

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RNF26 up-regulates PD-L1 to regulate the cancer immune response in ccRCC

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BIOCELL 2024年第9期48卷 1323-1330页

作者： WEIGANG REN JING LI RUIJIANG ZENG liang zhu Department of Urology Hunan Provincial People’s HospitalHunan Normal UniversityChangsha410000China Department of Rehabilitation The Second Xiangya HospitalCentral South UniversityChangsha410000China Department of Urology The Second Xiangya HospitalCentral South UniversityChangsha410000China Uro-Oncology Institute of Central South University Changsha410000China

Background:Clear cell renal cell carcinoma(ccRCC)stands as the most prevalent form of kidney cancer,accounting for a significant proportion of malignancies affecting the *** is well known as a type of tumour with *** checkpoint inhibitors(ICIs)aim to enhance the anticancer immune response in ccRCC by blocking programmed cell death 1 ligand 1/programmed death 1(PD-L1/PD-1)*** a previous study,we showed that RING finger protein 26(RNF26)degrades chromobox 7(CBX7)to activate the tumor necrosis factor(TNF)in ***:We analyzed The Cancer Genome Atlas(TCGA)database using the R package ESTIMATE and found that RNF26 was significantly associated with ccRCC immune *** relationship between RNF26 and the PD1 checkpoint signaling pathway was detected by enrichment *** addition,the molecular mechanism of RNF26 up-regulation of PD-L1 was detected by transcriptome sequencing,RT-qPCR,and Western Blot in ccRCC cell lineages 786-O and A498 *** transplantation tumor experiments in C57BL/6 mice were used to test the efficacy of anti-PD1 and knockdown of RNF26 in ***:We showed that RNF26 suppressed the immune response to ***,we revealed that RNF26 activated the PD-1 checkpoint pathway to suppress the immune response to ccRCC,possibly via the CBX7/PD-L1 ***:The suggestion derived from our results is that targeting RNF26 holds the potential to amplify the efficacy of anticancer immunotherapies in the treatment of ccRCC.

关键词： Clear cell renal cell carcinoma Ring finger protein 26 chromobox 7 PD-L1

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Realtime observation of “spring fracture” like AlGaN/GaN HEMT failure under bias

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Science China(Information Sciences) 2024年第1期67卷 303-305页

作者： qing zhu Zhenni WANG Yuxiang WEI Ling YANG Xiaoli LU Jiejie zhu Peng ZHONG Yimin LEI Xiaohua MA School of Microelectronics Xidian University State Key Discipline Laboratory of Wide Bandgap Semiconductor Technology Xidian University School of Advanced Materials and Nanotechnology Xidian University

The AlGaN/GaN HEMTs have been considered promising candidates for high-frequency and high-power applications,while the reliability issues greatly limit the commercialization of AlGaN/GaN HEMTs. In the past, the research on the reliability of devices was often based on Raman spectroscopy, cathodoluminescence, and TEM after failure of the devices, which is often considered to be the laborious and complicated “archaeological” kind of analysis [1].

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Engineering of geometrical configurations in dual-atom catalysts for electrocatalytic applications

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Journal of Energy Chemistry 2024年第7期94卷 273-287页

作者： Tao Zhang Yifan Liu liang Xue Jingwen Sun Pan Xiong Junwu zhu Key Laboratory for Soft Chemistry and Functional Materials of Ministry Education School of Chemistry and Chemical EngineeringNanjing University of Science and TechnologyNanjing210094JiangsuChina

Geometrical configurations play a crucial role in dual-atom catalysts(DACs)for electrocatalytic *** progress has been made to design DACs electrocatalysts with various geometri-cal configurations,but in-depth understanding the relationship between geometrical configurations and metal-metal interaction mechanisms for designing targeted DACs is still *** this review,the recent progress in engineering of geometrical configurations of DACs is systematically *** on the polarity of geometrical configuration,DACs can be classified into two different types that are homonuclear and heteronuclear ***,with regard to the geometrical configurations of the active sites,homonuclear DACs are identified into adjacent and bridged configurations,and heteronuclear DACs can be classified into adjacent,bridged,and separated ***,metal-metal interactions in DACs with different geometrical configurations are ***,the applications of DACs in different electrocatalytic reactions are discussed,including the oxygen reduction reaction(ORR),oxygen evolution reaction(OER),hydrogen evolution reaction(HER),and other ***,the future challenges and perspectives for advancements in DACs are *** review aims to provide inspiration for the design of highly effcient DACs towards energy relatedapplications.

关键词： Dual-atom catalysts Geometrical configurations Homonuclear Heteronuclear Electrocatalysis

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Gut flora in multiple sclerosis:implications for pathogenesis and treatment

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Neural Regeneration Research 2024年第7期19卷 1480-1488页

作者： Weiwei Zhang Ying Wang Mingqin zhu Kangding Liu Hong-liang Zhang Department of Neurology the First Hospital of Jilin UniversityJilin UniversityChangchunJilin ProvinceChina Department of Life Sciences National Natural Science Foundation of ChinaBeijingChina

Multiple sclerosis is an inflammatory disorder chara cterized by inflammation,demyelination,and neurodegeneration in the central nervous *** current first-line therapies can help manage symptoms and slow down disease progression,there is no cure for multiple *** gut-brain axis refers to complex communications between the gut flo ra and the immune,nervous,and endocrine systems,which bridges the functions of the gut and the *** in the gut flora,termed dys biosis,can lead to systemic inflammation,leaky gut syndrome,and increased susceptibility to *** pathogenesis of multiple sclerosis involves a combination of genetic and environmental factors,and gut flora may play a pivotal role in regulating immune responses related to multiple scle *** develop more effective therapies for multiple scle rosis,we should further uncover the disease processes involved in multiple sclerosis and gain a better understanding of the gut-brain *** review provides an overview of the role of the gut flora in multiple scle rosis.

关键词： gut flora gut-brain axis multiple sclerosis pathogenesis treatment

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Impact of mica on geotechnical behavior of weathered granitic soil using macro and micro investigations

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Journal of Rock Mechanics and Geotechnical Engineering 2024年第6期16卷 2250-2266页

作者： Xianwei Zhang Xinyu Liu Haodong Gao Gang Wang Ran An zhu liang State Key Laboratory of Geomechanics and Geotechnical Engineering Institute of Rock and Soil MechanicsChinese Academy of SciencesWuhan430071China School of Civil and Hydraulic Engineering Huazhong University of Science and TechnologyWuhan430074China College of Urban Construction Wuhan University of Science and TechnologyWuhan430065China University of Chinese Academy of Sciences Beijing100049China Guangzhou Urban Planning&Design Survey Research Institute Guangzhou510000China Guangdong Enterprise Key Laboratory for Urban Sensing Monitoring and Early WarningGuangzhou510000China

The micaceous weathered granitic soil(WGS)is frequently encountered in civil engineering worldwide,unfortunately little information is available regarding how mica affects the physico-mechanical behaviors of *** study prepares reconstituted WGS with different mica contents by removing natural mica in theWGS,and then mixes it with commercial mica *** geotechnical behavior as well as the microstructures of the mixtures are *** addition of mica enables the physical indices of WGS to be specific combinations of coarser gradation and high permeability but high Atterberg ***,high mica content in WGS was found to be associated with undesirable mechanical properties,including increased compressibility,disintegration,and swelling potential,as well as poor compactability and low effective frictional *** analysis indicates that the influence of mica on the responses of mixtures originates from the intrinsic nature of mica as well as the particle packing being formed *** exists in the mixture as stacks of plates that form a spongy structure with high compressibility and swelling *** among the plates give the soil high water retention and high Atterberg *** pores are also generated by soil particles with bridging packing,which enhances the permeability and water-soil interactions upon *** study provides a microlevel understanding of how mica dominates the behavior of WGS and provides new insights into the effective stabilization and improvement of micaceous soils.

关键词： Weathered granitic soil(WGS) Mica Microstructure Physical properties Mechanical properties Mechanism

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MTTSNet:Military time-sensitive targets stealth network via real-time mask generation

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Defence Technology（防务技术） 2024年第3期33卷 601-612页

作者： Siyu Wang Xiaogang Yang Ruitao Lu Zhengjie zhu Fangjia Lian qing-ge Li Jiwei Fan PLA Rocket Force University of Engineering Xi'an 710025China

The automatic stealth task of military time-sensitive targets plays a crucial role in maintaining national military security and mastering battlefield dynamics in military *** propose a novel Military Time-sensitive Targets Stealth Network via Real-time Mask Generation(MTTSNet).According to our knowledge,this is the first technology to automatically remove military targets in real-time from *** critical steps of MTTSNet are as follows:First,we designed a real-time mask generation network based on the encoder-decoder framework,combined with the domain expansion structure,to effectively extract mask ***,the ASPP structure in the encoder could achieve advanced semantic feature *** decoder stacked high-dimensional information with low-dimensional information to obtain an effective mask ***,the domain expansion module guided the adaptive expansion of mask ***,a context adversarial generation network based on gated convolution was constructed to achieve background restoration of mask positions in the original *** addition,our method worked in an end-to-end manner.A particular semantic segmentation dataset for military time-sensitive targets has been constructed,called the Military Time-sensitive Target Masking Dataset(MTMD).The MTMD dataset experiment successfully demonstrated that this method could create a mask that completely occludes the target and that the target could be hidden in real time using this *** demonstrated the concealment performance of our proposed method by comparing it to a number of well-known and highly optimized baselines.

关键词： Deep learning Military application Targets stealth network Mask generation Generative adversarial network

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Cycloastragenol induces apoptosis and protective autophagy through AMPK/ULK1/mTOR axis in human non-small cell lung cancer cell lines

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Journal of Integrative Medicine 2024年第4期22卷 503-514页

作者： Li-hua zhu Yu-pei liang Lian Yang Feng zhu Li-jun Jia He-gen Li Department of Oncology Longhua HospitalShanghai University of Traditional Chinese MedicineShanghai 200032China Cancer Institute of Traditional Chinese Medicine Longhua HospitalShanghai University of Traditional Chinese MedicineShanghai 200032China Department of Laboratory Medicine Huadong HospitalFudan UniversityShanghai 200237China

Objective:Studies have demonstrated that cycloastragenol induces antitumor effects in prostate,colorectal and gastric cancers;however,its efficacy for inhibiting the proliferation of lung cancer cells is largely *** study explores the efficacy of cycloastragenol for inhibiting non-small cell lung cancer(NSCLC)and elucidates the underlying molecular ***:The effects of cycloastragenol on lung cancer cell proliferation were assessed using an adenosine triphosphate monitoring system based on firefly luciferase and clonogenic formation ***-induced apoptosis in lung cancer cells was evaluated using dual staining flow cytometry with an annexin V-fluorescein isothiocyanate/propidium iodide *** elucidate the role of cycloastragenol in the induction of apoptosis,apoptosis-related proteins were examined using Western *** and Western blotting were used to determine whether cycloastragenol could induce autophagy in lung cancer *** techniques,including small interfering RNA technology,were used to investigate the underlying *** effects against lung cancer and biosafety of cycloastragenol were evaluated using a mouse subcutaneous tumor ***:Cycloastragenol triggered both autophagy and ***,cycloastragenol promoted apoptosis by facilitating the accumulation of phorbol-12-myristate-13-acetate-induced protein 1(NOXA),a critical apoptosis-related ***,cycloastragenol induced a protective autophagy response through modulation of the adenosine 5'-monophosphate-activated protein kinase(AMPK)/unc-51-like autophagy-activating kinase(ULK1)/mammalian target of rapamycin(mTOR)***:Our study sheds new light on the antitumor efficacy and mechanism of action of cycloastragenol in *** insight provides a scientific basis for exploring combination therapies that use cycloastragenol and inhibiting the AMPK/ULK1/mTOR pathway as a promising approach to

关键词： Non-small cell lung cancer Cycloastragenol Autophagy Apoptosis

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Celastrus orbiculatus Extract Inhibits Immune Inflammatory Thrombotic State of B-Lymphoma

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Chinese Journal of Integrative Medicine 2024年第11期30卷 1018-1026页

作者： zhu Miao SHI qing-qing NI Jun WU Wei SUN Xing SUN Mei XU Kai-lin LIU Yan-qing GU Jian GU Hao Department of Hematology Clinical Medical Col ege Yangzhou University Yangzhou Institute of Hematology Department of Hematology The Affiliated Hospital of Xuzhou Medical University Department of Oncology The Affiliated Hospital of Yangzhou University Yangzhou University Department of Neurology The Affiliated Brain Hospital of Nanjing Medical University

Objective:To investigate the inhibitory effect of Celastrus orbiculatus extracts（COE） on the proliferation of lymphoma cells and the immune regulation ability on inflammation and thrombophilia in ***:The 38B9 lymphoma cells were treated with COE（160μg/mL） and CTX（25 μmol/L）.The apoptosis rate and cell cycle of each group were detected by flow *** secretion of inflammatory factors,including interleukin（IL）-6,IL-10,and tumor necrosis factor α（TNF-α）,in cell supernatant was detected by enzyme-linked immunosorbent assay（ELISA）.In vivo,BALB/c mice were subcutaneously injected with 38B9 lymphoma cells to establish lymphoma ***(3 mg·kg-1·d-1) and CTX(40 mg-kg-1·d-1) were administered to the model mice,*** expression of plasma inflammatory factors（IL-6,IL-10 and TNF-α） and thrombus indexes,including D-dimer（D-D）,von Willebrand factor（vWF） and tissue factor（TF）,were detected by ELISA before tumor bearing（1 d）,after tumor formation（14 d） and after intervention（21 d）.PicoGreen dsDNA was used to detect the level of serum neutrophil extracellular traps（NETs）.Flow cytometry was used to detect the expression of platelet activation marker calcium-dependent lectin-like receptor 2（CLEC-2）.The tumor growth and survival of mice were ***:The 38B9 lymphoma cells were apoptotic after the intervention of COE and *** ratio of G2-M phase cells decreased in COE intervented cells compared with the control cells（P<0.05）,and S phase cells decreased in CTX intervented cells（P<0.05）.Also,the secretion level of IL-6 was significantly reduced after COE or CTX intervention（P<0.05）,and IL-10 was significantly increased（P<0.05）.Furthermore,the tumor mass was reduced,and the median survival time was longer in COE and CTX intervented tumor-bearing mice than in nonintervented *** significantly lower levels of TNF-α,IL-6,NETs,TF,DD and CLEC-2,as well as higher IL-10 were observed in COE and CTX treatment mice in comparision with the control mice（P

关键词： Celastrus orbiculatus extract immune regulation lymphoma murine lymphoma cells proliferation inhibition thrombotic state tumor inflammation

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Analyses on an electronic voltage transformer's failure by its resonance with very fast transient overvoltage and suppression

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High Voltage 2024年第1期9卷 150-162页

作者： Ruoyu Han Houda zhu qing Chen Hongbin Li Yue Tong Linshan Han Yang Jiao School of Electrical and Electronic Engineering Huazhong University of Science and TechnologyWuhanChina China Electric Power Research Institute WuhanChina School of Artificial Intelligence and Automation Huazhong University of Science and TechnologyWuhanChina

As voltage measuring devices are widely used in the high voltage power system with a primary-secondary-fusion structure,electronic voltage transformers are directly connected to the primary conductor and would face much more serious electromagnetic environments than general secondary *** a result,they would still experience failures even when general protection measures are adopted to suppress overvoltages'*** address this issue,an innovative method is proposed after analyses are conducted on the resonance between a transformer and an *** this method,an air-cored coil is installed in a transformer to artificially shift its natural frequency and to dodge the high-frequency dominant component of a transient overvoltage,avoiding the aforementioned resonance and suppressing the secondary *** addition,simulations and laboratory tests are conducted to prove this method's validity.

关键词： transient resonance mentioned

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