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The first data release(DR1. of the LAMOST regular survey

Research in Astronomy and Astrophysics 2015年第8期15卷 1095-1124页

作者： A-li Luo Yong-Heng zhao Gang zhao li-Cai Deng Xiao-Wei liu Yi-Peng Jing Gang wang Hao-Tong Zhang Jian-Rong Shi Xiang-Qun Cui Yao-Quan Chu Guo-Ping li Zhong-Rui Bai Yue Wu Yan Cai Shu-Yun Cao Zi-Huang Cao Jeffrey L.Carlin Hai-Yuan Chen Jian-Jun Chen Kun-Xin Chen li Chen Xue-Lei Chen Xiao-Yan Chen Ying Chen Norbert Christlieb Jia-Ru Chu Chen-Zhou Cui Yi-Qiao Dong Bing Du Dong-Wei Fan Lei feng Jian-Ning Fu Peng gao Xue-Fei Gong Bo-Zhong Gu Yan-Xin Guo Zhan-Wen Han Bo-liang He Jin-liang Hou Yong-Hui Hou Wen Hou Hong-Zhuan Hu Ning-Sheng Hu Zhong-Wen Hu Zhi-Ying Huo Lei Jia Fang-Hua Jiang Xiang Jiang Zhi-Bo Jiang Ge Jin Xiao Kong Xu Kong Ya-Juan Lei Ai-Hua li Chang-Hua li Guang-Wei li Hai-Ning li Jian li Qi li Shuang li Sha-Sha li Xin-Nan li Yan li Yin-Bi li Ye-Ping li Yuan liang Chien-Cheng lin Chao liu Gen-Rong liu Guan-Qun liu Zhi-Gang liu Wen-Zhi Lu Yu Luo Yin-Dun Mao Heidi Newberg Ji-Jun Ni zhao-Xiang Qi Yong-Jun Qi Shi-Yin Shen Huo-Ming Shi Jing Song Yi-Han Song Ding-Qiang Su Hong-Jun Su Zheng-Hong Tang Qing-Sheng Tao Yuan Tian Dan wang Da-Qi wang feng-Fei wang Guo-Min wang Hai wang Hong-Chi wang Jian wang Jia-Ning wang Jian-ling wang Jian-Ping wang Jun-Xian wang Lei wang Meng-Xin wang Shou-Guan wang Shu-Qing wang Xia wang Ya-Nan wang You wang Yue-Fei wang You-Fen wang Peng Wei Ming-Zhi Wei Hong Wu Ke-Fei Wu Xue-Bing Wu Yu-Zhong Wu Xiao-Zheng Xing ling-Zhe Xu Xin-Qi Xu Yan Xu Tai-Sheng Yan De-Hua Yang Hai-feng Yang Hui-Qin Yang Ming Yang Zheng-Qiu Yao Yong Yu Hui Yuan Hai-Bo Yuan Hai-Long Yuan Wei-Min Yuan Chao Zhai En-Peng Zhang Hua-Wei Zhang Jian-Nan Zhang li-Pin Zhang Wei Zhang Yong Zhang Yan-Xia Zhang Zheng-Chao Zhang Ming zhao Fang Zhou Xu Zhou Jie Zhu Yong-Tian Zhu Si-Cheng Zou Fang Zuo National Astronomical Observatories Chinese Academy of Sciences department of Astronomy Peking University Shanghai Astronomical Observatory Chinese Academy of Sciences Nanjing Institute of Astronomical Optics & Technology National Astronomical ObservatoriesChinese Academy of Sciences university of Science and Technology of{1. department of {1. Applied Physics and AstronomyRensselaer Polytechnic InstituteTroyNY 12180USA department of {1. and Astronomy Earlham CollegeRichmondIN 47374USA Universitt Heidelberg Zentrum für AstronomieLandessternwarteKnigstuhl 1269117 HeidelbergGermany department of Astronomy Beijing Normal University Yunnan Observatories Chinese Academy of Sciences Purple Mountain Observatory Chinese Academy of Sciences

The Large sky Area Multi-Object Fiber Spectroscopic Telescope（LAMOST） general survey is a spectroscopic survey that will eventually cover approximately half of the celestial sphere and collect 1. million spectra of stars, galaxies and QSOs. Objects in both the pilot survey and the first year regular survey are included in the LAMOST DR1. The pilot survey started in October 201. and ended in June 201., and the data have been released to the public as the LAMOST Pilot Data Release in August 201.. The regular survey started in September 201., and completed its first year of operation in June 201.. The LAMOST DR1.includes a total of 1.02 plates containing 2 955 336 spectra, of which 1.790 879 spectra have observed signalto-noise ratio（SNR） ≥ 1.. All data with SNR ≥ 2 are formally released as LAMOST DR1.under the LAMOST data policy. This data release contains a total of 2 204 696 spectra, of which 1.944 329 are stellar spectra, 1. 082 are galaxy spectra and 501. are quasars. The DR1.not only includes spectra, but also three stellar catalogs with measured parameters： late A,FGK-type stars with high quality spectra（1.061.91. entries）, A-type stars（1.0 073 entries）, and M-type stars（1.1.522 entries）. This paper introduces the survey design, the observational and instrumental limitations, data reduction and analysis, and some caveats. A description of the FITS structure of spectral files and parameter catalogs is also provided.

关键词： techniques: spectroscopic survey—data release—catalog

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Biomarkers of aging

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Science china({1.fe Sciences) 2023年第5期66卷 893-1066页

作者： Aging Biomarker Consortium Hainan Bao Jiani Cao Mengting Chen Min Chen Wei Chen Xiao Chen Yanhao Chen Yu Chen Yutian Chen Zhiyang Chen Jagadish K Chhetri Yingjie Ding Junlin feng Jun Guo Mengmeng Guo Chuting He Yujuan Jia Haiping Jiang Ying Jing Dingfeng li Jiaming li Jingyi li Qinhao liang Rui liang feng liu Xiaoqian liu Zuojun liu Oscar Junhong Luo Jianwei Lv Jingyi Ma Kehang Mao Jiawei Nie Xinhua Qiao Xinpei Sun Xiaoqiang Tang Jianfang wang Qiaoran wang Siyuan wang Xuan wang Yaning wang Yuhan wang Rimo Wu Kai Xia Fu-Hui Xiao lingyan Xu Yingying Xu Haoteng Yan liang Yang Ruici Yang Yuanxin Yang Yilin Ying Le Zhang Weiwei Zhang Wenwan Zhang Xing Zhang Zhuo Zhang Min Zhou Rui Zhou Qingchen Zhu Zhengmao Zhu feng Cao Zhongwei Cao Piu Chan Chang Chen Guobing Chen Hou-Zao Chen Jun Chen Weimin Ci Bi-Sen Ding Qiurong Ding feng gao Jing-Dong JHan Kai Huang Zhenyu Ju Qing-Peng Kong Ji li Jian li Xin li Baohua liu feng liu lin liu Qiang liu Qiang liu Xingguo liu Yong liu Xianghang Luo Shuai Ma Xinran Ma Zhiyong Mao Jing Nie Yaojin Peng Jing Qu Jie Ren Ruibao Ren Moshi Song Zhou Songyang Yi Eve Sun Yu Sun Mei Tian Shusen wang Si wang Xia wang Xiaoning wang Yan-Jiang wang Yunfang wang Catherine CL Wong Andy Peng Xiang Yichuan Xiao Zhengwei Xie Daichao Xu Jing Ye Rui Yue Cuntai Zhang Hongbo Zhang liang Zhang Weiqi Zhang Yong Zhang Yun-Wu Zhang Zhuohua Zhang Tongbiao zhao Yuzheng zhao Dahai Zhu Weiguo Zou Gang Pei Guang-Hui liu Aging Biomarker Consortium(ABC) Beijing 100101China CAS Key Laboratory of Genomic and Precision Medicine Beijing Institute of GenomicsChinese Academy of Sciences and China National Center for BioinformationBeijing 100101China State Key Laboratory of Stem Cell and Reproductive Biology Institute of ZoologyChinese Academy of SciencesBeijing 100101China department of Dermatology Xiangya HospitalCentral South UniversityChangsha 410008China Hunan Key Laboratory of Aging Biology Xiangya HospitalCentral South UniversityChangsha 410008China National Clinical Research Center for Geriatric Disorders Xiangya HospitalCentral South UniversityChangsha 410008China Clinic Center of Human Gene Research Union HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430022China Hubei Clinical Research Center of Metabo{1.c and Cardiovascular Disease Huazhong University of Science and TechnologyWuhan 430022China Hubei Key Laboratory of Metabolic Ab{1.ities and Vascular Aging Huazhong University of Science and TechnologyWuhan 430022China Stem Cell Translational Research Center Tongji HospitalTongji University School of MedicineShanghai 200065China department of Nuclear Medicine Daping HospitalThird Military Medical UniversityChongqing 400042China CAS Key Laboratory of Nutrition Metabolism and Food SafetyShanghai Institute of Nutrition and HealthUniversity of Chinese Academy of SciencesChinese Academy of SciencesShanghai 200031China Shanghai Key Laboratory of Maternal Fetal Medicine Clinical and Translational Research Center of Shanghai First Maternity and Infant HospitalFrontier Science Center for Stem Cell ResearchShanghai Key Laboratory of Signaling and Disease ResearchSchool of Life Sciences and TechnologyTongji UniversityShanghai 200092China The department of Endovascular Surgery The First Affiliated Hospital of Zhengzhou UniversityZhengzhou 450052China Key Laboratory of Regenerative Medicine of Ministry of Education Institute of Ageing and Regenerative MedicineJ

Aging biomarkers are a combination of biological parameters to(i)assess age-related changes,(ii)track the physiological aging process,and(iii)predict the transition into a pathological *** a broad spectrum of aging biomarkers has been developed,their potential uses and limitations remain poorly *** immediate goal of biomarkers is to help us answer the following three fundamental questions in aging research:How old are we?Why do we get old?And how can we age slower?This review aims to address this ***,we summarize our current knowledge of biomarkers developed for cellular,organ,and organismal levels of aging,comprising six pillars:physiological characteristics,medical imaging,histological features,cellular alterations,molecular changes,and secretory *** fulfill all these requisites,we propose that aging biomarkers should qualify for being specific,systemic,and clinically relevant.

关键词： aging senescence biomarker clock

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Timing analysis of the black hole candidate EXO 1.46–031.with Insight-HXMT monitoring

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Research in Astronomy and Astrophysics 2021年第3期21卷 193-204页

作者： He-Xin liu Yue Huang Guang-Cheng Xiao Qing-Cui Bu Jin-Lu Qu Shu Zhang Shuang-Nan Zhang Shu-Mei Jia Fang-Jun Lu Xiang Ma lian Tao Wei Zhang li Chen li-Ming Song Ti-Pei li Yu-Peng Xu Xue-Lei Cao Yong Chen Cong-Zhan liu Ce Cai Zhi Chang Gang Chen Tian-Xiang Chen Yi-Bao Chen Yu-Peng Chen Wei Cui Wei-Wei Cui Jing-Kang Deng Yong-Wei Dong Yuan-Yuan Du Min-Xue Fu Guan-Hua gao He gao Min gao Ming-Yu Ge Yu-Dong Gu Ju Guan Cheng-Cheng Guo Da-Wei Han Jia Huo Lu-Hua Jiang Wei-Chun Jiang Jing Jin Yong-Jie Jin ling-Da Kong Bing li Cheng-Kui li Gang li Mao-Shun li Wei li Xian li Xiao-Bo li Xu-Fang li Yang-Guo li Zheng-Wei li Xiao-Hua liang Jing-Yuan liao Bai-Sheng liu Guo-Qing liu Hong-Wei liu Xiao-Jing liu Yi-Nong liu Bo Lu Xue-feng Lu Qi Luo Tao Luo Bin Meng Yi Nang Jian-Yin Nie Ge Ou Na Sai Ren-Cheng Shang Xin-Ying Song liang Sun Ying Tan You-li Tuo Chen wang Guo-feng wang Juan wang ling-Jun wang Weng-Shuai wang Yu-Sa wang Xiang-Yang Wen Bai-Yang Wu Bo-Bing Wu Mei Wu Shuo Xiao Shao-lin Xiong He Xu Jia-Wei Yang Sheng Yang Yan-Ji Yang Yi-Jung Yang Qi-Bin Yi Qian-Qing Yin Yuan You Ai-Mei Zhang Cheng-Mo Zhang Fan Zhang Hong-Mei Zhang Juan Zhang Tong Zhang Wan-Chang Zhang Wen-zhao Zhang Yi Zhang Yi-Fei Zhang Yong-Jie Zhang Yuan-Hang Zhang Yue Zhang zhao Zhang Zhi Zhang Zi-liang Zhang Hai-Sheng zhao Xiao-Fan zhao Shi-Jie Zheng Yao-Guang Zheng Deng-Ke Zhou Jian-feng Zhou Yu-Xuan Zhu Ren-lin Zhuang Yue Zhu Key Laboratory of Particle Astrophysics Institute of High Energy PhysicsChinese Academy of SciencesBeijing 100049China university of Chinese Academy of Sciences Chinese Academy of SciencesBeijing 100049China Institut fur Astronomie und Astrophysik Kepler Center for Astro and Particle PhysicsEberhard Karls Universität72076 TubingenGermany department of Astronomy Beijing Normal UniversityBeijing 100088China department of Astronomy Tsinghua UniversityBeijing 100084China department of {1. Tsinghua UniversityBeijing 100084China department of Engineering {1. Tsinghua UniversityBeijing 100084China Key Laboratory of Space Astronomy and Technology National Astronomical ObservatoriesChinese Academy of SciencesBeijing 100101China College of physics Sciences&Technology Hebei UniversityBaoding 071002Hebei ProvinceChina

We present the observational results from a detailed timing analysis of the black hole candidate EXO 1.46-031.during its outburst in 201. with the observations of Insight-HXMT,NICER and *** outburst can be classified roughly into four different ***-C quasi-periodic oscillations(QPOs)observed by NICER(about 0.1.6 Hz)and Insight-HXMT(about 0.7-8 Hz)are also reported in this ***,we study various physical quantities related to QPO *** QPO rms-frequency relationship in the energy band 1.1. keV indicates that there is a turning pointing in frequency around2 Hz,which is similar to that of GRS 1.1.+1.5.A possible hypothesis for the relationship above may be related to the inclination of the source,which may require a high inclination to explain *** relationships between QPO frequency and QPO rms,hardness,total fractional rms and count rate have also been found in other transient sources,which can indicate that the origin of type-C QPOs is non-thermal.

关键词： X-ray binaries black hole candidate QPO EXO 1.46–031

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Measurement of the ^(232)Th(n,f)cross section in the 1.200 MeV range at the CSNS Back-n

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Nuclear Science and Techniques 2023年第8期34卷 142-153页

作者： Zhi-Zhou Ren Yi-Wei Yang Yong-Hao Chen Rong liu Bang-Jiao Ye Jie Wen Hai-Rui Guo Zi-Jie Han Qi-Ping Chen Zhong-Wei Wen Wei-li Sun Han Yi Xing-Yan liu Tao Ye Jiang-Bo Bai Qi An Jie Bao Yu Bao Ping Cao Hao-Lei Chen Zhen Chen Zeng-Qi Cui Rui-Rui Fan Chang-Qing feng Ke-Qing gao Xiao-Long gao Min-Hao Gu Chang-Cai Han Guo-Zhu He Yong-Cheng He Yang Hong Yi-Wei Hu Han-Xiong Huang Xi-Ru Huang Hao-Yu Jiang Wei Jiang Zhi-Jie Jiang Han-Tao Jing ling Kang Bo li Chao li Jia-Wen li Qiang li Xiao li Yang li Jie liu Shu-Bin liu Ze Long Guang-Yuan Luan Chang-Jun Ning Meng-Chen Niu Bin-Bin Qi Jie Ren Xi-Chao Ruan zhao-Hui Song Kang Sun Zhi-Jia Sun Zhi-Xin Tan Jing-Yu Tang Xin-Yi Tang Bin-Bin Tian li-Jiao wang Peng-Cheng wang zhao-Hui wang Xiao-Guang Wu Xuan Wu li-Kun Xie Xiao-Yun Yang li Yu Tao Yu Yong-Ji Yu Guo-Hui Zhang lin-Hao Zhang Qi-Wei Zhang Xian-Peng Zhang Yu-liang Zhang Zhi-Yong Zhang Lu-Ping Zhou Zhi-Hao Zhou Ke-Jun Zhu department of Modern {1. University of Science and Technology of ChinaHefei 230026China Institute of Nuclear physics and Chemistry China Academy of Engineering PhysicsMianyang 621900China Institute of High Energy physics Chinese Academy of Sciences(CAS)Beijing 100049China Spallation Neutron Source Science Center Dongguan 523803China Institute of Applied {1. and Computational Mathematics Beijing 100088China State Key Laboratory of Particle Detection and Electronics University of Science and Technology of ChinaHefei 230027China Key Laboratory of Nuclear Data China Institute of Atomic EnergyBeijing 102413China School of Nuclear Science and Technology University of Science and Technology of ChinaHefei 230027China State Key Laboratory of Nuclear physics and Technology School of PhysicsPeking UniversityBeijing 100871China State Key Laboratory of Particle Detection and Electronics Institute of High Energy PhysicsChinese Academy of SciencesBeijingChina Northwest Institute of Nuclear Technology Xi’an 710024China university of Chinese Academy of Sciences Beijing 100049China department of Engineering and App{1.ed physics University of Science and Technology of ChinaHefei 230026China

The ^(232)Th(n,f)cross section is very important in basic nuclear physics and app{1.cations based on the Th/U fuel *** the time-of-f{1.ght method and a multi-cell fast-fission ionization chamber,a novel measurement of the^(232)Th(n,f)cross sec-tion relative to^(235)U in the 1.200 MeV range was performed at the china Spallation Neutron Source Back-n white neutron source(Back-n).The fission event-neutron energy spectra of^(232)Th and^(235)U fission cells were measured in the single-bunch *** 232Th/235U fission cross-sectional ratios were obtained,and the measurement uncertainties were 2.5–3.7%for energies in the 2–20 MeV range and 3.6–6.2%for energies in the 20–200 MeV ***^(232)Th(n,f)cross section was obtained by introducing the standard cross section of^(235)U(n,f).The results were compared with those of previous theoreti-cal calculations,measurements,and *** measured 232Th fission cross section agreed with the main evaluation results in terms of the experimental uncertainty,and 232Th fission resonances were observed in the 1.3 MeV *** present results provide^(232)Th(n,f)cross-sectional data for the evaluation and design of Th/U cycle nuclear systems.

关键词： 232Th(n f)cross section Fast-fission ionization chamber Back-n white neutron source

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脑神经外科长时间手术患者围术期应用皮质类固醇的影响

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天津医科大学学报 2009年第4期15卷 633-635页

作者：王壮杨勇石钊高风王国林天津医科大学总医院麻醉科天津300052

目的:探讨脑神经外科长时间手术患者围术期应用激素对血浆皮质类固醇(COR)的影响。方法:择期长达1.h以上的手术35例,随机分为2组,激素组(n=20)于手术开始时静注甲强龙40mg;对照组(n=1.)静注等量生理盐水。所有患者采用静脉复合全身麻醉... 详细信息

目的:探讨脑神经外科长时间手术患者围术期应用激素对血浆皮质类固醇(COR)的影响。方法:择期长达1.h以上的手术35例,随机分为2组,激素组(n=20)于手术开始时静注甲强龙40mg;对照组(n=1.)静注等量生理盐水。所有患者采用静脉复合全身麻醉,分别于术前(基础值)、插管时、术中每4h(超过1.h不再测量)、术毕、术后1.3d各抽静脉血4ml测血浆COR浓度。结果:术后1.激素组与对照组COR相比差异有统计学意义(P1.与术前相比差异均有统计学意义(P1.COR下降。

关键词：神经外科激素皮质类固醇围术期

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志贺毒素A/B(ShT-A/B)亚单位基因的克隆与序列分析

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微生物学杂志 2003年第4期23卷 1-3,7页

作者：喻华英王景林高丰康琳吴东林赵金红军事医学科学院微生物流行病研究所解放军军需大学动物科学系吉林长春130062 解放军第208医院检验科吉林长春130062

应用PCR技术从Ⅰ型痢疾志贺茵(Shigella dysenteriae type Ⅰ)中,分别扩增出约895bp和225bp的成熟ShT-A,B基因片段,直接克隆至pGEM-T载体中,经蓝白斑筛选、PCR和双酶切鉴定正确后,命名为pGEM-ShTA_2和pGEM-ShTB_3。测序结果表明,插入的... 详细信息

应用PCR技术从Ⅰ型痢疾志贺茵(Shigella dysenteriae type Ⅰ)中,分别扩增出约895bp和225bp的成熟ShT-A,B基因片段,直接克隆至pGEM-T载体中,经蓝白斑筛选、PCR和双酶切鉴定正确后,命名为pGEM-ShTA_2和pGEM-ShTB_3。测序结果表明,插入的片段是ShT-A,ShT-B,且与GenBank中ShT-A,B核酸序列完全一致,从而为重组ShT-A,B的表达研究奠定了基础。

关键词：志贺毒素A/B 基因克隆序列分析 I型痢疾志贺菌 ShT-A/B

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冠状动脉粥样硬化性心脏病患者外周血单核细胞亚群CX3CR1.达的变化及意义

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上海交通大学学报（医学版） 2021年第3期41卷 328-333页

作者：赵倩高霖王长谦张俊峰张绘莉卓杨上海交通大学医学院附属第九人民医院心血管内科上海200011

目的·探讨不同类型冠状动脉粥样硬化性心脏病(冠心病)患者外周血单核细胞亚群趋化因子受体CCR2(C-C motif chemokine receptors 2)和CX3CR1.C-X3-C motif chemokine receptor 1.表达水平的变化及其临床意义。方法·选择201.年1.6月于... 详细信息

目的·探讨不同类型冠状动脉粥样硬化性心脏病(冠心病)患者外周血单核细胞亚群趋化因子受体CCR2(C-C motif chemokine receptors 2)和CX3CR1.C-X3-C motif chemokine receptor 1.表达水平的变化及其临床意义。方法·选择201.年1.6月于上海交通大学医学院附属第九人民医院住院并行冠状动脉造影(coronary angiography,CAG)的冠心病患者63例,其中急性冠脉综合征(acute coronary syndrome,ACS)患者46例(ACS组)、稳定型心绞痛(stable angina pectoris,SAP)患者1.例(SAP组)。收集患者的一般资料、临床资料及检测指标。入院24 h内,抽取2组患者静脉血。采用流式细胞术检测外周血单核细胞亚群趋化因子受体CCR2和CX3CR1.表达,并据此进行细胞亚群分类。采用酶联免疫吸附试验(enzyme linked immunosorbent assay,E{1.SA)检测血清趋化因子CCL2(C-C motif chemokine {1.gand 2)和CX3CL1.C-X3-C motif chemokine {1.gand 1.水平,并随访患者5年内主要不良心脏事件(major adverse cardiac event,MACE)的发生情况。结果·与SAP组相比,ACS组患者单核细胞CCR2^(+)CX3CR1.(+)和CCR2^(-)CX3CR1.(+)亚群比例、血清CCL2和CX3CL1.水平均较高(均P1.例、1.患者发生MACE。多因素Logistic回归分析显示,超敏C反应蛋白水平、CCR2^(+)CX3CR1.(-)和CCR2^(-)CX3CR1.(+)亚群比例均为患者5年MACE发生的独立危险因素(均P1.达情况与冠心病患者远期预后相关。

关键词：冠状动脉粥样硬化性心脏病冠状动脉造影主要不良心脏事件趋化因子受体

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Challenges and improvement in management of neonates born to mothers with COVID-1. in china

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Frigid Zone Medicine 2022年第2期2卷 94-102页

作者： Jie Yang Zhuxiao Ren lingkong Zeng Shiwen Xia lin wang Jiayu Miao Zhe zhao Chuanzhong Yang Xiuyong Cheng Huayan Zhang Yuanfang Zhu li liu Xirong gao Bin Yi Zhenlang lin Wei liu Xiaoyu Zhou Benqing Wu ling Chen Zhankui li Xuefeng Zhang Wei Lu lianhong Zhang Xiao Chen Xiaoyun Zhong Falin Xu Jinhui Wu Yong Ji Jiahua Pan Yanxiang Chen Carine Ronsmans Zhichun feng department of Neonatology Guangdong Women and Children HospitalGuangzhou 510000China department of Neonatology Wuhan Children’s HospitalTongji Medical CollegeHuazhong University of Science&TechnologyWuhan 430000China department of Neonatology Hubei Women and Children HospitalWuhan 430000China department of Neonatology Union HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430000China department of Neonatology Seventh Medical CenterPeople’s Liberation Army General HospitalBeijing 100010China department of Neonatology Affiliated Shenzhen Maternity&Child Healthcare HospitalSouthern Medical UniversityShenzhen 518000China department of Neonatology the First Affiliated Hospital of Zhengzhou UniversityZhengzhou 450000China Division of Neonatology and Center for Newborn Care Guangzhou Women and Children’s HospitalGuangzhou 510000China Division of Neonatology Children’s Hospital of PhiladelphiaPhiladelphiaPennsylvania 19104United States department of Obstetrics Shenzhen Baoan Women’s and Children’s HospitalJinan UniversityShenzhen 518000China department of Neonatology The First Affiliated Hospital of Xi’an Jiaotong UniversityXi'an 710000China department of Neonatology Hunan Children's HospitalChangsha410000China department of Neonatology Gansu Provincial Maternal and Child Health HospitalLanzhou 730000China department of Neonatology Yuying Children’s Hospital of Wenzhou Medical UniversityWenzhou 325000China department of Pediatrics Tongji HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430000China Neonatal Medical Centre Children's Hospital of Nanjing Medical UniversityNanjing 210000China department of Neonatology The University of Chinese Academy of Science-Shenzhen HospitalShenzhen 518000China department of Neonatology Northwest Women and Children's HospitalXi’an 730000China department of Neonatology The Fifth Medical CenterPeople’s Liberation Army General HospitalBeijing 100010China Neonatal Intensive Care

Objective:china was the first country suffering from the SARS-CoV-2 pandemic and one of the countries with stringent mother-neonate isolation measure *** increasing evidence suggests that coronavirus disease 201.(COVID-1.)should not be taken as an indication for formula feeding or isolation of the infant from the ***:We conducted a retrospective cohort study in 44 hospitals from 1. provinces in{1. to investigate the management of neonates whose mothers have confirmed or suspected *** addition,65 members of Chinese Neonatologist Association(CNA)were invited to give their comments and suggestions on the clinical management guidelines for high-risk ***:There were 1.1.neonates born to 1.8 mothers suspected with COVID-1. including 42 mothers with SARS-CoV-2 positive results and 76 mothers with SARS-CoV-2 negative *** neonates were born by caesarean section,isolated from their mothers immediately after birth and were *** neonates were positive for SARSCoV-2 at initial testing between 36 and 46 h after *** the confusion on the clinical management guidelines,58.78%of the newborns were put into isolation,32.22%were subject to PCR tests,and 5.1.%and 2.75%received breastfeeding and vaccination,***:The clinical symptoms of neonates born to mothers with confirmed SARS-CoV-2 were mild,though five neonates might have been infected in utero or during *** the favorable outcomes of neonates born to COVID-confirmed mothers,full isolation may not be ***,separation of the mother and her newborn should be assessed on a case-by-case basis,considering local facilities and risk factors for adverse outcomes,such as prematurity and fetal distress.

关键词： coronavirus disease 201. neonates pregnant women infection control

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胃癌群体性筛查联合机会性筛查的初步研究

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中华消化内镜杂志 2023年第11期40卷 886-891页

作者：褚衍六李冰宋向锋赵钦府王萍刘奉丛明刘琳林霖李田徐晓燕张亚琳姜坤苏秀峰高孝忠令狐恩强山东大学附属威海市立医院消化内科威海264200 威海市文登区中西医结合医院消化内科威海264400 乳山市人民医院消化内科威海264500 解放军总医院第一医学中心消化内科医学部北京100853

目的探讨胃癌群体性筛查联合机会性筛查的新模式对胃癌诊治的价值。方法利用群体性筛查联合机会性筛查进行胃癌普查。(1.群体性筛查:采用整群抽样法,201.年7月—2020年1.月对威海市农村居民中的高危人群(年龄40~<70岁)进行内镜普查,必... 详细信息

目的探讨胃癌群体性筛查联合机会性筛查的新模式对胃癌诊治的价值。方法利用群体性筛查联合机会性筛查进行胃癌普查。(1.群体性筛查:采用整群抽样法,201.年7月—2020年1.月对威海市农村居民中的高危人群(年龄40~lial neoplasia,HGIN)的检出率。(2)机会性筛查:同步观察201.年7月—2020年1.月威海市两家区县级医院机会性筛查早期胃癌检出率的变化。结果(1.群体性筛查:201.年7月—2020年1.月,首批完成8000例胃癌筛查。进展期胃癌、早期胃癌、HGIN分别检出36、28、62例,胃癌总例数为64例,胃癌检出率、早期胃癌检出占比分别为0.80%(64/8000)、43.75%(28/64)。早期胃癌+HGIN患者接受内镜黏膜下剥离术治疗者占77.78%(70/90),治愈性切除率1.0.00%(70/70)。(2)机会性筛查:201.年7月—2020年1.月,文登区中西医结合医院机会性筛查中每年早期胃癌检出占比分别1..67%(1.6)、20.00%(3/1.)、23.53%(4/1.)、33.33%(6/1.),乳山市人民医院机会性筛查中每年早期胃癌检出占比分别1..74%(1./95)、23.80%(60/252)、25.49%(65/255)、24.04%(50/208)。威海市医院机会性筛查早期胃癌检出占比呈逐年上升趋势。结论在胃癌高发区,一定规模的群体性筛查可进一步带动更广泛的机会性筛查,从而提高早期胃癌检出率,该胃癌诊治新模式值得推广。

关键词：胃肿瘤诊断模式筛查早期胃癌胃镜超级微创手术

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不同抗病毒方案对新型冠状病毒肺炎患者的临床疗效和安全性观察

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中华危重病急救医学 2020年第12期32卷 1423-1427页

作者：高小芳马春霞马玉杰王晓麒魏建华冯涛赵桂霞徐麟周玮郑西卫赵茜曹相原宁夏回族自治区人民医院重症医学科银川750001 宁夏医科大学总医院银川750004 宁夏回族自治区第四人民医院银川750001 宁夏回族自治区第三人民医院银川750001

目的通过对宁夏回族自治区确诊新型冠状病毒肺炎(新冠肺炎)患者住院期间抗病毒治疗和出院3个月复查追踪,观察和分析新冠肺炎不同抗病毒方案的临床疗效和近期及远期不良反应。方法采用单中心回顾性研究方法,选择2020年1.20日至3月1.日... 详细信息

目的通过对宁夏回族自治区确诊新型冠状病毒肺炎(新冠肺炎)患者住院期间抗病毒治疗和出院3个月复查追踪,观察和分析新冠肺炎不同抗病毒方案的临床疗效和近期及远期不良反应。方法采用单中心回顾性研究方法,选择2020年1.20日至3月1.日作者作为宁夏回族自治区卫生健康委员会派驻至本自治区唯一收治新冠肺炎患者的定点医院(宁夏回族自治区第四人民医院)时在隔离病房全程接管收治的新冠肺炎患者。根据抗病毒方案将患者分为常规抗病毒组和非常规抗病毒组,常规抗病毒组给予α-干扰素联合洛匹那韦/利托那韦治疗;非常规抗病毒组给予α-干扰素联合洛匹那韦/利托那韦和阿比多尔或利巴韦林或磷酸氯喹治疗;再按疾病严重程度不同将患者分为轻型(1.例)、普通型(45例)、重型(1.例)、危重型(1.)。收集患者临床资料、住院时间、首次新型冠状病毒(201.-nCoV)核酸转阴时间、住院费用、出院后1. d 201.-nCoV核酸复阳情况,以及联合使用激素和抗菌药物情况;比较不同抗病毒方案治疗两组入院1.3、7 d和出院1.月、出院3个月血常规、肝功能、血脂水平的差异及不良反应发生情况。结果①一般资料:共收治新冠肺炎确诊患者75例,最终纳入73例,其中常规抗病毒组47例,非常规抗病毒组26例。对不同临床分型患者分析显示,分型越重,患者年龄越大,合并基础疾病的比例越高,住院时间越长,治疗费用越高。与常规抗病毒组比较,非常规抗病毒组重型和危重型患者比例更高〔分别为34.6%(9/26)比1..6%(5/47),3.8%(1.26)比0(0/47)〕,住院时间(d:1..1.5.6比1..6±3.3)、首次核酸转阴时间更长(d:1..4±4.5比1..0±3.5),住院费用更高〔元:1.984.2(9000.6,24424.7)比81.0.4(671..7,9707.7)〕,差异均有统计学意义(均P1. d核酸复阳率比较差异均无统计学意义(均P>0.05)。②实验室检查:随时间延长,两组白细胞计数(WBC)、血小板计数(PLT)、总胆红素(TBil)、三酰甘油(TG)均呈先升高后降低趋势,淋巴细胞计数(LYM)呈先降低后升高趋势。非常规抗病毒组治疗后WBC、PLT、TG均于入院7 d达峰值,分别为(6.53±2.78)×1.^(9)/L、(250.77±96.1.)×1.^(9)/L、(1.94±0.96)μmol/L,TBil于入院3 d达峰值,为(23.69±1..1.)μmol/L,LYM于出院后1.月达峰值,为(1.82±0.50)×1.^(9)/L;但不同抗病毒方案组间上述指标比较差异均无统计学意义;两组各时间点丙氨酸转氨酶(ALT)、天冬氨酸转氨酶(AST)、总胆固醇(TC)比较差异均无统计学意义。③非抗病毒组联合使用激素的比例明显高于常规抗病毒组〔26.9%(7/26)比4.3%(2/47),P<0.05〕。结论年龄、合并基础疾病与新冠肺炎患者病情相关,非常规抗病毒治疗方案多用于病情重、病毒核酸长期未转阴的新冠肺炎患者,可根据患者对药物的反应和耐受程度,个体化使用抗病毒药物。

关键词：新型冠状病毒肺炎抗病毒临床分型不良反应

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