New targets for cancer promotion and therapy in gliomas: Scinderin
作者机构：The First Clinical CollegeGuangdong Medical UniversityZhanjiang 524023Guangdong ProvinceChina The Marine Biomedical Research InstituteGuangdong Medical UniversityZhanjiang 524000Guangdong ProvinceChina
出 版 物：《World Journal of Clinical Oncology》 (世界临床肿瘤学杂志（英文版）)
年 卷 期：2024年第15卷第6期
页 面：687-690页
学科分类：1002[医学-临床医学] 100214[医学-肿瘤学] 10[医学]
主 题：Glioma Scinderin Actin cytoskeleton RhoA/FAK signaling 1p/19q co-deletion
摘 要：Glioma is one of the most common primary intracranial tumors,characterized by invasive growth and poor *** cytoskeletal rearrangement is an essential event in tumor cell ***(SCIN),an actin severing and capping protein that regulates the actin cytoskeleton,is involved in the prolif-eration and migration of certain cancer ***,its biological role and molecular mechanism in glioma remain *** et al explored the role and mechanism of SCIN in *** results showed that SCIN mechanically affected cytoskeleton remodeling and inhibited the formation of lamellipodia via RhoA/FAK signaling *** study identifies the cancer-promoting role of SCIN and provides a potential therapeutic target for SCIN in glioma treatment.
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