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Multi-Objective Optimization for an Industrial Grinding and Classification Process Based on PBM and RSM

IEEE/CAA Journal of Automatica Sinica 2023年第11期10卷 2124-2135页

作者： Xiaoli Wang Luming Liu Lian Duan qian liao School of Automation Central South universityChangsha 410083China Changsha Research Institute of Mining and Metallurgy Changsha 410012China

The grinding and classification process is one of the key sub-processes in mineral processing, which influences the final process indexes significantly and determines energy and ball consumption of the whole plant. Therefore, optimal control of the process has been very important in practice. In order to stabilize the grinding index and improve grinding capacity in the process,a process model based on population balance model(PBM) is calibrated in this study. The correlation between the mill power and the operating variables in the grinding process is modelled by using the response surface method(RSM), which solves the problem where the traditional power modeling method relies on some unobservable mechanism-related parameters. On this basis, a multi-objective optimization model is established to maximize the useful power of the grinding circuit to improve the throughput of the grinding operation and improve the fraction of –0.074 mm particles in the hydrocyclone overflow to smooth the subsequent flotation operation. The elite non-dominated sorting genetic algorithm-II(NSGA-II) is then employed to solve the multi-objective optimization problem. Finally, subjective and objective weighting methods and integrated multi-attribute decision-making methods are used to select the optimal solution on the Pareto optimal solution set. The results demonstrate that the throughput of the mill and the fraction of –0.074 mm particles in the overflow of the cyclone are increased by 3.83 t/h and 2.53%, respectively.

关键词： Decision-making technique grinding process multiobjective optimization response surface method(RSM)

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CuCl-catalyzed Oxidative N-Demethylation of Arylamines with tButyl Hydroperoxide

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Chemical Research in Chinese Universities 2009年第6期25卷 861-865页

作者： liao qian XI Chan-juan Key Laboratory of Bioorganic Phosphorus Chemistry ＆ Chemical Biology Ministry of Education Department of Chemistry Tsinghua University Beoing 100084 P. R. China

CuCl-catalyzed oxidative N-demethylation of arylamines proceeded in the presence of tert-butyl hydroperoxide. The one-electron transfer route of oxidative N-demethylation competed favorably with the H-atom abstraction... 详细信息

关键词： Arylamine Cuprous chloride Catalytic oxidation N-Demethylation tert-Butyl hydroperoxide

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Influence of Kinematic Analysis Parameters of Drag Anchor Trajectory Prediction Using Yield Envelope Method

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China Ocean Engineering 2020年第2期34卷 257-266页

作者： WU Xiao-ni WANG Teng liao qian LI Ye State Key Laboratory of Ocean Engineering School of Naval ArchitectureOcean and Civil EngineeringShanghai Jiao Tong UniversityShanghai 200240China Department of Naval Architecture and Offshore Engineering China University of Petroleum(East China)Qingdao 266580China

Drag anchor is widely applied in offshore engineering for offshore mooring *** prediction of the invisible trajectory during its drag-in installation is challenging for anchor design in determining the anchor final position for ensuring sufficient holding *** yield envelope method based on deep anchor failure for kinematic analysis was proposed as a promising trajectory prediction method for drag ***,there is a lack of analysis on the effects of the parameters applied in the kinematic *** current work studies the effects of the yield envelope parameters,anchor line bearing capacity factor and the anchor/soil interface *** is found that the accuracy of the yield envelope parameters has large impact on the prediction results based on deep yield *** of cases with smooth fluke predict deeper embedment depth than that from analyses of cases with rough *** decrease of the capacity factor results in the increase of the anchor embedment depth,the anchor line load,the anchor chain angle and the stable value of the normalized horizontal load component for the same drag length,while the stable value of the normalized vertical load component decreases when the capacity factor *** illustrates the importance in applying reasonable parameters and improving the method for more reliable prediction of the anchor trajectory.

关键词： trajectory prediction kinematic analysis drag anchor yield envelope

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Non-scanning systems for far-infrared radiation detection from laser-induced plasmas

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High Power Laser Science and Engineering 2015年第2期3卷 1-5页

作者： Chun Li Guo-qian liao Yu-Tong Li Beijing National Laboratory of Condensed Matter Physics Institute of Physics CAS IFSA Collaborative Innovation Center Shanghai Jiao Tong University

With the development of ultraintense terawatt(TW) and petawatt(PW) laser systems, powerful terahertz(THz) radiation from laser–plasma interactions has been reported. Plasma-based THz systems, which are usually operated at extremely low repetition rates, call for single-shot diagnostics. In this paper, various state-of-the-art single-shot detection methods are introduced or designed for measurements and applications involved in high-power plasma-based THz sciences.

关键词： laser–plasma interaction single-shot detection ter

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Cerium Salt Promoted Homocoupling Reaction of Dialkylanilines in Water

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Chemical Research in Chinese Universities 2008年第2期24卷 226-230页

作者： YANG Xiang-hua LU Wen-chao liao qian XI Chan-juan Key Laboratory for Bioorganic Phosphorus Chemistry ＆ Chemical Biology Ministry of Education Department of Chemistry Tsinghua University Beijing 100084 P. R. China

Highly regioselective homocoupling of N,N-dialkylanilines can be achieved in water with cerium reagents, in which various N,N,N′,N′-tetraalkylbenzidines are obtained from N,N-dialkylanilines either by direct oxidati... 详细信息

关键词： Homocoupling Regioselectivity Cerium salts N,N-Dialkylaniline N,N,N′,N′-Tetraalkylbenzidine

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TOPK Activation Exerts Protective Effects on Cisplatin-induced Acute Kidney Injury

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Current Medical Science 2022年第4期42卷 742-753页

作者： Hui ZHANG Qing-qing DONG Hua-pan SHU Yu-chi TU qian-qian liao Li-jun YAO Department of Nephrology Union HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430022China

Objective:T-LAK-cell-originated protein kinase(TOPK),a PSD95-Disc large-ZO1(PDZ)binding kinase(PBK),is a novel member of the mitogen-activated protein kinase(MAPK)*** have shown that TOPK plays a critical role in the function of tumor cells,including apoptosis and ***,little is known on the effect of TOPK in cisplatin-induced acute kidney injury(CP-AKI).This study aimed to investigate the role and mechanism of TOPK in ***:Cisplatin was administered to C57BL/6 mice and cultured kidney tubular epithelial cells(TECs)to establish the CP-AKI murine or cellular *** were then stimulated with the specific inhibitor of TOPK OTS514 or transfected with the recombinant-activated plasmid TOPK-T9E to inhibit or activate *** TECs were treated with AKT inhibitorⅧfollowing stimulation with OTS514 or *** blotting and flow cytometry were used to evaluate the cell cycle and apoptosis of ***:The analysis revealed that the TOPK activity was significantly suppressed by cisplatin,both in vivo and in ***,the pharmacological inhibition of TOPK by OTS514,a specific inhibitor of TOPK,exacerbated the cisplatin-induced cell cycle arrest in the G2/M phase and apoptosis of cultured ***,the TOPK activation via the TOPK-T9E plasmid transfection could partially reverse the cell cycle arrest at the G2/M phase and apoptosis of cisplatin-treated *** addition,AKT/protein kinase B(PKB),as a TOPK target protein,was inhibited by cisplatin in cultured *** pharmaceutical inhibition of AKT further aggravated the apoptosis of TECs induced by cisplatin or TOPK *** systematically mediated the apoptosis via the AKT pathway in the CP-AKI cell ***:These results indicate that TOPK activation protects against CP-AKI by ameliorating the G2/M cell cycle arrest and cell apoptosis.

关键词： acute kidney injury cisplatin cell cycle apoptosis T-LAK-cell-originated protein kinase/PSD95-Disc large-ZO1 binding kinase

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铜催化含氮和硫化物的乙烯基化反应研究

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有机化学 2012年第6期32卷 986-993页

作者：廖骞席婵娟清华大学化学系北京100084

以铜为催化剂,结合不同的反应条件,分别阐述了酰胺、胺、唑类化合物和硫化物与卤代烯烃的交叉偶联反应,从而分别得到了各种烯酰胺、烯胺、N-烯基唑类化合物和烯基硫醚化合物.上述亲核试剂与1,4-二卤-1,3-二烯化合物反应,经过两次乙烯基... 详细信息

以铜为催化剂,结合不同的反应条件,分别阐述了酰胺、胺、唑类化合物和硫化物与卤代烯烃的交叉偶联反应,从而分别得到了各种烯酰胺、烯胺、N-烯基唑类化合物和烯基硫醚化合物.上述亲核试剂与1,4-二卤-1,3-二烯化合物反应,经过两次乙烯基化反应,可以高效地得到各种取代的吡咯和噻吩衍生物.进一步阐述了N—H键以及其邻位C—H键也能够和1,4-二卤-1,3-二烯反应,生成唑并吡啶衍生物.

关键词：铜催化 N-乙烯基化 S-乙烯基化 N-双乙烯基化 S-双乙烯基化

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The expression and clinical significance of long non-coding RNA LOC728040 in hepatocellular carcinoma

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广西医科大学学报 2017年第5期34卷 641-645页

作者： Xiaoyun Yang qian liao Xiaoqiang Qiu Guangxi Medical University

Objective:This study aimed to investigate the expression of long non-coding RNA LOC728040in hepatocellular carcinoma(HCC)tissues and normal ***:Quantitative reverse-transcription PCR(qPCR)was performed to detect the expression of LOC728040in HCC tissues and paracancer tissues to explore the differences of the clinical indicators of HCC between two groups of low and high *** the target genes prediction of LOC728040as a ***:The lower expression of LOC728040was found in HCC tissues compared with the paracancer tissues(P<0.05).According to the expression,Patients were divided into two groups,and their occupation,tumor capsular and serum alkaline phosphatase(ALP)were significantly different(P<0.05).We found LOC728040upstream existed an alpha albumin gene(AFM)through the Cis analysis by Blast ***:Long non-coding RNA LOC728040was markedly downregulated in HCC tissues and was correlated with occupation tumor capsular and serum *** LOC728040might be a biomarker for detection of HCC or other cancers,but its underlying mechanisms still need further study.

关键词： long non-coding RNA LOC728040 qPCR hep-atocellular carcinoma

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Origin and chromatin remodeling of young X/Y sex chromosomes in catfish with sexual plasticity

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National Science Review 2023年第2期10卷 91-106页

作者： Gaorui Gong Yang Xiong Shijun Xiao Xi-Yin Li Peipei Huang qian liao Qingqing Han Qiaohong Lin Cheng Dan Li Zhou Fan Ren Qi Zhou Jian-Fang Gui Jie Mei Hubei Hongshan Laboratory College of Fisheries Huazhong Agricultural University Jiaxing Key Laboratory for New Germplasm Breeding of Economic Mycology State Key Laboratory of Freshwater Ecology and Biotechnology Hubei Hongshan Laboratory Institute of HydrobiologyChinese Academy of Sciences University of the Chinese Academy of Sciences School of Animal Science and Nutritional Engineering Wuhan Polytechnic University MOE Laboratory of Biosystems Homeostasis & Protection Life Sciences InstituteZhejiang University

Assembly of a complete Y chromosome is a significant challenge in animals with an XX/XY sex-determination *** cently,we created YY-supermale yellow catfish by crossing XY males with sex-reversed XY females,providing a valuable model for Y-chromosome assembly and ***,we assembled highly homomorphic Y and X chromosomes by sequencing genomes of the YY supermale and XX female in yellow catfish,reve aling their nucleotide divergences with only less than 1% and with the same gene *** sex-determining region(SDR) was identified to locate within a physical distance of0.3 Mb by ***,the incipient sex chromosomes were revealed to originate via autosome-autosome fusion and were characterized by a highly rearranged region with an SDR downstream of the fusion *** found that the Y chromosome was at a very early stage of differentiation,as no clear evidence of evolutionary strata and classical structure features of recombination suppression for a rather late stage of Y-chromosome evolution were ***,a number of sex-antagonistic mutations and the accumulation of repetitive elements were discovered in the SDR,which might be the main driver of the initial establishment of recombination suppression between young X and Y ***,distinct three-dimensional chromatin organizations of the Y and X chromosomes were identified in the YY supermales and XX females,as the X chromosome exhibited denser chromatin structure than the Y chromosome,while they respectively have significantly spatial interactions with female-and male-related genes compared with other *** chromatin configuration of the sex chromosomes as well as the nucleus spatial organization of the XX neomale were remodeled after sex reversal and similar to those in YY supermales,and a male-specific loop containing the SDR was found in the open chromatin *** results elucidate the origin of young sex chromosomes and the chromatin remodel

关键词： Y chromosome sex-chromosome evolution chromosome fusion chromatin organization sexual reversal

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Biliary Cast Syndrome： Hepatic Artery Resistance Index, Pathological Changes, Morphology and Endoscopic Therapy

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Chinese Medical Journal 2015年第14期128卷 1910-1915页

作者： Hu Tian qian-De liao Nian-Feng Li Jian Peng Lian-Sheng Gong Ju Liu Hepatobiliary and Enteric Surgery Research Center Xiangya Hospital Central South University Changsha Hunan 410008 China Medical Research Center Shandong Provincial Qiantoshan Hospital Shandong University Jinan Shandong 250014 China

Background： BiNary cast syndrome （BCS） was a postoperative complication of orthotopic liver transplantation （OLT）, and the reason for BSC was considered to relate with ischemic type biliary lesions. This study aimed to evaluate the relationship between BCS following OLT and the hepatic artery resistance index （HARt）, and to observe pathological changes and morphology of biliary casts. Methods： Totally, 18 patients were diagnosed with BCS by cholangiography following OLT using choledochoscope or endoscopic retrograde cholangiopancreatography. In addition, 36 patients who did not present with BCS in the corresponding period had detectable postoperative HARI on weeks I, 2, 3 shown by color Doppler flow imaging. The compositions ofbiliary casts were analyzed by pathological examination and scanning electron microscopy. Results： HARI values of the BCS group were significantly decreased as compared with the non-BCS group on postoperative weeks 2 and 3 （P 〈 0.05）. Odds ratio （OR） analysis of HARI 1, HARI 2, HARI 3 following the operation was 〉1 （OR = 1.300： 1.223 and 1.889, respectively）. The OR of HARI 3 was statistically significant （OR - 1.889; 95% confidence interval - 1.166-7.490; P - 0.024）. The compositions of biliary casts were different when bile duct stones wcrc present. Furthermore, vascular epithelial cells were found by pathological examination in binary casts. Conclusions： HARI may possibly serve as an independent risk factor and early predictive factor of BCS. Components and formation of binary casts and bile duct stones are different.

关键词： Biliary Cast Syndrome Endoscopic Therapy Hepatic Artery Resistance Index lschemic Type Biliary Lesions: OrthotopicLiver Transplantation

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