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Detection of an anti-angina therapeutic module in the effective population treated by a multi-target drug Danhong injection:a randomized trial

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Signal Transduction and Targeted Therapy 2021年第10期6卷 3009-3018页

作者： Jun liu Dan-Dan li Wei Dong Yu-Qi liu Yang Wu Da-Xuan Tang Fu-Chun Zhang Meng Qiu Qi Hua Jing-Yu He Jun li Bai Du Ting-Hai Du lin-lin Niu Xue-Jun Jiang Bo Cui Jiang-Bin Chen Yang-Gan Wang Hai-Rong Wang Qin Yu Jing He Yi-lin mao Xiao-Fang Bin Yue Deng Yu-Dan Tian qing-Hua Han Da-Jin liu li-Qin Duan Ming-Jun Zhao Cui-Ying Zhang Hai-Ying Dai Ze-Hua li Ying Xiao You-Zhi Hu Xiao-Yu Huang Kun xing xin Jiang Chao-Feng liu Jing An Feng-Chun li Tao Tao Jin-Fa Jiang Ying Yang Yao-Rong Dong Lei Zhang Guang Fu Ying li Shu-Wei Huang li-Ping Dou Lan-Jun Sun Ying-Qiang Zhao Jie li Yun Xia Jun liu Fan liu Wen-Jin He Ying li Jian-Cong Tan Yang lin Ya-Bin Zhou Jian-Fei Yang Guo-qing Ma Hui-Jun Chen He-Ping liu Zong-Wu liu Jian-Xiong liu Xiao-Jia Luo Xiao-Hong Bin Ya-nan Yu Hai-Xia Dang Bing li Fei Teng Wang-Min Qiao Xiao-Long Zhu Bing-Wei Chen Qi-Guang Chen Chun-Ti Shen Yong-Yan Wang Yun-Dai Chen Zhong Wang institute of Basic Research in Clinical Medicine China Academy of Chinese Medical SciencesBeijingChina Department of Cardiology Chinese PLA General HospitalBeijingChina Department of Cardiology Dongfang Hospital Affiliated to Beijing University of Chinese MedicineBeijingChina Department of Geratology Peking University Third HospitalBeijingChina Department of Cardiology Xuan Wu HospitalCapital Medical UniversityBeijingChina Department of Cardiology Guang'anmen HospitalChina Academy of Chinese Medical SciencesBeijingChina Department of Cardiology First Affiliated Hospital of Henan University of Chinese MedicineZhengzhouHenanChina Department of Cardiology Wuhan University Renmin HospitalWuhanHubeiChina Department of Cardiology Wuhan University Zhongnan HospitalWuhanHubeiChina Affiliated Zhongshan Hospital of Dalian University DalianLiaoningChina Department of Cardiology Second Affiliated Hospital to Hunan University of Chinese MedicineChangshaHunanChina Department of Cardiology First Affiliated Hospital to Changchun University of Chinese MedicineChangchunJilinChina Department of Cardiology First Affiliated Hospital to Shanxi Medical UniversityTaiyuanShanxiChina Department of Cardiology Affiliated Hospital of Shanxi University of Chinese MedicineXianyangShanxiChina Department of Cardiology Changsha Central HospitalChangshaHunanChina Department of Cardiology Hubei Provincial Hospital of Traditional Chinese MedicineWuhanHubeiChina Department of Cardiology Shanxi Provincial People's HospitalXi'anShanxiChina Department of Cardiology Shanxi Province Hospital of Traditional Chinese MedicineXi'anShanxiChina Department of Cardiology Xi'an City Hospital of Traditional Chinese MedicineXi'anShanxiChina Department of Cardiology Shanghai Tongji HospitalShanghaiChina Department of Cardiology Shanghai Municipal Hospital of Traditional Chinese MedicineShanghaiChina Department of Cardiology The First Hospital of ChangshaChangshaHunanChina Department of Cardiology Xinhua Hospi

It's a challenge for detecting the therapeutic targets of a polypharmacological drug from variations in the responsed networks in thedfferentiated populations with complex diseases,as stable coronary heart ***,in an adaptive,31-center,randomized,double-blind trial invoving 920 patients with moderate symptomatic stable angina treated by 14-day Danhong injection(DHI),a kind of polyphamacological drug with high quality control,or placebo(0.9%saline),with 76-day following-up,we firstly confrmed that DHl couldincrease the proportion of patients with clinically significant changes on angina-frequency assessed by Seattle Angina Questionnaire(ASAQ-AF220)(12.78%at Day 30,95%confidence interval[C]5.86-19.71%,P=0.0003,13.82%at Day 6C0,95%CI 6.82-20.82%,P=0.0001and 8.95%at Day 90,95%CI 2.06-15.85%,P=0.01).We also found that there were no significant differences in new-onset major vascularevents(P=0.8502)and serious adverse events(P=0.9105)between DHl and *** performing the RNA sequencing in 62 selectedpatients,we developed a systemic modular approach tp identfy differentilly expressed modules(DEMs)of DHI with the Z_(summay)valueless than 0 compared with the control group,calculated by weighted gene co-expression network analysis(WGCNA),and sketched out thebasic framework on a modular map with 25 functional modules targeted by ***,the effective therapeutic module(ETM),defined as the highest corelation value with the phenotype alteration(SAQ-AF,the change in SAQ-AF at Day 30 from baseline)calculatedby WGCNA,was identifed in the population with the best effect(ASAQ-AF240),which is related to anticoagulation and regulation ofcholesterol *** assessed the modular flexbility of this ETM using the global topological D value based on Euclidean distance,which is corelated with phenotype alteration(r^(2):0.8204,P=0.019)by linear *** study identified the ant-angina therapeuticmodule in the effective population treated by the multi-target

关键词： angina injection sketch

Timing analysis of the black hole candidate EXO 1846–031 with Insight-HXMT monitoring

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Research in Astronomy and Astrophysics 2021年第3期21卷 193-204页

作者： He-xin liu Yue Huang Guang-Cheng Xiao qing-Cui Bu Jin-Lu Qu Shu Zhang Shuang-nan Zhang Shu-Mei Jia Fang-Jun Lu Xiang Ma lian Tao Wei Zhang li Chen li-Ming Song Ti-Pei li Yu-Peng Xu Xue-Lei Cao Yong Chen Cong-Zhan liu Ce Cai Zhi Chang Gang Chen Tian-Xiang Chen Yi-Bao Chen Yu-Peng Chen Wei Cui Wei-Wei Cui Jing-Kang Deng Yong-Wei Dong Yuan-Yuan Du Min-Xue Fu Guan-Hua Gao He Gao Min Gao Ming-Yu Ge Yu-Dong Gu Ju Guan Cheng-Cheng Guo Da-Wei Han Jia Huo Lu-Hua Jiang Wei-Chun Jiang Jing Jin Yong-Jie Jin ling-Da Kong Bing li Cheng-Kui li Gang li mao-Shun li Wei li Xian li Xiao-Bo li Xu-Fang li Yang-Guo li Zheng-Wei li Xiao-Hua liang Jing-Yuan liao Bai-Sheng liu Guo-qing liu Hong-Wei liu Xiao-Jing liu Yi-Nong liu Bo Lu Xue-Feng Lu Qi Luo Tao Luo Bin Meng Yi nang Jian-Yin Nie Ge Ou Na Sai Ren-Cheng Shang xin-Ying Song liang Sun Ying Tan You-li Tuo Chen Wang Guo-Feng Wang Juan Wang ling-Jun Wang Weng-Shuai Wang Yu-Sa Wang Xiang-Yang Wen Bai-Yang Wu Bo-Bing Wu Mei Wu Shuo Xiao Shao-lin Xiong He Xu Jia-Wei Yang Sheng Yang Yan-Ji Yang Yi-Jung Yang Qi-Bin Yi Qian-qing Yin Yuan You Ai-Mei Zhang Cheng-Mo Zhang Fan Zhang Hong-Mei Zhang Juan Zhang Tong Zhang Wan-Chang Zhang Wen-Zhao Zhang Yi Zhang Yi-Fei Zhang Yong-Jie Zhang Yuan-Hang Zhang Yue Zhang Zhao Zhang Zhi Zhang Zi-liang Zhang Hai-Sheng Zhao Xiao-Fan Zhao Shi-Jie Zheng Yao-Guang Zheng Deng-Ke Zhou Jian-Feng Zhou Yu-Xuan Zhu Ren-lin Zhuang Yue Zhu Key Laboratory of Particle Astrophysics Institute of High Energy PhysicsChinese Academy of SciencesBeijing 100049China University of Chinese Academy of Sciences Chinese Academy of SciencesBeijing 100049China Institut fur Astronomie und Astrophysik Kepler Center for Astro and Particle PhysicsEberhard Karls Universität72076 TubingenGermany Department of Astronomy Beijing Normal UniversityBeijing 100088China Department of Astronomy Tsinghua UniversityBeijing 100084China Department of Physics Tsinghua UniversityBeijing 100084China Department of Engineering Physics Tsinghua UniversityBeijing 100084China Key Laboratory of Space Astronomy and technology National Astronomical ObservatoriesChinese Academy of SciencesBeijing 100101China College of Physics Sciences&technology Hebei UniversityBaoding 071002Hebei ProvinceChina

We present the observational results from a detailed timing analysis of the black hole candidate EXO 1846-031 during its outburst in 2019 with the observations of Insight-HXMT,NICER and *** outburst can be classified roughly into four different ***-C quasi-periodic oscillations(QPOs)observed by NICER(about 0.1-6 Hz)and Insight-HXMT(about 0.7-8 Hz)are also reported in this ***,we study various physical quantities related to QPO *** QPO rms-frequency relationship in the energy band 1-10 keV indicates that there is a turning pointing in frequency around2 Hz,which is similar to that of GRS 1915+105.A possible hypothesis for the relationship above may be related to the inclination of the source,which may require a high inclination to explain *** relationships between QPO frequency and QPO rms,hardness,total fractional rms and count rate have also been found in other transient sources,which can indicate that the origin of type-C QPOs is non-thermal.

关键词： X-ray binaries black hole candidate QPO EXO 1846–031

二氧化锰纳米颗粒调控的紫外可见吸收-荧光双通道传感器的构建及D-青霉胺的检测

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无机化学学报 2023年第4期39卷 617-626页

作者：程莹柳夷冰赵卉垚南鑫达范小青李生玲丁莉峰王琦牛宇岚太原工业学院化学与化工系太原030008 浙江省衢州市龙游县检验检测研究院衢州324400

以聚乙烯亚胺(PEI)同时作为模板和还原剂,基于原位氧化还原反应,一步法制备二氧化锰纳米颗粒(MnO_(2)NPs),并对其形貌、组成、紫外可见吸收、催化氧化特性进行了表征。结果表明,MnO_(2)NPs能够催化氧化邻苯二胺(OPD)为2,3-二氨基吩嗪(DA... 详细信息

以聚乙烯亚胺(PEI)同时作为模板和还原剂,基于原位氧化还原反应,一步法制备二氧化锰纳米颗粒(MnO_(2)NPs),并对其形貌、组成、紫外可见吸收、催化氧化特性进行了表征。结果表明,MnO_(2)NPs能够催化氧化邻苯二胺(OPD)为2,3-二氨基吩嗪(DAP),产生420 nm处的紫外可见吸收和560 nm处的荧光发射。D-青霉胺(DPA)中的活性巯基可与MnO_(2)发生特异性反应,还原降解催化剂,抑制其催化氧化活性,使得体系紫外可见吸收-荧光信号减弱甚至消失。基于DPA浓度与体系光谱信号变化的关系,我们建立了MnO_(2)NPs介导的紫外可见吸收-荧光双通道传感DPA的新方法。荧光传感通道具有更好的线性范围和灵敏度,该方法线性范围为1~80μmol·L^(-1),检出限为0.54μmol·L^(-1)。此外,MnO_(2)NPs介导的荧光传感DPA应用于人体尿液样品分析中的回收率为98.31%~107.76%,证明了该方法的可靠性。

关键词：二氧化锰纳米颗粒紫外可见荧光 D-青霉胺

First experimental constraints on WIMP couplings in the effective field theory framework from CDEX

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Science china(Physics,Mechanics & Astronomy) 2021年第8期64卷 15-22页

作者： Yi Wang Zhi Zeng Qian Yue liTao Yang KeJun Kang YuanJing li Mehment Agartioglu HaiPeng An JianPing Chang JingHan Chen YunHua Chen JianPing Cheng Cheng Yi Chiang WenHan Dai Zhi Deng ChangHao Fang xinPing Geng Hui Gong QiuJu Guo XuYuan Guo HongJian He li He ShengMing He JinWei Hu TuChen Huang HanXiong Huang HaiTao Jia liPing Jia Xi Jiang HauBin li JianMin li Jin li MingXuan li RenMingJie li Xia li YuLan li Bin liao FongKay lin ShinTed lin ShuKui liu YanDong liu Yu liu YuanYuan liu ZhongZhi liu Hao Ma YuCai mao QiYuan Nie JinHua Ning Hui Pan NingChun Qi Jie Ren XiChao Ruan ChangSong Shang Vivek Sharma Ze She Lakhwinder Singh Monoj Kumar Singh TianXi Sun ChangJian Tang WeiYou Tang Yang Tian GuangFu Wang li Wang qing Wang Yu Chen Wang YunXiang Wang Zhen Wang Henry Tsz-King Wong ShiYong Wu YuCheng Wu HaoYang xing Yin Xu Tao Xue YuLu Yan nan Yi ChunXu Yu HaiJun Yu JianFeng Yue Ming Zeng BingTao Zhang Lei Zhang FengShou Zhang ZhenYu Zhang KangKang Zhao MingGang Zhao JiFang Zhou ZuYing Zhou JingJun Zhu Key Laboratory of Particle and Radiation Imaging(Ministry of Education) Department of Engineering PhysicsTsinghua UniversityBeijing 100084China Department of Physics Tsinghua UniversityBeijing 100084China institute of Physics Academia SinicaTaipei 11529China NUCTECH Company Beijing 100084China YaLong River Hydropower Development Company Chengdu 610051China College of Nuclear Science and technology Beijing Normal UniversityBeijing 100875China College of Physics Sichuan UniversityChengdu 610065China School of Physics Peking UniversityBeijing 100871China Sino-French institute of Nuclear and technology Sun Yet-sen UniversityZhuhai 519082China Department of Nuclear Physics China Institute of Atomic EnergyBeijing 102413China Department of Physics Banaras Hindu UniversityVaranasi 221005India Department of Physics Beijing Normal UniversityBeijing 100875China School of Physics Nankai UniversityTianjin 300071China

We present weakly interacting massive particles(WIMPs) search results performed using two approaches of effective field theory from the china Dark Matter Experiment(CDEX), based on the data from both CDEX-1B and CDEX-10 stages. In the nonrelativistic effective field theory approach, both time-integrated and annual modulation analyses were used to set new limits for the coupling of WIMP-nucleon effective operators at 90% confidence level(C.L.) and improve over the current bounds in the low mχregion. In the chiral effective field theory approach, data from CDEX-10 were used to set an upper limit on WIMP-pion coupling at 90% C.L. We for the first time extended the limit to the m_(χ)<6 GeV/c^(2) region.

关键词： WIMP EFT CDEX dark matter annual modulation

The Lyman-alpha Solar Telescope(LST) for the ASO-S mission——Ⅱ. design of LST

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Research in Astronomy and Astrophysics 2019年第11期19卷 33-48页

作者： Bo Chen Hui li Ke-Fei Song Quan-Feng Guo Pei-Jie Zhang ling-Ping He Shuang Dai Xiao-Dong Wang Hai-Feng Wang Chun-Long liu Hong-Ji Zhang Guang Zhang Yunqi Wang Shi-Jie liu Hong-xin Zhang Lei liu Shi-Lei mao Yang liu Jia-Hao Peng Peng Wang liang Sun Yang liu Zhen-Wei Han Yan-Long Wang Kun Wu Guang-xing ding Peng Zhou xin Zheng Ming-Yi Xia qing-Wen Wu Jin-Jiang Xie Ya Chen Shu-Mei Song Hong Wang Bo Zhu Chang-Bo Chu Wen-Gang Yang li Feng Yu Huang Wei-Qun Gan Ying li Jing-Wei li Lei Lu Jian-Chao Xue Bei-li Ying Ming-Zhe Sun Cheng Zhu Wei-Min Bao Lei Deng Zeng-Shan Yin Changchun institute of Optics FineMechanics and PhysicsChinese Academy of SciencesChangchun 130033China State Key Laboratory of Applied Optics Changchun 130033China Key Laboratory of Dark Matter and Space Astronomy Purple Mountain ObservatoryChinese Academy of SciencesNanjing 210034China School of Astronomy and Space Science University of Science and Technology of ChinaHefei 230026China Xi’an institute of Optics and Precision Mechanics Chinese Academy of SciencesXi’an 710119China Shandong University Weihai 264209China Innovation Academy for Microsatellites Chinese Academy of SciencesShanghai 201210China

As one of the three payloads for the Advanced Space-based Solar Observatory(ASO-S)mission,the Lyman-alpha(Lyα)Solar Telescope(LST)is composed of three instruments:a Solar Corona Imager(SCI),a LyαSolar Disk Imager(SDI)and a full-disk White-light Solar Telescope(WST).When working in-orbit,LST will simultaneously perform high-resolution imaging observations of all regions from the solar disk to the inner corona up to 2.5 R⊙(R⊙stands for the mean solar radius)with a spatial resolution of 4.8′′and 1.2′′for coronal and disk observations,respectively,and a temporal resolution of 30–120 s and 1–120 s for coronal and disk observations,*** maximum exposure time can be up to20 s due to precise pointing and image stabilization *** the three telescopes of LST,SCI is a dual-waveband coronagraph simultaneously and independently observing the inner corona in the HI Lyα(121.6±10 nm)line and white light(WL)(700±40 nm)wavebands by using a narrowband Lyαbeam splitter and has a field of view(FOV)from 1.1 to 2.5 R⊙.The stray-light suppression level can attainline and 360.0 nm wavebands,respectively,which adopt an off-axis two-mirror reflective structure with an FOV up to 1.2 R⊙,covering the inner coronal edge area and relating to coronal *** present the up-to-date design for the LST payload.

关键词： telescopes—instrumentation high angular resolution—Sun flares—Sun coronal mass ejections(CMEs)—Sun UV radiation

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Biomarkers of aging

Science china(life Sciences) 2023年第5期66卷 893-1066页

作者： Aging Biomarker Consortium Hainan Bao Jiani Cao Mengting Chen Min Chen Wei Chen Xiao Chen Yanhao Chen Yu Chen Yutian Chen Zhiyang Chen Jagadish K Chhetri Yingjie ding Junlin Feng Jun Guo Mengmeng Guo Chuting He Yujuan Jia Haiping Jiang Ying Jing dingfeng li Jiaming li Jingyi li Qinhao liang Rui liang Feng liu Xiaoqian liu Zuojun liu Oscar Junhong Luo Jianwei Lv Jingyi Ma Kehang mao Jiawei Nie xinhua Qiao xinpei Sun Xiaoqiang Tang Jianfang Wang Qiaoran Wang Siyuan Wang Xuan Wang Yaning Wang Yuhan Wang Rimo Wu Kai Xia Fu-Hui Xiao lingyan Xu Yingying Xu Haoteng Yan liang Yang Ruici Yang Yuanxin Yang Yilin Ying Le Zhang Weiwei Zhang Wenwan Zhang xing Zhang Zhuo Zhang Min Zhou Rui Zhou qingchen Zhu Zhengmao Zhu Feng Cao Zhongwei Cao Piu Chan Chang Chen Guobing Chen Hou-Zao Chen Jun Chen Weimin Ci Bi-Sen ding Qiurong ding Feng Gao Jing-Dong JHan Kai Huang Zhenyu Ju qing-Peng Kong Ji li Jian li xin li Baohua liu Feng liu lin liu Qiang liu Qiang liu xingguo liu Yong liu Xianghang Luo Shuai Ma xinran Ma Zhiyong mao Jing Nie Yaojin Peng Jing Qu Jie Ren Ruibao Ren Moshi Song Zhou Songyang Yi Eve Sun Yu Sun Mei Tian Shusen Wang Si Wang Xia Wang Xiaoning Wang Yan-Jiang Wang Yunfang Wang Catherine CL Wong Andy Peng Xiang Yichuan Xiao Zhengwei Xie Daichao Xu Jing Ye Rui Yue Cuntai Zhang Hongbo Zhang liang Zhang Weiqi Zhang Yong Zhang Yun-Wu Zhang Zhuohua Zhang Tongbiao Zhao Yuzheng Zhao Dahai Zhu Weiguo Zou Gang Pei Guang-Hui liu Aging Biomarker Consortium(ABC) Beijing 100101China CAS Key Laboratory of Genomic and Precision Medicine Beijing Institute of GenomicsChinese Academy of Sciences and China National Center for BioinformationBeijing 100101China State Key Laboratory of Stem Cell and Reproductive Biology Institute of ZoologyChinese Academy of SciencesBeijing 100101China Department of Dermatology Xiangya HospitalCentral South UniversityChangsha 410008China Hunan Key Laboratory of Aging Biology Xiangya HospitalCentral South UniversityChangsha 410008China National Clinical Research Center for Geriatric Disorders Xiangya HospitalCentral South UniversityChangsha 410008China Clinic Center of Human Gene Research Union HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430022China Hubei Clinical Research Center of Metabolic and Cardiovascular Disease Huazhong University of Science and TechnologyWuhan 430022China Hubei Key Laboratory of Metabolic Abnormalities and Vascular Aging Huazhong University of Science and TechnologyWuhan 430022China Stem Cell Translational Research Center Tongji HospitalTongji University School of MedicineShanghai 200065China Department of Nuclear Medicine Daping HospitalThird Military Medical UniversityChongqing 400042China CAS Key Laboratory of Nutrition Metabolism and Food SafetyShanghai Institute of Nutrition and HealthUniversity of Chinese Academy of SciencesChinese Academy of SciencesShanghai 200031China Shanghai Key Laboratory of Maternal Fetal Medicine Clinical and Translational Research Center of Shanghai First Maternity and Infant HospitalFrontier Science Center for Stem Cell ResearchShanghai Key Laboratory of Signaling and Disease ResearchSchool of Life Sciences and TechnologyTongji UniversityShanghai 200092China The Department of Endovascular Surgery The First Affiliated Hospital of Zhengzhou UniversityZhengzhou 450052China Key Laboratory of Regenerative Medicine of Ministry of Education Institute of Ageing and Regenerative MedicineJ

Aging biomarkers are a combination of biological parameters to(i)assess age-related changes,(ii)track the physiological aging process,and(iii)predict the transition into a pathological *** a broad spectrum of aging biomarkers has been developed,their potential uses and limitations remain poorly *** immediate goal of biomarkers is to help us answer the following three fundamental questions in aging research:How old are we?Why do we get old?And how can we age slower?This review aims to address this ***,we summarize our current knowledge of biomarkers developed for cellular,organ,and organismal levels of aging,comprising six pillars:physiological characteristics,medical imaging,histological features,cellular alterations,molecular changes,and secretory *** fulfill all these requisites,we propose that aging biomarkers should qualify for being specific,systemic,and clinically relevant.

关键词： aging senescence biomarker clock

大气湍流对高分辨率遥感卫星定位精度的影响分析

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中国光学（中英文） 2023年第3期16卷 550-558页

作者：曹宗新曹楠杨燕燕丁致雅毛红敏彭建涛樊丽娜陆焕钧孙会娟胡立发曹召良苏州科技大学物理科学与技术学院江苏苏州215009 江苏省微纳热流技术与能源应用重点实验室江苏苏州215009 江南大学理学院江苏无锡214122 中国航天科技集团公司上海卫星工程研究所上海201109 北京联合大学数理部北京100101

本文重点研究相机口径、大气湍流强度和卫星轨高对高分辨率遥感卫星定位精度的影响。首先,基于Kolmogorov湍流理论建立对地观测大气湍流模型和湍流模拟方法;然后,仿真分析了相机口径、卫星轨道高度和大气相干长度对卫星定位精度的影响规... 详细信息

本文重点研究相机口径、大气湍流强度和卫星轨高对高分辨率遥感卫星定位精度的影响。首先,基于Kolmogorov湍流理论建立对地观测大气湍流模型和湍流模拟方法;然后,仿真分析了相机口径、卫星轨道高度和大气相干长度对卫星定位精度的影响规律,推导出湍流波前倾斜与相机口径、卫星轨道高度和大气相干长度的普适公式;最后,基于该普适公式,得出卫星对地观测时抖动量的理论计算公式。本论文的研究可为后续高分辨率遥感卫星的设计、分析和评估提供大气湍流影响的理论依据。

关键词：大气湍流高分辨率遥感卫星对地观测倾斜像差跟踪精度

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Centralized isolation of Helicobacter pylori from multiple centers and transport condition influences

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World Journal of Gastroenterology 2015年第3期21卷 944-952页

作者： Ya-nan Gong You-Ming li Ning-Min Yang Hong-Zhang li Feng Guo Lang lin Qun-Ying Wang Jia-Kun Zhang Zi-Zhong Ji Ji-Bo mao Jun-liang mao Zheng-Chao Shi Wu-Heng Tang xin-Jian Zhu Wei Shao Xiao-Feng Zhang xing-Hua Wang Yue-Feng Tong Mi-Zu Jiang Guang-Lan Chen Zhi-Yong Wang Hui-Min Tu Guo-Fa Jiang Jian-Sheng Wu Xu-Peng Chen Qiu-Long ding Hong Ouyang Feng-Zhe Jin Yan-li Xu Jian-Zhong Zhang State Key Laboratory for Infectious Disease Prevention and Control National Institute for Communicable Disease Control and PreventionChinese Center for Disease Control and Prevention Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases The First Affiliated Hospital College of MedicineZhejiang University Zhiyuan Medical Inspection institute Co. Ltd. Sanmen People’s Hospital The First People’s Hospital of Xiaoshan District The First People’s Hospital of Cangnan Jinhua Municipal Central Hospital The First People’s Hospital of Pingyang The First Hospital of Jiaxing Zhoushan Hospital The First People’s Hospital of Wenling Rui’an People’s Hospital Maternal and Child Health Hospital of Zhoushan City Shangyu People’s Hospital People’s Hospital of Putuo District Zhoushan Hangzhou First People’s Hospital qingtian People’s Hospital The First People’s Hospital of Yongkang The Children’s Hospital Zhejiang University School of Medicine lishui People’s Hospital The Affiliated Hospital of Hangzhou Normal University Wuxi No.4 Hospital Affiliated to Suzhou University Jinhua Wenrong Hospital The First Affiliated Hospital of Wenzhou Medical College Yueqing People’s Hospital Tiantai People’s Hospital lin’an people’s Hospital Rui’an City TCM Hospital Medical College of Hebei University of Engineering

AIM:To evaluate the efficacy of centralized culture and possible influencing ***:From January 2010 to July 2012,66452 patients with suspected Helicobacter pylori(***) infection from 26 hospitals in Zhejiang and Jiangsu Provinces in china underwent gastrointestinal *** mucosal biopsies were taken from the antrum for *** biopsies were transported under natural environmental temperature to the central laboratory in Hangzhou city and divided into three groups based on their transport time:5,24 and 48 *** culture results were reported after 72 h and the positive culture rates were analyzed by a χ2 *** additional 5736 biopsies from ***-positive patients(5646 rapid urease test-positive and 90 14C-urease breath test-positive) were also cultured for quality control in the central laboratory ***:The positive culture rate was 31.66%(21036/66452) for the patient samples and 71.72%(4114/5736) for the ***-positive quality control *** the 5 h transport group,the positiveculture rate was 30.99%(3865/12471),and 32.84%(14960/45553) in the 24 h transport *** contrast,the positive culture rate declined significantly in the 48 h transport group(26.25%; P lined from 36.67%(1462/3987) to 24.12%(1799/7459).When the temperature exceeded 24℃,the positive culture rate decreased significantly,especially in the 48 h transport group(23.17%).CONCLUSION:Transportation of specimens within 24 h and below 24℃ is reasonable and acceptable for centralized culture of multicenter *** samples.

关键词： Centralized isolation Helicobacter pylori Influenc

潮汐灌溉供液高度对黄瓜穴盘苗生长发育与水肥利用的影响

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中国蔬菜 2020年第1期 56-62页

作者：李倩董春娟田雅楠曹玲玲尚庆茂中国农业科学院蔬菜花卉研究所农业农村部园艺作物生物学与种质创制重点实验室北京100081 北京市农业技术推广站北京100029

在潮汐灌溉条件下,以黄瓜品种中农18号为材料,分别在夏季和冬季进行穴盘育苗,比较1、2、3 cm供液高度对基质的吸水速率、黄瓜穴盘苗表观生长指标、根系活力、水分及氮素利用率的影响。结果表明:随着供液高度增加,基质吸水速率逐渐加快;... 详细信息

在潮汐灌溉条件下,以黄瓜品种中农18号为材料,分别在夏季和冬季进行穴盘育苗,比较1、2、3 cm供液高度对基质的吸水速率、黄瓜穴盘苗表观生长指标、根系活力、水分及氮素利用率的影响。结果表明:随着供液高度增加,基质吸水速率逐渐加快;夏季和冬季育苗供液高度为2 cm和3 cm时,穴盘苗的株高、叶面积、茎叶鲜质量和干质量均高于1 cm供液高度,3个供液高度间的根体积、根系鲜质量和干质量、根冠比、壮苗指数无显著差异,但3 cm供液高度的穴盘苗根系活力显著降低,供液和回液体积以及肥料施用量最大;而夏季育苗2 cm供液高度时,穴盘苗的水分利用率较高,且氮素利用率最大。基于穴盘苗表观生长指标与水肥利用率,夏季和冬季黄瓜潮汐穴盘育苗的适宜灌溉高度均为2 cm。

关键词：黄瓜潮汐灌溉穴盘育苗供液高度