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Three new pyrrolizidine alkaloids derivatives from Liparis nervosa

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Chinese Chemical Letters 2016年第5期27卷 757-760页

作者： Shuai Huang De-Xin Zhong lian-hai shan Ye-Zi Zheng Zhi-Kuan Zhang Ya-Heng Bu Hong-Wen Ma Xian-Li Zhou School of Life Science and Engineering Southwest Jiaotong University

Three new pyrrolizidine alkaloids, nervosineⅦ（1）, nervosine Ⅷ（2） and nervosine IX （3） were isolated from the whole plant extract of Liparis nervosa. Their structures were elucidated by extensive spectroscopic analyses （including 1 D, 2D NMR, and HR-ESI-MS） and chemical methods. Compounds 1-3 were evaluated for their cytotoxic activity against A549, MCF-7and H460 human cancer cell lines.

关键词： Orchidaceae Liparis nervosa Pyrrolizidine alkaloids Nervogenic acid derivatives

Diterpenoid Alkaloids from Delphinium anthriscifolium

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Diterpenoid Alkaloids from Delphinium anthriscifolium

中国化学会第十一届全国天然有机化学学术会议

作者： lian-hai shan Ji-Fa Zhang Shuai Huang Xian-Li Zhou School of Life Science and Engineering Southwest Jiaotong University

＜正＞Delphinium is a large genus comprising 250 species and distributed in the temperate regions of the Northern *** 1 8 Delphinium species in China are used as folk medicines for treatment of rheumatoid arthritis an...

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Diterpenoid alkaloids from Delphinium tianshanicum ***

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中国化学会第十一届全国天然有机化学学术会议

作者： Ji-Fa Zhang lian-hai shan Shuai Huang Xian-Li Zhou School of Life Science and Engineering Southwest Jiaotong University

Delphinium tianshanicum *** herbaceous plant belonging to the family Ranunculaceae,is a species endemic to the Xinjiang of *** contains many diterpenoid alkaloids having biological activities such as anti-inflammatory,analgesic,anti-arrhythmia,antifungal,and cytotoxic *** studies have revealed that fifteen diterpene alkaloids were isolated and identified from the whole herb of ***,including deltaline,delcorine,tianshanisine,tianshanine,tianshanidine,6-dehydrodelcorine,delbruninol,delavaine A,delavaine B,blacknidine,lappaconitine,vakhmatine,dehydroeldelidine,ajacine and *** our further phytochemical investigation and resulted in isolation of 15 diterpenoid alkaloids,including five new C-diterpenoid alkaloids tianshanitine A-E(1-5)(Fig.1),along with ten known compounds,methyllycaconitine,shawurensine,delavaine,delavaine B,delsemine,delsemine B,tianshanisine,delcorine,6-deoxydelpheline,blacknidine were identified by comparison of their spectroscopic data with the literature *** A is the first reported natural diterpenoid alkaloid that containing a benzoyl group at C-1 *** B is a rare natural diterpenoid alkaloid that include a hydroxyl group at C-16 position.

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C19-diterpenoid Alkaloids from Aconitum apetalum

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C19-diterpenoid Alkaloids from Aconitum apetalum

中国化学会第十一届全国天然有机化学学术会议

作者： Ji-Fa Zhang lian-hai shan Shuai Huang Xian-Li Zhou School of Life Science and Engineering Southwest Jiaotong University

The genus Aconitum belongs to the family Ranunculaceae with over 300 species,widely distributed in the northern temperate zones and the mountainous regions of the subtropics,113 of which are Chinese endemic species .Aconitum species are plants with strong toxin due to the diterpenoid alkaloid *** alkaloids are neurotoxic agents,causing bradycardia,muscle-system spasms,hypotension and death by arrest of *** preparations have been used in vary diluted forms as cardiotonics,febrifuges,sedatives,and ***,Aconitum is very popular in homoeopathy and is included in many pharmaka .Aconitum apetalum is distributed in Xinjiang Uygur Autonomous region in China,and its chemical constituents were investigated for the first *** the present study,from the root of this plant,twelve new C-diterpenoid alkaloids,Apetaldines A-L(1-12)(Fig.1) were isolated,along with eight known alkaloids songorine,songomine,taurenine,cammaconine,acobretine E,8-O-ethylcammaconine,aconorine and deoxyaconitine by comparing spectroscopic data in the ***,dimer anthranilic acid derivatives group was found in diterpenoid alkaloid for the first time.

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高分子材料与金属激光微焊接实验与仿真分析

激光技术 2013年第6期37卷 760-765页

作者：陈玉娇郭钟宁连海山广东工业大学机电工程学院广州510006

为了更好地理解高分子材料与金属材料的激光微焊接机理,利用软件ANSYS建立高斯热源模型,对生物高分子材料聚对苯二甲酸乙二酯(PET)与医用金属材料纯钛的激光微焊接温度场进行了动态模拟;利用红外热像仪测定焊接过程瞬态最高温度变化,用... 详细信息

为了更好地理解高分子材料与金属材料的激光微焊接机理,利用软件ANSYS建立高斯热源模型,对生物高分子材料聚对苯二甲酸乙二酯(PET)与医用金属材料纯钛的激光微焊接温度场进行了动态模拟;利用红外热像仪测定焊接过程瞬态最高温度变化,用超景深数字显微镜测量实际焊接中焊缝宽度,其测量结果与仿真结果基本吻合;最后对温度场仿真结果进行了分析。结果表明,移动热源前方的等温线分布密集且温度梯度大,后方的等温线稀疏且温度梯度小;在垂直于焊缝中心不同位置的节点都存在着快速升温及相对缓慢的降温过程,同时,节点越靠近焊缝中心,温度变化越剧烈,所能达到的最高温度就越大。该结果证明了所建立的移动高斯面热源模型在激光微焊接PET/Ti温度场模拟中的适用性。

关键词：激光技术激光微焊接温度场有限元仿真与实验聚对苯二甲酸乙二酯医用纯钛

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微细超声工作台的设计与微振幅测量

振动与冲击 2015年第7期34卷 199-203页

作者：连海山郭钟宁张伟何俊峰韩睿聪广东工业大学机电工程学院广州510006

微细超声工作台是微细超声加工机床与微细超声振动辅助加工机床的关键零部件,其振幅值直接影响加工精度与加工效率。传统的振幅测量方法很难准确的测出微细超声工作台的微振幅。基于精密微三维运动平台的高分辨率,提出了一种恒力控制的... 详细信息

微细超声工作台是微细超声加工机床与微细超声振动辅助加工机床的关键零部件,其振幅值直接影响加工精度与加工效率。传统的振幅测量方法很难准确的测出微细超声工作台的微振幅。基于精密微三维运动平台的高分辨率,提出了一种恒力控制的微振幅测量方法,成功的测量出能精确到0.1μm的微振幅。首先对微细超声工作台中的微细超声振动系统进行了理论设计,然后采用基于恒力控制的超声振幅测量方法,对不同功率作用下的微细超声振动系统的振幅值进行了测量。

关键词：微细超声工作台微细超声加工微振幅设计测量

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主轴微细超声振动系统的微振幅测量

仪表技术与传感器 2016年第12期 141-144页

作者：连海山弓满锋郭钟宁岭南师范学院机电工程研究所广东湛江524048 广东工业大学机电工程学院广东广州510006

在微细超声加工与微细超声振动辅助加工中,微振幅是关键的加工参数,直接影响到加工精度与加工效率。对于只有几μm甚至更小的振幅,很难用传统的振幅测量方法测量出来。针对主轴微细超声振动系统输出的微振幅,提出了一种新的微振幅在线... 详细信息

在微细超声加工与微细超声振动辅助加工中,微振幅是关键的加工参数,直接影响到加工精度与加工效率。对于只有几μm甚至更小的振幅,很难用传统的振幅测量方法测量出来。针对主轴微细超声振动系统输出的微振幅,提出了一种新的微振幅在线测量方法。利用精密微三维运动平台的高分辨率,将平台A轴的运动与微细工具所受实时力结合起来,使其形成闭环运动控制系统。通过设定相同的接触力,计算有超声与无超声作用于微细工具A轴坐标值的变化,即可获得微细工具的振幅值。应用这一新的振幅测量方法,成功地测量出精确到0.1μm的振幅值。

关键词：微振幅测量微细超声振动系统微三维运动平台闭环控制

New Pyrrolizidine Alkaloids from Liparis nervosa

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New Pyrrolizidine Alkaloids from Liparis nervosa

中国化学会第9届天然有机化学学术会议

作者： Shuai Huang,Ji-fa Zhang,Hui Li,You-song Wang,lian-hai shan,Xian-li Zhou~* School of Life Science and Engineering,Southwest Jiaotong University,Chengu 610031,Sichuan,.China.

＜正＞Liparis nervosa *** belonging to the Orchidaceae family,is a herbaceous plant that is widely distributed in *** has been used in folk medicine for detoxicating and hemostatic *** its chemical constituents and their bioactivities have not been studied in detail yet,only Kunisuke Nishkawa had investigated its chemical components which led to the identification of nervosine.[l,2]Here,the isolation

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微细超声加工机床关键零部件设计

机械设计与制造 2018年第7期 140-142页

作者：连海山郭钟宁弓满锋隋广洲岭南师范学院机电工程研究所广东湛江524048 广东工业大学机电工程学院广东广州510006

微细超声加工机床是实施微细超声加工的基础。针对微细超声加工的原理,对微细超声加工机床中的关键零部件进行了设计,包括主轴设计、微细超声振动工作液槽设计、运动控制系统硬件设计与数据采集系统硬件设计。块电极通过辅助夹具安装于... 详细信息

微细超声加工机床是实施微细超声加工的基础。针对微细超声加工的原理,对微细超声加工机床中的关键零部件进行了设计,包括主轴设计、微细超声振动工作液槽设计、运动控制系统硬件设计与数据采集系统硬件设计。块电极通过辅助夹具安装于微细超声振动工作液槽中,能够实现微细工具电极的在线加工。采用双超声振动系统设计结构,可以根据加工需要自由的选择将微细超声振动施加到工具或者工件上。宏微复合的运动控制模式能有效的保证运动控制精度,加工实时力与机床运动结合形成的闭环结构能满足微细超声加工中的恒力进给需求。

关键词：微细超声加工主轴设计微三维运动平台机床设计