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Development of a diagnostic nomogram for alpha-fetoproteinnegative hepatocellular carcinoma based on serological biomarkers

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World Journal of Gastrointestinal Oncology 2024年第6期16卷 2463-2475页

作者： li He Cui Zhang Lan-Lan liu li-ping huang Wen-Jing Lu Yuan-Yuan Zhang De-Yong Zou Yu-Fei Wang Qing Zhang Xiao-li Yang School of Clinical Medicine Weifang Medical UniversityWeifang 261053Shandong ProvinceChina Department of Organ Transplantation The Third Medical Centre of Chinese PLA General HospitalBeijing 100039China Department of Laboratory Medicine The Third Medical Centre of Chinese PLA General HospitalBeijing 100039China Department of Laboratory Medicine Jingyu County People’s HospitalBaishan 135200Jilin ProvinceChina School of Laboratory Medicine Weifang Medical UniversityWeifang 261053Shandong ProvinceChina

BACKGROUND Hepatocellular carcinoma(HCC)is the third leading cause of cancer-related death *** biomarkers play an important role in the early diagnosis and prognosis of *** a certain percentage of HCC patients are negative for alpha-fetoprotein(AFP),the diagnosis of AFP-negative HCC is essential to improve the detection rate of *** To establish an effective model for diagnosing AFP-negative HCC based on serum tumour *** A total of 180 HCC patients were enrolled in this *** expression levels of GP73,des-γ-carboxyprothrombin(DCP),CK18-M65,and CK18-M30 were detected by a fully automated chemiluminescence *** variables were selected by logistic regression *** models were constructed using stepwise backward logistic *** performance of the models was compared using the C statistic,integrated discrimination improvement,net reclassification improvement,and calibration *** clinical utility of the nomogram was assessed using decision curve analysis(DCA).RESULTS The results showed that the expression levels of GP73,DCP,CK18-M65,and CK18-M30 were significantly greater in AFP-negative HCC patients than in healthy controls(Plity(area under the curve=0.946)and good goodness of *** DCA curves indicated the good clinical utility of the *** Our study identified GP73 and CK18-M65 as serum biomarkers with certain application value in the diagnosis of AFP-negative *** diagnostic nomogram based on CK18-M65 combined with GP73 demonstrated good performance and effectively identified high-risk groups of patients with HCC.

关键词： Hepatocellular carcinoma Alpha-fetoprotein-negative Diagnostic Nomogram Biomarker

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Small modifications of endo-functionalized cavities lead to large changes in molecular interaction in water

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Science China Chemistry 2024年

作者： Song-Meng Wang Hao Nian Yan-Fang Wang li-Shuo Zheng Yu-Tao Zheng Yi-Wei Dong li-ping huang Xiao-ping Wang Wei Jiang liu-Pan Yang Department of Chemistry Southern University of Science and Technology School of Chemistry and Pharmaceutical Sciences State Key Laboratory for Chemistry and Molecular Engineering of Medicinal Resources Guangxi Normal University School of Pharmaceutical Science Hengyang Medical School University of South China

Studying molecular recognition in aqueous environments is crucial for understanding biological processes. Herein, we present a series of N-doped endo-functionalized anthracene-based cavities by introducing inward-directed pyridine units. The subtle modifications can significantly affect the binding properties of these receptors, which is similar to the mutations in biological systems. Combining theoretical calculations and molecular recognition experiments demonstrated that these “mutations” have an impact on the hydrophobicity and charge distribution of the hosts, consequently significantly influencing molecular *** is crucial for understanding the intricate mechanisms of molecular-level interactions in biological receptors.

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Diameter Preserving Surjection on Alternate Matrices

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Acta Mathematica Sinica,English Series 2009年第9期25卷 1517-1528页

作者： li ping huang School of Mathematics and Computing Science Changsha University of Science and Technology Changsha 410076 China

Let F be a field with ｜F｜ ≥ 3, Km be the set of all m × m （m ≥ 4） alternate matrices over F. The arithmetic distance of A, B ∈ Km is d（A, B）：= rank（A - B）. If d（A, B） = 2, then A and B are said to be a... 详细信息

Let F be a field with ｜F｜ ≥ 3, Km be the set of all m × m （m ≥ 4） alternate matrices over F. The arithmetic distance of A, B ∈ Km is d（A, B）：= rank（A - B）. If d（A, B） = 2, then A and B are said to be adjacent. The diameter of Km is max{d（A, B）： A, B ∈ km}. Assume that φ ： Km→Km is a map. We prove the following are equivalent：（a） φ is a diameter preserving surjection in both directions, （b） φ is both an adjacency preserving surjection and a diameter preserving map, （c） φ is a bijective map which preserves the arithmetic distance.

关键词： geometry of matrices alternate matrix arithmetic distance adjacency diameter

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Adjacency Preserving Bijection Maps of Hermitian Matrices over any Division Ring with an Involution

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Acta Mathematica Sinica,English Series 2007年第1期23卷 95-102页

作者： li ping huang School of Mathematics Changsha University of Science & Technology Changsha 410076 P. R. China

Let D be any division ring with an involution,Hn （D） be the space of all n × n hermitian matrices over D. Two hermitian matrices A and B are said to be adjacent if rank（A - B） = 1. It is proved that if φ is a bijective map from Hn（D）（n ≥ 2） to itself such that φ preserves the adjacency, then φ^-1 also preserves the adjacency. Moreover, if Hn（D） ≠J3（F2）, then φ preserves the arithmetic distance. Thus, an open problem posed by Wan Zhe-Xian is answered for geometry of symmetric and hermitian matrices.

关键词： division ring with involution hermitian inatrix adjacency geometry of matrices

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Geometry of Rectangular Block Triangular Matrices

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Acta Mathematica Sinica,English Series 2009年第12期25卷 2035-2054页

作者： li ping huang Su Wen ZOU School of Mathematics and Computing Science Changsha University of Science and Technology Changsha 410076 P. R. China liuzhou Senior High School Liuzhou 545006 P. R. China

Let D be any division ring, and let T（mi,ni,k） be the set of k × k （k ≥ 2） rectangular block triangular matrices over D. For A, B ∈ T（mi,ni,k）, if rank（A - B） = 1, then A and B are said to be adjacent and denoted by A -B. A map T ： T（mi,ni,k） -〉 T（mi,ni,k） is said to be an adjacency preserving map in both directions if A - B if and only if φ（A） φ（B）. Let G be the transformation group of all adjacency preserving bijections in both directions on T（mi,ni,k）. When m1,nk ≥ 2, we characterize the algebraic structure of G, and obtain the fundamental theorem of rectangular block triangular matrices over D.

关键词： geometry of matrices triangular matrix adjacency preserving maximal set

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A survey of high risk factors affecting retinopathy in full-term infants in China

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International Journal of Ophthalmology(English edition) 2012年第2期5卷 177-180页

作者： li-Na Chen Xiao-ping He and li-ping huang Department of Ophthalmology Boai Hospital of Zhongshan Zhongshan 528000 Guangdong Province China

AIM: To investigate the possible relationship between the influencing factors occurring before and during birth in full-term infants and the outcome of retinopathy. METHODS: Totally 816 full-term infants admitted in the neonate intensive unit of Boai Hospital of Zhongshan between 1 May, 2008 and 30 June, 2011 were included in the study. Fundus examination was performed and evaluated individually on them at the age of 48 hours after delivery, 2 weeks and 1 month. Some possible risk factors happening prenatally or during delivery such as pregnant related hypertension, placenta previa, placental abruption etc, as well as some neonatal risk factors such as neonatal asphyxia, hypoxic-ischemic encephalopathy (HIE), low birth weight etc, were recorded and evacuated. Then the effect of the risk factors of full-term infants on retinopathy was studied. RESULTS: The incidence of retinal hemorrhage of full-term infants with prenatal pregnant related hypertension (PRH) of the mother (43.6%) was significantly higher than that of full-term infants without (8.0%). (P<0.001). The incidence of retinal hemorrhage of full-term infants with neonatal asphyxia and /or hypoxic-ischemic encephalopathy (HIE)(29.3%) was significantly higher than that of those without (15.7%), but correlation was not found between the severity of retina hemorrhage and the degree of hypoxic disease. A pale color of optic disc was associated with a low birth weight of full-term infant. Full-term infants with birth weigh-less than 2500g had a significant higher incidence of retinopathy than those with birth weight equal or more than 2500g( P<0.001). CONCLUSION: The main influencing factors which lead to retinopathy of high risk full-term infants are prenatal factors such as PRH, and some neonatal risk factors such as asphyxia, hypoxic-ischemic encephalopathy, and low birth weight.

关键词： full-term infant high risk factor retinopathy

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Competitive adsorption and mobility sequence of heavy metals in urban soils of southeastern China

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Journal of Environmental Sciences 2006年第2期18卷 329-333页

作者： ZHANG Ming-kui FANG li-ping huang Chang-yong Department of Natural Resource Sciences College of Natural Resource and Environmental Sciences Zhejiang University Hangzhou 310029 China

Heavy metals can be introduced into urban soils at the same time. Therefore, their selective retention and competitive adsorption by the soils become of major importance in determining their availability and movement throughout the soil. In this study, the availability and mobility of six heavy metals in eight urban soils collected from different cities of Zhejiang Province, southeastern China were assessed using distribution coefficients（Kd） and retardation factor（Rf）. The results showed that there were great differences in the Kd and Rfamong the tested soils. The adsorption sequences were Cr〉Pb〉Cu〉Cd〉Zn〉Ni, and the Kd decreased with increasing levels of metal addition. Ni generally has the lowest Rf values followed closely by Cd, and Zn whereas Cr and Pb reached the highest values. The results suggest that Ni and Zn have the highest mobility associated to the lowest adsorption, Cr and Pb present the opposite behavior. Correlation analysis indicates that soil pH, CaCO3 content, and cation exchange capacity （CEC） are key factors controlling the solubility and mobility of the metals in the urban soils.

关键词： competitive adsorption mobility sequence heavy metal urban soil

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A technique for periorbital syringomas: intralesional radiofrequency ablation

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International Journal of Ophthalmology(English edition) 2012年第2期5卷 181-185页

作者： li-ping huang, Bi-Weng lin Department of Physical Therapy Chinese PLA General Hospital Beijing 100853 China Department of Physical Therapy Traditional Chinese Medical Hospital of Dalian Dalian 116013 Shandong Province China Department of Ophthalmology Chinese PLA General Hospital Beijing 100853 China Department of Dermatology Chinese PLA General Hospital Beijing 100853 China

AIM: To evaluate the efficacy of intralesional radiofrequency ablation in the treatment of periorbital syringomas. METHODS: We tried the intralesional radiofrequency ablation for 64 patients with periorbital syringomas from 2007 to 2011. The operation was performed under 2.5 loupe magnifications. The handpiece was assembled with a needle electrode and connected to the radiofrequency ablation apparatus. The electrode was then inserted into the target lesions in dermis and delivering injury to the base of these tumors. Results were assessed clinically by comparing pre- and post-treatment photographs and patient satisfaction rates. RESULTS: Clinical improvement increased with each subsequent treatment session. The percent of patients whose clinic improvement grade were >= 3 after each session was respectively 71.9% (Session1), 83.3% (Session2), and 100% (Session3). The statistical results indicated the concordance of the clinical assessment and the satisfaction level of patients (kappa=0.78 of the session1; kappa=0.82 of the session2). The majority of patients had good or excellent cosmetic results. Postoperatively, there were no permanent side effects or recurrences. CONCLUSION: As a new technique of minimally invasion, the intralesional radiofrequency ablation was found to be an effective, inexpensive, highly precise and safe way of treating periorbital syringomas.

关键词： periorbital syringomas radiofrequency ablation treatment

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Investigation of the cross-reaction mechanism of C_6H_5F-HNO_2 aqueous solution irradiated at 355 nm by transient absorbance spectrum technique

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Chinese Science Bulletin 2008年第7期53卷 998-1003页

作者： ZHANG RenXi SHEN Yan li ping huang li DONG WenBo HOU HuiQi Institute of Environmental Science Fudan University Shanghai 200433 China

The transient absorption spectrum technique was employed to investigate the cross-reaction mecha-nism of C6H5F-HNO2 aqueous solution irradiated at 355 nm. The characteristic and the kinetic parame-ters of transient species were also detected. Hydroxyl radical derived from the photolysis of HNO2 was added to monofluorobenzene with a second-order rate constant of (5.83±0.17)×109 L·mol-1·s-1 to form an adduct, C6H5F···OH, which was able to react with HNO2 as the main reaction pathway with a rate constant of (8.3±0.1)×107 L·mol-1·s-1. The C6F6···OH adduct can also be decayed by elimination of H2O to yield monofluorophenyl radical C6H4F·. By GC-MS technique, the final products were identified to be monofluorophenol, nitro-monofluorobenzene, nitro-monofluorophenol and para-fluorobiphenyl.

关键词：溶液作用瞬变现象吸收率光谱学

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Coupling effect of cement-stabilization and biopolymer-modification on the mechanical behavior of dredged sediment

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Journal of Rock Mechanics and Geotechnical Engineering 2024年第8期16卷 3284-3298页

作者： Lei Lang Jiangshan li Xiao huang ping Wang Wei Zhang State Key Laboratory of Geomechanics and Geotechnical Engineering Institute of Rock and Soil MechanicsChinese Academy of SciencesWuhan430071China Hubei Provincial Key Laboratory of Contaminated Sludge and Soil Science and Engineering Wuhan430071China University of Chinese Academy of Sciences Beijing100049China

Nowadays,biopolymer stabilization as a promising eco-friendly approach in soft ground improvement has attracted wide ***,the feasibility of using biopolymer as a green additive of cementstabilized dredged sediment(CDS)with high water content is still *** this study,guar gum(GG)and xanthan gum(XG)were adopted as typical biopolymers,and a series of unconfined compressive strength(UCS),splitting tensile strength(STS)and scanning electron microscopy(SEM)tests were performed to evaluate the mechanical and microstructural properties of XG-and GG-modified CDSs considering several factors including biopolymer modification,binderesoil ratio and wateresolid ***,the micro-mechanisms revealing the evolutions of mechanical properties of biopolymermodified CDS were *** results indicate that the addition of XG can effectively improve the strength of CDS,while the GG has a side *** XG content of 9%was recommended,which can improve the 7 d-and 28 d-UCSs by 196%and 51.8%,together with the 7 d-and 28 d-STSs by 118.3%and 42.2%,*** the binderesoil ratio or decreasing the wateresolid ratio significantly improved the strength gaining but aggravated the brittleness characteristics of *** XG to CDS contributed to the formation of microstructure with more compactness and higher cementation degrees of ordinary Portland cement(OPC)-XG-stabilized DS(CXDS).The micro-mechanism models revealing the interactions of multiple media including OPC cementation,biopolymer film bonding and bridging effects inside CXDS were *** key findings confirm the feasibility of XG modification as a green and high-efficiency mean for improving the mechanical properties of CDS.

关键词： Dredged sediment(DS) Stabilization Biopolymer modification Mechanical properties Micro-mechanism

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