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Persistent alterations in gray matter in COVID-19 patients experiencing sleep disturbances:a 3-month longitudinal study

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Neural Regeneration Research 2025年第10期20卷 3013-3024页

作者： Kaixuan Zhou Gaoxiong Duan Ying liu Bei Peng Xiaoyan Zhou lixia Qin lingyan liang Yichen Wei Qingping Zhang Xiaocheng li Haixia Qin Yinqi Lai Yian Lu Yan Zhang Jiazhu Huang Jinli Huang Yinfei Ouyang Bolin Bin Mingming Zhao Jun liu Jianrong Yang Demao deng Guangxi Key Laboratory of Special Biomedicine School of MedicineGuangxi UniversityNanningGuangxi Zhuang Autonomous RegionChina Department of Radiology the People’s Hospital of Guangxi Zhuang Autonomous RegionGuangxi Academy of Medical SciencesNanningGuangxi Zhuang Autonomous RegionChina Department of Sleep Medicine the People’s Hospital of Guangxi Zhuang Autonomous RegionNanningGuangxi Zhuang Autonomous RegionChina Department of Radiology The Second Xiangya HospitalCentral South UniversityChangshaHunan ProvinceChina Guangxi Clinical Research Center for Sleep Medicine the People’s Hospital of Guangxi Zhuang Autonomous RegionNanningGuangxi Zhuang Autonomous RegionChina

Sleep disturbances are among the most prevalent neuropsychiatric symptoms in individuals who have recovered from severe acute respiratory syndrome coronavirus 2 *** studies have demonstrated abnormal brain structures in patients with sleep disturbances who have recovered from coronavirus disease 2019(COVID-19).However,neuroimaging studies on sleep disturbances caused by COVID-19 are scarce,and existing studies have primarily focused on the long-term effects of the virus,with minimal acute phase *** a result,little is known about the pathophysiology of sleep disturbances in the acute phase of *** address this issue,we designed a longitudinal study to investigate whether alterations in brain structure occur during the acute phase of infection,and verified the results using 3-month follow-up data.A total of 26 COVID-19 patients with sleep disturbances(aged 51.5±13.57 years,8 women and 18 men),27 COVID-19 patients without sleep disturbances(aged 47.33±15.98 years,9 women and 18 men),and 31 age-and gender-matched healthy controls(aged 49.19±17.51 years,9 women and 22 men)were included in this *** COVID-19 patients with sleep disturbances were included in a longitudinal *** found that COVID-19 patients with sleep disturbances exhibited brain structural changes in almost all brain *** cortical thicknesses of the left pars opercularis and left precuneus were significantly negatively correlated with Pittsburgh Sleep Quality Index ***,we observed changes in the volume of the hippocampus and its subfield regions in COVID-19 patients compared with the healthy *** 3-month follow-up data revealed indices of altered cerebral structure(cortical thickness,cortical grey matter volume,and cortical surface area)in the frontal-parietal cortex compared with the baseline in COVID-19 patients with sleep *** findings indicate that the sleep disturbances patients had altered morphology in the cortical an

关键词： brain structure cortical gray matter volume cortical surface area cortical thickness hippocampus magnetic resonance imaging Pittsburgh Sleep Quality Index severe acute respiratory syndrome coronavirus 2 infections sleep disturbances sub-cortical volume

2011—2020年广州市肺结核死亡趋势及年龄-时期-队列模型分析

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中国防痨杂志 2025年第1期47卷 44-50页

作者：李雪秋刘群唐科吴迪广州市胸科医院结核病防治所一分所广州510095 广东省生物制品与药物研究所药理研究室广州510440 广州市疾病预防控制中心慢性非传染性疾病预防控制部广州510440 广东医科大学公共卫生学院东莞523808

目的:分析2011—2020年广州市肺结核患者的死亡情况和死亡率变化趋势,为制定防控策略和措施提供科学依据。方法:采用Joinpoint回归模型分析2011—2020年广州市全年龄段人群肺结核死亡率变化趋势,并计算年度变化百分比(annual percent ch... 详细信息

目的:分析2011—2020年广州市肺结核患者的死亡情况和死亡率变化趋势,为制定防控策略和措施提供科学依据。方法:采用Joinpoint回归模型分析2011—2020年广州市全年龄段人群肺结核死亡率变化趋势,并计算年度变化百分比(annual percent change,APC)和平均年度变化百分比(average annual percent change,AAPC);使用年龄-时期-队列模型分析广州市20~85岁人群肺结核死亡风险的年龄、时期和队列效应。结果:广州市2011—2020年报告肺结核死亡患者2144例,年均报告标化死亡率为2.57/10万;男性肺结核标化死亡率为4.19/10万,约为女性标化死亡率(0.96/10万)的4.4倍。10年间广州市肺结核年龄标化死亡率总体呈现下降趋势,AAPC为-4.15%(95%CI:-6.41%~-1.85%,P=0.003);其中,女性肺结核死亡率下降速度高于男性,AAPC分别为-6.72%(95%CI:-10.38%~-2.92%,P=0.004)和-3.55%(95%CI:-6.19%~-0.85%,P=0.017)。在不同年龄段人群中,0~49岁和≥65岁年龄段人群肺结核死亡率均呈现明显下降趋势,AAPC分别为-7.05%(95%CI:-11.52%~-2.34%,P=0.009)和-3.94%(95%CI:-6.22%~-1.62%,P=0.005)。年龄-时期-队列模型的年龄效应显示,随着年龄的增长,肺结核死亡风险不断上升,≥65岁人群尤为显著,发病率由66~67岁年龄组的2.93/10万增长至84~85岁年龄组的6.10/10万。时期效应显示,肺结核死亡风险随着时期的变化总体呈现下降趋势,相对危险度(risk ratio,RR)从2011—2012年时期组的1.35下降至2019—2020年时期组的0.81。队列效应显示,越晚出生的人群肺结核死亡风险越低,RR值从1926—1927年出生队列的5.91降低至1998—1999年出生队列的0.16。结论:广州市肺结核死亡率总体呈不断下降的趋势,但男性和女性肺结核死亡率差距较大。需重点关注男性和≥65岁年龄段的老年人群,并实施针对性的防控和治疗措施。

关键词：结核,肺死亡率回归分析队列研究

Efficacy of Wen-Luo-Tong on Peripheral Neuropathy Induced by Chemotherapy or Target Therapy: A Randomized, Double-Blinded, Placebo-Controlled Trial

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Chinese Journal of Integrative Medicine 2022年第7期28卷 579-585页

作者： deng Bo JIA li-qun WAN Dong-gui WANG Bao-yi CHENG Zhi-qiang deng Chao Center of Science and Technology China-Japan Friendship HospitalBeijing 100029China Integrative Oncology Department of Chinese Medicine and Western Medicine China-Japan Friendship HospitalBeijing 100029China

Objective: To evaluate the efficacy of Wen-Luo-Tong Granules(WLT) local administration in the treatment of patients with peripheral neuropathy(PN) induced by chemotherapy or target therapy. Methods: This study is a randomized, double-blinded, and placebo-controlled trial. Seventy-eight patients with PN induced by chemotherapy or target therapy were enrolled from China-Japan Friendship Hospital between July 2019 and January 2020. They were randomly assigned to WLT(39 cases) and control groups(39 cases) using a block randomization method. The WLT group received WLT(hand and foot bath) plus oral Mecobalamin for 1 week, while the control group received placebo plus oral Mecobalamin. The primary endpoint was PN grade evaluated by the National Cancer Institute-Common Toxicity Criteria for Adverse Events(NCI-CTCAE). The secondary endpoints included quantitative touch-detection threshold, neuropathy symptoms, Quality of life QuestionnaireChemotherapy Induced Peripheral Neuropathy(QLQ-CIPN20), and Quality of life Questionnaire-Core30(QLQ-C30). Results: After treatment, the PN grade in the WLT group was significantly lower than that in the control group(1.00±0.29 vs. 1.75±0.68, P<0.01). The total effective rate in the WLT group was significantly higher than that in the control group(82.05% vs. 51.28%, P<0.01). Compared with the control group, the touchdetection thresholds at fingertips, neuropathy symptom score, QLQ-CIPN 20(sensory scale, motor scale, autonomic scale, and sum score), and QLQ-C30(physical functioning, role functioning, emotional functioning, and global health) in the WLT group significantly improved after treatment(P<0.01 or P<0.05). Conclusion: WLT local administration was significantly effective in the treatment of patients with PN induced by chemotherapy or target therapy.(Trial registration No. ChiCTR1900023862)

关键词： peripheral neuropathy chemotherapy target therapy Chinese medicine Wen-Luo-Tong randomized controlled trial

Warehouse scheduling performance analysis considering LHRL

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Advances in Manufacturing 2013年第2期1卷 136-142页

作者： Wen-Qiang Yang li deng qun Niu Min-Rui Fei Shanghai Key Laboratory of Power Station Automation Technology School of Mechatronics Engineering and AutomationShanghai University

Warehouse scheduling efficiency has to do with the length-height ratio of location （LHRL） to some extent, which hasn＇t been well investigated until now. In this paper a mathematic model is built by analyzing the relation between the travel time of the stacker and LHRL. Mean- while, warehouse scheduling strategy is studied combining with the project on the automatic production line of an enterprise, and a warehouse scheduling strategy is pro- posed based on index of quality （IoQ） parameters. Besides, the process of getting the value of IoQ is also simplified with the idea of sparse matrix. Finally, the IoQ scheduling strategy is compared with random strategy and First Come First Out strategy in different LHRLs. The simulation results show that the IoQ scheduling strategy not only improves the quality of the product effectively, but also improves the efficiency of the scheduling substantially.

关键词： Warehouse scheduling Performance analysisIndex of quality (IoQ) Length-height ratio of location(LHRL) Sparse matrix

编码方式与叙事连贯性调节情绪对时间顺序记忆的影响

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心理学报 2025年第1期57卷 1-17页

作者：夏莲香刘凯歌李新宇叶群浙江师范大学心理学院浙江省儿童青少年心理健康与危机干预智能实验室金华321004 浙江全省智能教育技术与应用重点实验室金华321004

时间顺序信息作为记忆项目之间的重要联结要素之一,易受到情绪的干扰。本研究通过3项实验探究编码方式与叙事连贯性是否以及如何调节情绪对于时间顺序记忆的干扰。实验1采用2(编码方式:叙事编码/离散编码)×3(情绪类型:正性/负性/中性)... 详细信息

时间顺序信息作为记忆项目之间的重要联结要素之一,易受到情绪的干扰。本研究通过3项实验探究编码方式与叙事连贯性是否以及如何调节情绪对于时间顺序记忆的干扰。实验1采用2(编码方式:叙事编码/离散编码)×3(情绪类型:正性/负性/中性)的混合实验设计,其中编码方式为被试间变量,探究编码方式是否能调节图片材料中情绪信息对时间顺序记忆的干扰。结果显示,在离散编码组,负性情绪条件下的时间顺序记忆正确率显著比其他两种条件低;相反,在叙事编码组,三种情绪类型下的时间顺序记忆没有显著差异。实验2采用两种情绪类型(中性和负性)的词语刺激,检验编码方式对时间顺序记忆的影响是否跨材料具有普适性。实验3通过操纵项目之间的叙事连贯性程度,进一步探究上述效应是否依赖于项目间连贯性程度。结果显示,上述叙事编码效应仅在项目之间具有高连贯性时出现。本研究不仅发现了叙事编码对于情绪记忆中时间信息的保持机制,还指明了叙事编码效应中连贯性程度的重要性。

关键词：情绪叙事编码时间记忆情景记忆叙事连贯性

维普期刊数据库博看期刊

Price-based time and energy allocation in cognitive radio multiple access networks with energy harvesting

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Science China(Information Sciences) 2017年第10期60卷 258-260页

作者： Ding XU qun li Wireless Communication Key Lab of Jiangsu Province Nanjing University of Posts and Telecommunications

Cognitive radio(CR),a concept that can solve the conflict between spectrum scarcity and low spectrum utilization,has been researched widely recently[1].There are mainly three CR models:interweave,overlay and underlay[... 详细信息

关键词： CBS Price-based time and energy allocation in cognitive radio multiple access networks with energy harvesting

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西藏阿蠓属两新种(双翅目:蠓科)

四川动物 2004年第4期23卷 317-318页

作者：张有植薛群力邓成玉虞以新成都军区疾病预防控制中心成都610021 军事医学科学院五所六室

本文描述了发现于中国西藏的蠓科阿蠓属昆虫两新种 ,分别命名为钩茎阿蠓 (Alluadomyiarostrata)和双刺阿蠓 (A bispinula)。二新种模式标本保存于军事医学科学院医学昆虫标本馆。

关键词：蠓科模式标本双翅目新种医学昆虫描述发现军事医学科学院命名保存

Digital simulation of 3D turbulence wind field of Sutong Bridge based on measured wind spectra

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Journal of Zhejiang University-Science A(Applied Physics & Engineering) 2012年第2期13卷 91-104页

作者： Hao WANG Zhou-hong ZONG Ai-qun li Teng TONG Jie NIU Wen-ping deng Key Laboratory of Concrete and Prestressed Concrete Structures of Ministry of Education Southeast UniversityNanjing 210096China Key Laboratory of Environmental Impact and Structural Safety in Engineering China University of Mining&TechnologyXuzhou 221116China

Time domain analysis is an essential implement to study the buffeting behavior of long-span bridges for it can consider the non-linear effect which is significant in long-span bridges. The prerequisite of time domain analysis is the accurate description of 3D turbulence winds. In this paper, some hypotheses for simplifying the 3D turbulence simulation of long-span cable-stayed bridges are conducted, considering the structural characteristics. The turbulence wind which is a 3D multivariate stochastic vector process is converted into four independent 1D univariate stochastic processes. Based on recorded wind data from structural health monitoring system (SHMS) of the Sutong Bridge, China, the measured spectra expressions are then presented using the nonlinear least-squares fitting method. Turbulence winds at the Sutong Bridge site are simulated based on the spectral representation method and the Fast Fourier transform (FFT) technique, and the relevant results derived from target spectra including measured spectra and recommended spectra are compared. The reliability and accuracy of the presented turbulence simulation method are validated through comparisons between simulated and target spectra (measured and recommended spectra). The obtained turbulence si-mulations can not only serve further analysis of the buffeting behavior of the Sutong Bridge, but references for structural anti-wind design in adjacent regions.

关键词： Turbulence simulation Spectral representation method Fast Fourier transform (FFT) Cable-stayed bridges Struc-tural health monitoring system (SHMS) Power spectral density

面向远程内存图数据库的应用感知分离式存储设计

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计算机科学 2025年第1期52卷 151-159页

作者：李纯羽邓龙李永坤许胤龙中国科学技术大学计算机科学与技术学院合肥230026 高性能计算安徽省重点实验室合肥230026

图数据在各种应用中日益普及,其因涵盖多种实体类型和存在丰富的关联关系而备受关注.对于图数据库用户而言,高效的图查询服务是保障系统性能的关键因素.随着数据量增加,单机图数据库很难满足将所有数据存储在内存中的需求,而分布式图数... 详细信息

图数据在各种应用中日益普及,其因涵盖多种实体类型和存在丰富的关联关系而备受关注.对于图数据库用户而言,高效的图查询服务是保障系统性能的关键因素.随着数据量增加,单机图数据库很难满足将所有数据存储在内存中的需求,而分布式图数据库在拓展性和资源利用率方面受到挑战.基于RDMA的远程内存系统的引入为克服这些挑战提供了一种新的选择,通过分离计算和存储资源,实现了更为灵活的内存使用方式.然而,在使用远程内存的情况下如何最大程度地优化图查询性能成为了当前研究的重点问题.文中首先分析了利用操作系统分页机制透明使用远程内存构建图数据库存在的问题,并在应用层次上设计了远程内存图数据库的存储模型.根据不同数据的特点和访问模式,设计了属性图在远程内存中的存储结构,优化了数据布局和访问路径.实验结果表明,在本地内存受限的情况下,与透明使用远程内存相比,应用感知的设计方式的端到端性能最高提升了12倍.

关键词：图查询图数据库图存储远程内存属性图模型