The expression and clinical significance of long non-coding RNA LOC728040 in hepatocellular carcinoma

作     者：Xiaoyun Yang Qian Liao Xiaoqiang Qiu Xiaoyun Yang;Qian Liao;Xiaoqiang Qiu

作者机构：Guangxi Medical University 

出 版 物：《广西医科大学学报》 (Journal of Guangxi Medical University)

年 卷 期：2017年第34卷第5期

页      面：641-645页

学科分类：1002[医学-临床医学] 100214[医学-肿瘤学] 10[医学] 

基　　金：supported by the National Natural Science Foundation of China(No. 81660563) 

主　　题：long non-coding RNA LOC728040 qPCR hep-atocellular carcinoma 

摘      要：Objective:This study aimed to investigate the expression of long non-coding RNA LOC728040in hepatocellular carcinoma(HCC)tissues and normal ***:Quantitative reverse-transcription PCR(qPCR)was performed to detect the expression of LOC728040in HCC tissues and paracancer tissues to explore the differences of the clinical indicators of HCC between two groups of low and high *** the target genes prediction of LOC728040as a ***:The lower expression of LOC728040was found in HCC tissues compared with the paracancer tissues(P0.05).According to the expression,Patients were divided into two groups,and their occupation,tumor capsular and serum alkaline phosphatase(ALP)were significantly different(P0.05).We found LOC728040upstream existed an alpha albumin gene(AFM)through the Cis analysis by Blast ***:Long non-coding RNA LOC728040was markedly downregulated in HCC tissues and was correlated with occupation tumor capsular and serum *** LOC728040might be a biomarker for detection of HCC or other cancers,but its underlying mechanisms still need further study.