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Defects in the grain interiors of 3 mol%yttria-stabilized tetragonal zirconia polycrystal ceramics with 0.25 wt%alumina

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Journal of Advanced Ceramics 2024年第4期13卷 469-477页

作者： Yan Xiong lian luo Yao Cheng Zhi Liu Qi Liu Weimin Wang Wei Ji School of Materials&Chemical Engineering Hubei Province Key Laboratory of Green Materials for Light IndustryHubei University of TechnologyWuhan 430068China Fujian Institute of Research on the Structure of Mater Chinese Academy of SciencesFuzhou 350002China Jiangxi Provincial Engineering Research Center for Multifunction Zirconia Materials Jiangxi Size Materials Co.Ltd.Jiujiang 332500China State Key Laboratory of Advance Technology for Materials Synthesis and Processing Wuhan University of TechnologyWuhan 430070China

The presence of high-density defects is rarely observed in bulk 3 mol%yttria-stabilized tetragonal zirconia polycrystal(3Y-TZP)ceramics obtained through conventional pressureless *** the present work,fine-grained dense 147 nm 3Y-TZP ceramics were prepared by pressureless sintering of commercial 0.25 wt%alumina-doped zirconia powders at 1300℃.A novel discovery was reported in which large amounts of defects were present in the grain interiors of the *** phenomenon was further examined using three types of powder samples,and the reasons for defect formation were investigated by microstructural characterization using high-resolution transmission electron microscopy(HRTEM)analysis and Rietveld *** results confirmed the essential dependence of the defect formation on the alumina *** authors attributed the defect formation to the significant difference in ionic radii of the solvent and solute during the dissolution of alumina into the zirconia *** sintering kinetics were proposed to be enhanced by the presence of substantial defects,which consequently favored the low-temperature sintering of the alumina-doped zirconia ceramics.

关键词： 3 mol%yttria-stabilized tetragonal zirconia polycrystal(3Y-TzP)ceramics alumina addition microstructure defect

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Effects of high-quality neurosurgical nursing care on improving clinical nursing quality

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World Journal of Clinical Cases 2024年第22期12卷 4999-5007页

作者： Xiu-Rong Li Qing-lian luo Department of Neurosurgery The Affiliated Hospital of Southwest Medical UniversityLuzhou 646000Sichuan ProvinceChina

BACKGROUND With continuous advancements in medical technology,neurosurgical nursing is constantly developing and improving to provide higher-quality nursing *** To explore the effects of different types of high-quality nursing care on clinical nursing quality and patient satisfaction in neurosurgical *** Eighty patients who received neurosurgical treatment in the Affiliated Hospital of Southwest Medical University from June to December 2020 were selected as study participants and categorised into study and control *** study group comprised 40 patients who received 4 different types of high-quality nursing care,whereas the control group comprised 40 patients who received conventional nursing *** a specific period,nursing satisfaction levels and adverse event and complication rates were compared between the two *** Satisfaction with high-quality care was higher than that with conventional care,and high-quality health services and regional services showed the highest satisfaction levels,with an average score of 12 on the Glasgow *** satisfaction levels of the study and control groups were 75%and 57%,respectively,with a statistically significant difference(t=7.314,P<0.05).During the nursing period,the adverse event and complication rates were the highest in patients with level III pathology grade and those who underwent neurosurgery(40.02%and 85.93%,respectively),and the difference was statistically *** In neurosurgical nursing,employing appropriate high-quality nursing methods can effectively reduce adverse event and complication rates in patients,thereby improving the quality of nursing care and increasing clinical nursing value.

关键词： High-quality nursing Neurosurgery Quality care Adverse event Complication

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New targets for cancer promotion and therapy in gliomas: Scinderin

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World Journal of Clinical Oncology 2024年第6期15卷 687-690页

作者： Xi Wang lian-Xiang luo The First Clinical College Guangdong Medical UniversityZhanjiang 524023Guangdong ProvinceChina The Marine Biomedical Research Institute Guangdong Medical UniversityZhanjiang 524000Guangdong ProvinceChina

Glioma is one of the most common primary intracranial tumors,characterized by invasive growth and poor *** cytoskeletal rearrangement is an essential event in tumor cell ***(SCIN),an actin severing and capping protein that regulates the actin cytoskeleton,is involved in the prolif-eration and migration of certain cancer ***,its biological role and molecular mechanism in glioma remain *** et al explored the role and mechanism of SCIN in *** results showed that SCIN mechanically affected cytoskeleton remodeling and inhibited the formation of lamellipodia via RhoA/FAK signaling *** study identifies the cancer-promoting role of SCIN and provides a potential therapeutic target for SCIN in glioma treatment.

关键词： Glioma Scinderin Actin cytoskeleton RhoA/FAK signaling 1p/19q co-deletion

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TM9SF1 is implicated in promoting the proliferation and invasion of bladder cancer cells

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World Journal of Clinical Oncology 2024年第2期15卷 175-177页

作者： Shu-Qing Zhou lian-Xiang luo The First Clinical College Guangdong Medical UniversityZhanjiang 524023Guangdong ProvinceChina The Marine Biomedical Research Institute Guangdong Medical UniversityZhanjiang 524000Guangdong ProvinceChina

Zhuo et al looked into the part of transmembrane 9 superfamily member 1(TM9SF1)in bladder cancer(BC),and evaluated if it can be used as a therapeutic *** created a permanent BC cell line and tested the effects of TM9SF1 overexpression and suppression on BC cell growth,movement,invasion,and cell cycle *** results show that TM9SF1 can boost the growth,movement,and invasion of BC cells and their access into the G2/M stage of the cell *** research gives a novel direction and concept for targeted therapy of BC.

关键词： Bladder cancer TM9SF1 Cell proliferation Migration Invasion TM9SF1 overexpression TM9SF1 silencing inhibits

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An overview of the contemporary diagnosis and management approaches for anaplastic thyroid carcinoma

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World Journal of Clinical Oncology 2024年第6期15卷 674-676页

作者： Shu-Yue Zhou lian-Xiang luo The First Clinical College Guangdong Medical UniversityZhanjiang 524023Guangdong ProvinceChina The Marine Biomedical Research Institute Guangdong Medical UniversityZhanjiang 524000Guangdong ProvinceChina

Thyroid carcinoma is a complex disease with several types,the most common being well-differentiated and *** latter,“undifferentiated carcinoma”,also known as anaplastic thyroid carcinoma(ATC),is a highly aggr-essive malignant tumor accounting for less than 0.2%of all thyroid carcinomas and carries a poor prognosis with a median survival of 5 *** gene mutations are the most common molecular factor associated with this type of thyroid *** advances in targeted biological agents,immuno-therapy,stem cell therapy,nanotechnology,the dabrafenib/trametinib com-bination therapy,immune checkpoint inhibitors(ICI)and artificial intelligence offer novel treatment *** combination therapy of dabrafenib and tra-metinib is the current standard treatment for patients with BRAF-V600E gene ***,the dabrafenib/trametinib combination therapy,ICI,used alone or in combination with targeted therapies have raised some hopes for improving the prognosis of this deadly *** age,earlier tumor stage and radiotherapy are all prognostic factors for improved ***,therapeutic regimens should be tailored to the individual patient based on surveillance and epidemiological data,and a multidisciplinary approach is ess-ential.

关键词： Thyroid diseases Thyroid cancers Anaplastic carcinoma Undifferentiated carcinoma Neck mass Aggressive malignancies

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Six transmembrane epithelial antigens of the prostate to illustrate inflammatory response in gastrointestinal cancers

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World Journal of Clinical Oncology 2024年第8期15卷 961-964页

作者： Yi-Han Wu lian-Xiang luo The First Clinical College Guangdong Medical UniversityZhanjiang 524023Guangdong ProvinceChina The Marine Biomedical Research Institute Guangdong Medical UniversityZhanjiang 524000Guangdong ProvinceChina

Gastrointestinal cancer(GIC)is a common and widespread form of tumor,with colonoscopy and upper gastrointestinal endoscopy available to detect relevant precancerous polyps and ***,many patients are already in the late stages when first diagnosed with such cancer,resulting in a poor ***,it is necessary to explore new methods and research directions in order to improve the treatment of *** the specific nature of the gastrointestinal tract,research should focus on the mechanisms of various inflammations and the interactions between food entering and exiting from the gastrointestinal tract and cancer ***,six transmembrane epithelial antigens of the prostates(STEAPs)have been found to be significantly linked to the progression of malignant tumors,associated with intracellular oxidative stress and playing a major role in inflammation with their structure and *** paper explores the mechanism of STEAPs in the inflammatory response of GIC,providing a theoretical basis for the prevention and early intervention of *** basic properties of the STEAP family as metal reductase are also *** it comes to intervention for GIC prevention,STEAPs can affect the activity of Fe3+,Cu2+reductase and regulate metal ion uptake in vivo,participating in inflammation-related iron and copper ***,the mechanism of STEAPs on inflammation is of important value in the prevention of GIC.

关键词： Six transmembrane epithelial antigens of the prostate Gastrointestinal cancer Inflammation Gastric cancer Colorectal cancer Hepatocellular carcinoma

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Mechanisms and potential applications of COPS6 in pan-cancer therapy

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World Journal of Clinical Oncology 2024年第3期15卷 367-370页

作者： Tong Wu Miao-Rong Ji lian-Xiang luo The First Clinical College Guangdong Medical UniversityZhanjiang 524023Guangdong ProvinceChina The Marine Biomedical Research Institute Guangdong Medical UniversityZhanjiang 524000Guangdong ProvinceChina

The COP9 signalosome subunit 6(COPS6)is abnormally overexpressed in many malignancies,yet its precise role in carcinogenesis is *** gain a better understanding of COPS6's role,the authors conducted a pan-cancer analysis using various bioinformatics techniques such as differential expression patterns,prognostic value,gene mutations,immune infiltration,correlation analysis,and functional enrichment *** showed that COPS6 was highly correlated with prognosis,immune cell infiltration level,tumor mutation burden,and microsatellite instability in patients with a range of tumor *** suggests that COPS6 may be a potential target for cancer ***,this research provides insight into COPS6's role in cancer development and its potential therapeutic applications.

关键词： COPS6 Biomarker Tumor mutational burden Immune infiltration Prognostic analysis

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Role of targeting ferroptosis as a component of combination therapy in combating drug resistance in colorectal cancer

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World Journal of Clinical Oncology 2024年第3期15卷 375-377页

作者： Xiao-Ting Xie Qiang-Hu Pang lian-Xiang luo The First Clinical College Guangdong Medical UniversityZhanjiang 524023Guangdong ProvinceChina The Marine Biomedical Research Institute Guangdong Medical UniversityZhanjiang 524023Guangdong ProvinceChina

Colorectal cancer(CRC)is a form of cancer that is often resistant to chemotherapy,targeted therapy,radiotherapy,and immunotherapy due to its genomic instability and inflammatory tumor ***,a type of non-apoptotic cell death,is characterized by the accumulation of iron and the oxidation of *** have revealed that the levels of reactive oxygen species and glutathione in CRC cells are significantly lower than those in healthy colon *** has emerged as a promising candidate for CRC treatment by diminishing stemness and ***,the gut,responsible for regulating iron absorption and release,could influence CRC susceptibility through iron metabolism *** into ferroptosis offers new insights into CRC pathogenesis and clinical management,potentially revolutionizing treatment approaches for therapy-resistant cancers.

关键词： Colorectal cancer Ferroptosis Immunotherapy Drug resistance Chemotherapy Nanodrug delivery systems

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Feasibility and limitations of combined treatment for lateral pelvic lymph node metastases in rectal cancer

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World Journal of Clinical Oncology 2024年第5期15卷 591-593页

作者： Ying-Zi Zheng Fang-Fang Yan lian-Xiang luo The First Clinical College Guangdong Medical UniversityZhanjiang 524023Guangdong ProvinceChina The Marine Biomedical Research Institute Guangdong Medical UniversityZhanjiang 524000Guangdong ProvinceChina

Colorectal cancer ranks among the most commonly diagnosed cancers globally,and is associated with a high rate of pelvic recurrence after *** efforts to mitigate recurrence,pelvic lymph node dissection(PLND)is commonly advocated as an adjunct to radical *** chemoradiotherapy(NACRT)is a therapeutic approach employed in managing locally advanced rectal cancer,and has been found to increase the survival *** et al have proposed a combination of NACRT with selective PLND for addressing lateral pelvic lymph node metastases in rectal cancer patients,with the aim of reducing recurrence and improving survival ***,certain studies have indicated that the addition of PLND to NACRT and total mesorectal excision did not yield a significant reduction in local recurrence rates or improvement in ***,meticulous patient selection and perioperative chemotherapy may prove indispensable in ensuring the efficacy of PLND.

关键词： Rectal cancer Lateral pelvic lymph nodes metastases Pelvic lymph node dissection Neoadjuvant chemoradiotherapy Total mesorectal excision

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容器集群GPU资源共享调度优化

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计算机应用与软件 2024年第7期41卷 207-214页

作者：罗恋顾进广李奇缘高峰武汉科技大学计算机科学与技术学院湖北武汉430065

在容器集群环境中,整块的物理GPU资源通常只能被单个容器独享调度,存在大量的资源浪费。现有的GPU共享调度方案中仍存在调度失败、资源开销大或没有实现资源隔离的问题,改进的GPU Sharing利用LD_PRELOAD机制有效地实现了GPU显存资源的隔... 详细信息

在容器集群环境中,整块的物理GPU资源通常只能被单个容器独享调度,存在大量的资源浪费。现有的GPU共享调度方案中仍存在调度失败、资源开销大或没有实现资源隔离的问题,改进的GPU Sharing利用LD_PRELOAD机制有效地实现了GPU显存资源的隔离,并优化了原有的调度算法,极大提高了集群显存资源的利用率。实验结果验证了改进后GPU Sharing在资源隔离实现上的有效性,同时,改进后的GPU Sharing同在物理机上执行应用程序只多了1.008%的额外开销,而且优化后的调度算法提高了53.01%的GPU显存利用率。

关键词： GPU集群 GPU共享调度容器资源共享 GPU利用率

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