Three new pyrrolizidine alkaloids derivatives from Liparis nervosa

作     者：Shuai Huang De-Xin Zhong Lian-Hai Shan Ye-Zi Zheng Zhi-Kuan Zhang Ya-Heng Bu Hong-Wen Ma Xian-Li Zhou 

作者机构：School of Life Science and Engineering Southwest Jiaotong University 

出 版 物：《Chinese Chemical Letters》 (中国化学快报（英文版）)

年 卷 期：2016年第27卷第5期

页      面：757-760页

核心收录：

学科分类：081704[工学-应用化学] 07[理学] 08[工学] 0817[工学-化学工程与技术] 070303[理学-有机化学] 0703[理学-化学] 

基　　金：financially supported by the National Natural Science Foundation of China (Nos. 81402803, 31171695) the Science and Technology Support Programs of Sichuan Province (No. 2013SZ0083, 2015GZ0233) the Research Foundation for Educational Commission of Sichuan Province (No. 15TD0048) the Fundamental Research Funds for Central Universities (No. 2682014RC15) national undergraduate training programs for innovation and entrepreneurship (No. 201510613065) 

主　　题：Orchidaceae Liparis nervosa Pyrrolizidine alkaloids Nervogenic acid derivatives 

摘      要：Three new pyrrolizidine alkaloids, nervosineⅦ（1）, nervosine Ⅷ（2） and nervosine IX （3） were isolated from the whole plant extract of Liparis nervosa. Their structures were elucidated by extensive spectroscopic analyses （including 1 D, 2D NMR, and HR-ESI-MS） and chemical methods. Compounds 1-3 were evaluated for their cytotoxic activity against A549, MCF-7and H460 human cancer cell lines.