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TIST: Transcriptome and Histopathological Image Integrative Analysis for Spatial Transcriptomics

Genomics, Proteomics & Bioinformatics 2022年第5期20卷 974-988页

作者： Yiran Shan Qian Zhang Wenbo guo Yanhong Wu Yuxin Miao Hongyi Xin Qiuyu lian Jin Gu MOE Key Laboratory of Bioinformatics BNRIST Bioinformatics DivisionDepartment of AutomationTsinghua UniversityBeijing 100084China UM-SJTU Joint Institute Shanghai Jiao Tong UniversityShanghai 200240China Department of Automation Shanghai Jiao Tong UniversityShanghai 200240China

Sequencing-based spatial transcriptomics(ST)is an emerging technology to study in situ gene expression patterns at the whole-genome ***,ST data analysis is still complicated by high technical noises and low *** addition to the transcriptomic data,matched histopathological images are usually generated for the same tissue sample along the ST *** matched high-resolution histopathological images provide complementary cellular phenotypical information,providing an opportunity to mitigate the noises in ST *** present a novel ST data analysis method called transcriptome and histopathological image integrative analysis for ST(TIST),which enables the identification of spatial clusters(SCs)and the enhancement of spatial gene expression patterns by integrative analysis of matched transcriptomic data and *** devises a histopathological feature extraction method based on Markov random field(MRF)to learn the cellular features from histopathological images,and integrates them with the transcriptomic data and location information as a network,termed *** on TIST-net,SCs are identified by a random walk-based strategy,and gene expression patterns are enhanced by neighborhood *** benchmark TIST on both simulated datasets and 32 real samples against several state-of-the-art *** show that TIST is robust to technical noises on multiple analysis tasks for sequencing-based ST data and can find interesting microstructures in different biological *** is available at http://***/software/tist/and https://***/biocode/tools/BT007317.

关键词： Spatial transcriptomics Multimodal information integration Network-based analysis Spatial cluster identification Gene expression enhancement

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Explosion limits for combustible gases

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Mining Science and Technology 2009年第2期19卷 182-184页

作者： TONG Min-ming WU guo-qing HAO Ji-fei DAI Xin-lian School of lnformation and Electrical Engineering China University of Mining ＆ Technology Xuzhou Jiangsu 221008 China

Combustible gases in coal mines are composed of methane, hydrogen, some multi-carbon alkane gases and other gases. Based on a numerical calculation, the explosion limits of combustible gases were studied, showing that these limits are related to the concentrations of different components in the mixture. With an increase of C4H10 and C6H14, the Lower ExplosionLimit （LEL） and Upper Explosion-Limit （UEL） of a combustible gas mixture will decrease clearly. For every 0.1% increase in C4H10 and C6H14, the LEL decreases by about 0.19% and the UEL by about 0.3%. The results also prove that, by increasing the amount of H2, the UEL of a combustible gas mixture will increase considerably. If the level of HE increases by 0.1%, the UEL will increase by about 0.3%. However, H2 has only a small effect on the LEL of the combustible gas mixture. Our study provides a theoretical foundation for judging the explosion risk of an explosive gas mixture in mines.

关键词： coal mine gas explosive gases explosion limits

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Sensitivity analysis of regional rainfall-induced landslide based on UAV photogrammetry and LSTM neural network

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Journal of Mountain Science 2023年第11期20卷 3312-3326页

作者： ZHAO lian-heng XU Xin LYU guo-shun HUANG Dong-liang LIU Min CHEN Qi-min School of Civil Engineering Central South UniversityChangsha 410075China Key Laboratory of Heavy-haul Railway Engineering Structure Ministry of EducationCentral South UniversityChangsha410075China Hunan Provincial Key Laboratory for Disaster Prevention and Mitigation of Rail Transit Engineering Structures CentralSouth UniversityChangsha 410075China Hunan Tieyuan Civil Engineering Testing Co. LTDChangsha 410075China

Rainfall stands out as a critical trigger for landslides,particularly given the intense summer rainfall experienced in Zheduotang,a transitional zone from the southwest edge of Sichuan Basin to Qinghai Tibet *** area is characterized by adverse geological conditions such as rock piles,debris slopes and unstable ***,due to the absence of historical rainfall records and landslide inventories,empirical methods are not applicable for the analysis of rainfall-induced *** we employ a physically based landslide susceptibility analysis model by using highprecision unmanned aerial vehicle(UAV)photogrammetry,field boreholes and long short term memory(LSTM)neural network to obtain regional topography,soil properties,and rainfall *** applied the Transient Rainfall Infiltration and Grid-Based Regional Slope-Stability(TRIGRS)model to simulate the distribution of shallow landslides and variations in porewater pressure across the region under different rainfall intensities and three rainfall patterns(advanced,uniform,and delayed).The landslides caused by advanced rainfall pattern mostly occurred in the first 12 hours,but the landslides caused by delayed rainfall pattern mostly occurred in the last 12 ***,all the three rainfall patterns yielded landslide susceptibility zones categorized as high(1.16%),medium(8.06%),and low(90.78%).Furthermore,total precipitation with a rainfall intensity of 35 mm/h for 1 hour was less than that with a rainfall intensity of 1.775 mm/h for 24hours,but the areas with high and medium susceptibility increased by 3.1%.This study combines UAV photogrammetry and LSTM neural networks to obtain more accurate input data for the TRIGRS model,offering an effective approach for predicting rainfall-induced shallow landslides in regions lacking historical rainfall records and landslide inventories.

关键词： Regional landslide TRIGRS UAV photography Rainfall landslide LSTM neural network

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Effect of net carriers at the interconnection layer in tandem organic solar cells

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Chinese Physics B 2022年第3期31卷 631-635页

作者： Li-Jia Chen guo-Xi Niu lian-Bin Niu Qun-liang Song College of Physics and Electronic Engineering Chongqing Normal UniversityChongqing 401331China Institute for Clean Energy&Advanced Materials School of Materials and EnergySouthwest UniversityChongqing 400715China

Tandem cell with structure of indium tin oxide(ITO)/molybdenum oxide(MoO_(3))/fullerene(C60)/copper phthalocyanine(CuPc)/C60/tris-8-hydroxy-quinolinato aluminum(Alq_(3))/Al was fabricated to study the effect of net carriers at the interconnection layer. The open circuit voltage and short circuit current were found to be 1.15 V and 0.56 mA/cm^(2),respectively. Almost the same performance(1.05 V, 0.58 mA/cm^(2)) of tandem cell with additional recombination layer(ITO/MoO_(3)/C60/Alq_(3)/Al/Ag/MoO_(3)/CuPc/C60/Alq_(3)/Al) demonstrates that the carrier balance is more crucial than carrier recombination. The net holes at the interconnection layer caused by more carrier generation from the back cell on one hand would enhance the recombination with electrons from the front cell and on the other hand would quench the excitons produced in CuPc of the back cell.

关键词： tandem organic solar cells interconnection layer carrier balance carrier-exciton interaction

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Phase engineering oriented defect-rich amorphous/crystalline RuO_(2) nanoporous particles for boosting oxygen evolution reaction in acid media

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Nano Research Energy 2023年第3期2卷 48-55页

作者： Chengming Wang Qinghong Geng Longlong Fan Jun-xuan Li lian Ma Cuiling Li Key Laboratory of Cluster Science Ministry of EducationBeijing Key Laboratory of Photoelectronic/Electrophotonic Conversion MaterialsSchool of Chemistry and Chemical EngineeringBeijing Institute of TechnologyBeijing 100081China CAS Key Laboratory of Bio-inspired Materials and Interfacial Science Technical Institute of Physics and ChemistryChinese Academy of SciencesBeijing 100190China Binzhou Institute of Technology Binzhou 256600China

Imposing phase engineering to porous materials is promising to realize outperforming electrocatalytic performances by taking advantages of the merits of porous nanoarchitecture and heterophase *** this work,amorphous/crystalline ruthenium oxide(RuO_(2))porous particles with rationally regulated heterophases are successfully prepared by integrating the phase engineering into the porous material *** resultant defect-rich amorphous/crystalline RuO_(2)porous particles exhibit excellent electrocatalytic performance toward the oxygen evolution reaction,achieving a low overpotential of 165 mV at a current density of 10 mA·cm^(−2)and a high mass activity up to 133.8 mA·cm^(-2)at a low overpotential of 200 *** work indicates that the synergistic effect of amorphous/crystalline heterophase and porous structural characteristics enables RuO_(2)to trigger a superior electrocatalytic activity.

关键词： porous material phase engineering ruthenium oxide(RuO_(2)) oxygen evolution reaction(OER) electrocatalysis

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Evolution of surface morphologies of CaMoO_(4)films and their luminescent properties

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Rare Metals 2022年第8期41卷 2789-2793页

作者： lian-Ping Chen School of Materials Science and Engineering Jiangxi University of Science and TechnologyGanzhou341000China

Alkaline earth molybdate and tungstate thin films are widely prepared by electrochemical *** solutions,these crystals often grow into large ***,it is difficult to obtain nanomolybdate and tungstate thin films via *** morphologies of CaMoO_(4)thin films synthesized by galvanic cell route at different stages were compared and *** electron microscope(SEM)observations reveal that CaMoO_(4)thin films consist of two layers,sub-layer and top *** force microscope(AFM)examination confirms that the roughness of sub-layer is within several *** AFM analysis and the calculation based on XRD results favor that the average size of CaMoO_(4)crystallites is approximately several tens of *** top layer is usually rough due to large crystals in shapes of *** study shows that the luminescence intensities of samples only with smooth layers are about four times of those filled with micrometer-sized CaMoO_(4)*** reason accounting for the improvement of luminescent properties may lie in that there are much less lateral scattering for smooth samples.

关键词： Morphology CaMoO_(4) Thin films Electrochemical

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Endoscopic palliative resection of a giant 26-cm esophageal tumor: A case report

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World Journal of Clinical Cases 2020年第19期8卷 4624-4632页

作者： Yan Li Lin-Jie guo Ying-Cai Ma lian-Song Ye Bing Hu Department of Gastroenterology West China HospitalSichuan UniversityChengdu 610041Sichuan ProvinceChina Department of Digestion Qinghai Provincial People's HospitalXining 810007Qinghai ProvinceChina

BACKGROUND Esophageal carcinosarcoma,usually presenting as a pedunculated polypoid mass,is a rare malignancy with coexisting sarcomatoid and carcinomatous *** imaging and endoscopic characteristics are similar to those of leiomyosarcoma,liposarcoma and so *** diagnosis needs histological *** resection is the traditional *** resection is minimally invasive but still *** paper reports the case of a patient with a giant esophageal carsinosarcoma who underwent a palliative endoscopic ***^E SUMMARY A 55-year-old male patient presented with dysphagia and weight loss for 1 *** and endoscopy showed a gray-white,polypoid,stalk-like mass,with a bulky pedicle located in the middle and lower *** mass almost filled the whole esophageal lumen,but the endoscope could still pass *** the suspicion of a malignancy,repeated biopsies indicated necrosis and *** multidisciplinary team consultation,an endoscopic resection to diagnose and relieve the obstruction was *** pedicle of the mass was cut off,the bleeding was stopped,and the mass was cut into pieces and pulled *** mass was 26 cm x 5 cm x 4 cm in *** final diagnosis was esophageal *** postoperative complications *** 1 mo,the patient gained 6 kg and endoscopic reexamination revealed no *** surgery with lymph node dissection was carried out *** lesion was the largest endoscopically resected esophageal carcinosarcoma reported to *** Endoscopic palliative resection can help obtain adequate tissue for diagnosis and relieve obstructions in patients with giant esophageal carcinosarcoma.

关键词： Case report Dysphagia Endoscopic resection Esophageal carcinosarcoma Polypoid mass

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考虑地层冲刷的桥梁桩基础竖向承载力分析

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科学技术创新 2025年第2期 177-180页

作者：廉宇晗沧州交发工程设计有限公司河北沧州

为了探究地层冲刷对桥梁桩基础竖向承载力的影响,本文通过介绍试桩概况,详细描述了桩基冲刷数值模拟的过程。首先,建立了桩基模型并设置了桩基与土体的相互作用条件系数;随后,进行了冲刷过程的数值模拟。基于模拟结果,分析了地层冲刷条... 详细信息

为了探究地层冲刷对桥梁桩基础竖向承载力的影响,本文通过介绍试桩概况,详细描述了桩基冲刷数值模拟的过程。首先,建立了桩基模型并设置了桩基与土体的相互作用条件系数;随后,进行了冲刷过程的数值模拟。基于模拟结果,分析了地层冲刷条件下桥梁桩基础的竖向承载特性。此外,通过算例验证分析,进一步证实了研究方法的可靠性。研究结果表明,地层冲刷会显著影响桥梁桩基础的竖向承载力,需要在实际工程中予以充分考虑。这一发现对于提高桥梁结构的稳定性和安全性具有重要意义。

关键词：地层冲刷桩基础竖向承载力桥梁

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An online survey of non-compressible torso hemorrhage:training is needed

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World Journal of Emergency Medicine 2022年第4期13卷 297-300页

作者： Hua-yu Zhang Yong guo Xiao-ying Huang Yang Li lian-yang Zhang Department of Trauma Surgery War Trauma Medical CenterState Key Laboratory of TraumaBurn and Combined InjuryDaping HospitalArmy Medical UniversityChongqing 400042China

Hemorrhage is the leading cause of combat deaths,which is a primary lesson learned from modern warfare.[1]If temporary hemostasis is not available,the mortality of non-compressible torso hemorrhage(NCTH),a potentially... 详细信息

关键词： survey tor lesson

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Surficial stability analysis of soil slope under seepage based on a novel failure mode

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Frontiers of Structural and Civil Engineering 2021年第3期15卷 712-726页

作者： Jifeng lian Jiujiang WU School of Emergency Science Xihua UniversityChengdu610039China Shock and Vibration of Engineering Materials and Structures Key Laboratory of Sichuan Province Southwest University of Science and TechnologyMianyang621010China College of Civil Engineering and Architecture Wenzhou UniversityWenzhou325035China

Normally,the edge effects of surficial landslides are not considered in the infinite slope method for surficial stability analysis of soil *** this study,the limit stress state and discrimination equation of an infinite slope under saturated seepage flow were analyzed based on the Mohr-Coulomb strength ***,a novel failure mode involving three sliding zones(upper tension zone,middle shear sliding zone,and lower compression zone)was ***,based on the limit equilibrium analysis,a semi-analytical framework considering the edge effect for the surficial stability of a soil slope under downslope seepage was ***,the new failure mode was verified via a numerical finite element analysis based on the reduced strength theory with ABAQUS and some simplified methods using SLIDE *** results obtained by the new failure mode agree well with those obtained by the numerical analysis and traditional simplified methods,and can be efficiently used to assess the surficial stability of soil slopes under rainwater ***,an evaluation of the infinite slope method was performed using the semi-analytical method proposed in this *** results show that the infinite slope tends to be conservative because the edge effect is neglected,particularly when the ratio of surficial slope length to depth is relatively small.

关键词： soil slope seepage surficial failure mode stress state edge effects

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