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Chinese Medicine Prolongs Overall Survival of Chinese Patients with Advanced Gastric Cancer: Treatment Pattern and Survival Analysis of a 20-Year Real-World Study

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Chinese Journal of Integrative Medicine 2024年第6期30卷 489-498页

作者： CAO Ni-da ZHU Xiao-hong MA Fang-qi XU Yan DONG Jia-huan QIN Meng-meng liu Tian-shu ZHU Chun-chao GUO Wei-jian DING Hong-hua GUO Yuan-biao liu li-kun SONG Jin-jie WU Ji-ping CHENG Yue-lei ZENG lin ZHAO Ai-guang Oncology Department I Longhua Hospital Shanghai University of Traditional Chinese MedicineShanghai200032China Oncology Department Zhongshan HospitalFudan UniversityShanghai200032China Gastrointestinal Surgery Department Renji HospitalShanghai Jiaotong University School of MedicineShanghai200127China Oncology Department Fudan University Shanghai Cancer CenterShanghai200032China Oncology Department Shanghai General HospitalShanghai Jiaotong University School of MedicineShanghai200080China Traditional Chinese Medicine Department Ruijin HospitalShanghai Jiaotong University School of MedicineShanghai200025China Oncology Department Shanxi Traditional Chinese Medicine HospitalTaiyuan030012China Oncology Department Xiyuan HospitalChina Academy of Chinese Medical ScienceBeijing102445China Oncology Department Yunnan Province Hospital of Traditional Chinese MedicineKunming650021China Oncology Department Shuguang HospitalShanghai University of Traditional Chinese MedicineShanghai201203China Shanghai NewCore Biotechnology Co. Ltd.Shanghai200240China

Objective To describe the treatment patterns and survival status of advanced gastric cancer(AGC)in China in the past two decades,and objectively evaluate the impact of standardized Chinese medicine(CM)treatment on the survival of AGC *** This multicenter registry designed and propensity score analysis study described the diagnosis characteristics,treatment-pattern development and survival status of AGC from 10 hospitals in China between January 1,2000 and July 31,*** survival(OS)was evaluated between non-CM cohort(standard medical treatment)and CM cohort(integrated standard CM treatment≥3 months).Propensity score matching(PSM)and inverse probability of treatment weighting(IPTW)were performed to adjust any difference in average outcomes for *** A total of 2,001 patients histologically confirmed locally advanced and/or metastasis stomach and gastroesophageal junction adenocarcinoma were *** them,1,607 received systemic chemotherapy,215(10.74%)accepted molecular targeted therapy,44(2.2%)received checkpoint inhibitor therapy,and 769(38.43%)received ***-drug regimen was the main choice for first-line treatment,with fluoropyrimidine plus platinum as the most common regimen(530 cases,60.09%).While 45.71%(16 cases)of patients with HER2 amplification received trastuzumab in *** application of apatinib increased(33.33%)in *** application of checkpoint inhibitors has increased since *** analysis showed that Lauren mixed type(P=0.017),cycles of first-line treatment>6(P=0.000),CM(P=0.000),palliative gastrectomy(P=0.000),trastuzumab(P=0.011),and apatinib(P=0.008)were independent prognostic factors for the OS of *** PSM and IPTW,the median OS of CM cohort and non-CM cohort was 18.17 and 12.45 months,respectively(Pline *** CM treatment was an independent

关键词： advancedgastriccancer real-world study treatment pattern survival analysis Chinese medicine

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市政工程建设中园林工程技术的应用

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工程建设与设计 2024年第12期 141-143页

作者：刘坤利山东华隆集团有限公司山东东营257091

研究了市政工程建设中园林工程技术的应用,在明确园林工程特点和分类的基础上,从园林绿化工程技术和园林构筑工程技术两个方面出发,分析了园林工程技术应用要点,重点介绍了土地整理技术、液压喷播技术、节水灌溉技术、大树移植技术、假... 详细信息

研究了市政工程建设中园林工程技术的应用,在明确园林工程特点和分类的基础上,从园林绿化工程技术和园林构筑工程技术两个方面出发,分析了园林工程技术应用要点,重点介绍了土地整理技术、液压喷播技术、节水灌溉技术、大树移植技术、假山造景技术、雨水花园技术,充分融入新工艺、新材料,从而促进园林工程技术的创新发展。

关键词：市政工程园林工程技术应用园林造景

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乳腺癌核仁磷蛋白乙酰化及其修饰位点突变体的构建和表达

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解剖学报 2024年第2期55卷 196-202页

作者：郝经伟潘婷李月朱文斌段文博刘立琨岳丽玲刘云龙高秀丽齐齐哈尔医学院医学技术学院黑龙江齐齐哈尔161006 齐齐哈尔医学院药学院黑龙江齐齐哈尔161006 齐齐哈尔医学院医药科学研究院肿瘤分子生物学研究室黑龙江齐齐哈尔161006 齐齐哈尔医学院附属第二医院肿瘤外科黑龙江齐齐哈尔161006

目的明确女性乳腺癌中核仁磷蛋白(NPM)乙酰化修饰水平,并通过修饰位点突变体的构建探讨其功能。方法蛋白质修饰组学方法检测对比人乳腺癌组织及癌旁正常组织(各3例)NPM乙酰化水平及乙酰化位点;基因定点突变PCR构建NPM乙酰化突变体,限制... 详细信息

目的明确女性乳腺癌中核仁磷蛋白(NPM)乙酰化修饰水平,并通过修饰位点突变体的构建探讨其功能。方法蛋白质修饰组学方法检测对比人乳腺癌组织及癌旁正常组织(各3例)NPM乙酰化水平及乙酰化位点;基因定点突变PCR构建NPM乙酰化突变体,限制性内切酶(DpnI)消化及大肠埃希菌转化获得特异性突变体重组质粒;双酶切与测序验证各突变体序列准确性;瞬时转染及RT-PCR方法检测各突变体过表达效果。Western blotting验证NPM乙酰化水平,蛋白质定量组学及生物信息学分析NPM乙酰化功能。结果乳腺癌组织样本中NPM第27及第32位赖氨酸乙酰化水平分别为癌旁正常组织的2.76及2.22倍;构建的NPM乙酰化位点突变体与野生型NPM分子量一致且出现预期突变位点;转染NPM各突变体的BT-549细胞相应NPM mRNA表达水平明显升高。随着野生型NPM表达水平增加,蛋白乙酰化水平增加,27位赖氨酸发生负向突变后,修饰水平下降。NPM乙酰化可使BT-549细胞中101种蛋白表达水平发生明显变化,上述蛋白在细胞大分子生物合成,以DNA为模板的转录过程,RNA生物合成以及RNA代谢过程中富集。结论乳腺癌NPM呈高乙酰化水平并可能在细胞大分子生物合成,转录过程,RNA生物合成以及RNA代谢过程中发挥关键功能。

关键词：乳腺癌核仁磷蛋白乙酰化定点突变蛋白质组学人

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Efficacy and safety of Nafamostat mesylate in patients with endstage renal failure

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World Journal of Clinical Cases 2024年第1期12卷 68-75页

作者： kun liu Zhen-Hua li Department of Critical Care Medicine The Third People's Hospital Of Hubei ProvinceWuhan 430030Hubei ProvinceChina Department of Critical Care Medicine General Hospital of The Yangtze River ShippingWuhan Brain HospitalWuhan 430015Hubei ProvinceChina

BACKGROUND Recent studies on dialysis anticoagulation therapy in patients with renal failure have shown that Nafamostat mesylate,a broad-spectrum potent serine protease inhibitor,has strong anticoagulation and anti-fiber *** To evaluate the efficacy and safety of Nafamostat mesylate in patients with end-stage renal *** Seventy-five patients with end-stage renal failure who received hemodialysis at our hospital between January 2020 and August 2021 were selected and divided into the observation group(Nafamostat mesylate for injection,n=33)and control group(heparin sodium injection,n=32).General patient data,indicators of clinical efficacy,dialyzer hemocoagulation parameters,coagulation function indices,and hemoglobin concentration and platelet count before and after treatment,and the occurrence of adverse reactions after treatment were compared between the two *** The two groups showed no significant differences in general patient data(P>0.05).The post-treatment effectiveness rate in the control group was lower than that in the observation group(P0.05),while the number of patients in grade 0 was lower in the control group,and the number of patients in grades II and III was higher in the control group(Plized ratio values in the control group were higher than those in the observation group,while the fibrinogen level in the control group was lower than that in the observation group(P0.05).The total number of post-treatment adverse reactions in the observation group was lower than that in the control group(P<0.05).CONCLUSION Treatment of patients showing end-stage renal failure with Nafamostat mesylate can s

关键词： End-stage renal failure Nafamostat mesylate Effectiveness Safety study Chronic kidney diseases

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Inhibition of Escherichia coli nitroreductase by the constituents in Syzygium aromaticum

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Chinese Journal of Natural Medicines 2022年第7期20卷 506-517页

作者： CHEN Lu CHEN Xi BAI Yue ZHAO Zi-Nan CAO Yun-Feng liu li-kun JIANG Tao HOU Jie College of Basic Medical Sciences Dalian Medical UniversityDalian 116044China Dalian Runsheng Kangtai Medical Laboratory Co. Ltd.Dalian 116000China

Gut bacterial nitroreductases play an important role in reduction of various nitroaromatic compounds to the corresponding N-nitroso compounds,hydroxylamines or aromatic amines,most of which are carcinogenic and mutagenic *** of gut nitroreductases has been recognized as an attractive approach for reducing mutagen metabolites in the colon,so as to prevent colon *** this study,the inhibitory effects of 55 herbal medicines against Escherichia coli(***)nitroreductase(EcNfsA)were *** with other herbal extracts,Syzygium aromaticum extract showed superior inhibitory potency toward EcNf-sA mediated nitrofurazone ***,the inhibitory effects of 22 major constituents in Syzygium aromaticum against EcNfsA were *** with other tested natural compounds,ellagic acid,corilagin,betulinic acid,oleanic acid,ursolic acid,urolith-in M5 and isorhamnetin were found with strong to moderate inhibitory effect against EcNfsA,with IC50 values ranging from 0.67 to 28.98 mol·L^(−1).Furthermore,the inhibition kinetic analysis and docking simulation demonstrated that ellagic acid and betulinic acid potently inhibited EcNfsA(Ki<2μmol·L−1)in a competitively inhibitory manner,which created strong interactions with the catalytic triad of *** summary,our findings provide new scientific basis for explaining the anti-mutagenic activity of Syzygium aromaticum,where some newly identified EcNfsA inhibitors can be used for developing novel agents to reduce the toxicity induced by bacteri-al nitroreductase.

关键词： Gut bacterial nitroreductase EcNfsA inhibitor Syzygium aromaticum Anti-mutagenic activity

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Highly efficient CO_(2) capture using 2-methylimidazole aqueous solution on laboratory and pilot-scale

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Chinese Journal of Chemical Engineering 2024年第3期67卷 148-156页

作者： kun li Han Tang Shuangshuang li Zixuan Huang Bei liu Chun Deng Changyu Sun Guangjin Chen State Key Laboratory of Heavy Oil Processing China University of PetroleumBeijing 102249China Zhejiang Tiandi Environmental Protection Technology Co. Ltd.Hangzhou 310012China

To date,the primary industrial carbon capture approach is still absorption using aqueous solutions of ***,to pursue a substitute for the amine-based approach to improve the CO_(2) capture efficiency and decrease the energy cost further,we report a new carbon capture approach using a 2-methylimidazole(mIm)aqueous *** properties and sorption behaviors of this approach have been experimentally *** results show that the mIm solution has higher CO_(2) absorption capacity under relatively higher equilibrium pressure(>130 kPa)and lower desorption heat than the methyldiethanolamine solution.91.6%sorption capacity of mIm solution can be recovered at 353.15 K and 80 *** selectivity for CO_(2)/N_(2) and CO_(2)/CH_(4) can reach an exceptional 7609 and 4324,***,the pilot-scale tests were also performed,and the results demonstrate that more than 98%of CO_(2) in the feed gas could be removed and cyclic absorption capacity can reach 1 mol·L^(-1).This work indicates that mIm is an excellent alternative to alkanolamines for carbon capture in the industry.

关键词： CO_(2) capture Absorption 2-Methylimidazole Separation Pilot-scale tests

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A Two-Layer Active Power Optimization and Coordinated Control for Regional Power Grid Partitioning to Promote Distributed Renewable Energy Consumption

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Energy Engineering 2024年第9期121卷 2479-2503页

作者： Wentao li Jiantao liu Yudun li GuoxinMing Kaifeng Zhang kun Yuan Key Laboratory of Measurement and Control of CSE Southeast UniversityNanjing210096China China Electric Power Research Institute Nanjing210003China State Grid Shandong Electric Power Research Institute Jinan250003China

With the large-scale development and utilization of renewable energy,industrial flexible loads,as a kind of loadside resource with strong regulation ability,provide new opportunities for the research on renewable energy consumption problem in power *** paper proposes a two-layer active power optimization model based on industrial flexible loads for power grid partitioning,aiming at improving the line over-limit problem caused by renewable energy consumption in power grids with high proportion of renewable energy,and achieving the safe,stable and economical operation of power ***,according to the evaluation index of renewable energy consumption characteristics of line active power,the power grid is divided into several partitions,and the interzone tie lines are taken as the optimization ***,on the basis of partitioning,a two-layer active power optimization model considering the power constraints of industrial flexible loads is *** upper-layer model optimizes the planned power of the inter-zone tie lines under the constraint of the minimum peak-valley difference within a day;the lower-layer model optimizes the regional source-load dispatching plan of each resource in each partition under the constraint of theminimumoperation cost of the partition,so as to reduce the line overlimit phenomenon caused by renewable energy consumption and save the electricity cost of industrial flexible ***,through simulation experiments,it is verified that the proposed model can effectively mobilize industrial flexible loads to participate in power grid operation and improve the economic stability of power grid.

关键词： Renewable energy consumption active power optimization power grid partitioning industrial flexible loads line over-limit

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Pt nanoclusters modified porous g-C_(3)N_(4)nanosheets to significantly enhance hydrogen production by photocatalytic water reforming of methanol

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Chinese Journal of Chemical Engineering 2024年第2期66卷 40-50页

作者： Yi-Fei liang Jin-Rong Lu Shang-kun Tian Wen-Quan Cui li liu Hebei Provincial Key Laboratory of Environmental Photocatalytic and Electrocatalytic Materials College of Chemical EngineeringNorth China University of Science and TechnologyTangshan 063210China

For the use of green hydrogen energy,it is crucial to have efficient photocatalytic activity for hydrogen generation by water reforming of methanol under mild *** attention has been paid to gC_(3)N_(4)as a promising photocatalyst for the generation of *** improve the separation of photogenerated charge,porous nanosheet g-C_(3)N_(4)was modified with Pt nanoclusters(Pt/g-C_(3)N_(4))through impregnation and following photo-induced *** catalyst showed excellent photocatalytic activity of water reforming of methanol fo r hydrogen production with a 17.12 mmol·g^(-1)·h^(-1)rate at room temperature,which was 311 times higher than that of the unmodified g-C_(3)N_(4).The strong interactions of Pt-N in Pt/g-C_(3)N_(4)constructed effective electron transfer channels to promote the separation of photogenerated electrons and holes *** addition,in-situ infrared spectroscopy was used to investigate the intermediates of the hydrogen production reaction,which proved that methanol and water eventually turn into H_(2)and CO_(2)via formaldehyde and *** study provides insights for understanding the photocatalytic hydrogen production in the water reforming of methanol.

关键词： Water reforming of methanol Photocatalysis g-C_(3)N_(4) Pt nanoclusters Hydrogen production

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Mode-switchable dual-color infrared quantum cascade detector

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Photonics Research 2024年第2期12卷 253-259页

作者： YIXUAN ZHU SHENQIANG ZHAI kun li KAI GUO QIANGQIANG GUO JINCHUAN ZHANG SHUMAN liu liJUN WANG FENGQI liu JUNQI liu Key Laboratory of Semiconductor Materials Science Beijing Key Laboratory of Low Dimensional Semiconductor Materials and DevicesInstitute of SemiconductorsChinese Academy of SciencesBeijing 100083China Center of Materials Science and Optoelectronics Engineering University of Chinese Academy of SciencesBeijing 100049China

In this paper,a patch-antenna-array enhanced quantum cascade detector with freely switchable operating modes among mid-wave,long-wave,and dual-color was proposed and *** dual-color absorption occurs in a single active region through an optimized coupled miniband diagonal-transition subbands arrangement,and a successful separation of the operation regimes was realized by two nested antenna arrays with different patch sizes up to room *** 77 K,the 5.7-μm channel achieved a peak responsivity of 34.6 mA/W and exhibited a detectivity of 2.0×10^(10)Jones,while the 10.0-μm channel achieved a peak responsivity of 87.5 mA/W,giving a detectivity of 5.0×10^(10)*** a polarization modulation of the incident light,the minimum cross talk of the mid-wave and the long-wave operating modes was 1:22.5 and 1:7.6,*** demonstration opens a new prospect for multicolor infrared imaging chip integration technology.

关键词： antenna polarization quantum

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Hippocampal dopamine as a key regulator for learning deficits in Parkinson's disease

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Neural Regeneration Research 2024年第6期19卷 1193-1194页

作者： kun Wu Shuai liu Shanghai Key Laboratory of Brain Functional Genomics (Ministry of Education) Affiliated Mental Health Center (ECNU) School of Psychology and Cognitive Science East China Normal University Shanghai Changning Mental Health Center NYU-ECNU Institute of Brain and Cognitive Science at NYU Shanghai

Parkinson’s disease(PD) is a progressive neurodegenerative disorder with clinical symptoms of involuntary or uncontrollable movements such as tremors,rigidity,and *** learning deficit is largely overlooked in the pas... 详细信息

关键词： MEMORY

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