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肝硬化食管静脉曲张破裂出血的危险因素分析

医药论坛杂志 2024年第10期45卷 1050-1053页

作者：郑文凤殷琳琳李山林吴玉卓刘学进周口市中心医院消化内科二病区河南周口466000

目的研究肝硬化食管静脉曲张破裂出血的危险因素。方法以周口市中心医院消化内科2022年1月—2023年12月293例肝硬化食管静脉曲张患者为研究对象,据患者出血情况将其分为对照组(未破裂出血)和研究组(破裂出血),收集并比较两组患者基本信... 详细信息

目的研究肝硬化食管静脉曲张破裂出血的危险因素。方法以周口市中心医院消化内科2022年1月—2023年12月293例肝硬化食管静脉曲张患者为研究对象,据患者出血情况将其分为对照组(未破裂出血)和研究组(破裂出血),收集并比较两组患者基本信息、超声检查信息、血液指标及内镜检查信息,行logistic回归分析,分析患者发生破裂出血的危险因素。结果293例患者中出现破裂出血82例,占比27.99%(82/293),未出现破裂出血211例,占比72.01%(211/293);行单因素分析显示,两组患者性别、年龄、饮酒史、肝癌史、肝性脑病、肝硬化类型、PTA、ALT、BUN、脾脏厚度、消化性溃疡、胃底静脉曲张及门脉高压性胃病等方面差异无统计学意义(P>0.05);两组患者食管静脉曲张程度、门静脉内径、脾静脉内径、腹水情况、凝血酶原时间(prothrombin time,PT)、血小板计数(platelet count,PLT)及血清白蛋白(serum albumin,ALB)等方面差异有统计学意义(χ^(2)/t=27.895、13.756、9.336、24.541、11.538、5.464、7.161,P<0.05);logistic分析显示,食管静脉曲张程度、门静脉内径、PT、PLT及ALB为肝硬化食管静脉曲张破裂出血的危险因素(OR=1.578、0.317、0.542、0.002、1.187,P<0.05)。结论食管静脉曲张程度、门静脉内径、PT、PLT及ALB为肝硬化食管静脉曲张破裂出血的危险因素,针对存在危险因素的患者应高度重视,积极干预,从而预防出血,改善预后。

关键词：肝硬化静脉曲张危险因素

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某型火炮射击药筒压痕问题分析及措施研究

机电产品开发与创新 2024年第5期37卷 145-147页

作者：刘圣强李成富李山林米海涛闫加伟李伯林郑州机电工程研究所河南郑州450015 中国人民解放军第七八一四工厂辽宁大连116001 中国人民解放军陆军装备部驻沈阳地区军事代表局辽宁沈阳110001

本文主要对某型火炮射击时药筒压痕问题进行分析,通过故障树分析定位了问题原因,并对改进措施进行了实弹射击验证,解决了药筒压痕问题,提高了装备可靠性。

关键词：火炮药筒压痕故障树分析

Signalling pathways in autism spectrum disorder:mechanisms and therapeutic implications

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Signal Transduction and Targeted Therapy 2022年第8期7卷 2863-2898页

作者： Chen-Chen Jiang li-shan lin Sen Long Xiao-Yan Ke Kohji Fukunaga Ying-Mei Lu Feng Han International Joint Laboratory for Drug Target of Critical Illnesses Key Laboratory of Cardiovascular&Cerebrovascular MedicineSchool of PharmacyNanjing Medical UniversityNanjing 211166China Department of Physiology School of Basic Medical SciencesNanjing Medical UniversityNanjing 211166China Department of Pharmacy Hangzhou Seventh People’s HospitalMental Health Center Zhejiang University School of MedicineHangzhou 310013China Child Mental Health Research Center Nanjing Brain HospitalNanjing Medical UniversityNanjing 210029China Department of CNS Drug Innovation Graduate School of Pharmaceutical SciencesTohoku UniversitySendai 980-8578Japan Institute of Brain Science The Affiliated Brain Hospital of Nanjing Medical UniversityNanjing 210029China Gusu School Nanjing Medical UniversitySuzhou Municipal HospitalThe Affiliated Suzhou Hospital of Nanjing Medical UniversitySuzhou 215002China

Autism spectrum disorder(ASD)is a prevalent and complex neurodevelopmental disorder which has strong genetic *** the rapidly rising incidence of autism,little is known about its aetiology,risk factors,and disease *** are currently neither validated biomarkers for diagnostic screening nor specific medication for *** the last two decades,there have been remarkable advances in genetics,with hundreds of genes identified and validated as being associated with a high risk for *** convergence of neuroscience methods is becoming more widely recognized for its significance in elucidating the pathological mechanisms of *** have been devoted to exploring the behavioural functions,key pathological mechanisms and potential treatments of ***,as we highlight in this review,emerging evidence shows that signal transduction molecular events are involved in pathological processes such as transcription,translation,synaptic transmission,epigenetics and immunoinflammatory *** involvement has important implications for the discovery of precise molecular targets for ***,we review recent insights into the mechanisms and clinical implications of signal transduction in autism from molecular,cellular,neural circuit,and neurobehavioural ***,the challenges and future perspectives are discussed with regard to novel strategies predicated on the biological features of autism.

关键词： mechanisms spectrum behaviour

Field survey and analysis on near-fault severely damaged high-speed railway bridge in 2022 M6.9 Menyuan earthquake

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Earthquake Engineering and Engineering Vibration 2024年第4期23卷 1043-1055页

作者： lin Xuchuan liu Fuxiang shan Wenchen Key Laboratory of Earthquake Engineering and Engineering Vibration Institute of Engineering MechanicsChina Earthquake AdministrationHarbin 150080China Key Laboratory of Earthquake Disaster Mitigation Ministry of Emergency ManagementHarbin 150080China Institute of Smart City and Intelligent Transportation Southwest Jiaotong UniversityChengdu610000China

The 2022 M6.9 Menyuan earthquake caused severe damage to a high-speed railway bridge,which was designed for high-speed trains running at speeds of above 250 km/h and is located right next to the *** of this type have been widely used for rapidly constructing the high-speed railway network,but few bridges have been tested by near-fault devastating *** potential severe impact of the earthquake on the high-speed railway is not only the safety of the infrastructure,trains and passengers,but also economic loss due to interrupted railway ***,a field survey was carried out immediately after the earthquake to collect time-sensitive *** damage to the bridge was carefully investigated,and quantitative analyses were conducted to better understand the mechanism of the bridge *** was found that seismic action perpendicular to the bridge’s longitudinal direction caused severe damage to the girders and rails,while none of the piers showed obvious deformation or *** maximum values of transverse displacement,out-of-plane rotation and twisting angle of girders reached 212.6 cm,3.1 degrees and 19.9 degrees,respectively,causing severe damage to the bearing supports and anti-seismic retaining *** observations provide a basis for improving the seismic design of high-speed railway bridges located in near-fault areas.

关键词： Menyuan earthquake field survey high-speed railway bridge near fault seismic damage

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缓解期溃疡性结肠炎早期复发的影响因素分析

中国肛肠病杂志 2024年第8期44卷 47-49页

作者：郑文凤王戊辰李山林刘学进周口市中心医院消化内科河南周口466000

目的:探讨缓解期溃疡性结肠炎(UC)早期复发的影响因素。方法:选择2021年1月至2023年5月治疗后处于UC缓解期1周内的200例患者为研究对象,采集粪便进行钙卫蛋白(FC)检测,并行结肠镜检查。前瞻性随访至少3个月,监测患者早期复发情况。分析... 详细信息

目的:探讨缓解期溃疡性结肠炎(UC)早期复发的影响因素。方法:选择2021年1月至2023年5月治疗后处于UC缓解期1周内的200例患者为研究对象,采集粪便进行钙卫蛋白(FC)检测,并行结肠镜检查。前瞻性随访至少3个月,监测患者早期复发情况。分析缓解期UC早期复发的影响因素。结果:200例患者中,早期复发50例(25.0%)。在性别、临床分型、白细胞计数、C反应蛋白及粪便FC水平方面,复发组与未复发组均有明显差异,P<0.05。Logistic多元回归分析显示,性别、临床分型及粪便FC水平是缓解期UC患者早期复发的独立影响因素,P<0.05。结论:缓解期UC早期复发率较高,除性别和临床分型外,粪便FC升高是缓解期UC早期复发的独立危险因素,监测FC水平对于筛选缓解期UC早期复发倾向者具有一定指导意义。

关键词：溃疡性结肠炎钙卫蛋白早期复发相关性

Insights into sensitizing and eliciting capacity of gastric and gastrointestinal digestion products of shrimp(Penaeus vannamei)proteins in BALB/c mice

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Food Science and Human Wellness 2024年第1期13卷 339-348页

作者： Yao liu Songyi lin Kexin liu shan Wang Wang li Na Sun National Engineering Research Center of Seafood School of Food Science and TechnologyDalian Polytechnic UniversityDalian 116034China Collaborative Innovation Center of Seafood Deep Processing Dalian Polytechnic UniversityDalian 116034China

Shrimp(Penaeus vannamei)proteins have been shown an allergenic potential;however,little information is available on the sensitizing and eliciting capacity of shrimp protein digestion *** this study,a BALB/c mice model was used to explore the allergenicity of shrimp protein sample(SPS)and their gastric and gastrointestinal digestion products(GDS/GIDS).As compared with the SPS groups,the GDS/GIDS groups caused lower specific immunoglobulins(Ig E/Ig G1)levels(Plity and histopathological changes of tissues were ***,the allergenicity of digestion products cannot be eliminated and still cause systemic allergic reactions in *** study showed that the digestion products of shrimp still had high sensitizing and eliciting capacity.

关键词： Penaeus vannamei Allergenicity Digestion BALB/c mice model

Ultra-conservative noncoding RNA uc.243 confers chemo-resistance by facilitating the efflux of the chemotherapeutic drug in ovarian cancer

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BIOCELL 2024年第8期48卷 1265-1273页

作者： shan JIANG XIUFENG lin YANFEI CHEN XINNING li JIAli KANG Department of Gynecology and Obstetrics The First Affiliated Hospital of Jinan UniversityGuangzhou510180China Reproductive Medical Center Boai Hospital of Zhongshan Affiliated to Southern Medical UniversityZhongshan528400China Department of Gynecology and Obstetrics Boai Hospital of Zhongshan Affiliated to Southern Medical UniversityZhongshan528400China Department of Gynecology and Obstetrics Guangzhou First People’s HospitalGuangzhou Medical UniversityGuangzhou510180China

Background:Despite improvements in objective response rates to cisplatin-based combination chemotherapy,the majority of advanced ovarian cancer remains suboptimal,resulting in poor *** has been found that non-coding RNAs(ncRNAs)not only participate in the transmission of signals between various cells but also participate in tumor immunity and anti-tumor immune responses,thereby regulating tumor occurrence and ***,the function and detailed mechanism of ultraconserved RNA(ucRNA)in ovarian cancer chemoresistance is still ***:Western blotting assay,Quantitative real-time PCR analysis(qPCR),and Kaplan-Meier Plotter analysis were performed to analyze the expression and prognosis of uc.243 in ovarian *** assay and Annexin V assay were performed to analyze the function of uc.243 in cisplatin resistance in ovarian cancer *** pull-down and qPCR experiments were performed to explore the molecular mechanism of uc.243 enhancing cisplatin resistance in ovarian cancer ***:Herein,we found that uc.243 was remarkably upregulated and correlated with patient survival in chemoresistance ovarian cancer patients compared with chemo-sensitive ovarian *** experiment displayed that uc.243 induced cisplatin resistance on ovarian cancer cells by facilitating the efflux of cisplatin(CDDP);but inhibiting the expression of uc.243 significantly reverses this ***,uc.243 can inhibit the binding of RNA binding protein DGCR8 microprocessor complex subunit to pri-miR-155,thereby inhibiting the cleavage of pri-miR-155 and decrease in mature miR-155,subsequently upregulates the expression of ATP binding cassette subfamily B member(ABCB1,ABCC2).Conclusion:Our research findings indicate that uc.243 can induce chemotherapy resistance in ovarian cancer,suggesting that it may become a new prognostic biomarker for malignant ovarian cancer.

关键词： Ultra-conserved non-coding RNA uc.243 Drug efflux Drug transporters Chemoresistance Ovarian cancer

Isotopic dependence of the yield ratios of light fragments from different projectiles and their unified neutron skin thicknesses

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Nuclear Science and Techniques 2024年第3期35卷 228-236页

作者： Ting-Zhi Yan shan li School of Energy and Power Engineering Northeast Electric Power UniversityJilin 132012China

The yield ratios of neutron-proton(R(n/p))and^(3)H-^(3)He(R(^(3)H∕^(3)He))with reduced rapidity from 0 to 0.5 were simulated at 50 MeV/u even-even ^(36−56)Ca+^(40)Ca,even-even ^(48−78)Ni+^(58)Ni,and ^(100−139)Sn(every third isotopes)+112 Sn for full reduced impact parameters using the isospin-dependent quantum molecular dynamics(IQMD)*** neutron and proton density distributions and root-mean-square radii of the reaction systems were obtained using the Skyrme-Hartree-Fock model,which was used for the phase space initialization of the projectile and target in *** defined the unified neutron skin thickness asΔRnp=^(1∕2) n−^(1∕2)p,which was negative for neutron-deficient *** unifiedΔRnp values for nuclei with the same relative neutron excess from different isotopic chains were nearly equal,except for extreme neutron-rich isotopes,which is a type of scaling *** yield ratios of the three isotopic chain-induced reactions,which depended on the reduced impact parameter and unified neutron skin thickness,were *** results showed that both R(n/p)and R(^(3)H∕^(3)He)decreased with a reduced impact parameter for extreme neutron-deficient isotopes;however,they increased with reduced impact parameters for extreme neutron-rich isotopes,and increased with theΔRnp of the projectiles for all reduced impact *** addition,a scaling phenomenon was observed betweenΔR np and the yield ratios in peripheral colli-sions from different isotopic chain projectiles(except for extreme neutron-rich isotopes).Thus,R(n/p)and R(^(3)H∕^(3)He)from peripheral collisions were suggested as experimental probes for extracting the neutron or proton skin thicknesses of non-extreme neutron-rich nuclei from different isotopic chains.

关键词： Exotic nuclei Unified neutron skin thickness Yield ratios IQMD

Influence of cerium and yttrium addition on strength and electrical conductivity of pure aluminum alloys

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Journal of Rare Earths 2024年第3期42卷 600-611,I0006页

作者： Guojian lin Lu li Zhengwei Guo Xianjun Jia Xiao Wang Zhentao Yuan Guoxing Zhang Yun Zhan Quan shan Zulai li Faculty of Materials Science and Engineering Kunming University of Science and TechnologyKunming650093China Research Center for Analysis and Measurement Kunming University of Science and TechnologyKunming650093China City College Kunming University of Science and TechnologyKunming650051China

To develop pure aluminum alloys with high conductivity and strength, Al-0.2Ce and Al-0.2Ce-0.1Y alloys were prepared by rolling and annealing processes in this study. The effects of trace rare earth elements on the strength and electrical conductivity of the pure aluminum alloys were investigated. It is revealed that the addition of Ce and Y to pure aluminum can effectively enhance the strength and electrical conductivity of the alloys. In Al-0.2Ce, the addition of Ce can effectively refine the grain size of a-Al, with an average grain size of 90.68 μm in the as-cast state. The grain size of the alloy is further reduced to 87.55 μm by the simultaneous addition of Y. The synergistic addition of Ce and Y changes the properties of the alloy. The addition of Ce and Y also produces the Al_(11)Ce_(3) and Al_(3)Y second phases, which have coherent relationship with a-Al. The two-dimensional mismatch degree was calculated to be only 4.43%and 0.85%, respectively, which can provide a certain amount of nucleation substrate for a-Al in the incubation stage. The interfacial match between the L1_(2)structure of Al_(3)Y and a-Al was calculated using first-principles simulations. The results indicate that Al_(3)Y has a strong bonding effect with a-Al. Nanoscale second phases at grain boundaries can be effective in reducing resistivity due to dislocation *** second phases with better matching interfaces to the substrate have no positive effect on the scattering motion of electrons.

关键词： Pure aluminum Rare earths Impurity purification First-principles calculations Strength-conductivity contradiction