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Expressions of Antimicrobial Peptides LL-37, Human Beta Defensin-2 and -3 in the Lesions of Cutaneous Tuberculosis and Tuberculids

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Chinese Medical Journal 2016年第6期129卷 696-701页

作者： Zheng Zhao Zhang-Lei Mu Xi-Wan liu xiao-jing liu Department of Dermatology Peking University People's Hospital Beijing 100044 China Department of Dermatology Peking University International Hospital Beijing 102206 China

Background： Antimicrobial peptides, including cathelicidin LL-37, human beta defensin （HBD）-2, and HBD-3, are important elements of the innate immune response and involved in modulation of the adaptive immunity, and they also play an important role in cutaneous defense against Mycobacterium tuberculosis. Methods： The fresh skin tissues and paraffin-embedded biopsy samples from three cutaneous tuberculosis, two tuberculids, and ten healthy individuals were collected. The expressions ofLL-37, HBD-2, and HBD-3 mRNA in the lesions of three cutaneous tuberculosis and two tuberculids were detected by quantitative real-time polymerase chain reaction; the protein expressions were detected by immunohistochemistry and Western blotting methods. Results： The expressions of LL-37 mRNA and protein in the lesions of cutaneous tuberculosis and tuberculids were similar to that of normal skin. The expression of HBD-2 mRNA had an increasing trend in the lesions of cutaneous tuberculosis and tuberculids compared with that of normal skin; however, the expression of HBD-2 protein in the lesions of cutaneous tuberculosis had a decreasing trend compared with that of normal skin, and the expression of HBD-2 protein in the lesions of tubereulids was similar to that of normal skin. The expressions of HBD-3 mRNA and protein in lesions of cutaneous tuberculosis and tuberculids were similar to that of normal skin. Conclusions： Our study indicated that the expression of HBD-2 and HBD-3 mRNA and protein in lesions of cutaneous tuberculosis may be not consistent with that of tuberculids. However, an inherent limitation of the present study was that the sample size was small, and the roles and regulation mechanisms ofLL-37, HBD-2, and HBD-3 in cutaneous tuberculosis and tuberculids need to be further investigated.

关键词： Antimicrobial Peptides Cutaneous Tuberculosis Expression Lesions Tuberculids

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锂掺杂对氧化铜薄膜光电性能的影响

光学与光电技术 2024年第4期22卷 43-48页

作者：向玉春朱建雷刘晓静咸阳职业技术学院陕西咸阳712000 陕西科技大学陕西西安710000

通过脉冲激光沉积的方法在玻璃衬底上制备Li掺杂的CuO薄膜,并研究了Li掺杂对CuO薄膜结构及性能的影响。Li掺杂浓度从0 wt%增加到2 wt%时CuO薄膜的结晶性变好,再由2 wt%增加到3 wt%时结晶性变差;在掺杂了Li之后,载流子浓度提高了至少3个... 详细信息

通过脉冲激光沉积的方法在玻璃衬底上制备Li掺杂的CuO薄膜,并研究了Li掺杂对CuO薄膜结构及性能的影响。Li掺杂浓度从0 wt%增加到2 wt%时CuO薄膜的结晶性变好,再由2 wt%增加到3 wt%时结晶性变差;在掺杂了Li之后,载流子浓度提高了至少3个数量级,并且呈现出先增大后减小的趋势,迁移率的变化正好与之相反。当掺杂浓度为2wt%时,载流子浓度达到最大,为1.10×10^(19) cm^(-3),电阻率低至76Ω·cm。这主要是由于不同浓度Li掺杂时,Li原子进入CuO不同的晶格位置造成的。通过Li掺杂,CuO薄膜光电性能有了一定改善,为下一步研究CuO薄膜太阳能电池提供了理论指导。

关键词：脉冲激光沉积氧化铜 Li掺杂导电类型电阻率

Synthesis, Crystal Structure and Property Studies on a Bipyridine Adduct of Nickel Xanthogenate

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Chinese Journal of Structural Chemistry 2021年第5期40卷 588-594,528页

作者： liu xiao-jing liu E LI Zhuang-Yu JIAN Fang-Fang School of Chemical Engineering and Pharmaceutics Henan University of Science and TechnologyLuoyang 471000China School of Materials Science and Engineering&Center for Molecular Engineering and Applied Chemistry Anhui University of TechnologyMaanshan 243002China Heke University Renewable Energy Co.LTD Luoyang 471000China

A new coordination polymer containing mixed ligands, namely [Ni(S_(2)COiBu)_(2)(DBPMF)·(CHCl_(3))]_(∞)(DBPMF = 2,7-dibromo-9,9-(4-pyridylmethyl)fluorine), has been synthesized and structurally characterized by elemental analysis and single-crystal X-ray diffractions. X-ray structural analysis reveals that each Ni atom is coordinated by two isobutyl xanthogenate molecules and two nitrogen atoms from two DBPMF ligands to form octahedral coordination geometry. DBPMF acts as a bridge to form a coordination polymer. Fluorescence property of this coordination polymer displays a broad emission band at λ = 413 nm. Thermal analysis shows that the solvent molecule CHCl_(3) can be stabilized in the crystal structure until 140 ℃.

关键词： DBPMF coordination polymer xantghogenate crystal structure fluorescence

An efficient parallel algorithm of variational nodal method for heterogeneous neutron transport problems

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Nuclear Science and Techniques 2024年第4期35卷 29-45页

作者： Han Yin xiao-jing liu Teng-Fei Zhang School of Nuclear Science and Engineering Shanghai Jiao Tong UniversityShanghai 2002040China

The heterogeneous variational nodal method(HVNM)has emerged as a potential approach for solving high-fidelity neutron transport ***,achieving accurate results with HVNM in large-scale problems using high-fidelity models has been challenging due to the prohibitive computational *** paper presents an efficient parallel algorithm tailored for HVNM based on the Message Passing Interface *** algorithm evenly distributes the response matrix sets among processors during the matrix formation process,thus enabling independent construction without *** the formation tasks are completed,a collective operation merges and shares the matrix sets among the *** the solution process,the problem domain is decomposed into subdomains assigned to specific processors,and the red-black Gauss-Seidel iteration is employed within each subdomain to solve the response matrix ***-to-point communication is conducted between adjacent subdomains to exchange data along the *** accuracy and efficiency of the parallel algorithm are verified using the KAIST and JRR-3 test *** results obtained with multiple processors agree well with those obtained from Monte Carlo *** parallelization of HVNM results in eigenvalue errors of 31 pcm/-90 pcm and fission rate RMS errors of 1.22%/0.66%,respectively,for the 3D KAIST problem and the 3D JRR-3 *** addition,the parallel algorithm significantly reduces computation time,with an efficiency of 68.51% using 36 processors in the KAIST problem and 77.14% using 144 processors in the JRR-3 problem.

关键词： Neutron transport Variational nodal method Parallelization KAIST JRR-3

基于红外热成像技术探讨心脏表面温度与代谢相关脂肪性肝病诊断的相关性

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中西医结合肝病杂志 2024年第6期34卷 500-504页

作者：张丹璇刘静刘金霄周晓玲陶萍萍唐春凤张成磊柳州市中医医院(柳州市壮医医院)治未病中心柳州545001 广西中医医用红外热成像应用研究重点实验室广西科技大学

目的:基于红外热成像技术探讨心脏表面温度与代谢相关脂肪性肝病(MAFLD)的相关性。方法:选取2021年7月至2022年12月在柳州市中医医院(柳州市壮医医院)体检的430例患者为研究对象,采集一般资料、生理、生化、医用红外热成像等信息。根据... 详细信息

目的:基于红外热成像技术探讨心脏表面温度与代谢相关脂肪性肝病(MAFLD)的相关性。方法:选取2021年7月至2022年12月在柳州市中医医院(柳州市壮医医院)体检的430例患者为研究对象,采集一般资料、生理、生化、医用红外热成像等信息。根据采集结果,分为脂肪肝组及非脂肪肝组。Spearman相关系数法及Logistic回归分析影响MAFLD的危险因素。运用随机森林及决策树分析上焦(心脏)温度与MAFLD的相关性。结果:采用Spearman相关系数法和Logistic回归,发现年龄、性别、上焦(心脏)、腋-眼、中焦-下焦、腋-胁这6个变量是影响MAFLD的危险因素。运用随机森林和决策树发现,当上焦(心脏)温度在30.34℃及以下时,患MAFLD的风险为100%。当上焦(心脏)的温度为30.34~31.38℃且年龄>41岁时,患MAFLD的风险较高。当上焦(心脏)温度为31.38~32.51℃且双腋窝-双胁肋的温度差值为0.63~1.33℃时,患MAFLD的风险较高。当上焦(心脏)温度为32.51~33.6℃、年龄>37岁的男性时,患MAFLD的风险较高。且该模型总预测准确率97.4%。结论:上焦(心脏)凉偏离与MAFLD发生风险正相关,上焦(心脏)表面温度越低,患MAFLD的风险越高。在临床上,可对持续上焦(心脏)凉偏离的人群进行健康管理,以延缓MAFLD的发生与进展。

关键词：代谢相关脂肪性肝病心脏表面温度红外热成像技术危险因素

Potential regulation of linoleic acid and volatile organic compound contents in meat of chickens by PLCD1

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Journal of Integrative Agriculture 2023年第1期22卷 222-234页

作者： liu xiao-jing WANG Yong-li liu Li liu Lu ZHAO Gui-ping WEN Jie JIA Ya-xiong CUI Huan-xian State Key Laboratory of Animal Nutrition Institute of Animal SciencesChinese Academy of Agricultural SciencesBeijing 100193P.R.China

Omega-3(linolenic acid(ALA),docosapentaenoic acid,eicosapentaenoic acid)and omega-6(linoleic acid(LA),arachidonic acid)polyunsaturated fatty acids are essential for health and normal physiological functioning in *** we report a genome-wide association study(GWAS)on LA content in chicken *** 19 significant single nucleotide polymorphisms(SNPs)identified by the GWAS approach were annotated in VILL,PLCD1 and OXSR1 genes with highly polymorphic linkage blocks,and explained 4.5%of the phenotypic variation in the LA ***,the PLCD1 mRNA expression level was negatively correlated with the LA content,and significantly higher in chickens with low LA content than in those with high LA *** addition,PLCD1 was found to be involved in metabolic pathways,***,the LA content was correlated with volatile organic compounds(e.g.,octanal,etc.),but no relationship was found with intramuscular fat and triglycerides in chicken *** results indicated that there are key SNPs in PLCD1 that regulate the content of LA,and it has no significant effect on fat deposition,but may affect the content of volatile organic compounds(VOCs).

关键词： linoleic acid flavor quality intramuscular fat PLCD1 chicken meat

甘肃不同区域青贮紫花苜蓿乳酸菌群落特征及其驱动因子研究

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草业学报 2024年第2期33卷 112-124页

作者：唐璎刘晓静赵雅姣董霖甘肃农业大学草业学院草业生态系统教育部重点实验室甘肃省草业工程实验室中-美草地畜牧业可持续发展研究中心甘肃兰州730070

为精细化调控不同地区紫花苜蓿青贮乳酸菌及青贮品质,采用单分子实时测序技术对甘肃不同地区紫花苜蓿叶面附生乳酸菌及青贮乳酸菌群落结构进行全面分析,并探讨影响其变化的因素。结果表明,甘肃不同地区紫花苜蓿自然青贮过程中乳酸菌的... 详细信息

为精细化调控不同地区紫花苜蓿青贮乳酸菌及青贮品质,采用单分子实时测序技术对甘肃不同地区紫花苜蓿叶面附生乳酸菌及青贮乳酸菌群落结构进行全面分析,并探讨影响其变化的因素。结果表明,甘肃不同地区紫花苜蓿自然青贮过程中乳酸菌的群落结构具有区域性的分布特征,在河西干旱灌区,以植物乳杆菌为主;在陇中、陇东干旱半干旱雨养区以植物乳酸菌、鼠李糖乳杆菌和戊糖片球菌为主;在雨水充沛湿热的陇南地区,以乳酸片球菌和戊糖片球菌为主;在高寒的甘南州地区,以植物乳杆菌和鼠李糖乳杆菌为主。通过冗余分析发现,紫花苜蓿附生乳酸菌群落对青贮乳酸菌群落组成影响最大(解释度为88.27%),其中乳酸杆菌属、片球菌属起主要作用。同时,影响紫花苜蓿附生乳酸菌分布的因素程度大小为年平均气温>年平均降水量>平均相对湿度>年平均日照时数>海拔>纬度>经度。综上所述,不同区域由于其温度和降水的不同改变了紫花苜蓿附生乳酸菌的组成及丰度,进而使紫花苜蓿青贮时乳酸菌的群落结构发生改变。因此,区域性气候条件通过决定紫花苜蓿附生乳酸菌种类,是主导青贮乳酸菌群落呈区域性分布特征的驱动因素。

关键词：甘肃紫花苜蓿青贮乳酸菌群落特征驱动因子关联性分析

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岩藻多糖调控肠道黏膜屏障功能及其在动物生产中的应用

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饲料研究 2024年第7期47卷 151-156页

作者：韩丰韦王哲奇刘晓静红雷史彬林徐元庆内蒙古农业大学动物科学学院内蒙古呼和浩特010018 中国农业科学院草原研究所内蒙古呼和浩特010010 乌兰察布市科学技术事业发展中心内蒙古乌兰察布012000

肠道是动物机体重要的免疫器官之一,肠道黏膜是机体内环境与外界直接接触和交流的主要场所,是机体抵御肠道抗原的第一道防线。肠道黏膜屏障的完整性是维持肠道正常功能和健康的前提。岩藻多糖是富含硫酸基团的大分子多糖,具有抗炎、抗... 详细信息

肠道是动物机体重要的免疫器官之一,肠道黏膜是机体内环境与外界直接接触和交流的主要场所,是机体抵御肠道抗原的第一道防线。肠道黏膜屏障的完整性是维持肠道正常功能和健康的前提。岩藻多糖是富含硫酸基团的大分子多糖,具有抗炎、抗氧化和抗病毒等功能,可以通过调节肠上皮屏障功能、胆汁的分泌、肠上皮细胞紧密连接、肠道菌群结构和免疫细胞功能维护肠道内环境的稳态。文章主要综述岩藻多糖对动物肠道黏膜屏障的影响及其在动物生产中的应用,旨在为新型饲料添加剂的开发提供参考。

关键词：岩藻多糖肠道黏膜屏障黏膜免疫肠道菌群结构

Effect of Blood Circulation in Veins on Resonance Suppression of the Dragonfly Wing Constructed by Numerical Method

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Journal of Bionic Engineering 2024年第2期21卷 877-891页

作者： Lijun Zhang Xu Zhang Kaifei Wang Zhenwei Gan Shibo liu xiao liu Zhengjun jing Xudong Cui Jiahui Lu jing liu College of Mechanical and Electronic Engineering China University of PetroleumQingdao266580China

To reveal the resonance suppression mechanism of the blood circulation in dragonfly wings,a numerical modeling method of dragonfly wings based on Voronoi diagrams is proposed,and the changes in mass,aerodynamic damping,and natural frequencies caused by blood circulation in veins are *** equivalent mass of blood,boundary conditions,and aerodynamic damping are calculated *** analysis and harmonic response analysis of wing models with different blood circulation paths are performed using the finite-element method(FEM).The vibration reduction ratioδis introduced to compare the damping efficiency of different mass ***,a natural frequency testing device is constructed to measure the natural frequencies of dragonfly *** results indicate that the shape,mass,and natural frequencies of the dragonfly wing model constructed by numerical method agree well with *** mass distribution on the wing can be altered by blood circulation,thereby adjusting the natural frequencies and achieving resonance *** highestδof 1.013 is observed in the C region when blood circulates solely in secondary veins,but it is still lower than theδof 1.017 when blood circulates in complete *** aerodynamic damping ratio(1.19–1.79%)should not be neglected in the vibration analysis of the beating wing.

关键词： Dragonfly wings Blood circulation Resonance suppression Voronoi diagram FEM